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1. 发明授权

US07360202B1 User interface system and methods for providing notification(s) 有权
标题翻译：用户界面系统和提供通知的方法
公开(公告)号：US07360202B1
公开(公告)日：2008-04-15
申请号：US10375300
申请日：2003-02-27
申请人： Praveen Seshadri , Shahaf Abileah , Niranjan Nilakantan , Holly Knight , Shyamalan Pather , Robert H. Gerber , Charles Tete Mensa-Annan , Philip Garrett , Michael Anthony Faoro , Darryn Owen Lavery
发明人： Praveen Seshadri , Shahaf Abileah , Niranjan Nilakantan , Holly Knight , Shyamalan Pather , Robert H. Gerber , Charles Tete Mensa-Annan , Philip Garrett , Michael Anthony Faoro , Darryn Owen Lavery
IPC分类号： G06F9/44
CPC分类号： G06F17/30867 , H04L12/1859 , H04L51/24 , Y10S707/99933
摘要： The present invention relates to a system and methodology to facilitate development, debug, and deployment of a notification platform application. This includes providing various editor and display tools that interact with diverse components of the application in the context of a dynamic framework and development environment adapted to the nuances of the components. Visual displays and interfaces are provided that depict the various components of an application along with the relationships between the components. Developers are then directed though the components of the application in a visual manner, wherein various editors can be invoked to design a portion of the application relating to the selected component. Other aspects include providing a debug environment for troubleshooting a notification application along with deployment options to install and execute the application.
摘要翻译：本发明涉及一种促进通知平台应用的开发，调试和部署的系统和方法。这包括提供各种编辑器和显示工具，在动态框架和适合于组件细微差别的开发环境的上下文中与应用程序的各种组件进行交互。提供了可视化显示和界面，其中描述了应用程序的各种组件以及组件之间的关系。开发者然后以可视方式引导应用程序的组件，其中可以调用各种编辑器来设计与所选择的组件相关的应用的一部分。其他方面包括提供一个用于排除通知应用程序的调试环境以及安装和执行应用程序的部署选项。

2. 发明申请

US20050176125A1 Alternatively spliced isoform of CDC25A phosphatase and methods of use 审中-公开
标题翻译： CDC25A磷酸酶的剪接异构体及其使用方法
公开(公告)号：US20050176125A1
公开(公告)日：2005-08-11
申请号：US11022042
申请日：2004-12-22
申请人： John Castle , Christopher Armour , Philip Garrett-Engele , Zhengyan Kan , Christopher Raymond , Nicholas Tsinoremas
发明人： John Castle , Christopher Armour , Philip Garrett-Engele , Zhengyan Kan , Christopher Raymond , Nicholas Tsinoremas
IPC分类号： C07H21/04 , C12N9/16
CPC分类号： C12N9/16 , C07H21/04
摘要： The present invention features nucleic acids and polypeptides encoding a novel splice variant isoform of cell division cycle 25A (Cdc25A) phosphatase. The polynucleotide sequence of Cdc25Asv1 is provided by SEQ ID NO:2. The amino acid sequence for Cdc25Asv1 is provided by SEQ ID NO:3. The present invention also provides methods for using Cdc25Asv1 polynucleotides and proteins to screen for compounds that bind to Cdc25Asv1.
摘要翻译：本发明的特征在于编码细胞分裂周期25A（Cdc25A）磷酸酶的新型剪接变体同种型的核酸和多肽。 Cdc25Asv1的多核苷酸序列由SEQ ID NO：2提供。 Cdc25Asv1的氨基酸序列由SEQ ID NO：3提供。本发明还提供了使用Cdc25Asv1多核苷酸和蛋白质筛选结合Cdc25Asv1的化合物的方法。

3. 发明申请

US20050112633A1 Alternatively spliced isoforms of sodium channel, voltage gated, type VIII, alpha (SCN8A) 审中-公开
标题翻译：钠通道，电压门控，VIII型，α（SCN8A）
公开(公告)号：US20050112633A1
公开(公告)日：2005-05-26
申请号：US10942522
申请日：2004-09-16
申请人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
发明人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
IPC分类号： C07K14/705 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/705
摘要： The present invention features nucleic acids and polypeptides encoding three novel splice variant isoforms of sodium channel, voltage gated, type VIII, alpha (SCN8A). The polynucleotide sequences of SCN8Asv1.1, SCN8Asv1.2 and SCN8Asv2 are provided by SEQ ID NO 3, SEQ ID NO 5, and SEQ ID NO 7, respectively. The amino acid sequences for SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2 are provided by SEQ ID NO 4, SEQ ID NO 6, and SEQ ID NO 8, respectively. The present invention also provides methods for using SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2 polynucleotides and proteins to screen for compounds that bind to SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2, respectively.
摘要翻译：本发明的特征在于编码三种新型的钠通道，电压门控，VIII型，α型（SCN8A）的剪接变异体亚型的核酸和多肽。 SCN8Asv1.1，SCN8Asv1.2和SCN8Asv2的多核苷酸序列分别由SEQ ID NO 3，SEQ ID NO 5和SEQ ID NO 7提供。分别由SEQ ID NO 4，SEQ ID NO 6和SEQ ID NO 8提供SCN8Asv1.1，SCN8Asv1.2和SCN8Asv2的氨基酸序列。本发明还提供了使用SCN8Asv1.1，SCN8Asv1.2和SCN8Asv2多核苷酸和蛋白质分别筛选结合SCN8Asv1.1，SCN8Asv1.2和SCN8Asv2的化合物的方法。

4. 发明申请

US20080102475A1 Alternatively spliced isoform of phosphodiesterase 4B (PDE4B) 审中-公开
标题翻译：磷酸二酯酶4B（PDE4B）的可选剪接同工型
公开(公告)号：US20080102475A1
公开(公告)日：2008-05-01
申请号：US11973939
申请日：2007-10-10
申请人： Zhengyan Kan , Philip Garrett-Engele , John Castle
发明人： Zhengyan Kan , Philip Garrett-Engele , John Castle
IPC分类号： C07H21/04 , C07K16/00 , C12N15/00 , G01N33/53
CPC分类号： C12N9/16 , C12Q1/44
摘要： The present invention features nucleic acids and polypeptides encoding novel splice variant isoform of phosphodiesterase 4B (PDE4B). The polynucleotide sequence of PDE4Bsv1 is provided by SEQ ID NO: 3. The amino acid sequence of PDE4Bsv1 is provided by SEQ ID NO: 4. The present invention also provides methods for using PDE4B polynucleotides and proteins to screen for compounds that bind to PDE4B.
摘要翻译：本发明的特征在于编码磷酸二酯酶4B（PDE4B）的剪接变体同种型的核酸和多肽。 PDE4Bsv1的多核苷酸序列由SEQ ID NO：3提供.PDE4Bsv1的氨基酸序列由SEQ ID NO：4提供。本发明还提供了使用PDE4B多核苷酸和蛋白质筛选结合PDE4B的化合物的方法。

5. 发明申请

US20060127913A1 Alternatively spliced isoforms of human PHKA2 审中-公开
标题翻译：人PHKA2的可选剪接同种型
公开(公告)号：US20060127913A1
公开(公告)日：2006-06-15
申请号：US10648139
申请日：2003-08-26
申请人： Jason Johnson , Philip Garrett-Engele , Christopher Armour , John Castle
发明人： Jason Johnson , Philip Garrett-Engele , Christopher Armour , John Castle
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1205 , C12Y207/01019
摘要： The present invention features nucleic acids and polypeptides encoding four novel splice variant isoforms of PHKA2. The polynucleotide sequences of PHKA2sv3, PHKA2sv4, PHKA2sv6 and PHKA2sv7 are provided by SEQ ID NO 1, SEQ ID NO 3, SEQ ID NO 5 and SEQ ID NO 6, respectively. The amino acid sequences for PHKA2sv3, PHKA2sv4, and PHKA2sv7 are provided by SEQ ID NO 2, SEQ ID NO 4, and SEQ ID NO 7, respectively. The present invention also provides methods for using PHKA2sv3, PHKA2sv4, and PHKA2sv7 polynucleotides and proteins to screen for compounds that bind to PHKA2sv3, PHKA2sv4, and PHKA2sv7, respectively.
摘要翻译：本发明的特征在于编码PHKA2的四种新型剪接变体同种型的核酸和多肽。分别由SEQ ID NO 1，SEQ ID NO 3，SEQ ID NO 5和SEQ ID NO 6提供了PHKA2sv3，PHKA2sv4，PHKA2sv6和PHKA2sv7的多核苷酸序列。 PHKA2sv3，PHKA2sv4和PHKA2sv7的氨基酸序列分别由SEQ ID NO 2，SEQ ID NO 4和SEQ ID NO 7提供。本发明还提供了使用PHKA2sv3，PHKA2sv4和PHKA2sv7多核苷酸和蛋白质分别筛选结合PHKA2sv3，PHKA2sv4和PHKA2sv7的化合物的方法。

6. 发明申请

US20060121508A1 Alternatively spliced isoforms of purinergic receptor P2X, ligand-gated ion channel, subunits 3 and 4 (P2RX3, P2RX4) 审中-公开
标题翻译：嘌呤能受体P2X，配体门控离子通道，亚基3和4（P2RX3，P2RX4）的可选剪接同种型，
公开(公告)号：US20060121508A1
公开(公告)日：2006-06-08
申请号：US11284978
申请日：2005-11-22
申请人： Philip Garrett-Engele , Christopher Raymond
发明人： Philip Garrett-Engele , Christopher Raymond
IPC分类号： C12Q1/68 , G01N33/53 , C07H21/04 , C12P21/06 , C07K14/705 , C07K16/28
CPC分类号： C07K14/705 , G01N33/6872 , G01N2500/02
摘要： The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of purinergic receptor P2X, ligand-gated ion channel, subunits 3 and 4 (P2RX3, P2RX4). The polynucleotide sequences of P2RX3sv1 and P2RX3sv2 are provided by SEQ ID NO 6 and SEQ ID NO 8, respectively. The polynucleotide sequences of P2RX4sv1, P2RX4sv2, and P2RX4sv3 are provided by SEQ ID NO 10, SEQ ID NO 12, and SEQ ID NO 14, respectively. The amino acid sequences of P2RX3sv1 and P2RX3sv2 are provided by SEQ ID NO 7 and SEQ ID NO 9, respectively. The amino acid sequences of P2RX4sv1, P2RX4sv2, and P2RX4sv3 are provided by SEQ ID NO 11, SEQ ID NO 13, and SEQ ID NO 15, respectively. The present invention also provides methods for using P2RX3sv1, P2RX3sv2, P2RX4sv1, P2RX4sv2, and P2RX4sv3 polynucleotides and proteins to screen for compounds that bind to P2RX3sv1, P2RX3sv2, P2RX4sv1, P2RX4sv2, and P2RX4sv3, respectively.
摘要翻译：本发明的特征在于编码嘌呤能受体P2X，配体门控离子通道，亚基3和4（P2RX3，P2RX4）的新的剪接变体同种型的核酸和多肽。 P2RX3sv1和P2RX3sv2的多核苷酸序列分别由SEQ ID NO 6和SEQ ID NO 8提供。 P2RX4sv1，P2RX4sv2和P2RX4sv3的多核苷酸序列分别由SEQ ID NO 10，SEQ ID NO 12和SEQ ID NO 14提供。 P2RX3sv1和P2RX3sv2的氨基酸序列分别由SEQ ID NO 7和SEQ ID NO 9提供。 P2RX4sv1，P2RX4sv2和P2RX4sv3的氨基酸序列分别由SEQ ID NO 11，SEQ ID NO 13和SEQ ID NO 15提供。本发明还提供了使用P2RX3sv1，P2RX3sv2，P2RX4sv1，P2RX4sv2和P2RX4sv3多核苷酸和蛋白质分别筛选结合P2RX3sv1，P2RX3sv2，P2RX4sv1，P2RX4sv2和P2RX4sv3的化合物的方法。

7. 发明申请

US20050266469A1 Alternatively spliced isoforms of checkpoint kinase 1 (CHK1) 审中-公开
标题翻译：检查点激酶1（CHK1）的可选剪接同种型
公开(公告)号：US20050266469A1
公开(公告)日：2005-12-01
申请号：US11137315
申请日：2005-05-25
申请人： Christopher Raymond , Philip Garrett-Engele , John Castle
发明人： Christopher Raymond , Philip Garrett-Engele , John Castle
IPC分类号： C07H21/04 , C12N9/12 , C12P21/06 , C12Q1/48 , C12Q1/68
CPC分类号： C12N9/1205 , C12Q1/485 , G01N2500/04
摘要： The present invention features nucleic acids and polypeptides encoding two novel splice variant isoforms of checkpoint kinase 1 (CHK1). The polynucleotide sequences of CHK1sv1 and CHK1sv2 are provided by SEQ ID NO 3 and SEQ ID NO 5, respectively. The amino acid sequences for CHK1sv1 and CHK1sv2 are provided by SEQ ID NO 4 and SEQ ID NO 6, respectively. The present invention also provides methods for using CHK1sv1 and CHK1sv2 polynucleotides and proteins to screen for compounds that bind to CHK1sv1 and CHK1sv2, respectively.
摘要翻译：本发明的特征在于编码检查点激酶1（CHK1）的两个新的剪接变体同种型的核酸和多肽。 CHK1sv1和CHK1sv2的多核苷酸序列分别由SEQ ID NO 3和SEQ ID NO 5提供。 CHK1sv1和CHK1sv2的氨基酸序列分别由SEQ ID NO 4和SEQ ID NO 6提供。本发明还提供了使用CHK1sv1和CHK1sv2多核苷酸和蛋白质分别筛选结合CHK1sv1和CHK1sv2的化合物的方法。

8. 发明授权

US07797306B1 System and method for providing notification(s) in accordance with middleware technologies 失效
标题翻译：根据中间件技术提供通知的系统和方法
公开(公告)号：US07797306B1
公开(公告)日：2010-09-14
申请号：US10375628
申请日：2003-02-26
申请人： Shyamalan Pather , Lon Eugene Fisher , Richard Dievendorff , Praveen Seshadri , Philip Garrett , Holly Knight , Vincent H. Curley , Robert F. Blanch , Charles Tete Mensa-Annan
发明人： Shyamalan Pather , Lon Eugene Fisher , Richard Dievendorff , Praveen Seshadri , Philip Garrett , Holly Knight , Vincent H. Curley , Robert F. Blanch , Charles Tete Mensa-Annan
IPC分类号： G06F7/00
CPC分类号： G06F17/30867 , H04L12/1859 , H04L51/24 , Y10S707/99933
摘要： The present invention relates to a system and methodology to facilitate subscription, delivery, processing, and reception of notification services. A global service framework is provided that operates in conjunction with a notification platform architecture to deliver information from one or more event sources to one or more notification sinks that receive information from the services. The global framework includes discovery and description components that provide information relating to available notification services. Subscriptions can be obtained via subscription events, whereby notifications can be delivered via notification events, wherein such events can be modeled as part of the global service framework. Various communications protocols can also be provided to facilitate communications with the notification services and global services framework. Furthermore, various notification delivery protocols can be provided that operate with structured database technologies to facilitate bulk message delivery and service in a reliable manner while mitigating network problems such as delivering notifications under power-interrupting conditions.
摘要翻译：本发明涉及一种便于订阅，传送，处理和接收通知服务的系统和方法。提供了全球服务框架，其与通知平台架构一起运行，以将信息从一个或多个事件源传送到从服务接收信息的一个或多个通知汇点。全球框架包括提供与可用通知服务有关的信息的发现和描述组件。可以通过订阅事件获得订阅，借此可以通过通知事件传递通知，其中可以将这些事件建模为全球服务框架的一部分。还可以提供各种通信协议以促进与通知服务和全球服务框架的通信。此外，可以提供各种通知传递协议，其以结构化数据库技术操作，以便以可靠的方式促进批量消息传递和服务，同时减轻网络问题，例如在断电条件下传送通知。

9. 发明授权

US07698276B2 Framework for providing a subscription based notification system 有权
标题翻译：提供基于订阅的通知系统的框架
公开(公告)号：US07698276B2
公开(公告)日：2010-04-13
申请号：US10376197
申请日：2003-02-26
申请人： Praveen Seshadri , Shyamalan Pather , Philip Garrett , Robert F. Blanch , Holly Knight , Charles Tete Mensa-Annan
发明人： Praveen Seshadri , Shyamalan Pather , Philip Garrett , Robert F. Blanch , Holly Knight , Charles Tete Mensa-Annan
IPC分类号： G06F17/30
CPC分类号： G06Q30/02 , G06F17/30867
摘要： The present invention relates to a system and methodology to facilitate automated delivery of notifications according to various applications that can be employed with the framework of a notification platform. The applications are described by models that enable users to easily/conveniently interact with the notification platform. The application models can be incorporated within and/or associated with the notification platform. Moreover, the models can be employed to enhance subscription experiences for users, whereby users can easily and economically subscribe and unsubscribe to one or more notification services. In addition, subscriptions can be dynamically adjusted based upon explicit commands from the user, inferred from contextual user states, and/or based upon incentives or other factors directed to the user.
摘要翻译：本发明涉及根据可以与通知平台的框架一起使用的各种应用来促进通知的自动递送的系统和方法。应用程序由模型描述，使用户能够轻松/方便地与通知平台进行交互。应用模型可以并入和/或与通知平台相关联。此外，可以使用这些模型来增强用户的订阅体验，由此用户可以容易且经济地订阅并取消订阅一个或多个通知服务。此外，可以基于来自用户的显式命令，从上下文用户状态推断和/或基于针对用户的激励或其他因素来动态地调整订阅。

10. 发明授权

US07209916B1 Expression and flexibility framework for providing notification(s) 有权
标题翻译：提供通知的表达和灵活性框架
公开(公告)号：US07209916B1
公开(公告)日：2007-04-24
申请号：US10375250
申请日：2003-02-27
申请人： Praveen Seshadri , Philip Garrett , Holly Knight , Robert F. Blanch , Shyamalan Pather
发明人： Praveen Seshadri , Philip Garrett , Holly Knight , Robert F. Blanch , Shyamalan Pather
IPC分类号： G06F7/00 , G06F9/46 , G06F15/16
CPC分类号： G06F17/30867 , H04L12/1859 , H04L51/24 , Y10S707/99933
摘要： The present invention relates to a system and methodology to facilitate timely delivery of notifications and performance of automated actions for users in the framework of an ad-hoc rules processing environment. An information agent operates as a distributed application to perform automated actions for users in accordance with user preferences and context. Various rules can be executed to delay, inhibit, and/or enable an action such as sending notifications according to the preferences and current user states as determined from the context. The rules can include data centric matching logic, set-oriented execution rules, rule ordering/interaction hierarchies, and ad-hoc Boolean combinations, for example.
摘要翻译：本发明涉及一种系统和方法，以便于在特定规则处理环境的框架内及时地传递用户的自动化动作的通知和执行。信息代理作为分布式应用来操作，以根据用户偏好和上下文对用户执行自动化动作。可以执行各种规则来延迟，禁止和/或启用诸如根据从上下文确定的偏好和当前用户状态发送通知的动作。例如，规则可以包括以数据为中心的匹配逻辑，面向集合的执行规则，规则排序/交互层次结构和自组织布尔组合。

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