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1. 发明授权

US06787974B2 Ultrasound transducer unit and planar ultrasound lens 有权
标题翻译：超声波传感器单元和平面超声镜
公开(公告)号：US06787974B2
公开(公告)日：2004-09-07
申请号：US09988997
申请日：2001-11-21
申请人： Todd Fjield , Edward Paul Harhen , Patrick David Lopath
发明人： Todd Fjield , Edward Paul Harhen , Patrick David Lopath
IPC分类号： H01L4108
CPC分类号： G10K11/30
摘要： A lens for focusing an ultrasound wave having a wavelength, includes a plurality of substantially concentric rings disposed about a central point, at least one of the rings having a substantially triangular cross-section defined by first, second, and third sections, the first section extending from a proximal end radially away from the central point to a distal end, the second section extending from the distal end of, and substantially perpendicular to, the first section and terminating at a peak, and the third section smoothly sloping from the proximal end of the first section to the peak of the second section, and wherein the first, second and third sections have lengths with respect to the wavelength of the ultrasound wave such that (i) phases of the ultrasound wave are substantially additive at a focal point located on an axis perpendicular to the lens that passes through the central point, and (ii) aggregate focused ultrasound energy would not be predicted at the focal point by Snell's law refraction.
摘要翻译：用于聚焦具有波长的超声波的透镜包括围绕中心点设置的多个基本同心的环，所述环中的至少一个具有由第一，第二和第三部分限定的基本上三角形的横截面，第一部分从近端径向远离中心点延伸到远端，第二部分从第一部分的远端延伸并基本上垂直于第一部分并终止于峰顶，并且第三部分从近端平滑地倾斜的第一部分的峰值，并且其中第一，第二和第三部分相对于超声波的波长具有长度，使得（i）超声波的相位在位于焦点处的基本上是相加的在垂直于穿过中心点的透镜的轴上，和（ii）聚焦的聚焦超声能量不会在焦点处被Sn预测埃尔的法律折射。

2. 发明授权

US06763722B2 Ultrasonic transducers 有权
标题翻译：超声波换能器
公开(公告)号：US06763722B2
公开(公告)日：2004-07-20
申请号：US09904620
申请日：2001-07-13
申请人： Todd Fjield , Patrick David Lopath , Edward Paul Harhen
发明人： Todd Fjield , Patrick David Lopath , Edward Paul Harhen
IPC分类号： G01N2900
CPC分类号： B06B1/0674 , A61B17/2202 , A61B18/1492 , A61B18/24 , A61B2017/00274 , A61B2018/00214 , A61B2018/00547 , A61N7/00 , A61N7/022 , A61N2007/0043 , G10K11/004
摘要： A compact, high-power ultrasonic emitting transducer has an active element such as a piezoelectric element and structure defining a reflective backing interface such as an air interface behind the rear surface of the active element. A liquid is provided in the resonant unit between the backing interface and the active element.
摘要翻译：紧凑的大功率超声发射换能器具有有源元件，例如压电元件和限定反射背衬界面的结构，例如有源元件后表面之后的空气界面。在背衬界面和有源元件之间的谐振单元中提供液体。

3. 发明申请

US20110118632A1 CARDIAC ABLATION DEVICES 审中-公开
标题翻译：心脏消融装置
公开(公告)号：US20110118632A1
公开(公告)日：2011-05-19
申请号：US12946735
申请日：2010-11-15
申请人： Yegor Sinelnikov , Yong Zou , Reinhard Warnking , James Savage , Robert C. Pacheco , Jaime Merino , Patrick David Lopath , John Hotmer , Todd Fjield
发明人： Yegor Sinelnikov , Yong Zou , Reinhard Warnking , James Savage , Robert C. Pacheco , Jaime Merino , Patrick David Lopath , John Hotmer , Todd Fjield
IPC分类号： A61N7/00
CPC分类号： A61B17/22004 , A61B17/22012 , A61B17/2202 , A61B17/2251 , A61B2017/00243 , A61B2017/00991 , A61B2017/22027 , A61B2017/22054 , A61B2017/22061
摘要： A cardiac ablation device treats atrial fibrillation by directing and focusing ultrasonic waves into a ring-like ablation region (A). The device desirably is steerable and can be moved between a normal disposition, in which the ablation region lies parallel to the wall of the heart for ablating a loop-like lesion, and a canted disposition, in which the ring-like focal region is tilted relative to the wall of the heart, to ablate only a short, substantially linear lesion. The ablation device desirably includes a balloon reflector structure (18, 1310) and an ultrasonic emitter assembly (23, 1326), and can be steered and positioned without reference to engagement between the device and the pulmonary vein or ostium. A contrast medium (C) can be injected through the ablation device to facilitate imaging, so that the device can be positioned based on observation of the images.
摘要翻译：心脏消融装置通过将超声波引导并聚焦到环形消融区域（A）中来治疗房颤。该装置理想地是可操纵的，并且可以在其中消融区域平行于心脏壁平行以消除环状病变的正常设置和倾斜位置之间移动，其中环形聚焦区域倾斜相对于心脏壁，仅消融短暂的，基本上线性的损伤。消融装置理想地包括球囊反射器结构（18,1310）和超声波发射器组件（23,1326），并且可以被引导和定位，而不参考装置与肺静脉或口腔之间的接合。可以通过消融装置注入造影剂（C）以促进成像，使得可以基于对图像的观察来定位装置。

4. 发明授权

US06808524B2 Balloon alignment and collapsing system 失效
标题翻译：气球对齐和倒塌系统
公开(公告)号：US06808524B2
公开(公告)日：2004-10-26
申请号：US10244271
申请日：2002-09-16
申请人： Patrick David Lopath , Edward Paul Harhen
发明人： Patrick David Lopath , Edward Paul Harhen
IPC分类号： A61B1804
CPC分类号： A61N7/02 , A61B17/2202 , A61B2017/22054 , A61B2017/22062
摘要： A balloon catheter is provided with engagement elements disposed within the balloon so that, upon inflation of the balloon, the engagement elements move in the proximal to distal direction of the catheter so as to abut one another and form a substantially rigid column to maintain alignment of the distal end of the balloon with the proximal end of the balloon and with the catheter.
摘要翻译：球囊导管设置有设置在球囊内的接合元件，使得当气囊膨胀时，接合元件沿导管的近端至远端方向移动，以便彼此邻接并形成基本上刚性的柱，以保持对准球囊的远端具有球囊的近端和导管。

5. 发明授权

US06605084B2 Apparatus and methods for intrabody thermal treatment 有权
公开(公告)号：US06605084B2
公开(公告)日：2003-08-12
申请号：US09815863
申请日：2001-03-23
申请人： David E. Acker , Patrick David Lopath , Todd Fjield , Keith A. Reisinger
发明人： David E. Acker , Patrick David Lopath , Todd Fjield , Keith A. Reisinger
IPC分类号： A61B1804
CPC分类号： A61B17/2202 , A61B2017/00243 , A61B2017/22028 , A61B2017/22054 , A61B2017/22069 , A61N7/022 , A61N2007/0078
摘要： A treatment catheter (10) carries an elongated ultrasonic emitter (20) extending in the lengthwise direction of the catheter. The array is flexible in all directions transverse to the lengthwise direction. The treatment catheter is inserted into a chamber of the heart and brought to a desired configuration such as a substantially closed loop. The treatment catheter is then biased into engagement with the wall of the heart by an expansible balloon (62) or other expansible structure, which may be carried on a separate stabilizer catheter (60). While the treatment catheter is engaged with the heart wall, the array is actuated to ablate tissue along a path having a shape corresponding to the configuration of the treatment catheter.

6. 发明授权

US07540846B2 Energy application with inflatable annular lens 有权
公开(公告)号：US07540846B2
公开(公告)日：2009-06-02
申请号：US11267123
申请日：2005-11-04
申请人： Edward Paul Harhen , Todd Fjield , Patrick David Lopath , David E. Acker
发明人： Edward Paul Harhen , Todd Fjield , Patrick David Lopath , David E. Acker
IPC分类号： A61H1/00 , A61H1/02 , A61H5/00
CPC分类号： A61B17/2202 , A61B17/2251 , A61B18/1492 , A61B18/24 , A61B2017/00274 , A61B2017/22024 , A61B2017/22027 , A61B2017/22068 , A61B2018/00214 , A61B2018/00547 , A61M2025/1059 , A61N7/022
摘要： Apparatus and methods for ablating tissue surrounding a tubular anatomical structure such as the wall of a blood vessel or prostatic tissue surrounding the urethra. The apparatus includes an ultrasonic emitter such as a cylindrical emitter and an inflatable annular lens balloon surrounding the ultrasonic emitter. The lens balloon is inflated with a liquid having acoustic velocity different than that of the surrounding medium, so as to form an annular refracting surface. The acoustic energy from the emitter is focused into an annular focal region.

7. 发明授权

US07083614B2 Thermal treatment methods and apparatus with focused energy application 有权
公开(公告)号：US07083614B2
公开(公告)日：2006-08-01
申请号：US10227092
申请日：2002-08-23
申请人： Todd Fjield , Edward Paul Harhen , David E. Acker , Patrick David Lopath
发明人： Todd Fjield , Edward Paul Harhen , David E. Acker , Patrick David Lopath
IPC分类号： A61B18/18
CPC分类号： A61B17/2202 , A61B17/2251 , A61B18/1492 , A61B18/24 , A61B2017/00274 , A61B2017/22024 , A61B2017/22027 , A61B2017/22068 , A61B2018/00214 , A61B2018/00547 , A61M2025/1059 , A61N7/022
摘要： A collapsible ultrasonic reflector incorporates a gas-filled reflector balloon, a liquid-filled structural balloon an ultrasonic transducer disposed within the structural balloon. Acoustic energy emitted by the transducer is reflected by a highly reflective interface between the balloons. In a cardiac ablation procedure, the ultrasonic energy is focused into an annular focal region to ablate cardiac tissue extending in an annular path along the wall. Devices for stabilizing the balloon structure and for facilitating collapse and withdrawal of the balloon structure are also disclosed.

8. 发明授权

US06635054B2 Thermal treatment methods and apparatus with focused energy application 有权
公开(公告)号：US06635054B2
公开(公告)日：2003-10-21
申请号：US09905227
申请日：2001-07-13
申请人： Todd Fjield , Edward Paul Harhen , David E. Acker , Patrick David Lopath
发明人： Todd Fjield , Edward Paul Harhen , David E. Acker , Patrick David Lopath
IPC分类号： A61B1804
CPC分类号： A61B17/2202 , A61B17/2251 , A61B18/1492 , A61B18/24 , A61B2017/00274 , A61B2017/22024 , A61B2017/22027 , A61B2017/22068 , A61B2018/00214 , A61B2018/00547 , A61M2025/1059 , A61N7/022
摘要： A collapsible ultrasonic reflector incorporates a gas-filled reflector balloon, a liquid-filled structural balloon an ultrasonic transducer disposed within the structural balloon. Acoustic energy emitted by the transducer is reflected by a highly reflective interface between the balloons. In a cardiac ablation procedure, the ultrasonic energy is focused into an annular focal region to ablate cardiac tissue extending in an annular path along the wall. Devices for stabilizing the balloon structure and for facilitating collapse and withdrawal of the balloon structure are also disclosed.

9. 发明授权

US06508774B1 Hifu applications with feedback control 有权
标题翻译： Hifu应用与反馈控制使用气泡检测
公开(公告)号：US06508774B1
公开(公告)日：2003-01-21
申请号：US09523915
申请日：2000-03-09
申请人： David E. Acker , Patrick David Lopath
发明人： David E. Acker , Patrick David Lopath
IPC分类号： A61N700
CPC分类号： A61N7/02 , A61B8/0833
摘要： High intensity focused ultrasound heating is provided by applying therapeutic ultrasonic waves using an array of transducers. Cavitation is detected by using some or all of the transducers in the array to detect ultrasonic waves emanating from or reflected from the patient's body or the interface. A feedback signal is generated based on such detection. If the feedback signal indicates the presence of cavitation, the therapeutic ultrasonic waves are terminated or altered. Obstacles to ultrasound transmission, such as bony structures or bubbles at the interface between the transducer array and the patient can be detected using the same transducers.
摘要翻译：通过使用换能器阵列应用治疗性超声波来提供高强度聚焦超声加热。通过使用阵列中的一些或全部换能器检测从患者身体或界面发出或反射的超声波来检测气蚀。基于这种检测产生反馈信号。如果反馈信号指示存在空化，则治疗性超声波被终止或改变。可以使用相同的换能器检测超声波传输的障碍，例如在换能器阵列和患者之间的界面处的骨结构或气泡。

10. 发明授权

US07837676B2 Cardiac ablation devices 有权
标题翻译：心脏消融装置
公开(公告)号：US07837676B2
公开(公告)日：2010-11-23
申请号：US10783310
申请日：2004-02-20
申请人： Yegor Sinelnikov , Yong Zou , Reinhard Warnking , James Savage , Robert C. Pacheco , Jaime Merino , Patrick David Lopath , John Hotmer , Todd Fjield
发明人： Yegor Sinelnikov , Yong Zou , Reinhard Warnking , James Savage , Robert C. Pacheco , Jaime Merino , Patrick David Lopath , John Hotmer , Todd Fjield
IPC分类号： A61B18/04
CPC分类号： A61B17/22004 , A61B17/22012 , A61B17/2202 , A61B17/2251 , A61B2017/00243 , A61B2017/00991 , A61B2017/22027 , A61B2017/22054 , A61B2017/22061
摘要： A cardiac ablation device treats atrial fibrillation by directing and focusing ultrasonic waves into a ring-like ablation region (A). The device desirably is steerable and can be moved between a normal disposition, in which the ablation region lies parallel to the wall of the heart for ablating a loop-like lesion, and a canted disposition, in which the ring-like focal region is tilted relative to the wall of the heart, to ablate only a short, substantially linear lesion. The ablation device desirably includes a balloon reflector structure (18, 1310) and an ultrasonic emitter assembly (23, 1326), and can be steered and positioned without reference to engagement between the device and the pulmonary vein or ostium. A contrast medium (C) can be injected through the ablation device to facilitate imaging, so that the device can be positioned based on observation of the images.
摘要翻译：心脏消融装置通过将超声波引导并聚焦到环形消融区域（A）中来治疗房颤。该装置理想地是可操纵的，并且可以在其中消融区域平行于心脏壁平行以消除环状病变的正常设置和倾斜位置之间移动，其中环形聚焦区域倾斜相对于心脏壁，仅消融短暂的，基本上线性的损伤。消融装置理想地包括球囊反射器结构（18,1310）和超声波发射器组件（23,1326），并且可以被引导和定位，而不参考装置与肺静脉或口腔之间的接合。可以通过消融装置注入造影剂（C）以促进成像，使得可以基于对图像的观察来定位装置。

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