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1. 发明专利

AU2005270092A1 Method of producing fully carbamylated erythropoietin 未知
公开(公告)号：AU2005270092A1
公开(公告)日：2006-02-09
申请号：AU2005270092
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , QIAO WEN XIE , CERAMI ANTHONY , CARLA HAND
发明人： BRINES MICHAEL
IPC分类号： A61K38/00 , C07K14/505
摘要： The present invention relates to a method of carbamylating an erythropoietin such that the resulting carbamylated erythropoietin has less that about 10% free primary amines on the lysines and the N-terminal amino acids, is not digested when exposed to Lys-C proteolysis, exhibits no erythropoietic activity in a TF-1 or UT-7/EPOR cell viability assay at a concentration of 1 mug/ml, and demonstrates a static sciatic index of less than about 0.65 within a Sciatic Nerve Assay. Additionally, the invention is related to pharmaceutical compositions containing carbamylated erythropoietins of the invention and the use of the pharmaceutical compositions for the treatment of conditions and diseases of excitable tissues.

2. 发明公开

EP1771190A4 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：用于生产氨甲酰COMPLETELY促红细胞生成素
公开(公告)号：EP1771190A4
公开(公告)日：2009-07-22
申请号：EP05802878
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO WEN
发明人： BRINES MICHAEL
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00

3. 发明公开

EP1771190A2 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：用于生产氨甲酰COMPLETELY促红细胞生成素
公开(公告)号：EP1771190A2
公开(公告)日：2007-04-11
申请号：EP05802878.8
申请日：2005-07-01
申请人： The Kenneth S. Warren Institute, Inc. , Cerami, Anthony , Hand Carla Cerami , Xie, Qiao-wen
发明人： BRINES, Michael
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to a method of carbamylating an erythropoietin such that the resulting carbamylated erythropoietin has less that about 10% free primary amines on the lysines and the N-terminal amino acids, is not digested when exposed to Lys-C proteolysis, exhibits no erythropoietic activity in a TF-1 or UT-7/EPOR cell viability assay at a concentration of 1 µg/ml, and demonstrates a static sciatic index of less than about .65 within a Sciatic Nerve Assay. Additionally, the invention is related to pharmaceutical compositions containing carbamylated erythropoietins of the invention and the use of the pharmaceutical compositions for the treatment of conditions and diseases of excitable tissues.

4. 发明申请

WO2012054904A3 MICROFLUIDICS WITH WIRELESSLY POWERED ELECTRONIC CIRCUITS 审中-公开
标题翻译：带有无线供电电子电路的微型流体系统
公开(公告)号：WO2012054904A3
公开(公告)日：2012-08-30
申请号：PCT/US2011057399
申请日：2011-10-21
申请人： UNIV CALIFORNIA , LO YU-HWA , QIAO WEN , CHO GYOUJIN
发明人： LO YU-HWA , QIAO WEN , CHO GYOUJIN
IPC分类号： G01N27/447 , B01J19/00 , G01N35/08
CPC分类号： G01N27/44704 , B01J19/0093 , B01J2219/00853 , B01J2219/00912 , B01L3/502715 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/022 , B01L2300/023 , B01L2300/0645 , B01L2300/0822 , B01L2300/0887 , B01L2400/0421 , B01L2400/0424 , G01N2015/1422
摘要： Techniques, devices and systems are described for incorporating a printed circuit with a microfluidic device and wirelessly powering the microfluidic device. In one aspect, a microfluidic device includes a substrate with a fluidic channel to provide a path for a fluid with particles. The fluidic channel includes fluid inlet and outlet. A pair of electrodes near the inlet and the outlet guides the particles toward a center of the fluidic channel using negative-dielectrophoresis (DEP) effect in response to an alternating current (AC) frequency voltage received at the pairs of electrodes. Additional pairs of electrodes are disposed along a border of the fluidic channel between the pairs of electrodes near the inlet and the outlet of the fluidic channel to isolate a subpopulation of the particles using positive and negative DEP effects in response to AC voltages of different frequencies received at different ones of the additional pairs of electrodes.
摘要翻译：描述了用于将印刷电路与微流体装置并且无线供电微流体装置的技术，装置和系统。在一个方面，微流体装置包括具有流体通道的基板，以提供具有颗粒的流体的路径。流体通道包括流体入口和出口。响应于在电极对处接收的交流（AC）频率电压，入口和出口附近的一对电极使用负介电泳（DEP）效应将粒子引向流体通道的中心。另外的电极对沿着流体通道的入口和出口附近的电极对之间的流体通道的边界设置，以响应于接收的不同频率的AC电压使用正和负DEP效应隔离粒子的亚群在另外一对电极中。

5. 发明申请

WO2012064896A2 WIRELESS POWER MECHANISMS FOR LAB-ON-A-CHIP DEVICES 审中-公开
标题翻译：无线电设备的无线电力机构
公开(公告)号：WO2012064896A2
公开(公告)日：2012-05-18
申请号：PCT/US2011060061
申请日：2011-11-09
申请人： UNIV CALIFORNIA , LO YU-HWA , QIAO WEN
发明人： LO YU-HWA , QIAO WEN
IPC分类号： H02J17/00 , H04B5/00
CPC分类号： B81B7/02 , H01L25/167 , H01L2924/0002 , H02J17/00 , H02J50/10 , H02J50/20 , H04B5/0031 , H04B5/0037 , H01L2924/00
摘要： Methods, devices and systems are provided for wirelessly powering and controlling a lab-on-a-chip device. Direct current (DC) and alternating current (AC) signals can be produced at the lab-on-a-chip device in a wireless manner. In some configurations, integrated RF components and optoelectronic components of the lab-on-a-chip device are used to collaboratively produce the DC and AC signals. In other configurations only optoelectronic components on the lab-on-a-chip system can produce the DC and/or AC signals in response to incident light. By modulating the incident light, AC signals of various frequencies and waveforms can be generated. The DC and AC signals can be used by additional integrated electronic circuits and by a microfluidic chip lactated on the lab-on-a- chip device to control the behavior of the bioparticles in the microfluidic device.
摘要翻译：提供了用于无线供电和控制芯片实验室设备的方法，设备和系统。直流（DC）和交流（AC）信号可以在无线方式的芯片实验室设备上产生。在一些配置中，使用片上实验室器件的集成RF组件和光电子组件来协同产生DC和AC信号。在其他配置中，只有芯片实验室上的光电元件才能响应入射光而产生直流和/或交流信号。通过调制入射光，可以产生各种频率和波形的交流信号。 DC和AC信号可以由额外的集成电子电路和由芯片实验室上的乳化的微流控芯片使用，以控制微流体装置中的生物颗粒的行为。

6. 发明申请

WO2012054904A2 MICROFLUIDICS WITH WIRELESSLY POWERED ELECTRONIC CIRCUITS 审中-公开
标题翻译：无电力电子电路的微流控
公开(公告)号：WO2012054904A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/057399
申请日：2011-10-21
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , LO, Yu-hwa , QIAO, Wen , CHO, Gyoujin
发明人： LO, Yu-hwa , QIAO, Wen , CHO, Gyoujin
IPC分类号： G01N27/447 , G01N35/08 , B01J19/00
CPC分类号： G01N27/44704 , B01J19/0093 , B01J2219/00853 , B01J2219/00912 , B01L3/502715 , B01L3/502761 , B01L3/502776 , B01L2200/0652 , B01L2200/0668 , B01L2200/10 , B01L2200/12 , B01L2300/022 , B01L2300/023 , B01L2300/0645 , B01L2300/0822 , B01L2300/0887 , B01L2400/0421 , B01L2400/0424 , G01N2015/1422
摘要： Techniques, devices and systems are described for incorporating a printed circuit with a microfluidic device and wirelessly powering the microfluidic device. In one aspect, a microfluidic device includes a substrate with a fluidic channel to provide a path for a fluid with particles. The fluidic channel includes fluid inlet and outlet. A pair of electrodes near the inlet and the outlet guides the particles toward a center of the fluidic channel using negative-dielectrophoresis (DEP) effect in response to an alternating current (AC) frequency voltage received at the pairs of electrodes. Additional pairs of electrodes are disposed along a border of the fluidic channel between the pairs of electrodes near the inlet and the outlet of the fluidic channel to isolate a subpopulation of the particles using positive and negative DEP effects in response to AC voltages of different frequencies received at different ones of the additional pairs of electrodes.
摘要翻译：描述了技术，装置和系统，用于将具有微流体装置的印刷电路并入到微流体装置的无线供电中。在一个方面，微流体装置包括具有流体通道以提供具有颗粒的流体的路径的基底。流体通道包括流体入口和出口。入口和出口附近的一对电极响应于在电极对接收的交流（AC）频率电压，使用负介电电泳（DEP）效应将颗粒引向流体通道的中心。附加的电极对在沿着流体通道的入口和出口附近的电极对之间的流体通道的边界处设置，以响应于接收到的不同频率的AC电压，使用正和负DEP效应来隔离颗粒的亚群在不同的附加电极对上。

7. 发明申请

WO2006014349A3 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：生产完全氨基甲酰化红细胞生成素的方法
公开(公告)号：WO2006014349A3
公开(公告)日：2006-07-20
申请号：PCT/US2005023505
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO WEN , BRINES MICHAEL
发明人： BRINES MICHAEL
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to a method of carbamylating an erythropoietin such that the resulting carbamylated erythropoietin has less that about 10% free primary amines on the lysines and the N-terminal amino acids, is not digested when exposed to Lys-C proteolysis, exhibits no erythropoietic activity in a TF-1 or UT-7/EPOR cell viability assay at a concentration of 1 µg/ml, and demonstrates a static sciatic index of less than about .65 within a Sciatic Nerve Assay. Additionally, the invention is related to pharmaceutical compositions containing carbamylated erythropoietins of the invention and the use of the pharmaceutical compositions for the treatment of conditions and diseases of excitable tissues.
摘要翻译：本发明涉及使促红细胞生成素氨基甲酰化的方法，使得所得的氨基甲酰化促红细胞生成素具有少于赖氨酸上约10％的游离伯胺和N端氨基酸，当暴露于Lys-C蛋白水解时不被消化，在浓度为1μg/ ml的TF-1或UT-7 / EPOR细胞活力测定中的促红细胞生成活性，并且在坐骨神经分析中显示小于约.65的静态坐骨指数。此外，本发明涉及含有本发明的氨基甲酰化促红细胞生成素的药物组合物以及该药物组合物用于治疗可兴奋组织的病症和疾病的用途。

8. 发明申请

WO2006014466A2 NOVEL CARBAMYLATED EPO AND METHOD FOR ITS PRODUCTION 审中-公开
标题翻译：新型的CARBAMYLATED EPO及其生产方法
公开(公告)号：WO2006014466A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/023910
申请日：2005-07-01
申请人： THE KENNETH S. WARREN INSTITUTE, INC. , LUNDBECK, H., A/S , BRINES, Michael , CERAMI, Anthony , HAND, Carla, Cerami , XIE, Qiao-wen , CHRISTENSEN, Soren , FOLDAGER, J , VLABJORN, M., H. , THEUSEN, A., H. , PEDERSEN, M. , MUNK, M.
发明人： BRINES, Michael , CERAMI, Anthony , HAND, Carla, Cerami , XIE, Qiao-wen , CHRISTENSEN, Soren , FOLDAGER, J , VLABJORN, M., H. , THEUSEN, A., H. , PEDERSEN, M. , MUNK, M.
IPC分类号： C12N14/505
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention comprises an optimal process for carbamylation yielding a product with a low degree of polymerisation and aggregation. The fully carbamylated erythropoietin with all of the N-terminal and all lysine residues was obtained. The resulting fully carbamylated pure EPO is along with pharmaceutical compositions comprising the compound are part of the invention.
摘要翻译：本发明包括用于氨甲酰化产生具有低聚合度和聚集度的产物的最佳方法。获得具有所有N-末端和所有赖氨酸残基的完全氨基甲酰化促红细胞生成素。得到的完全氨基甲酰化的纯EPO与包含该化合物的药物组合物一起是本发明的一部分。

9. 发明申请

WO03020161A3 IMMUNE MODULATION DEVICE FOR USE IN ANIMALS 审中-公开
标题翻译：用于动物的免疫调节装置
公开(公告)号：WO03020161A3
公开(公告)日：2003-06-05
申请号：PCT/US0214759
申请日：2002-05-09
申请人： APPLIED VACCINE TECHNOLOGIES C , CERAMI ANTHONY , CERAMI CARLA , XIE QIAO-WEN , TENHUISEN KEVOR S , ROSENBLATT JOEL , KOYFMAN ILYA S
发明人： CERAMI ANTHONY , CERAMI CARLA , XIE QIAO-WEN , TENHUISEN KEVOR S , ROSENBLATT JOEL , KOYFMAN ILYA S
IPC分类号： A61K9/00 , A61K9/16 , A61K35/14 , A61K38/00 , A61K39/00 , C07K14/00 , C12N5/06 , C12Q1/06 , G01N33/53 , G01N33/543 , A61K45/05
CPC分类号： A61K9/0024 , A61K9/1641 , A61K9/1647 , Y10T442/2525
摘要： The present invention is directed to an implantable immune modulation device (Figure 1) that is useful for modulating an immune response in mammals, comprising a plurality of fibers, within a porous shell. The fiber filling is loaded with single or multiple antigens, and optionally one or more biologically active compounds such as cytokines (e.g. lymphokines, chemokines etc.), attachment factors, genes, peptides, proteins, nucleotides, carbohydrates or cells depending on the application.
摘要翻译：本发明涉及可用于在多孔壳内调节包含多种纤维的哺乳动物的免疫应答的可植入免疫调节装置（图1）。取决于应用，纤维填充物装载有单个或多个抗原，以及任选地一种或多种生物活性化合物，例如细胞因子（例如淋巴因子，趋化因子等），附着因子，基因，肽，蛋白质，核苷酸，碳水化合物或细胞。

10. 发明申请

WO02062301A3 METHOD AND COMPOSITION FOR REJUVINATING CELLS, TISSUES, ORGANS, HAIR AND NAILS 审中-公开
标题翻译：重组细胞，组织，器官，头发和指甲的方法和组合
公开(公告)号：WO02062301A3
公开(公告)日：2002-10-17
申请号：PCT/US0203714
申请日：2002-02-07
申请人： FARRINGTON PHARMACEUTICALS LLC , ULRICH PETER C , FANG SHENG DING , BRINES MICHAEL , XIE QIAO WEN , CERAMI ANTHONY
发明人： ULRICH PETER C , FANG SHENG DING , BRINES MICHAEL , XIE QIAO WEN , CERAMI ANTHONY
IPC分类号： C07D233/60 , A61K8/49 , A61K31/415 , A61K31/4174 , A61K31/425 , A61K31/426 , A61K31/427 , A61K31/428 , A61K31/44 , A61K31/452 , A61K31/495 , A61K31/496 , A61K31/50 , A61K31/505 , A61K31/519 , A61K31/535 , A61K31/5377 , A61K31/5383 , A61P3/10 , A61P9/00 , A61P9/10 , A61P9/12 , A61P13/02 , A61P13/12 , A61P17/00 , A61P19/02 , A61P25/02 , A61P25/28 , A61P27/02 , A61P27/12 , A61P27/16 , A61P43/00 , A61Q3/00 , A61Q3/02 , A61Q5/00 , A61Q5/12 , A61Q19/00 , A61Q19/08 , C07D213/20 , C07D213/50 , C07D213/57 , C07D213/73 , C07D233/54 , C07D239/26 , C07D239/42 , C07D265/36 , C07D277/22 , C07D277/24 , C07D277/84 , C07D417/06 , C07D487/04 , C07D498/02 , C07D513/04 , C07D521/00 , C07D213/02 , C07D239/02 , C07D277/20 , C07D277/30 , C07D277/60 , C07D401/00 , C07D403/02 , C07D413/02 , C07D417/00
CPC分类号： C07D213/20 , A61K8/49 , A61K8/4986 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/495 , A61K31/50 , A61K31/505 , A61K31/535 , A61Q3/00 , A61Q3/02 , A61Q5/00 , A61Q5/02 , A61Q5/12 , A61Q7/00 , A61Q19/08 , A61Q19/10 , C07D213/50 , C07D213/57 , C07D213/73 , C07D231/12 , C07D233/54 , C07D233/56 , C07D233/64 , C07D239/26 , C07D239/42 , C07D249/08 , C07D277/22 , C07D277/24 , C07D277/84 , C07D417/06 , C07D487/04 , C07D513/04
摘要： In one embodiment, the present invention relates to compounds and compositions including pharmaceutical compositions containing the compounds and associated methods that uncouple sugar-mediated coupling of proteins, lipids, nucleic acids, and other biomaterials, and any combination thereof. In another embodiment, the compositions and associated methods have utility in vivo to reduce the deleterious effects of sugar-mediated coupling processes in an organism, when the organism is exposed to the compound or composition internally, by ingestion, transdermal application, or other means. In yet another embodiment, the compositions and associated methods are useful for the ex-vivo treatment of organs, cells and tissues and external treatment of hair, nails and skin to rejuvenate them by changing deformability and increase the tissue fissuion coefficient. In a further embodiment, the present invention relates to novel compounds and pharmaceutical compositions.
摘要翻译：在一个实施方案中，本发明涉及包含药物组合物的化合物和组合物，所述药物组合物含有化合物和解离糖介导的蛋白质，脂质，核酸和其他生物材料偶联的相关方法及其任何组合。在另一个实施方案中，组合物和相关方法在体内通过摄入，经皮施用或其它方式在生物体内部暴露于化合物或组合物时，有效地降低糖介导的生物体中的偶联过程的有害作用。在另一个实施方案中，组合物和相关方法可用于器官，细胞和组织的离体处理以及毛发，指甲和皮肤的外部治疗，以通过改变变形性和增加组织裂隙系数来使其恢复活力。在另一个实施方案中，本发明涉及新化合物和药物组合物。

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