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1. 发明专利

JP2005508910A Neuroprotective therapeutic methods using selective iNOS inhibitor 审中-公开
公开(公告)号：JP2005508910A
公开(公告)日：2005-04-07
申请号：JP2003530275
申请日：2002-09-24
申请人：ジェーン・アール・コナーJane R. CONNOR , パメラ・ティ・マニングPamela T. MANNING , ファルマシア・コーポレイションPharmacia Corporation
发明人：ジェーン・アール・コナー , パメラ・ティ・マニング
IPC分类号： C07D223/12 , A61K31/155 , A61K31/198 , A61K31/41 , A61K31/55 , A61P9/10 , A61P17/02 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/28 , A61P43/00 , C07D257/06
CPC分类号： A61K31/155
摘要：神経変性疾患の予防および処置のための治療方法が記載され、該方法は誘導型一酸化窒素合成酵素の選択的阻害剤の神経保護的に有効な量をそれを必要とする対象に投与することを含む。

2. 发明授权

US07102013B2 Methods of making amidino compounds useful as nitric oxide synthase inhibitors 有权
标题翻译：制备脒基化合物可用作一氧化氮合酶抑制剂的方法
公开(公告)号：US07102013B2
公开(公告)日：2006-09-05
申请号：US10321969
申请日：2002-12-17
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： C07D233/40 , C07C271/00 , C07C323/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： Method of making an alpha-amino acid compound having the structure of Formula 32: comprising treating under hydrolyzing conditions a hydantoin compound having the structure of Formula 33: where the substituents are described herein.
摘要翻译：制备具有式32结构的α-氨基酸化合物的方法：包括在水解条件下处理具有结构式33的乙内酰脲化合物：其中取代基在本文中描述。

3. 发明授权

US06653350B1 Methods of treating osteoarthritis with inducible nitric oxide synthase inhibitors 失效
标题翻译：用诱导型一氧化氮合酶抑制剂治疗骨关节炎的方法
公开(公告)号：US06653350B1
公开(公告)日：2003-11-25
申请号：US09390440
申请日：1999-09-07
申请人： Pamela T. Manning , Jane R. Connor , Mark G. Currie , Jean Pierre Pelletier , Johanne Martel Pelletier
发明人： Pamela T. Manning , Jane R. Connor , Mark G. Currie , Jean Pierre Pelletier , Johanne Martel Pelletier
IPC分类号： A61K31195
CPC分类号： A61K31/198 , A61K31/00
摘要： Methods of treating osteoarthritis by administering an therapeutically effective amount of NOS inhibitor are provided.
摘要翻译：提供了通过施用治疗有效量的NOS抑制剂治疗骨关节炎的方法。

4. 发明申请

US20140363442A1 THERAPEUTIC CD47 ANTIBODIES 审中-公开
标题翻译：治疗性CD47抗体
公开(公告)号：US20140363442A1
公开(公告)日：2014-12-11
申请号：US14302348
申请日：2014-06-11
申请人： William A. FRAZIER , Pamela T. MANNING , Gerhard FREY , Hwai Wen CHANG
发明人： William A. FRAZIER , Pamela T. MANNING , Gerhard FREY , Hwai Wen CHANG
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K2039/505 , C07K16/2896 , C07K2317/24 , C07K2317/33 , C07K2317/71 , C07K2317/73 , C07K2317/75 , C07K2317/76 , C07K2317/92
摘要： Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to CD47 of multiple mammalian species, block the binding of SIRPalpha and TSP1 to CD47, promote phagocytosis of susceptible cancer cells, and reverse TSP1 inhibition of nitric oxide signaling, as well as monoclonal antibodies and antigen binding fragments thereof that compete with the former for binding to CD47 and that exhibit similar biological activities. Also provided are combinations of any of the foregoing. Such antibody compounds are variously effective in 1) treating tissue ischemia and ischemia-reperfusion injury (IRI) in the setting of organ preservation and transplantation, pulmonary hypertension, sickle cell disease, myocardial infarction, stroke, and other instances of surgery and/or trauma in which IRI is a component of pathogenesis; 2) in treating autoimmune and inflammatory diseases; and 3) as anti-cancer agents for treating susceptible cancer cells, promoting their phagocytic uptake and clearance.
摘要翻译：提供了结合多种哺乳动物物种的CD47的单克隆抗体及其抗原结合片段，阻断SIRPalpha和TSP1与CD47的结合，促进易感癌细胞的吞噬，并逆转一氧化氮信号传导的TSP1抑制，以及单克隆抗体与抗原结合片段与前者竞争结合CD47并表现出类似的生物活性。还提供了上述任何一种的组合。这种抗体化合物在1）在器官保存和移植，肺动脉高压，镰状细胞病，心肌梗塞，中风和其他手术和/或创伤实例的设置中治疗组织缺血和缺血再灌注损伤（IRI）是各种有效的其中IRI是发病机制的组成部分; 2）治疗自身免疫性疾病和炎性疾病; 和3）作为用于治疗敏感性癌细胞的抗癌剂，促进其吞噬摄取和清除。

5. 发明申请

US20140161799A1 Therapeutic CD47 Antibodies 有权
标题翻译：治疗性CD47抗体
公开(公告)号：US20140161799A1
公开(公告)日：2014-06-12
申请号：US14104007
申请日：2013-12-12
申请人： William A. Frazier , Pamela T. Manning , Gerhard Frey , Hwai Wen Chang
发明人： William A. Frazier , Pamela T. Manning , Gerhard Frey , Hwai Wen Chang
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K39/3955 , A61K45/06 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/73
摘要： Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of, CD47, as well as monoclonal antibodies and antigen binding fragments thereof that compete with the former for binding to CD47. Also provided are combinations of any of the foregoing. Such antibody compounds are variously effective in 1) treating tissue ischemia and ischemia-reperfusion injury (IRI) in the setting of organ preservation and transplantation, pulmonary hypertension, sickle cell disease, myocardial infarction, stroke, and other instances of surgery and/or trauma in which IRI is a component of pathogenesis; 2) in treating autoimmune and inflammatory diseases; and 3) as anti-cancer agents that are toxic to susceptible cancer cells, promoting their phagocytic uptake and clearance, or directly killing such cells.
摘要翻译：提供与CD47相结合并且抑制CD47的活性的单克隆抗体及其抗原结合片段，以及与前者竞争结合CD47的单克隆抗体及其抗原结合片段。还提供了上述任何一种的组合。这种抗体化合物在1）在器官保存和移植，肺动脉高压，镰状细胞病，心肌梗塞，中风和其他手术和/或创伤实例的设置中治疗组织缺血和缺血再灌注损伤（IRI）是各种有效的其中IRI是发病机制的组成部分; 2）治疗自身免疫性疾病和炎性疾病; 和3）作为对敏感性癌细胞有毒性的抗癌剂，促进其吞噬摄取和清除，或直接杀死此类细胞。

6. 发明授权

US06586471B1 Halogenated 2-amino-3, 4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：用作一氧化氮合酶抑制剂的卤化2-氨基-3,4-庚烯酸衍生物
公开(公告)号：US06586471B1
公开(公告)日：2003-07-01
申请号：US09835193
申请日：2001-04-13
申请人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi
发明人： Donald W. Hansen, Jr. , Barnett S. Pitzele , Ronald Keith Webber , Mihaly V. Toth , Pamela T. Manning , Alok K. Awasthi , Mahima Trivedi
IPC分类号： A61K3122
CPC分类号： C07D209/48 , C07C257/14 , C07D263/04 , C07D263/06 , C07D413/06
摘要： The present invention contains halogenated 2-amino-3,4 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
摘要翻译：本发明包含可用作一氧化氮合酶抑制剂的卤代2-氨基-3,4-庚烯酸衍生物。

7. 发明授权

US06465518B2 Halogenated 2-amino-4, 5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors 失效
标题翻译：用作一氧化氮合酶抑制剂的卤代2-氨基-4,5-庚烯酸衍生物
公开(公告)号：US06465518B2
公开(公告)日：2002-10-15
申请号：US09834361
申请日：2001-04-13
申请人： Donald W. Hansen, Jr. , Ronald Keith Webber , Alok K. Awasthi , Pamela T. Manning
发明人： Donald W. Hansen, Jr. , Ronald Keith Webber , Alok K. Awasthi , Pamela T. Manning
IPC分类号： A01N3712
CPC分类号： C07C257/14
摘要： The present invention contains halogenated 2-amino-4,5 heptenoic acid derivatives useful as nitric oxide synthase inhibitors.
摘要翻译：本发明包含可用作一氧化氮合酶抑制剂的卤代2-氨基-4,5-庚烯酸衍生物。

8. 发明授权

US06914158B2 Amidino compounds useful as nitric oxide synthase inhibitors 有权
标题翻译：可用作一氧化氮合酶抑制剂的脒基化合物
公开(公告)号：US06914158B2
公开(公告)日：2005-07-05
申请号：US10815375
申请日：2004-04-01
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61P1/00 , A61K31/198 , A61K31/4166 , A61K31/4245 , A61P1/02 , A61P1/04 , A61P1/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/02 , A61P11/06 , A61P13/12 , A61P15/00 , A61P15/08 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/04 , A61P19/06 , A61P21/00 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P25/30 , A61P25/32 , A61P25/34 , A61P25/36 , A61P27/02 , A61P27/06 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/02 , A61P37/06 , A61P39/02 , A61P43/00 , C07C317/48 , C07C317/50 , C07C323/58 , C07C323/59 , C07D233/76 , C07D271/06 , C07D271/07 , C07D277/56 , C07C323/00
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译：本发明涉及脒基化合物及其盐和前药。在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。在另一个实施方案中，本发明提供了制备脒基化合物的方法。

9. 发明授权

US07196118B2 Amidino compounds useful as nitric oxide synthase inhibitors 有权
标题翻译：可用作一氧化氮合酶抑制剂的脒基化合物
公开(公告)号：US07196118B2
公开(公告)日：2007-03-27
申请号：US11032650
申请日：2005-01-10
申请人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
发明人： Ronald Keith Webber , Richard C. Durley , Alok K. Awasthi , Arija A. Bergmanis , Kam F. Fok , Scott S. Ganser , Timothy J. Hagen , E. Ann Hallinan , Donald W. Hansen, Jr. , Brian S. Hickory , Pamela T. Manning , Michael Mao , Alan E. Moormann , Barnett S. Pitzele , Michelle A. Promo , Richard R. Schartman , Jeffrey A. Scholten , Jeffrey S. Snyder , Mihaly V. Toth , Mahima Trivedi , Sofya Tsymbalov , Foe Siong Tjoeng
IPC分类号： A61K31/195
CPC分类号： C07D271/07 , C07C317/48 , C07C323/58 , C07C323/59 , C07D233/76 , C07D277/56
摘要： The present invention relates to amidino compounds and salts and prodrugs thereof. In another embodiment the present invention also provides a use of the present compounds in therapy, particular as nitric oxide synthase inhibitors. In a further embodiment, the present invention provides methods of making the amidino compounds.
摘要翻译：本发明涉及脒基化合物及其盐和前药。在另一个实施方案中，本发明还提供本发明化合物在治疗中的用途，特别是作为一氧化氮合酶抑制剂。在另一个实施方案中，本发明提供了制备脒基化合物的方法。

10. 发明授权

US07012098B2 Inhibitors of inducible nitric oxide synthase for chemoprevention and treatment of cancers 失效
标题翻译：诱导型一氧化氮合酶抑制剂用于化学预防和治疗癌症
公开(公告)号：US07012098B2
公开(公告)日：2006-03-14
申请号：US09961969
申请日：2001-09-24
申请人： Pamela T. Manning , Jane R. Connor , Karen Seibert , Chinthalapally V. Rao , Bandaru S. Reddy
发明人： Pamela T. Manning , Jane R. Connor , Karen Seibert , Chinthalapally V. Rao , Bandaru S. Reddy
IPC分类号： A61K31/195
CPC分类号： A61K31/19 , A61K31/198 , A61K31/415 , A61K31/55 , A61K31/60 , A61K31/66 , A61K2300/00
摘要： Agents and methods for chemoprevention and treatment of neoplasia are described, the agents including a selective inhibitor of inducible nitric oxide synthase and a combination of a selective inhibitor of inducible nitric oxide synthase and an inhibitor of cylcooxygenase-2 in a pharmaceutical composition. The agents and methods are used for chemoprevention and treatment of neoplasia including colorectal cancer and other cancers affecting epithelial cells throughout the body. The agents can also be used to treat the fibrosis that occurs with radiation therapy, as well as adenomatous polyps, including those with familial adenomatous polyposis (FAP).
摘要翻译：描述了用于化学预防和治疗肿瘤的药剂和方法，所述药物包括诱导型一氧化氮合酶的选择性抑制剂和诱导型一氧化氮合酶的选择性抑制剂和环氧合酶-2的抑制剂在药物组合物中的组合。药物和方法用于化学预防和治疗包括结肠直肠癌和其他影响整个身体上皮细胞的癌症的瘤形成。这些药物也可用于治疗放射治疗发生的纤维化，以及腺瘤性息肉，包括家族性腺瘤性息肉病（FAP）的息肉。

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