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1. 发明申请

US20060127913A1 Alternatively spliced isoforms of human PHKA2 审中-公开
标题翻译：人PHKA2的可选剪接同种型
公开(公告)号：US20060127913A1
公开(公告)日：2006-06-15
申请号：US10648139
申请日：2003-08-26
申请人： Jason Johnson , Philip Garrett-Engele , Christopher Armour , John Castle
发明人： Jason Johnson , Philip Garrett-Engele , Christopher Armour , John Castle
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/12
CPC分类号： C12N9/1205 , C12Y207/01019
摘要： The present invention features nucleic acids and polypeptides encoding four novel splice variant isoforms of PHKA2. The polynucleotide sequences of PHKA2sv3, PHKA2sv4, PHKA2sv6 and PHKA2sv7 are provided by SEQ ID NO 1, SEQ ID NO 3, SEQ ID NO 5 and SEQ ID NO 6, respectively. The amino acid sequences for PHKA2sv3, PHKA2sv4, and PHKA2sv7 are provided by SEQ ID NO 2, SEQ ID NO 4, and SEQ ID NO 7, respectively. The present invention also provides methods for using PHKA2sv3, PHKA2sv4, and PHKA2sv7 polynucleotides and proteins to screen for compounds that bind to PHKA2sv3, PHKA2sv4, and PHKA2sv7, respectively.
摘要翻译：本发明的特征在于编码PHKA2的四种新型剪接变体同种型的核酸和多肽。分别由SEQ ID NO 1，SEQ ID NO 3，SEQ ID NO 5和SEQ ID NO 6提供了PHKA2sv3，PHKA2sv4，PHKA2sv6和PHKA2sv7的多核苷酸序列。 PHKA2sv3，PHKA2sv4和PHKA2sv7的氨基酸序列分别由SEQ ID NO 2，SEQ ID NO 4和SEQ ID NO 7提供。本发明还提供了使用PHKA2sv3，PHKA2sv4和PHKA2sv7多核苷酸和蛋白质分别筛选结合PHKA2sv3，PHKA2sv4和PHKA2sv7的化合物的方法。

2. 发明申请

US20050089912A1 Alternatively spliced isoforms of nuclear factor kappa-B, subunit 1 (NFKB1) 审中-公开
标题翻译：核因子κB，亚基1（NFKB1）的可选剪接同种型
公开(公告)号：US20050089912A1
公开(公告)日：2005-04-28
申请号：US10960409
申请日：2004-10-06
申请人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Christopher Raymond , Nicholas Tsinoremas
发明人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Christopher Raymond , Nicholas Tsinoremas
IPC分类号： C07K14/47 , C07K14/72 , C07K16/18 , C12Q1/68 , G01N33/50 , G01N33/53
CPC分类号： C07K14/4702 , G01N33/5005 , G01N2333/4703
摘要： The present invention features nucleic acids and polypeptides encoding two novel splice variant isoforms of nuclear factor kappa-B, subunit 1 (NFKB1). The polynucleotide sequences of NFKB1sv1 and NFKB1sv2 are provided by SEQ ID NO 3 and SEQ ID NO 5, respectively. The amino acid sequences for NFKB1sv1 and NFKB1sv2 are provided by SEQ ID NO 4 and SEQ ID NO 6, respectively. The present invention also provides methods for using NFKB1sv1 and NFKB1sv2 polynucleotides and proteins to screen for compounds that bind to NFKB1sv1 and NFKB1sv2, respectively.
摘要翻译：本发明的核酸和多肽编码核因子κB，亚基1（NFKB1）的两个新的剪接变体同种型。 NFKB1sv1和NFKB1sv2的多核苷酸序列分别由SEQ ID NO 3和SEQ ID NO 5提供。 NFKB1sv1和NFKB1sv2的氨基酸序列分别由SEQ ID NO 4和SEQ ID NO 6提供。本发明还提供了使用NFκB1sv1和NFκBsv2多核苷酸和蛋白质分别筛选结合NFκB1sv1和NFκB1sv2的化合物的方法。

3. 发明申请

US20050260650A1 Alternatively spliced isoforms of interleukin-4 receptor subunit alpha (IL-4Ralpha) 审中-公开
标题翻译：白细胞介素-4受体亚基α（IL-4Ralpha）的可选剪接同种型
公开(公告)号：US20050260650A1
公开(公告)日：2005-11-24
申请号：US11104923
申请日：2005-04-12
申请人： John Castle , Philip Garrett-Engele , Zhengyan Kan , Christopher Armour , Christopher Raymond
发明人： John Castle , Philip Garrett-Engele , Zhengyan Kan , Christopher Armour , Christopher Raymond
IPC分类号： C07H21/04 , C07K14/54 , C07K14/715 , C12P21/04 , C12Q1/68 , G01N33/53 , G01N33/567 , G01N33/68
CPC分类号： G01N33/6869 , C07K14/7155 , G01N2500/00
摘要： The present invention features nucleic acids and polypeptides encoding a novel splice variant isoform of interleukin 4, subunit alpha (IL-4Rα). The polynucleotide sequence of IL-4Rαsv1 is provided by SEQ ID NO 4. The amino acid sequence for IL-4Rαsv1 is provided by SEQ ID NO 5. The present invention also provides methods for using IL-4Rαsv1 polynucleotides and proteins to screen for compounds that bind to IL-4Rαsv1.
摘要翻译：本发明的特征在于编码白介素4，亚单位α（IL-4Ralpha）的新型剪接变体同种型的核酸和多肽。 IL-4Ralpha1的多核苷酸序列由SEQ ID NO 4提供。IL-4Rαα1的氨基酸序列由SEQ ID NO 5提供。本发明还提供了使用IL-4Rα多核苷酸和蛋白质筛选化合物的方法，绑定到IL-4Ralphasv1。

4. 发明申请

US20050003402A1 Novel isoforms of centromere protein E (CENPE) 审中-公开
标题翻译：着丝粒蛋白E（CENPE）的新型同工型
公开(公告)号：US20050003402A1
公开(公告)日：2005-01-06
申请号：US10828985
申请日：2004-04-21
申请人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
发明人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
IPC分类号： C07H21/04 , C07K14/47 , C12Q1/68 , C12N9/12 , C12N9/22
CPC分类号： C07K14/47 , C07H21/04 , C12Q1/6883 , C12Q1/6886 , C12Q2600/136
摘要： The present invention features nucleic acids and polypeptides encoding three novel variant isoform of centromere protein E (CENPE). The polynucleotide sequence of CENPEv2, CENPEv3, and CENPEv4 are provided by SEQ ID NO 6, SEQ ID NO 8, and SEQ ID NO 10, respectively. The amino acid sequences for CENPEv2, CENPEv3, and CENPEv4 are provided by SEQ ID NO 7, SEQ ID NO 9, and SEQ ID NO 11, respectively. The present invention also provides methods for using CENPEv2, CENPEv3, and CENPEv4 polynucleotides and proteins to screen for compounds that bind to CENPEv2, CENPEv3, and CENPEv4, respectively. The present invention also provides for methods to detect the presence of cancer and for inhibiting abnormal cell proliferation.
摘要翻译：本发明的特征在于编码着丝粒蛋白E（CENPE）的三种新型变体同种型的核酸和多肽。分别由SEQ ID NO 6，SEQ ID NO 8和SEQ ID NO 10提供了CENPEv2，CENPEv3和CENPEv4的多核苷酸序列。 SEQ ID NO 7，SEQ ID NO 9和SEQ ID NO 11分别提供了CENPEv2，CENPEv3和CENPEv4的氨基酸序列。本发明还提供了使用CENPEv2，CENPEv3和CENPEv4多核苷酸和蛋白质分别筛选结合CENPEv2，CENPEv3和CENPEv4的化合物的方法。本发明还提供了检测癌症存在和抑制异常细胞增殖的方法。

5. 发明申请

US20050176125A1 Alternatively spliced isoform of CDC25A phosphatase and methods of use 审中-公开
标题翻译： CDC25A磷酸酶的剪接异构体及其使用方法
公开(公告)号：US20050176125A1
公开(公告)日：2005-08-11
申请号：US11022042
申请日：2004-12-22
申请人： John Castle , Christopher Armour , Philip Garrett-Engele , Zhengyan Kan , Christopher Raymond , Nicholas Tsinoremas
发明人： John Castle , Christopher Armour , Philip Garrett-Engele , Zhengyan Kan , Christopher Raymond , Nicholas Tsinoremas
IPC分类号： C07H21/04 , C12N9/16
CPC分类号： C12N9/16 , C07H21/04
摘要： The present invention features nucleic acids and polypeptides encoding a novel splice variant isoform of cell division cycle 25A (Cdc25A) phosphatase. The polynucleotide sequence of Cdc25Asv1 is provided by SEQ ID NO:2. The amino acid sequence for Cdc25Asv1 is provided by SEQ ID NO:3. The present invention also provides methods for using Cdc25Asv1 polynucleotides and proteins to screen for compounds that bind to Cdc25Asv1.
摘要翻译：本发明的特征在于编码细胞分裂周期25A（Cdc25A）磷酸酶的新型剪接变体同种型的核酸和多肽。 Cdc25Asv1的多核苷酸序列由SEQ ID NO：2提供。 Cdc25Asv1的氨基酸序列由SEQ ID NO：3提供。本发明还提供了使用Cdc25Asv1多核苷酸和蛋白质筛选结合Cdc25Asv1的化合物的方法。

6. 发明申请

US20050112633A1 Alternatively spliced isoforms of sodium channel, voltage gated, type VIII, alpha (SCN8A) 审中-公开
标题翻译：钠通道，电压门控，VIII型，α（SCN8A）
公开(公告)号：US20050112633A1
公开(公告)日：2005-05-26
申请号：US10942522
申请日：2004-09-16
申请人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
发明人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
IPC分类号： C07K14/705 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/705
摘要： The present invention features nucleic acids and polypeptides encoding three novel splice variant isoforms of sodium channel, voltage gated, type VIII, alpha (SCN8A). The polynucleotide sequences of SCN8Asv1.1, SCN8Asv1.2 and SCN8Asv2 are provided by SEQ ID NO 3, SEQ ID NO 5, and SEQ ID NO 7, respectively. The amino acid sequences for SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2 are provided by SEQ ID NO 4, SEQ ID NO 6, and SEQ ID NO 8, respectively. The present invention also provides methods for using SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2 polynucleotides and proteins to screen for compounds that bind to SCN8Asv1.1, SCN8Asv1.2, and SCN8Asv2, respectively.
摘要翻译：本发明的特征在于编码三种新型的钠通道，电压门控，VIII型，α型（SCN8A）的剪接变异体亚型的核酸和多肽。 SCN8Asv1.1，SCN8Asv1.2和SCN8Asv2的多核苷酸序列分别由SEQ ID NO 3，SEQ ID NO 5和SEQ ID NO 7提供。分别由SEQ ID NO 4，SEQ ID NO 6和SEQ ID NO 8提供SCN8Asv1.1，SCN8Asv1.2和SCN8Asv2的氨基酸序列。本发明还提供了使用SCN8Asv1.1，SCN8Asv1.2和SCN8Asv2多核苷酸和蛋白质分别筛选结合SCN8Asv1.1，SCN8Asv1.2和SCN8Asv2的化合物的方法。

7. 发明申请

US20060177828A1 Alternatively spliced isoform of mitotic centromere-associated kinesin (MCAK) 审中-公开
标题翻译：有丝分裂着丝粒相关驱动蛋白（MCAK）的可选剪接同种型
公开(公告)号：US20060177828A1
公开(公告)日：2006-08-10
申请号：US10942521
申请日：2004-09-16
申请人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
发明人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/00
CPC分类号： C12N9/14
摘要： The present invention features a nucleic acid and a polypeptide encoding a novel splice variant isoform of mitotic centromere-associated kinesin (MCAK). The polynucleotide sequence of MCAKsv1 is provided by SEQ ID NO 2. The amino acid sequence for MCAKsv1 is provided by SEQ ID NO 3. The present invention also provides methods for using MCAKsv1 polynucleotide and protein to screen for compounds that bind to MCAKsv1 and to screen for compounds that bind to other kinesin isoform polypeptides but not to MCAKsv1.
摘要翻译：本发明的特征在于核酸和编码有丝分裂着丝粒相关驱动蛋白（MCAK）的新型剪接变体同种型的多肽。 MCAKsv1的多核苷酸序列由SEQ ID NO 2提供.MCAKsv1的氨基酸序列由SEQ ID NO 3提供。本发明还提供了使用MCAKsv1多核苷酸和蛋白质筛选结合MCAKsv1的化合物并筛选的方法对于结合其他驱动蛋白同种型多肽但不与MCAKsv1结合的化合物。

8. 发明申请

US20050272082A1 Alternatively spliced isoform of acetyl-CoA carboxylase 2 (ACC2) 有权
标题翻译：乙酰辅酶A羧化酶2（ACC2）的可选剪接同种型
公开(公告)号：US20050272082A1
公开(公告)日：2005-12-08
申请号：US11144368
申请日：2005-06-03
申请人： Zhengyan Kan , Philip Garrett-Engele , Christopher Armour , Christopher Raymond , John Castle
发明人： Zhengyan Kan , Philip Garrett-Engele , Christopher Armour , Christopher Raymond , John Castle
IPC分类号： C07H21/04 , C12N9/00 , C12N9/10 , C12Q1/68
CPC分类号： C12N9/93
摘要： The present invention features nucleic acids and polypeptides encoding novel splice variant isoforms of acetyl-CoA carboxylase 2 (ACC2). The polynucleotide sequence of ACC2sv1 is provided by SEQ ID NO 3. The amino acid sequence of ACC2sv1 is provided by SEQ ID NO 4. The present invention also provides methods for using ACC2sv1 polynucleotides and proteins to screen for compounds that bind to ACC2sv1.
摘要翻译：本发明的特征在于编码乙酰辅酶A羧化酶2（ACC2）的剪接变异体亚型的核酸和多肽。 ACC2sv1的多核苷酸序列由SEQ ID NO 3提供。ACC2sv1的氨基酸序列由SEQ ID NO 4提供。本发明还提供了使用ACC2sv1多核苷酸和蛋白质筛选结合ACC2sv1的化合物的方法。

9. 发明申请

US20050059088A1 Alternatively spliced isoforms of receptor-interacting serine-threonine kinase 2 (RIPK2) 审中-公开
标题翻译：受体相互作用的丝氨酸 - 苏氨酸激酶2（RIPK2）的可选剪接同种型
公开(公告)号：US20050059088A1
公开(公告)日：2005-03-17
申请号：US10901779
申请日：2004-07-29
申请人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
发明人： Christopher Armour , John Castle , Philip Garrett-Engele , Zhengyan Kan , Patrick Loerch , Nicholas Tsinoremas
IPC分类号： C07H21/04 , C12N9/12 , G01N33/53 , C07K14/705
CPC分类号： C12N9/1205 , C07H21/04 , C12Y207/01037 , G01N2500/00
摘要： The present invention features nucleic acids and polypeptides encoding three novel splice variant isoforms of receptor-interacting serine-threonine kinase 2 (RIPK2). The polynucleotide sequences of RIPK2sv1.1, RIPK2sv1.2, and RIPK2s2 are provided by SEQ ID NO 1, SEQ ID NO 3, and SEQ ID NO 5, respectively. The amino acid sequences for RIPK2sv1.1, RIPK2sv1.2, and RIPK2sv2 are provided by SEQ ID NO 2, SEQ ID NO 4, and SEQ ID NO 6, respectively. The present invention also provides methods for using RIPK2sv1.1, RIPK2sv1.2, and RIPK2sv2 polynucleotides and proteins to screen for compounds that bind to RIPK2sv1.1, RIPK2sv1.2, and RIPK2sv2, respectively.
摘要翻译：本发明的特征在于编码三种受体相互作用的丝氨酸 - 苏氨酸激酶2（RIPK2）的剪接变体同种型的核酸和多肽。 RIPK2sv1.1，RIPK2sv1.2和RIPK2s2的多核苷酸序列分别由SEQ ID NO 1，SEQ ID NO 3和SEQ ID NO 5提供。 RIPK2sv1.1，RIPK2sv1.2和RIPK2sv2的氨基酸序列分别由SEQ ID NO 2，SEQ ID NO 4和SEQ ID NO 6提供。本发明还提供了使用RIPK2sv1.1，RIPK2sv1.2和RIPK2sv2多核苷酸和蛋白质分别筛选结合RIPK2sv1.1，RIPK2sv1.2和RIPK2sv2的化合物的方法。

10. 发明申请

US20110039732A1 cDNA Synthesis Using Non-Random Primers 审中-公开
标题翻译：使用非随机引物的cDNA合成
公开(公告)号：US20110039732A1
公开(公告)日：2011-02-17
申请号：US12767542
申请日：2010-04-26
申请人： Christopher Raymond , Christopher Armour , John Castle
发明人： Christopher Raymond , Christopher Armour , John Castle
IPC分类号： C40B40/08 , C12P19/34 , C40B50/06 , C12Q1/68 , C12N9/10 , C12N9/00 , C12N9/22
CPC分类号： C12N15/1093 , C12Q1/686 , C12Q2525/179 , C12Q2525/161 , C12Q2525/143
摘要： The present invention provides methods for selectively amplifying a target population of nucleic acid molecules in a population of RNA template molecules (e.g., all mRNA molecules expressed in a cell type except for the most highly expressed mRNA species). The present invention also provides a first population of oligonucleotides including the nucleic acid sequences set forth in SEQ ID NOS:1-749 and a second population of oligonucleotides including the nucleic acid sequences set forth in SEQ ID NOS:750-1498. The first population of oligonucleotides can be used, for example, to prime the synthesis of first strand cDNA molecules complementary to mRNA molecules isolated from mammalian cells without priming the synthesis of cDNA molecules complementary to ribosomal RNA molecules. The second population of oligonucleotides can be used, for example, to prime the second strand synthesis of primer extension products (first strand cDNA) complementary to mRNA molecules isolated from mammalian cells without priming the second strand synthesis of primer extension products synthesized from ribosomal RNA molecules.
摘要翻译：本发明提供了用于选择性扩增RNA模板分子群体中的核酸分子的靶群的方法（例如，除了最高度表达的mRNA种类之外以细胞类型表达的所有mRNA分子）。本发明还提供了第一寡核苷酸群，包括SEQ ID NO：1-749所示的核酸序列和第二寡核苷酸群，包括SEQ ID NO：750-1498所示的核酸序列。第一寡核苷酸群可用于例如引发与哺乳动物细胞分离的mRNA分子互补的第一链cDNA分子的合成，而不引发与核糖体RNA分子互补的cDNA分子的合成。第二寡核苷酸群可以用于例如引发与从哺乳动物细胞分离的mRNA分子互补的引物延伸产物（第一链cDNA）的第二链合成，而不引发由核糖体RNA分子合成的引物延伸产物的第二链合成。

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