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1. 发明授权

US07118712B1 Non-planar chemical preconcentrator 有权
标题翻译：非平面化学预浓缩器
公开(公告)号：US07118712B1
公开(公告)日：2006-10-10
申请号：US10696649
申请日：2003-10-28
申请人： Ronald P. Manginell , Douglas R. Adkins , Sara S. Sokolowski , Patrick R. Lewis
发明人： Ronald P. Manginell , Douglas R. Adkins , Sara S. Sokolowski , Patrick R. Lewis
IPC分类号： B01L11/00
CPC分类号： G01N1/40 , G01N1/405 , Y10T436/2575
摘要： A non-planar chemical preconcentrator comprises a high-surface area, low mass, three-dimensional, flow-through sorption support structure that can be coated or packed with a sorptive material. The sorptive material can collect and concentrate a chemical analyte from a fluid stream and rapidly release it as a very narrow temporal plug for improved separations in a microanalytical system. The non-planar chemical preconcentrator retains most of the thermal and fabrication benefits of a planar preconcentrator, but has improved ruggedness and uptake, while reducing sorptive coating concerns and extending the range of collectible analytes.
摘要翻译：非平面化学预浓缩器包括可以被吸附材料涂覆或包装的高表面积，低质量，三维，流通的吸附支撑结构。吸附材料可以从流体流中收集和浓缩化学分析物，并将其快速释放为非常窄的时间插塞，以改进微量分析系统中的分离。非平面化学预浓缩器保留了平面预浓缩器的大部分热和制造优点，但具有改进的耐用性和吸收性，同时减少了吸附性涂层问题并扩大了可收集分析物的范围。

2. 发明授权

US08298488B1 Microfabricated thermionic detector 有权
标题翻译：微型热离子检测器
公开(公告)号：US08298488B1
公开(公告)日：2012-10-30
申请号：US10981010
申请日：2004-11-04
申请人： Patrick R. Lewis , Ronald P. Manginell , David R. Wheeler , Daniel E. Trudell
发明人： Patrick R. Lewis , Ronald P. Manginell , David R. Wheeler , Daniel E. Trudell
IPC分类号： G01N27/00
CPC分类号： G01N30/64 , G01N2030/647
摘要： A microfabricated TID comprises a microhotplate and a thermionic source disposed on the microhotplate. The microfabricated TID can provide high sensitivity and selectivity to nitrogen- and phosphorous-containing compounds and other compounds containing electronegative function groups. The microfabricated TID can be microfabricated with semiconductor-based materials. The microfabricated TID can be combined with a microfabricated separation column and used in microanalytical system for the rapid on-site detection of pesticides, chemical warfare agents, explosives, pharmaceuticals, and other organic compounds that contain nitrogen or phosphorus.
摘要翻译：微制造的TID包括设置在微电子板上的微型板和热离子源。微加工的TID可以为含氮和磷的化合物和其他含有负官能团的化合物提供高灵敏度和选择性。微制造的TID可以用半导体材料进行微制造。微制造的TID可以与微加工的分离柱结合使用，用于微量分析系统，用于快速现场检测农药，化学战剂，爆炸物，药物和含氮或磷的其他有机化合物。

3. 发明授权

US06786716B1 Microcombustor 有权
标题翻译：微型燃烧器
公开(公告)号：US06786716B1
公开(公告)日：2004-09-07
申请号：US10369442
申请日：2003-02-18
申请人： Timothy J. Gardner , Ronald P. Manginelli , Patrick R. Lewis , Gregory C. Frye-Mason , Chris Colburn
发明人： Timothy J. Gardner , Ronald P. Manginelli , Patrick R. Lewis , Gregory C. Frye-Mason , Chris Colburn
IPC分类号： F23Q1100
CPC分类号： F23C13/00 , F23C2900/03001
摘要： A microcombustor comprises a microhotplate and a catalyst for sustained combustion on the microscale. The microhotplate has very low heat capacity and thermal conductivity that mitigate large heat losses arising from large surface-to-volume ratios typical of the microdomain. The heated catalyst enables flame ignition and stabilization, permits combustion with lean fuel/air mixtures, extends a hydrocarbon's limits of flammability, and lowers the combustion temperature. The reduced operating temperatures enable a longer microcombustor lifetime and the reduced fuel consumption enables smaller fuel supplies, both of which are especially important for portable microsystems applications. The microcombustor can be used for on-chip thermal management and for sensor applications, such as heating of a micro gas chromatography column and for use as a micro flame ionization detector.
摘要翻译：微燃烧器包括微孔板和用于在微尺度上持续燃烧的催化剂。微孔板具有非常低的热容量和导热性，可以减轻由微区域典型的大的表面与体积比引起的大的热损失。加热的催化剂使得火焰点燃和稳定化，允许用贫燃料/空气混合物燃烧，延长碳氢化合物的可燃性极限，并降低燃烧温度。降低的工作温度使得更长的微型燃烧器寿命和降低的燃料消耗能够实现更小的燃料供应，这两者对便携式微系统的应用尤为重要。微型燃烧器可用于片上热管理和传感器应用，例如微气相色谱柱的加热和用作微火焰离子化检测器。

4. 发明授权

US07273517B1 Non-planar microfabricated gas chromatography column 有权
标题翻译：非平面微细气相色谱柱
公开(公告)号：US07273517B1
公开(公告)日：2007-09-25
申请号：US11067107
申请日：2005-02-25
申请人： Patrick R. Lewis , David R. Wheeler
发明人： Patrick R. Lewis , David R. Wheeler
IPC分类号： B01D53/02
CPC分类号： G01N30/6095 , G01N2030/025
摘要： A non-planar microfabricated gas chromatography column comprises a planar substrate having a plurality of through holes, a top lid and a bottom lid bonded to opposite surfaces of the planar substrate, and inlet and outlet ports for injection of a sample gas and elution of separated analytes. A plurality of such planar substrates can be aligned and stacked to provide a longer column length having a small footprint. Furthermore, two or more separate channels can enable multi-channel or multi-dimensional gas chromatography. The through holes preferably have a circular cross section and can be coated with a stationary phase material or packed with a porous packing material. Importantly, uniform stationary phase coatings can be obtained and band broadening can be minimized with the circular channels. A heating or cooling element can be disposed on at least one of the lids to enable temperature programming of the column.
摘要翻译：非平面微细气相色谱柱包括具有多个通孔的平面基板，与平面基板的相对表面接合的顶盖和底盖，以及用于注入样品气体的入口和出口以及分离的分析物。多个这样的平面基板可以对准和堆叠，以提供具有小占地面积的较长的列长度。此外，两个或更多个单独的通道可以实现多通道或多维气相色谱。通孔优选具有圆形横截面，并且可以涂覆有固定相材料或填充有多孔包装材料。重要的是，可以获得均匀的固定相涂层，并且能够使圆形通道使带宽增宽最小化。加热或冷却元件可以设置在至少一个盖子上以使得柱的温度编程。

5. 发明授权

US07168298B1 Mass-sensitive chemical preconcentrator 有权
标题翻译：质量敏感的化学预浓缩器
公开(公告)号：US07168298B1
公开(公告)日：2007-01-30
申请号：US10903329
申请日：2004-07-29
申请人： Ronald P. Manginell , Douglas R. Adkins , Patrick R. Lewis
发明人： Ronald P. Manginell , Douglas R. Adkins , Patrick R. Lewis
IPC分类号： G01N11/10 , G01N30/00 , G01N30/12
CPC分类号： G01N30/08 , G01N1/2214 , G01N30/12 , G01N2030/085
摘要： A microfabricated mass-sensitive chemical preconcentrator actively measures the mass of a sample on an acoustic microbalance during the collection process. The microbalance comprises a chemically sensitive interface for collecting the sample thereon and an acoustic-based physical transducer that provides an electrical output that is proportional to the mass of the collected sample. The acoustic microbalance preferably comprises a pivot plate resonator. A resistive heating element can be disposed on the chemically sensitive interface to rapidly heat and release the collected sample for further analysis. Therefore, the mass-sensitive chemical preconcentrator can optimize the sample collection time prior to release to enable the rapid and accurate analysis of analytes by a microanalytical system.
摘要翻译：微量化质量敏感化学预浓缩器在收集过程中主动测量声学微量天平上样品的质量。微量天平包括用于在其上收集样品的化学敏感界面和基于声学的物理换能器，其提供与所收集的样品的质量成比例的电输出。声学微量天平优选地包括枢轴板谐振器。电阻加热元件可以设置在化学敏感界面上，以快速加热和释放收集的样品进行进一步分析。因此，质量敏感的化学预浓缩器可以在释放前优化样品收集时间，以便通过微量分析系统快速准确地分析分析物。

6. 发明授权

US07799280B1 Tortuous path chemical preconcentrator 有权
标题翻译：曲折路径化学预浓缩器
公开(公告)号：US07799280B1
公开(公告)日：2010-09-21
申请号：US11355480
申请日：2006-02-16
申请人： Ronald P. Manginell , Patrick R. Lewis , Douglas R. Adkins , David R. Wheeler , Robert J. Simonson
发明人： Ronald P. Manginell , Patrick R. Lewis , Douglas R. Adkins , David R. Wheeler , Robert J. Simonson
IPC分类号： B01L99/00
CPC分类号： B01L3/502753 , B01L2200/0668 , B01L2300/0883 , B01L2300/16 , B01L2400/086 , G01N1/405 , Y10T436/2575
摘要： A non-planar, tortuous path chemical preconcentrator has a high internal surface area having a heatable sorptive coating that can be used to selectively collect and concentrate one or more chemical species of interest from a fluid stream that can be rapidly released as a concentrated plug into an analytical or microanalytical chain for separation and detection. The non-planar chemical preconcentrator comprises a sorptive support structure having a tortuous flow path. The tortuosity provides repeated twists, turns, and bends to the flow, thereby increasing the interfacial contact between sample fluid stream and the sorptive material. The tortuous path also provides more opportunities for desorption and readsorption of volatile species. Further, the thermal efficiency of the tortuous path chemical preconcentrator is comparable or superior to the prior non-planar chemical preconcentrator. Finally, the tortuosity can be varied in different directions to optimize flow rates during the adsorption and desorption phases of operation of the preconcentrator.
摘要翻译：非平面曲折路径化学预浓缩器具有高内表面积，其具有可加热吸附涂层，其可用于选择性地收集和浓缩一种或多种感兴趣的化学物质，所述流体物流可作为集中塞快速释放用于分离和检测的分析或微量分析链。非平面化学预浓缩器包括具有曲折流动路径的吸附支撑结构。弯曲度为流动提供了反复的扭转，弯曲和弯曲，从而增加了样品流体流与吸附材料之间的界面接触。曲折的路径还为挥发物种的解吸和吸收提供了更多的机会。此外，曲折路径化学预浓缩器的热效率相当于或优于现有的非平面化学预浓缩器。最后，曲折度可以在不同的方向上变化，以优化预浓缩器的吸附和解吸阶段的流速。

7. 发明授权

US07727314B1 Methods for improved preconcentrators 有权
标题翻译：改善预浓缩器的方法
公开(公告)号：US07727314B1
公开(公告)日：2010-06-01
申请号：US11699904
申请日：2007-01-30
申请人： Ronald P. Manginell , Patrick R. Lewis , Murat Okandan
发明人： Ronald P. Manginell , Patrick R. Lewis , Murat Okandan
IPC分类号： B01D53/02 , G01N25/00
CPC分类号： G01N1/405 , G01N1/4022 , G01N30/08 , G01N30/6095
摘要： The present invention relates generally to chemical analysis (e.g. by gas chromatography), and in particular to a compact chemical preconcentrator formed on a substrate with a heatable sorptive membrane that can be used to accumulate and concentrate one or more chemical species of interest over time and then rapidly release the concentrated chemical species upon demand for chemical analysis.
摘要翻译：本发明一般涉及化学分析（例如通过气相色谱法），特别涉及形成在具有可加热吸附膜的基底上的紧凑型化学预浓缩器，其可用于在一段时间内积聚和浓缩一种或多种感兴趣的化学物种，然后根据化学分析的需要快速释放浓缩的化学物质。

8. 发明授权

US07314505B1 Stationary phase deposition based on onium salts 有权
标题翻译：基于鎓盐的固相沉积
公开(公告)号：US07314505B1
公开(公告)日：2008-01-01
申请号：US11156975
申请日：2005-06-20
申请人： David R. Wheeler , Patrick R. Lewis , Shawn M. Dirk , Daniel E. Trudell
发明人： David R. Wheeler , Patrick R. Lewis , Shawn M. Dirk , Daniel E. Trudell
IPC分类号： B01D53/02
CPC分类号： G01N30/56 , B01J2220/54 , B01J2220/86 , G01N2030/025 , G01N2030/567
摘要： Onium salt chemistry can be used to deposit very uniform thickness stationary phases on the wall of a gas chromatography column. In particular, the stationary phase can be bonded to non-silicon based columns, especially microfabricated metal columns. Non-silicon microfabricated columns may be manufactured and processed at a fraction of the cost of silicon-based columns. In addition, the method can be used to phase-coat conventional capillary columns or silicon-based microfabricated columns.
摘要翻译： ium盐化学可用于在气相色谱柱的壁上沉积非常均匀的厚度固定相。特别地，固定相可以结合到非硅基柱，特别是微结构的金属柱。可以以硅基柱的成本的一小部分来制造和处理非硅微加工柱。此外，该方法可用于相涂常规毛细管柱或硅基微细柱。

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