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1. 发明申请

WO2006014758A3 ION SENSOR FOR LONG TERM USE IN COMPLEX MEDIUM 审中-公开
标题翻译：离子传感器长时间使用复合介质
公开(公告)号：WO2006014758A3
公开(公告)日：2007-09-13
申请号：PCT/US2005025775
申请日：2005-07-20
申请人： MEDTRONIC INC , QINGSHAN YE
发明人： QINGSHAN YE
IPC分类号： G01N27/333 , A61B5/00
CPC分类号： A61B5/14542 , A61B5/14546 , A61B5/1473
摘要： Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
摘要翻译：用于测量目标离子浓度的装置和方法使用电极对。该对包括工作电极和参考电极。工作电极和参比电极是离子选择电极（ISE）。参考ISE可以包括钠ISE。 ISE对与体液相互作用，其中目标离子浓度随时间而变化超过钠离子浓度。一对一对ISE膜基本上仅在离子载体中变化。 ISE对可以确定目标离子浓度与体内钠离子浓度之比。抽取血液中钠浓度的定期测定可用于校准ISE对，并提供目标离子浓度作为输出。或者，在心脏或肾衰竭患者中，钾/钠ISE对有效地监测钾浓度随时间的变化。然后，可以实施手动或自动滴定利尿剂材料以维持所需的钾浓度。

2. 发明申请

WO2006014758A9 ION SENSOR FOR LONG TERM USE IN COMPLEX MEDIUM 审中-公开
标题翻译：离子传感器长期用于复杂介质
公开(公告)号：WO2006014758A9
公开(公告)日：2006-03-23
申请号：PCT/US2005025775
申请日：2005-07-20
申请人： MEDTRONIC INC , QINGSHAN YE
发明人： QINGSHAN YE
IPC分类号： G01N27/333 , A61B5/00
CPC分类号： A61B5/14542 , A61B5/14546 , A61B5/1473
摘要： Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
摘要翻译：用于测量目标离子浓度的装置和方法使用电极对。这一对包括一个工作电极和一个参考电极。工作电极和参比电极是离子选择电极（ISE）。参考ISE可以包括钠ISE。 ISE对与目标离子浓度随时间变化超过钠离子浓度的体液相互作用。一对中的一些ISE膜基本上仅在离子载体中变化。 ISE对可以确定体内靶离子浓度与钠离子浓度的比率。抽取血液中钠浓度的定期测量可用于校准ISE对并提供目标离子浓度作为输出。或者，钾/钠ISE对有利地监测心衰或肾衰竭患者的钾浓度随时间的变化。然后，可以实施手动或自动滴定利尿剂材料以维持所需的钾浓度。

3. 发明申请

WO2006014758A2 ION SENSOR FOR LONG TERM USE IN COMPLEX MEDIUM 审中-公开
标题翻译：离子传感器长时间使用复合介质
公开(公告)号：WO2006014758A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/025775
申请日：2005-07-20
申请人： MEDTRONIC, INC. , QINGSHAN, Ye
发明人： QINGSHAN, Ye
IPC分类号： G01N27/333 , A61B5/00
CPC分类号： A61B5/14542 , A61B5/14546 , A61B5/1473
摘要： Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
摘要翻译：用于测量目标离子浓度的装置和方法使用电极对。该对包括工作电极和参考电极。工作电极和参比电极是离子选择电极（ISE）。参考ISE可以包括钠ISE。 ISE对与体液相互作用，其中目标离子浓度随时间而变化超过钠离子浓度。一对一对ISE膜基本上仅在离子载体中变化。 ISE对可以确定目标离子浓度与体内钠离子浓度之比。抽取血液中钠浓度的定期测定可用于校准ISE对，并提供目标离子浓度作为输出。或者，在心脏或肾衰竭患者中，钾/钠ISE对有效地监测钾浓度随时间的变化。然后，可以实施手动或自动滴定利尿剂材料以维持所需的钾浓度。

4. 发明授权

US08958891B2 Reinforced suture sleeve 有权
标题翻译：加强缝合套管
公开(公告)号：US08958891B2
公开(公告)日：2015-02-17
申请号：US12833061
申请日：2010-07-09
申请人： Larry Kane , Qingshan Ye
发明人： Larry Kane , Qingshan Ye
IPC分类号： A61N1/00 , A61N1/05
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/057 , A61N1/059 , A61N2001/0582
摘要： A reinforced suture sleeve designed to cover and protect a medical lead from physical damage resulting from an over tightened suture is described. The reinforced suture sleeve comprises a metallic tubular insert with at least one slot that cut through the surface of the insert in a spiraled pattern. A biocompatible and pliable polymeric body is molded over the insert. The spiraled cut slot in the metallic tubular insert provides flexibility without degrading structural integrity. An alternate embodiment comprises a polymeric body provided with an embedded fiber mesh made of polymeric fibers, metallic fibers or combinations thereof. The fiber mesh prevents an over tightened suture from cutting through the suture sleeve and damaging the medical lead.
摘要翻译：描述了一种设计用于覆盖和保护医疗用铅的增强缝合套筒免受由过紧的缝合引起的物理伤害。加强缝合套筒包括具有至少一个槽的金属管状插入件，其以螺旋形图案穿过插入件的表面。在插入物上模制生物相容且柔韧的聚合物体。金属管状插入件中的螺旋切割槽提供了灵活性，而不降低结构完整性。另一个实施方案包括聚合物主体，其设置有由聚合物纤维，金属纤维或其组合制成的嵌入的纤维网。纤维网防止过紧的缝合线穿过缝合套筒并损坏医用引线。

5. 发明授权

US08109908B1 Biodegradable shroud for a dilator/sheath assembly 有权
标题翻译：用于扩张器/护套组件的可生物降解护罩
公开(公告)号：US08109908B1
公开(公告)日：2012-02-07
申请号：US12357732
申请日：2009-01-22
申请人： Mark C. Kraus , Qingshan Ye
发明人： Mark C. Kraus , Qingshan Ye
IPC分类号： A61M5/178
CPC分类号： A61M29/00 , A61L29/148 , A61M25/0009 , A61M25/0045 , A61M25/0662 , A61M2025/0687
摘要： An introducer assembly includes a sheath and a dilator. A biodegradable shroud covers the distal portion of the introducer assembly on the surface of both the sheath and the dilator. The biodegradable shroud dissolves in blood after being exposed for a predetermined time. Afterwards, the dilator can be separated from the sheath without breaking the sheath. The shroud improves movement of the introducer assembly through a venous system by preventing body tissue from getting caught in the space between the dilator and the shroud, for example should a “fish mouth” separation occur between them.
摘要翻译：导引器组件包括护套和扩张器。可生物降解的护罩覆盖导管器组件在护套和扩张器的表面上的远端部分。暴露于预定时间后，可生物降解的护罩溶解于血液中。之后，扩张器可以与护套分离，而不破坏护套。护罩通过防止身体组织被捕获在扩张器和护罩之间的空间中来改善导引器组件通过静脉系统的运动，例如在它们之间发生“鱼嘴”分离。

6. 发明授权

US08108042B1 Capacitor and inductor elements physically disposed in series whose lumped parameters are electrically connected in parallel to form a bandstop filter 有权
公开(公告)号：US08108042B1
公开(公告)日：2012-01-31
申请号：US13273658
申请日：2011-10-14
申请人： Robert Shawn Johnson , Kishore Kumar Kondabatni , Christopher Michael Williams , Ryan Thomas Bauer , Scott Brainard , Qingshan Ye , Warren S. Dabney , Robert A. Stevenson , Jeff Fleigle , Holly Noell Moschiano
发明人： Robert Shawn Johnson , Kishore Kumar Kondabatni , Christopher Michael Williams , Ryan Thomas Bauer , Scott Brainard , Qingshan Ye , Warren S. Dabney , Robert A. Stevenson , Jeff Fleigle , Holly Noell Moschiano
IPC分类号： A61N1/00
CPC分类号： H01F27/027 , A61N1/086 , A61N1/3718 , A61N1/3754 , H01F27/40 , H01F2017/065 , H01G4/40 , H03H1/0007 , H03H7/0115 , H03H2001/0042 , H03H2007/013
摘要： One or more inductors and one or more capacitors are physically disposed relative to one another in series and are electrically connected to one another in parallel to form a bandstop filter. Chip inductors and chip capacitors having spaced apart conductive terminals are physically arranged in end-to-end abutting relation to minimize electrical potential between adjacent conductive terminals. The bandstop filter may be hermetically sealed within a biocompatible container for use with an implantable lead or electrode of a medical device. The values of the inductors and the capacitors are selected such that the bandstop filter is resonant at one or more selected frequencies, such as an MRI pulsed frequency.

7. 发明授权

US07920916B2 Capacitor and inductor elements physically disposed in series whose lumped parameters are electrically connected in parallel to form a bandstop filter 有权
标题翻译：电容器和电感器元件物理地串联布置，其集总参数并联电连接以形成带阻滤波器
公开(公告)号：US07920916B2
公开(公告)日：2011-04-05
申请号：US12795190
申请日：2010-06-07
申请人： Robert Shawn Johnson , Kishore Kumar Kondabatni , Christopher Michael Williams , Ryan Thomas Bauer , Scott Brainard , Qingshan Ye , Warren S. Dabney , Robert A. Stevenson , Jeff Fleigle , Holly Noelle Moschiano
发明人： Robert Shawn Johnson , Kishore Kumar Kondabatni , Christopher Michael Williams , Ryan Thomas Bauer , Scott Brainard , Qingshan Ye , Warren S. Dabney , Robert A. Stevenson , Jeff Fleigle , Holly Noelle Moschiano
IPC分类号： A61N1/00
CPC分类号： H01F27/027 , A61N1/086 , A61N1/3718 , A61N1/3754 , H01F27/40 , H01F2017/065 , H01G4/40 , H03H1/0007 , H03H7/0115 , H03H2001/0042 , H03H2007/013
摘要： One or more inductors and one or more capacitors are physically disposed relative to one another in series and are electrically connected to one another in parallel to form a bandstop filter. Chip inductors and chip capacitors having spaced apart conductive terminals are physically arranged in end-to-end abutting relation to minimize electrical potential between adjacent conductive terminals. The bandstop filter may be hermetically sealed within a biocompatible container for use with an implantable lead or electrode of a medical device. The values of the inductors and the capacitors are selected such that the bandstop filter is resonant at one or more selected frequencies, such as an MRI pulsed frequency.
摘要翻译：一个或多个电感器和一个或多个电容器彼此相互物理地布置并且彼此并联电连接以形成带阻滤波器。具有间隔开的导电端子的片式电感器和片式电容器以端对端邻接的方式物理地布置，以使相邻的导电端子之间的电位最小化。带阻滤波器可以气密地密封在生物相容性容器内，以与医疗装置的可植入引线或电极一起使用。选择电感器和电容器的值，使得带阻滤波器在一个或多个选定的频率（例如MRI脉冲频率）下共振。

8. 发明申请

US20110009935A1 Reinforced Suture Sleeve 有权
标题翻译：加强缝合套管
公开(公告)号：US20110009935A1
公开(公告)日：2011-01-13
申请号：US12833061
申请日：2010-07-09
申请人： Larry Kane , Qingshan Ye
发明人： Larry Kane , Qingshan Ye
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/057 , A61N1/059 , A61N2001/0582
摘要： A reinforced suture sleeve designed to cover and protect a medical lead from physical damage resulting from an over tightened suture is described. The reinforced suture sleeve comprises a metallic tubular insert with at least one slot that cut through the surface of the insert in a spiraled pattern. A biocompatible and pliable polymeric body is molded over the insert. The spiraled cut slot in the metallic tubular insert provides flexibility without degrading structural integrity. An alternate embodiment comprises a polymeric body provided with an embedded fiber mesh made of polymeric fibers, metallic fibers or combinations thereof. The fiber mesh which an over tightened suture from cutting through the suture sleeve and damaging the medical lead.
摘要翻译：描述了一种设计用于覆盖和保护医疗用铅的增强缝合套筒免受由过紧的缝合引起的物理伤害。加强缝合套筒包括具有至少一个槽的金属管状插入件，其以螺旋形图案穿过插入件的表面。在插入物上模制生物相容且柔韧的聚合物体。金属管状插入件中的螺旋切割槽提供了灵活性，而不降低结构完整性。另一个实施方案包括聚合物主体，其设置有由聚合物纤维，金属纤维或其组合制成的嵌入的纤维网。纤维网，其过度紧固的缝合线从切割穿过缝合套筒并损坏医用引线。

9. 发明申请

US20100231327A1 CAPACITOR AND INDUCTOR ELEMENTS PHYSICALLY DISPOSED IN SERIES WHOSE LUMPED PARAMETERS ARE ELECTRICALLY CONNECTED IN PARALLEL TO FORM A BANDSTOP FILTER 有权
标题翻译：串联电容器和电感器元件在串联中被电连接并且并联连接到一个带状过滤器
公开(公告)号：US20100231327A1
公开(公告)日：2010-09-16
申请号：US12795190
申请日：2010-06-07
申请人： Robert Shawn Johnson , Kishore Kumar Kondabatni , Christopher Michael Williams , Ryan Thomas Bauer , Scott Brainard , Qingshan Ye , Warren S. Dabney , Robert A. Stevenson , Jeff Fleigle , Holly Noelle Moschiano
发明人： Robert Shawn Johnson , Kishore Kumar Kondabatni , Christopher Michael Williams , Ryan Thomas Bauer , Scott Brainard , Qingshan Ye , Warren S. Dabney , Robert A. Stevenson , Jeff Fleigle , Holly Noelle Moschiano
IPC分类号： H03H7/01
CPC分类号： H01F27/027 , A61N1/086 , A61N1/3718 , A61N1/3754 , H01F27/40 , H01F2017/065 , H01G4/40 , H03H1/0007 , H03H7/0115 , H03H2001/0042 , H03H2007/013
摘要： One or more inductors and one or more capacitors are physically disposed relative to one another in series and are electrically connected to one another in parallel to form a bandstop filter. Chip inductors and chip capacitors having spaced apart conductive terminals are physically arranged in end-to-end abutting relation to minimize electrical potential between adjacent conductive terminals. The bandstop filter may be hermetically sealed within a biocompatible container for use with an implantable lead or electrode of a medical device. The values of the inductors and the capacitors are selected such that the bandstop filter is resonant at one or more selected frequencies, such as an MRI pulsed frequency.
摘要翻译：一个或多个电感器和一个或多个电容器彼此相互物理地布置并且彼此并联电连接以形成带阻滤波器。具有间隔开的导电端子的片式电感器和片式电容器以端对端邻接的方式物理地布置，以使相邻的导电端子之间的电位最小化。带阻滤波器可以气密地密封在生物相容性容器内，以与医疗装置的可植入引线或电极一起使用。选择电感器和电容器的值，使得带阻滤波器在一个或多个选定的频率（例如MRI脉冲频率）下共振。

10. 发明申请

US20100114281A1 MRI CONDITIONALLY SAFE LEAD EXTENSION AND METHODS 审中-公开
标题翻译： MRI条件安全引线延伸和方法
公开(公告)号：US20100114281A1
公开(公告)日：2010-05-06
申请号：US12610585
申请日：2009-11-02
申请人： John M. SWOYER , Qingshan YE
发明人： John M. SWOYER , Qingshan YE
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61N1/0539 , A61N1/0551 , A61N1/086 , H03H1/0007 , H03H7/1766
摘要： Lead extensions, systems, and methods providing MRI compatible deep brain stimulation (DBS) and spinal cord stimulation (SCS) systems are described. Lead extensions are provided having band stop filters (BSFs) which resonate at a frequency expected from MRI systems to create a very high impedance which can effectively decouple the implanted lead from the lead extension proximal of the BSF and change the effective length. Changing the effective length can reduce the likelihood of undesirably heating tissue near the DBS/SCS electrodes during MRI. Some lead extensions include BSFs in a distal connector for coupling to the lead contacts. The BSFs can be included within a burr hole cap base which can also include a connector for connecting to the DBS lead. DBS and SCS leads having a sacrificial proximal portion and intermediate electrical contacts are also provided.
摘要翻译：描述了提供MRI兼容的深部脑刺激（DBS）和脊髓刺激（SCS）系统的引线扩展，系统和方法。提供引线延伸器具有以从MRI系统预期的频率谐振的带阻滤波器（BSF），以产生非常高的阻抗，其可以有效地将注入的引线与BSF的近端的引线延伸分离并改变有效长度。改变有效长度可以降低在MRI期间不利地加热DBS / SCS电极附近的组织的可能性。一些引线延伸部分包括用于连接到引线触点的远端连接器中的BSF。 BSF可以包括在钻孔盖底座内，还可以包括用于连接到DBS导线的连接器。还提供了具有牺牲近端部分和中间电触头的DBS和SCS引线。

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