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1. 发明授权

US08206705B2 KIM-1 antibodies for treatment of TH2-mediated conditions 失效
标题翻译：用于治疗TH2介导的病症的KIM-1抗体
公开(公告)号：US08206705B2
公开(公告)日：2012-06-26
申请号：US11817638
申请日：2006-03-02
申请人： Paul Rennert , Patricia McCoon , Veronique Bailly , Alexey Lugovskoy
发明人： Paul Rennert , Patricia McCoon , Veronique Bailly , Alexey Lugovskoy
IPC分类号： A61K39/395
CPC分类号： A61K39/39533 , A61K2039/505 , C07K16/2803 , C07K2317/34 , C07K2317/73 , C07K2317/74
摘要： Compositions and methods for treating Th2- and ThI-mediated disease are provided.
摘要翻译：提供了治疗Th2和Th1介导的疾病的组合物和方法。

2. 发明申请

US20120027751A1 ANTAGONISTS OF TWEAK AND OF TWEAK RECEPTOR AND THEIR USE TO TREAT IMMUNOLOGICAL DISORDERS 有权
标题翻译：双向和双重受体的拮抗剂及其用于治疗免疫缺陷症
公开(公告)号：US20120027751A1
公开(公告)日：2012-02-02
申请号：US13173604
申请日：2011-06-30
申请人： Paul Rennert
发明人： Paul Rennert
IPC分类号： A61K39/395 , A61P37/00 , A61P37/06 , A61P13/12
CPC分类号： C07K14/70575 , A61K2039/505 , C07K16/2875 , C07K16/2878 , C07K2319/30
摘要： The present invention relates to reagents which modify the activity of TWEAK and their use as therapeutic agents for the treatment of immunological disorders.
摘要翻译：本发明涉及改变TWEAK活性的试剂及其用作治疗免疫学疾病的治疗剂。

3. 发明申请

US20100150905A1 KIM-1 ANTIBODIES FOR TREATMENT OF TH2-MEDIATED CONDITIONS 失效
标题翻译：用于治疗TH2介导的病症的KIM-1抗体
公开(公告)号：US20100150905A1
公开(公告)日：2010-06-17
申请号：US11817638
申请日：2006-03-02
申请人： Paul Rennert , Patricia McCoon , Veronique Bailly , Alexey Lugovskoy
发明人： Paul Rennert , Patricia McCoon , Veronique Bailly , Alexey Lugovskoy
IPC分类号： A61K39/395 , C07K16/18 , C12N5/12 , C07K14/00 , A61P11/06
CPC分类号： A61K39/39533 , A61K2039/505 , C07K16/2803 , C07K2317/34 , C07K2317/73 , C07K2317/74
摘要： Compositions and methods for treating Th2- and ThI-mediated disease are provided.
摘要翻译：提供了治疗Th2和Th1介导的疾病的组合物和方法。

4. 发明申请

US20100061985A1 ANTAGONISTS OF TWEAK AND OF TWEAK RECEPTOR AND THEIR USE TO TREAT IMMUNOLOGICAL DISORDERS 审中-公开
标题翻译：双向和双重受体的拮抗剂及其用于治疗免疫缺陷症
公开(公告)号：US20100061985A1
公开(公告)日：2010-03-11
申请号：US12506006
申请日：2009-07-20
申请人： Paul Rennert
发明人： Paul Rennert
IPC分类号： A61K39/395 , C07K16/18 , C12N5/16
CPC分类号： C07K14/70575 , A61K2039/505 , C07K16/2875 , C07K16/2878 , C07K2319/30
摘要： The present invention relates to reagents which modify the activity of TWEAK and their use as therapeutic agents for the treatment of immunological disorders.
摘要翻译：本发明涉及改变TWEAK活性的试剂及其作为治疗免疫学障碍的治疗剂的用途。

5. 发明申请

US20060013832A1 Methods for treating HIV infected subjects 有权
标题翻译：治疗艾滋病毒感染者的方法
公开(公告)号：US20060013832A1
公开(公告)日：2006-01-19
申请号：US11029188
申请日：2005-01-04
申请人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
发明人： Carl June , Craig Thompson , Gary Nabel , Gary Gray , Paul Rennert
IPC分类号： A61K39/21 , C12N15/86
CPC分类号： C12N5/0636 , A61K35/17 , A61K38/00 , A61K39/02 , A61K39/12 , A61K48/00 , A61K2039/505 , A61K2039/507 , A61K2039/5158 , C07K14/705 , C07K14/70521 , C07K14/70532 , C07K16/00 , C07K16/2806 , C07K16/2809 , C07K16/2812 , C07K16/2815 , C07K16/2818 , C07K16/2833 , C07K16/2866 , C07K16/289 , C07K16/2896 , C07K2317/24 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/74 , C07K2319/00 , C07K2319/30 , C12N2501/51 , C12N2501/515 , C12N2501/599 , C12N2710/00088 , C12N2740/16011
摘要： Methods for inducing a population of T cells to proliferate by activating the population of T cells and stimulating an accessory molecule on the surface of the T cells with a ligand which binds the accessory molecule are described. T cell proliferation occurs in the absence of exogenous growth factors or accessory cells. T cell activation is accomplished by stimulating the T cell receptor (TCR)/CD3 complex or the CD2 surface protein. To induce proliferation of an activated population T cells, an accessory molecule on the surface of the T cells, such as CD28, is stimulated with a ligand which binds the accessory molecule. The T cell population expanded by the method of the invention can be genetically transduced and used for immunotherapy or can be used in methods of diagnosis.
摘要翻译：描述了通过激活T细胞群并用结合附属分子的配体刺激T细胞表面上的辅助分子来诱导T细胞群体增殖的方法。 T细胞增殖发生在没有外源生长因子或附属细胞的情况下。通过刺激T细胞受体（TCR）/ CD3复合物或CD2表面蛋白来完成T细胞活化。为了诱导活化的群体T细胞的增殖，T细胞表面上的辅助分子如CD28被与配合分子结合的配体刺激。通过本发明的方法扩增的T细胞群体可以被遗传转导并用于免疫治疗，或可用于诊断方法。

6. 发明授权

US08440189B2 Antagonists of TWEAK and of TWEAK receptor and their use to treat immunological disorders 有权
公开(公告)号：US08440189B2
公开(公告)日：2013-05-14
申请号：US13173604
申请日：2011-06-30
申请人： Paul Rennert
发明人： Paul Rennert
IPC分类号： A61K39/395
CPC分类号： C07K14/70575 , A61K2039/505 , C07K16/2875 , C07K16/2878 , C07K2319/30
摘要： The present invention relates to reagents which modify the activity of TWEAK and their use as therapeutic agents for the treatment of immunological disorders.

7. 发明申请

US20130089539A1 KIM-1 ANTIBODIES FOR TREATMENT OF TH2-MEDIATED CONDITIONS 审中-公开
标题翻译：用于治疗TH2介导的病症的KIM-1抗体
公开(公告)号：US20130089539A1
公开(公告)日：2013-04-11
申请号：US13439413
申请日：2012-04-04
申请人： Paul Rennert , Patricia McCoon , Veronique Bailly , Alexey Lugovskoy
发明人： Paul Rennert , Patricia McCoon , Veronique Bailly , Alexey Lugovskoy
IPC分类号： A61K39/395
CPC分类号： A61K39/39533 , A61K2039/505 , C07K16/2803 , C07K2317/34 , C07K2317/73 , C07K2317/74
摘要： Compositions and methods for treating Th2- and Th1-mediated disease are provided.
摘要翻译：提供了治疗Th2和Th1介导的疾病的组合物和方法。

8. 发明授权

US07592007B2 Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA-4 specific antibodies 失效
标题翻译：用CTLA-4特异性抗体抑制T细胞增殖或IL-2积累的方法
公开(公告)号：US07592007B2
公开(公告)日：2009-09-22
申请号：US10732847
申请日：2003-12-09
申请人： John G. Gribben , Gordon J. Freeman , Lee M. Nadler , Paul Rennert , Cindy L. Jellis , Edward Greenfield , Gary S. Gray
发明人： John G. Gribben , Gordon J. Freeman , Lee M. Nadler , Paul Rennert , Cindy L. Jellis , Edward Greenfield , Gary S. Gray
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K14/70521 , A61K38/00 , C07K14/70532 , C07K16/2818 , C07K2317/34
摘要： Isolated ligands which bind a molecule expressed on the surface of T cells and induce antigen specific apoptosis in activated T cells are disclosed. Preferably, the T cell surface molecule is CTLA4 and the ligand is a monoclonal anti-CTLA4 antibody that binds to an epitope of CTLA4 distinct from the binding sites of B7-1 and B7-2. Upon binding of the antibody to CTLA4 on an activated T cell, in the presence of an antigenic signal, antigen specific apoptosis is induced. The invention also describes a novel natural CTLA4 ligand, distinct from B7-1 and B7-2, which mediates induction of apoptosis. Pharmaceutical compositions of anti-CTLA4 antibodies or other isolated CTLA4 ligands which can be administered to subjects to induce T cell apoptosis, thereby clonally deleting antigen specific T cells, such as alloreactive T cells in transplantation situations or autoreactive T cells in autoimmune disorders, are also disclosed. Methods for inducing T cell apoptosis in vitro with an anti-CTLA4 antibody or other ligand of the invention together with an antigen specific signal are also disclosed, e.g., for use in purging alloreactive T cells from donor bone marrow prior to bone marrow transplantation to inhibit graft versus host disease.
摘要翻译：公开了结合在T细胞表面上表达并在活化的T细胞中诱导抗原特异性凋亡的分子的分离的配体。优选地，T细胞表面分子是CTLA4，并且配体是结合与B7-1和B7-2的结合位点不同的CTLA4的表位的单克隆抗CTLA4抗体。当抗体与CTLA4在活化的T细胞上结合时，在抗原信号存在下，诱导抗原特异性凋亡。本发明还描述了一种与介导细胞凋亡诱导的B7-1和B7-2不同的新型天然CTLA4配体。抗CTLA4抗体或其他分离的CTLA4配体的药物组合物也可以被给予受试者诱导T细胞凋亡，从而克隆地删除抗原特异性T细胞，例如移植情况下的同种异体反应性T细胞或自身免疫性疾病中的自身反应性T细胞，披露还公开了用本发明的抗CTLA4抗体或其他配体与抗原特异性信号一起体外诱导T细胞凋亡的方法，例如用于在骨髓移植之前从供体骨髓中清除同种异体反应性T细胞以抑制移植物抗宿主病。

9. 发明申请

US20050008636A1 Antagonists of tweak and of tweak receptor and their use to treat immunological disorders 有权
标题翻译：调节和调节受体的拮抗剂及其用于治疗免疫疾病的用途
公开(公告)号：US20050008636A1
公开(公告)日：2005-01-13
申请号：US10916141
申请日：2004-08-11
申请人： Paul Rennert
发明人： Paul Rennert
IPC分类号： A61K45/00 , A61K38/00 , A61K38/17 , A61K39/395 , A61P7/00 , A61P7/06 , A61P13/12 , A61P21/00 , A61P21/04 , A61P29/00 , A61P31/18 , A61P35/00 , A61P37/02 , A61P37/06 , A61P37/08 , A61P43/00 , C07K14/705 , C07K16/28
CPC分类号： C07K14/70575 , A61K2039/505 , C07K16/2875 , C07K16/2878 , C07K2319/30
摘要： The present invention relates to reagents which modify the activity of TWEAK and their use as therapeutic agents for the treatment of immunological disorders.
摘要翻译：本发明涉及改变TWEAK活性的试剂及其作为治疗免疫学障碍的治疗剂的用途。

10. 发明授权

US07276241B2 Methods of treating a tumor that expresses APRIL by administering BCMA 有权
标题翻译：通过施用BCMA治疗表达APRIL的肿瘤的方法
公开(公告)号：US07276241B2
公开(公告)日：2007-10-02
申请号：US10115192
申请日：2002-04-02
申请人： Pascal Schneider , Jeffrey Thompson , Teresa Cachero , Christine Ambrose , Paul Rennert
发明人： Pascal Schneider , Jeffrey Thompson , Teresa Cachero , Christine Ambrose , Paul Rennert
IPC分类号： A61K39/00 , A61K38/00
CPC分类号： C07K14/70575 , A61K38/00 , A61K2039/505 , C07K2319/30
摘要： A novel receptor in the TNF family is provided: APRIL-R. Chimeric molecules and antibodies to APRIL-R and methods of use thereof are also provided.
摘要翻译：提供TNF家族中的新型受体：APRIL-R。还提供了嵌合分子和对APRIL-R的抗体及其使用方法。

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