专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2006014466A3 NOVEL CARBAMYLATED EPO AND METHOD FOR ITS PRODUCTION 审中-公开
标题翻译：新型碳酸酯EPO及其生产方法
公开(公告)号：WO2006014466A3
公开(公告)日：2006-06-29
申请号：PCT/US2005023910
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , LUNDBECK H AS , BRINES MICHAEL , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO-WEN , CHRISTENSEN SOREN , FOLDAGER J , VLABJORN M H , THEUSEN A H , PEDERSEN M , MUNK M
发明人： BRINES MICHAEL , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO-WEN , CHRISTENSEN SOREN , FOLDAGER J , VLABJORN M H , THEUSEN A H , PEDERSEN M , MUNK M
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention comprises an optimal process for carbamylation yielding a product with a low degree of polymerisation and aggregation. The fully carbamylated erythropoietin with all of the N-terminal and all lysine residues was obtained. The resulting fully carbamylated pure EPO is along with pharmaceutical compositions comprising the compound are part of the invention.
摘要翻译：本发明包括氨基甲酰化的最佳方法，产生具有低聚合度和聚集度的产物。获得具有所有N-末端和所有赖氨酸残基的完全氨基甲酰化促红细胞生成素。所得完全氨基甲酰化的纯EPO以及包含该化合物的药物组合物是本发明的一部分。

2. 发明申请

WO2006014349A2 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：生产完全碳酸化红细胞生成素的方法
公开(公告)号：WO2006014349A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/023505
申请日：2005-07-01
申请人： THE KENNETH S. WARREN INSTITUTE, INC. , CERAMI, Anthony , HAND, Carla, Cerami , XIE, Qiao-wen , BRINES, Michael
发明人： BRINES, Michael
IPC分类号： C07K14/505
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to a method of carbamylating an erythropoietin such that the resulting carbamylated erythropoietin has less that about 10% free primary amines on the lysines and the N-terminal amino acids, is not digested when exposed to Lys-C proteolysis, exhibits no erythropoietic activity in a TF-1 or UT-7/EPOR cell viability assay at a concentration of 1 µg/ml, and demonstrates a static sciatic index of less than about .65 within a Sciatic Nerve Assay. Additionally, the invention is related to pharmaceutical compositions containing carbamylated erythropoietins of the invention and the use of the pharmaceutical compositions for the treatment of conditions and diseases of excitable tissues.
摘要翻译：本发明涉及一种氨基甲酰化促红细胞生成素的方法，使得所得到的氨基甲酰化促红细胞生成素在赖氨酸和N-末端氨基酸上具有少于约10％的游离伯胺，当暴露于Lys-C蛋白水解时不被消化，在1μg/ ml浓度的TF-1或UT-7 / EPOR细胞活力测定中的红细胞生成活性，并且在Sciatic Nerve Assay中证实静态坐骨指数小于约.65。另外，本发明涉及含有本发明的氨基甲酰化促红细胞生成素的药物组合物以及药物组合物用于治疗可兴奋组织的病症和疾病的用途。

3. 发明公开

EP1771190A4 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：用于生产氨甲酰COMPLETELY促红细胞生成素
公开(公告)号：EP1771190A4
公开(公告)日：2009-07-22
申请号：EP05802878
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO WEN
发明人： BRINES MICHAEL
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00

4. 发明公开

EP1771190A2 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：用于生产氨甲酰COMPLETELY促红细胞生成素
公开(公告)号：EP1771190A2
公开(公告)日：2007-04-11
申请号：EP05802878.8
申请日：2005-07-01
申请人： The Kenneth S. Warren Institute, Inc. , Cerami, Anthony , Hand Carla Cerami , Xie, Qiao-wen
发明人： BRINES, Michael
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to a method of carbamylating an erythropoietin such that the resulting carbamylated erythropoietin has less that about 10% free primary amines on the lysines and the N-terminal amino acids, is not digested when exposed to Lys-C proteolysis, exhibits no erythropoietic activity in a TF-1 or UT-7/EPOR cell viability assay at a concentration of 1 µg/ml, and demonstrates a static sciatic index of less than about .65 within a Sciatic Nerve Assay. Additionally, the invention is related to pharmaceutical compositions containing carbamylated erythropoietins of the invention and the use of the pharmaceutical compositions for the treatment of conditions and diseases of excitable tissues.

5. 发明申请

WO2006014349A3 METHOD OF PRODUCING FULLY CARBAMYLATED ERYTHROPOIETIN 审中-公开
标题翻译：生产完全氨基甲酰化红细胞生成素的方法
公开(公告)号：WO2006014349A3
公开(公告)日：2006-07-20
申请号：PCT/US2005023505
申请日：2005-07-01
申请人： KENNETH S WARREN INST INC , CERAMI ANTHONY , HAND CARLA CERAMI , XIE QIAO WEN , BRINES MICHAEL
发明人： BRINES MICHAEL
IPC分类号： A61K38/00
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention relates to a method of carbamylating an erythropoietin such that the resulting carbamylated erythropoietin has less that about 10% free primary amines on the lysines and the N-terminal amino acids, is not digested when exposed to Lys-C proteolysis, exhibits no erythropoietic activity in a TF-1 or UT-7/EPOR cell viability assay at a concentration of 1 µg/ml, and demonstrates a static sciatic index of less than about .65 within a Sciatic Nerve Assay. Additionally, the invention is related to pharmaceutical compositions containing carbamylated erythropoietins of the invention and the use of the pharmaceutical compositions for the treatment of conditions and diseases of excitable tissues.
摘要翻译：本发明涉及使促红细胞生成素氨基甲酰化的方法，使得所得的氨基甲酰化促红细胞生成素具有少于赖氨酸上约10％的游离伯胺和N端氨基酸，当暴露于Lys-C蛋白水解时不被消化，在浓度为1μg/ ml的TF-1或UT-7 / EPOR细胞活力测定中的促红细胞生成活性，并且在坐骨神经分析中显示小于约.65的静态坐骨指数。此外，本发明涉及含有本发明的氨基甲酰化促红细胞生成素的药物组合物以及该药物组合物用于治疗可兴奋组织的病症和疾病的用途。

6. 发明申请

WO2006014466A2 NOVEL CARBAMYLATED EPO AND METHOD FOR ITS PRODUCTION 审中-公开
标题翻译：新型的CARBAMYLATED EPO及其生产方法
公开(公告)号：WO2006014466A2
公开(公告)日：2006-02-09
申请号：PCT/US2005/023910
申请日：2005-07-01
申请人： THE KENNETH S. WARREN INSTITUTE, INC. , LUNDBECK, H., A/S , BRINES, Michael , CERAMI, Anthony , HAND, Carla, Cerami , XIE, Qiao-wen , CHRISTENSEN, Soren , FOLDAGER, J , VLABJORN, M., H. , THEUSEN, A., H. , PEDERSEN, M. , MUNK, M.
发明人： BRINES, Michael , CERAMI, Anthony , HAND, Carla, Cerami , XIE, Qiao-wen , CHRISTENSEN, Soren , FOLDAGER, J , VLABJORN, M., H. , THEUSEN, A., H. , PEDERSEN, M. , MUNK, M.
IPC分类号： C12N14/505
CPC分类号： C07K14/505 , A61K38/00
摘要： The present invention comprises an optimal process for carbamylation yielding a product with a low degree of polymerisation and aggregation. The fully carbamylated erythropoietin with all of the N-terminal and all lysine residues was obtained. The resulting fully carbamylated pure EPO is along with pharmaceutical compositions comprising the compound are part of the invention.
摘要翻译：本发明包括用于氨甲酰化产生具有低聚合度和聚集度的产物的最佳方法。获得具有所有N-末端和所有赖氨酸残基的完全氨基甲酰化促红细胞生成素。得到的完全氨基甲酰化的纯EPO与包含该化合物的药物组合物一起是本发明的一部分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式