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1. 发明授权

CN103797113B 遗传修饰的噬菌体及其用途有权转让
公开(公告)号：CN103797113B
公开(公告)日：2018-08-10
申请号：CN201280042917.7
申请日：2012-07-06
申请人：德尔菲遗传学公司
发明人： C·斯派尔
IPC分类号： C12N7/00 , C12N15/70
CPC分类号： C12N7/00 , C12N15/70 , C12N2710/00088 , C12N2795/00011 , C12N2795/10311
摘要：本发明涉及遗传修饰的噬菌体及其在生产目的生物分子的方法中的用途。

2. 发明公开

CN103797113A 遗传修饰的噬菌体及其用途有权转让
公开(公告)号：CN103797113A
公开(公告)日：2014-05-14
申请号：CN201280042917.7
申请日：2012-07-06
申请人：德尔菲遗传学公司
发明人： C·斯派尔
IPC分类号： C12N7/00 , C12N15/70
CPC分类号： C12N7/00 , C12N15/70 , C12N2710/00088 , C12N2795/00011 , C12N2795/10311
摘要：本发明涉及遗传修饰的噬菌体及其在生产目的生物分子的方法中的用途。

3. 发明授权

US06287569B1 Vaccines with enhanced intracellular processing 失效
标题翻译：具有增强细胞内加工的疫苗
公开(公告)号：US06287569B1
公开(公告)日：2001-09-11
申请号：US09056105
申请日：1998-04-06
申请人： Thomas J. Kipps , Yunqi Wu
发明人： Thomas J. Kipps , Yunqi Wu
IPC分类号： A61K3912
CPC分类号： A61K39/0005 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/53 , A61K2039/57 , C12N2710/00088
摘要： Method for generating in a patient a cellular immune response to a target protein or portion thereof comprising the step of introducing into cells of the patient a vector containing a nucleotide sequence encoding a chimeric immunogen comprising a protein processing signal and the target protein or portion thereof, so that the chimeric immunogen is made within the cells and subsequently processed such that the target protein or portion thereof is presented to the patient's immune system so as to generate a cellular immune response.
摘要翻译：在患者中产生对靶蛋白或其部分的细胞免疫应答的方法，其包括将含有编码包含蛋白处理信号和靶蛋白或其部分的嵌合免疫原的核苷酸序列的载体导入患者细胞的步骤，使得嵌合免疫原在细胞内进行并随后进行处理，使得靶蛋白或其部分被呈递给患者的免疫系统以产生细胞免疫应答。

4. 发明公开

EP0840797A1 METHODS AND MEANS FOR TARGETED GENE DELIVERY 失效
标题翻译：的方法和手段的基因靶向递送
公开(公告)号：EP0840797A1
公开(公告)日：1998-05-13
申请号：EP96925173.0
申请日：1996-07-25
申请人： Introgene B.V.
发明人： VALERIO, Domenico, Introgene B.V. , VAN BEUSECHEM, Victor, Willem, Introgene B.V.
IPC分类号： C12N15 , A61K35 , A61K47 , A61K48 , C07K14 , C12N5 , C12Q1
CPC分类号： C07K14/005 , A61K47/6898 , A61K47/6901 , A61K48/00 , B82Y5/00 , C07K14/70535 , C07K2319/32 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/00088 , C12N2740/13043 , C12N2740/13045 , C12N2740/13052 , C12N2740/15022 , C12N2810/855 , C12N2810/859
摘要： The present invention provides a method of producing viral gene delivery vehicles which can be transferred to preselected cell types by using targeting conjugates. The gene delivery vehicules comprise: 1) the gene of interest (to be delivered); 2) a viral capsid or envelope carrying a member of a specific binding pair, the counterpart of which is not directly associated with the surface of the target cell. These vehicles can be made unable to bind to their natural receptor on the cell. The targeting conjugates are composed of the counterpart member of the specific binding pair linked to a targeting moiety which is a cell-type specific ligand (or fragments thereof). The number of the specific binding pair present on the viral vehicles can be for example an immunoglobulin binding moiety (e.g. capable of binding to a Fc fragment, protein A, protein G, FcR or an anti-Ig antibody), or biotin, avidin or streptavidin. The outer membrane or capsid of the virus may contain a substance which mediates entrance of the gene delivery vehicle into the target cell. Due to the specificity of the ligand, the high affinity of the binding pair and to the inability of the gene delivery vehicle to be targeted when used alone, the universality of the method for gene delivery, together with its high cell type selectively can easily be achievied by the use of various adequate targeting conjugates.

5. 发明公开

EP2543720A1 Genetically modified phage and use thereof 审中-公开
标题翻译： Genetisch modifizierte Phagen und Verwendungdafür
公开(公告)号：EP2543720A1
公开(公告)日：2013-01-09
申请号：EP11173033.9
申请日：2011-07-07
申请人： Delphi Genetics
发明人： Szpirer, Cédric
IPC分类号： C12N7/00 , C12N15/70
CPC分类号： C12N7/00 , C12N15/70 , C12N2710/00088 , C12N2795/10311
摘要： The present invention relates to a genetically modified phage and use thereof in a method for producing a biomolecule of interest.
摘要翻译：本发明涉及遗传修饰的噬菌体及其在生产感兴趣的生物分子的方法中的用途。

6. 发明申请

WO1997005266A1 METHODS AND MEANS FOR TARGETED GENE DELIVERY 审中-公开
标题翻译：目的基因交付的方法和手段
公开(公告)号：WO1997005266A1
公开(公告)日：1997-02-13
申请号：PCT/NL1996000302
申请日：1996-07-25
申请人： INTROGENE B.V. , VALERIO, Domenico , VAN BEUSECHEM, Victor, Willem
发明人： INTROGENE B.V.
IPC分类号： C12N15/87
CPC分类号： C07K14/005 , A61K47/6898 , A61K47/6901 , A61K48/00 , B82Y5/00 , C07K14/70535 , C07K2319/32 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/00088 , C12N2740/13043 , C12N2740/13045 , C12N2740/13052 , C12N2740/15022 , C12N2810/855 , C12N2810/859
摘要： The present invention provides a method of producing viral gene delivery vehicles which can be transferred to preselected cell types by using targeting conjugates. The gene delivery vehicules comprise: 1) the gene of interest (to be delivered); 2) a viral capsid or envelope carrying a member of a specific binding pair, the counterpart of which is not directly associated with the surface of the target cell. These vehicles can be made unable to bind to their natural receptor on the cell. The targeting conjugates are composed of the counterpart member of the specific binding pair linked to a targeting moiety which is a cell-type specific ligand (or fragments thereof). The number of the specific binding pair present on the viral vehicles can be for example an immunoglobulin binding moiety (e.g. capable of binding to a Fc fragment, protein A, protein G, FcR or an anti-Ig antibody), or biotin, avidin or streptavidin. The outer membrane or capsid of the virus may contain a substance which mediates entrance of the gene delivery vehicle into the target cell. Due to the specificity of the ligand, the high affinity of the binding pair and to the inability of the gene delivery vehicle to be targeted when used alone, the universality of the method for gene delivery, together with its high cell type selectively can easily be achievied by the use of various adequate targeting conjugates.
摘要翻译：本发明提供了可以通过使用靶向缀合物转移到预选细胞类型的病毒基因递送载体的生产方法。基因输送车辆包括：1）感兴趣的基因（待交付）; 2）携带特异性结合对的成员的病毒衣壳或信封，其对应物不与靶细胞的表面直接相关。这些载体可能不能与细胞上的天然受体结合。靶向缀合物由与作为细胞型特异性配体（或其片段）的靶向部分连接的特异性结合对的对应成员组成。存在于病毒载体上的特异性结合对的数目可以是例如免疫球蛋白结合部分（例如能够结合Fc片段，蛋白A，蛋白G，FcR或抗-Ig抗体）或生物素，抗生物素蛋白或链亲和素。病毒的外膜或衣壳可以含有介导基因递送载体进入靶细胞的入口的物质。由于配体的特异性，当单独使用时，结合对的高亲和力和基因递送载体的靶向性不足，基因递送方法的普及性及其高细胞型选择性可容易地通过使用各种适当的目标缀合物实现。

7. 发明申请

WO98045444A1 VACCINES WITH ENHANCED INTRACELLULAR PROCESSING 审中-公开
标题翻译：具有增强细胞内加工的疫苗
公开(公告)号：WO98045444A1
公开(公告)日：1998-10-15
申请号：PCT/US1998/007290
申请日：1998-04-10
IPC分类号： A61K39/00 , A61K39/12 , A61K48/00 , A61P37/04 , C12N15/12
CPC分类号： A61K39/0005 , A61K39/00 , A61K39/0011 , A61K48/00 , A61K2039/53 , A61K2039/57 , C12N2710/00088
摘要： Method for generating in a patient a cellular immune response to a target protein or portion thereof comprising the step of introducing into cells of the patient a vector containing a nucleotide sequence encoding a chimeric immunogen comprising a protein processing signal and the target protein or portion thereof, so that the chimeric immunogen is made within the cells and subsequently processed such that the target protein or portion thereof is presented to the patient's immune system so as to generate a cellular immune response.
摘要翻译：在患者中产生对靶蛋白或其部分的细胞免疫应答的方法，其包括将包含编码包含蛋白质加工信号和靶蛋白或其部分的嵌合免疫原的核苷酸序列的载体导入患者的细胞的步骤，使得嵌合免疫原在细胞内进行并随后进行处理，使得靶蛋白或其部分被呈递给患者的免疫系统以产生细胞免疫应答。

8. 发明申请

WO2012098243A1 HOMOMULTIMERIC STRUCTURE BY ASSEMBLY OF SIRV2 P98 PROTEINS OR P98 VARIANTS, CONJUGATE AND USES THEREOF 审中-公开
标题翻译：通过组装SIRV2 P98蛋白质或P98变体的共同结构，结合及其用途
公开(公告)号：WO2012098243A1
公开(公告)日：2012-07-26
申请号：PCT/EP2012/050902
申请日：2012-01-20
申请人： INSTITUT PASTEUR , UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , UNIVERSITE PARIS-SUD 11 , QUAX, Tessa E.F. , LUCAS, Soizick , FORTERRE, Patrick , PRANGISHVILI, David
发明人： QUAX, Tessa E.F. , LUCAS, Soizick , FORTERRE, Patrick , PRANGISHVILI, David
IPC分类号： C07K14/01 , B82Y5/00
CPC分类号： C07K14/01 , B82Y5/00 , C12N2710/00088 , C12N2795/10011
摘要： The present invention relates to a homomultimeric protein structure constituted by assembled monomers of the P98 protein of Sulfolobus islandicus rod-shaped virus 2 (SIRV2) or assembled monomer variants of said P98 protein. In a particular embodiment, this homomultimeric protein structure has a seven-fold rotational symmetry, and is found in an open conformation or closed conformation. A particular structure has the form of baseless 7-face pyramid. The invention also relates to a conjugate comprising or consisting of a homomultimeric protein structure of the invention to which one or more heterologous molecule(s) is attached. Furthermore, the invention also concerns a homomultimeric protein structure or a conjugate of the invention, inserted into or exposed at the surface of a lipid layer or bilayer, of a vesicle or of a cell, and their uses thereof.
摘要翻译：本发明涉及通过组合的Sulfolobus islandicus杆状病毒2（SIRV2）的P98蛋白的单体或所述P98蛋白的组装的单体变体构成的同源多聚体蛋白结构。在一个具体实施方案中，该同源多聚体蛋白质结构具有7倍的旋转对称性，并且以开放构象或封闭构象发现。特定的结构具有无根的7面金字塔的形式。本发明还涉及包含一个或多个异源分子所连接的本发明的同源多聚体蛋白质结构或由其组成的缀合物。此外，本发明还涉及插入或暴露于脂质层或双层的囊泡或细胞的表面的本发明的同源多聚体蛋白质结构或缀合物及其用途。

9. 发明授权

EP0840797B1 METHODS AND MEANS FOR TARGETED GENE DELIVERY 失效
标题翻译：的方法和手段的基因靶向递送
公开(公告)号：EP0840797B1
公开(公告)日：2014-09-03
申请号：EP96925173.5
申请日：1996-07-25
申请人： Crucell Holland B.V.
发明人： VALERIO, Domenic , VAN BEUSECHEM, Victor Willem
IPC分类号： C12N15/87 , A61K48/00 , A61K47/48 , C12Q1/70 , C12N15/86
CPC分类号： C07K14/005 , A61K47/6898 , A61K47/6901 , A61K48/00 , B82Y5/00 , C07K14/70535 , C07K2319/32 , C12N7/00 , C12N15/86 , C12N15/87 , C12N2710/00088 , C12N2740/13043 , C12N2740/13045 , C12N2740/13052 , C12N2740/15022 , C12N2810/855 , C12N2810/859

10. 发明公开

EP2729563A1 GENETICALLY MODIFIED PHAGE AND USE THEREOF 有权转让
标题翻译： GENERTISCH MODIFIZIERTE PHAGEN UND VERWENDUNG DAVON
公开(公告)号：EP2729563A1
公开(公告)日：2014-05-14
申请号：EP12732669.2
申请日：2012-07-06
申请人： Delphi Genetics
发明人： SZPIRER, Cédric
IPC分类号： C12N7/00 , C12N15/70
CPC分类号： C12N7/00 , C12N15/70 , C12N2710/00088 , C12N2795/00011 , C12N2795/10311
摘要： The present invention relates to a genetically modified phage and use thereof in a method for producing a biomolecule of interest.
摘要翻译：本发明涉及遗传修饰的噬菌体及其在生产感兴趣的生物分子的方法中的用途。

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