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    • 7. 发明授权
    • Splittable valved introducer apparatus
    • 可分离阀门导引装置
    • US07993305B2
    • 2011-08-09
    • US12603596
    • 2009-10-22
    • Qingshan YeAaron Opbroek
    • Qingshan YeAaron Opbroek
    • A61M5/178
    • A61M25/0668
    • An improved splittable medical device introducer designed to introduce a medical device such as a lead or catheter, into a patient's vasculature without loss of blood or the introduction of air is described. The introducer assembly is designed to easily separate in a smooth tactile manner without disrupting placement of the medical device during removal of the introducer. The introducer is composed of a fluoropolymeric material which combined with an internal stress confining structure propagates a stress initiated by the operator that tears the entire introducer assembly in two without creating a jagged separated edge.
    • 描述了一种改进的可分开的医疗装置引导器,其被设计成将诸如引线或导管的医疗装置引入患者的脉管系统中而不会损失血液或引入空气。 导引器组件设计成容易地以平滑的触觉方式分离,而不会在移除导引器期间中断医疗装置的放置。 引导器由含氟聚合物材料组成,其与内部应力限制结构组合,传播由操作者发起的应力,其将两个整个导引器组件撕裂而不产生锯齿状的分离边缘。
    • 8. 发明申请
    • Implantable Medical Lead Having Coil Electrode
    • 具有线圈电极的可植入医用铅
    • US20080147158A1
    • 2008-06-19
    • US11956724
    • 2007-12-14
    • Jeffrey ZweberJesse GeroyQingshan Ye
    • Jeffrey ZweberJesse GeroyQingshan Ye
    • A61N1/05
    • A61N1/056A61N1/0534A61N1/0551A61N1/0563
    • Medical electrical leads including coil electrodes having polymeric material between but not over the coil turns. Some leads can be used for neurological sensing and/or stimulation applications. The coil electrodes are more flexible, bendable, and stretchable relative to corresponding cylindrical band electrodes. The polymer fill between the coil turns provides more column strength than coil electrodes having empty space between the coil turns. Some leads have a lumen for receiving stiffening members while others do not have such lumens. An introducer needle can be used to introduce a steerable sheath containing the lead. The sheath and lead can be advanced to near the target site and the sheath removed. The present invention can be used to advantage in peripheral nerve and other applications. Some leads are made by masking the coil electrode outer surface with heat shrink material and filling the coil inter-strand regions with polymer.
    • 医用电引线包括线圈电极,其具有聚合材料,但不超过线圈匝。 一些引线可用于神经感觉和/或刺激应用。 线圈电极相对于相应的圆柱形带状电极更灵活,可弯曲和可拉伸。 线圈之间的聚合物填充提供比在线圈匝之间具有空白空间的线圈电极更多的柱强度。 一些引线具有用于接收加强构件的内腔,而其他导线不具有这样的腔。 导引针可用于引入含有铅的可导向护套。 护套和铅可以前进到目标位置附近,鞘被去除。 本发明可以用于周围神经和其他应用中。 通过用热收缩材料掩蔽线圈电极外表面并用聚合物填充线圈股间区域来制造一些引线。
    • 10. 发明申请
    • Ion sensor for long term use in complex medium
    • 离子传感器长期在复杂介质中使用
    • US20060025748A1
    • 2006-02-02
    • US10903377
    • 2004-07-30
    • Qingshan Ye
    • Qingshan Ye
    • A61M31/00A61B5/05
    • A61B5/14542A61B5/14546A61B5/1473
    • Devices and methods for measuring a target ion concentration uses an electrode pair. The pair includes a working electrode and a reference electrode. The working and reference electrodes are ion-selective electrodes (ISEs). The reference ISE can include a sodium ISE. The ISE pair interacts with body fluids where a target ion concentration changes more than sodium ion concentration over time. Some ISE membranes of a pair vary essentially only in the ionophore. An ISE pair can determine the ratio of a target ion concentration to sodium ion concentration in vivo. Periodic measurement of sodium concentration in drawn blood can be used to calibrate an ISE pair and provide target ion concentration as an output. Or, a potassium/sodium ISE pair beneficially monitors potassium concentration changes over time in heart- or kidney-failure patients. Then, manual or automatic titration of a diuretic material can be implemented to maintain a desired potassium concentration.
    • 用于测量目标离子浓度的装置和方法使用电极对。 该对包括工作电极和参考电极。 工作电极和参比电极是离子选择电极(ISE)。 参考ISE可以包括钠ISE。 ISE对与体液相互作用,其中目标离子浓度随时间而变化超过钠离子浓度。 一对一对ISE膜基本上仅在离子载体中变化。 ISE对可以确定目标离子浓度与体内钠离子浓度之比。 抽取血液中钠浓度的定期测定可用于校准ISE对,并提供目标离子浓度作为输出。 或者,在心脏或肾衰竭患者中,钾/钠ISE对有效地监测钾浓度随时间的变化。 然后,可以实施手动或自动滴定利尿剂材料以维持所需的钾浓度。