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1. 发明申请

WO9810750A3 NUCLEIC ACID PARTICLE DELIVERY 审中-公开
标题翻译：核酸颗粒递送
公开(公告)号：WO9810750A3
公开(公告)日：1998-06-25
申请号：PCT/GB9702478
申请日：1997-09-11
申请人： POWDERJECT RES LTD , BURKOTH TERRY LEE , MUDDLE ANDREW GORDON , PORTER LINDA MAREE
发明人： BURKOTH TERRY LEE , MUDDLE ANDREW GORDON , PORTER LINDA MAREE
IPC分类号： A61K47/36 , A61K9/14 , A61K9/16 , A61K31/7088 , A61K48/00 , C12N15/89
CPC分类号： A61K9/0021 , A61K9/145 , A61K9/1623 , A61K48/00 , C12N15/89
摘要： Particles comprising a nucleic acid molecule are suitable for needleless injection, to skin or mucosal tissue, without a metal carrier.

2. 发明专利

JP2002179557A NEEDLELESS SYRINGE USING SUPERSONIC GAS FLOW FOR PARTICLE DELIVERY 审中-公开
公开(公告)号：JP2002179557A
公开(公告)日：2002-06-26
申请号：JP2001298589
申请日：2001-09-27
申请人： POWDERJECT RES LTD
发明人： BELLHOUSE BRIAN J , SARPHIE DAVID F , GREENFORD JOHN C
IPC分类号： C12M1/00 , A61K9/16 , A61K9/48 , A61K38/28 , A61K39/04 , A61K39/095 , A61K39/29 , A61M5/20 , A61M5/30 , A61M5/307 , A61M5/46 , C12M3/00
摘要： PROBLEM TO BE SOLVED: To provide a noninvasive apparatus for administering a medicinal agent used for administering a controlled dosage of the medicinal agent into an unharmed skin and using a needleless syringe means injecting light medicinal agent-containing particles. SOLUTION: This needleless syringe has a membrane ruptured by gas pressure generating a supersonic gas flow in which particles containing a therapeutic agent are injected. Medicines, products and compositions used in the syringe are also provided.

3. 发明专利

JP2006320737A NEEDLELESS SYRINGE USING SUPERSONIC GAS FLOW FOR PARTICLE DELIVERY 审中-公开
公开(公告)号：JP2006320737A
公开(公告)日：2006-11-30
申请号：JP2006192130
申请日：2006-07-12
申请人： POWDERJECT RES LTD
发明人： BELLHOUSE BRIAN J , SARPHIE DAVID F , GREENFORD JOHN C
IPC分类号： A61M5/30 , C12M1/00 , A61K9/16 , A61K9/48 , A61K9/50 , A61K38/28 , A61K39/04 , A61K39/095 , A61K39/29 , A61K48/00 , A61M5/20 , A61M5/307 , A61M5/46 , C12M3/00
摘要： PROBLEM TO BE SOLVED: To provide a non-invasive drug delivery system, giving a dose which is controlled into the intact skin, and using a needleless syringe means firing light-containing particles. SOLUTION: This needleless syringe includes: an elongate tubular nozzle 26; a rupturable membrane 34 initially closing a passage through the nozzle adjacent to the upstream end of the nozzle; particles disposed adjacent to the membrane; and energizing means 10 for applying a gas pressure enough to rupture the membrane and generate a supersonic gas flow in which the particles are entrained through the nozzle to the upstream side of the membrane. The particles are covered with DNA, and the particles are disposed between two rupturable diaphragms 33, 34 where the particles extend across the interior of the nozzle. COPYRIGHT: (C)2007,JPO&INPIT

4. 发明申请

WO03056033A8 NON- OR MINIMALLY INVASIVE MONITORING METHODS 审中-公开
标题翻译：非侵入性或微创侵入性监测方法
公开(公告)号：WO03056033A8
公开(公告)日：2003-09-12
申请号：PCT/US0237604
申请日：2002-12-13
申请人： POWDERJECT RES LTD , KWON SUNG-YUN , BURKOTH TERRY L
发明人： KWON SUNG-YUN , BURKOTH TERRY L
IPC分类号： A61B5/00 , A61B10/00 , A61B17/00 , A61B17/54 , C12M1/34 , C12Q1/54 , G01N33/66 , C12M1/00 , C12Q1/00
CPC分类号： A61B5/14532 , A61B5/14514 , A61B5/1486 , A61B17/545 , A61B2010/008 , A61B2017/00747 , A61B2017/00765 , G01N33/66
摘要： An apparatus for sensing an analyte is described, wherein the apparatus includes an interface contact element that is used to establish an interface with a quantity of body fluid. The interface contact element is adapted to facilitate diffusion of a target analyte across the interface essentially free of net mass fluid transport. The quantity of body fluid is exposed to the interface contact element through micro-pathways. The apparatus can also include a sensing material adapted to sense the target analyte with at least one analytical method. Methods for using the apparatus in a non- or minimally invasive monitoring technique are also described. Figure (1) illustrates a non-limiting embodiment of the apparatus used to test the principles of the invention.
摘要翻译：描述了用于感测分析物的设备，其中该设备包括界面接触元件，该界面接触元件用于与一定量的体液建立界面。界面接触元件适于促进目标分析物穿过界面扩散，基本上没有净质量流体输送。体液量通过微通道暴露于界面接触元件。该设备还可以包括适于利用至少一种分析方法来感测目标分析物的感测材料。还描述了在非侵入性或微创监测技术中使用该装置的方法。图（1）示出了用于测试本发明原理的设备的非限制性实施例。

5. 发明申请

WO02101412A3 SPRAY FREEZE-DRIED COMPOSITIONS 审中-公开
标题翻译：喷雾冷冻干燥组合物
公开(公告)号：WO02101412A3
公开(公告)日：2003-03-20
申请号：PCT/GB0202677
申请日：2002-06-10
申请人： POWDERJECT VACCINES INC , POWDERJECT RES LTD
发明人： MAA YUH-FUN , PRESTRELSKI STEVEN JOSEPH , BURKOTH TERRY LEE
IPC分类号： A61J3/02 , A61J3/07 , A61K9/16 , A61K9/19 , A61K9/48 , A61K39/00 , A61K39/02 , A61K39/12 , A61K47/02 , A61K47/10 , A61K47/18 , A61K47/26 , A61K47/30 , A61K47/36 , A61M5/30 , A61P31/04 , A61P31/12
CPC分类号： A61K9/1694 , A61K9/0021 , A61K9/1617 , A61K9/1623 , A61K9/1635 , A61K9/1652 , A61K39/00
摘要： A process for producing a powder comprises spray freeze-drying an aqueous solution or suspension comprising a pharmaceutical agent, said solution or suspension having a solids content of 20 % by weight or more. The spray freeze-dried powder may be administered to a subject via a needleless syringe.
摘要翻译：制备粉末的方法包括将包含药剂，所述溶液或悬浮液的固体含量为20重量％以上的水溶液或悬浮液喷雾冷冻干燥。可以通过无针注射器将喷雾冷冻干燥的粉末施用于受试者。

6. 发明申请

WO0045792A8 HYDROGEL PARTICLE FORMULATIONS 审中-公开
标题翻译：氢化颗粒配方
公开(公告)号：WO0045792A8
公开(公告)日：2001-11-29
申请号：PCT/GB0000349
申请日：2000-02-03
申请人： POWDERJECT RES LTD , CONNOR BARBARA H O , BURKOTH TERRY LEE , PRESTRELSKI STEVEN JOSEPH , MAA YUH FUN , MUDDLE ANDREW , HAFNER RODERICK
发明人： O'CONNOR BARBARA H , BURKOTH TERRY LEE , PRESTRELSKI STEVEN JOSEPH , MAA YUH-FUN , MUDDLE ANDREW , HAFNER RODERICK
IPC分类号： A61K47/36 , A61K9/14 , A61K9/16 , A61K9/19 , A61K38/00 , A61K39/00 , A61K45/00 , A61K48/00
CPC分类号： A61K9/1652 , A61K9/0021
摘要： New compositions formed from the combination of an active substance with a hydrogel carrier moiety are provided. The compositions are suitable for use in high-velocity transdermal particle injection techniques. Methods of providing the new compositions are also provided. In addition, methods for administering pharmacologically active agent to a subject are provided. These methods are useful for delivering drugs, biopharmaceuticals, vaccines and diagnostics agents.
摘要翻译：提供了由活性物质与水凝胶载体部分的组合形成的新组合物。该组合物适用于高速透皮颗粒注射技术。还提供了提供新组合物的方法。此外，提供了向受试者施用药理活性剂的方法。这些方法可用于递送药物，生物制药，疫苗和诊断试剂。

7. 发明申请

WO2007141501A3 IMPROVEMENTS IN, OR RELATING TO, PARTICLE CASSETTES 审中-公开
标题翻译：改进或相关于颗粒CASSETTES
公开(公告)号：WO2007141501A3
公开(公告)日：2008-01-31
申请号：PCT/GB2007002047
申请日：2007-06-04
申请人： POWDERJECT RES LTD , BATES NIGEL ROBERT , PRICE PHILIP THOMAS , WEEKES STUART GRAHAM , WATSON JOHN
发明人： BATES NIGEL ROBERT , PRICE PHILIP THOMAS , WEEKES STUART GRAHAM , WATSON JOHN
IPC分类号： A61M5/30 , A61M5/24 , B65B11/50
CPC分类号： A61M5/2459 , A61M5/3015 , Y10T29/49826 , Y10T29/49908
摘要： A method of producing a particle cassette (200) for a needleless syringe device which alleviates problems of providing a chamber (218) for the confinement of particles which is hermetically sealed from the environment. A predetermined force is applied in the longitudinal direction to push first and second cassette parts (210, 250) together so as to cause plastic deformation of a portion of the first cassette part (210) so as to create said hermetically sealed chamber (218). The cassette parts (210, 250) are preferably made of PETG and have bonded thereto rupturable membranes (202, 204) preferably made of PET. The sealing is preferably achieved at the end (220) of a protrusion (216) on the first cassette part (210) which is tapered and which interacts with the membrane (204) of the second cassette part (250).
摘要翻译：一种生产用于无针注射器装置的颗粒盒（200）的方法，其减轻了提供用于限制与环境密封的颗粒的室（218）的问题。沿纵向施加预定的力以将第一和第二盒部件（210,250）推到一起，从而引起第一盒部件（210）的一部分的塑性变形，从而形成所述密封室（218）。盒部件（210,250）优选地由PETG制成并且已经与优选由PET制成的可破裂膜（202,204）结合。密封优选地在第一盒部分（210）上的突起（216）的端部（220）处实现，该第一盒部分（210）是锥形的并且与第二盒部分（250）的膜（204）相互作用。

8. 发明申请

WO03011380A2 SILENCING DEVICE AND METHOD FOR NEEDLELESS SYRINGE 审中-公开
标题翻译：用于无瞄准器的静音装置和方法
公开(公告)号：WO03011380A2
公开(公告)日：2003-02-13
申请号：PCT/GB0203412
申请日：2002-07-25
申请人： POWDERJECT RES LTD , KENDALL MARK ANTHONY FERNANCE
发明人： KENDALL MARK ANTHONY FERNANCE
IPC分类号： A61M5/24 , A61M5/30
CPC分类号： A61M5/3015 , A61M5/24
摘要： The invention provides a silencer and silencing method which ensures adequate silencing with no deleterious increase in back pressure (which creates a lift-off force) or decrease in device performance. Pressurised gas is supplied to a driver chamber by a bleed-hole having an effective bleed-hole area and, during use of the device for particle delivery, gas is vented to the atmosphere via a silencer having an effective venting area. The bleed-hole area and venting area are chosen to ensure that the mass flow rate of gas through the effective venting are is substantially equal to or greater than the mass flow rate of gas through the effective bleed-hole area. This ensures that there is no build up of gas in the silencer device which tends to increase back pressure and hence lift-off force. Preferred embodiments of the device comprise a silencer having a large volume and a small particle exit opening. Further, there is disclosed an embodiment using one or more transfer ducts to assist particle mixing.
摘要翻译：本发明提供了一种消音器和消音方法，其确保足够的消音而没有有害的背压增加（产生剥离力）或降低了装置性能。通过具有有效排气孔区域的排放孔将加压气体供应到驱动器腔室，并且在使用用于颗粒输送的装置期间，通过具有有效排气区域的消音器将气体排放到大气中。选择排气孔面积和排气面积以确保通过有效排气的气体的质量流率基本上等于或大于通过有效排气孔面积的气体的质量流率。这确保了在消音器装置中没有积聚气体，其倾向于增加背压和因此提升力。该装置的优选实施例包括具有大体积和小颗粒出口的消音器。此外，公开了使用一个或多个传输管道来辅助颗粒混合的实施例。

9. 发明申请

WO2009074861A3 IMPROVED VACCINE 审中-公开
标题翻译：改进的疫苗
公开(公告)号：WO2009074861A3
公开(公告)日：2009-12-17
申请号：PCT/IB2008003451
申请日：2008-12-09
申请人： POWDERJECT RES LTD , LYNCH DEBORAH TAYLOR
发明人： LYNCH DEBORAH TAYLOR
IPC分类号： A61K39/145 , C07K14/11
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/53 , A61K2039/545 , A61K2039/6075 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： The present invention relates to the fields of molecular biology and immunology and generally to reagents useful in nucleic acid immunisation techniques and vaccination. The present invention further relates to novel vaccine compositions capable of eliciting an enhanced immune response against influenza virus. More specifically, the present invention relates to a vaccine comprising a nucleic acid sequence encoding at least one influenza virus antigen and a protein comprising the at least one antigen for separate, sequential or concomitant administration. The present invention further provides a process for preparing the vaccine and a method of eliciting an immune response against influenza virus infection. The present invention is also directed to a use of a vaccine for profilatic or therapeutic immunization against infections caused by influenza virus.
摘要翻译：本发明涉及分子生物学和免疫学领域，通常涉及可用于核酸免疫技术和疫苗接种的试剂。本发明还涉及能够引发针对流感病毒的增强的免疫应答的新型疫苗组合物。更具体地，本发明涉及包含编码至少一种流感病毒抗原的核酸序列和包含至少一种抗原的蛋白质的疫苗，用于单独，顺序或伴随施用。本发明还提供了制备疫苗的方法和引发针对流感病毒感染的免疫应答的方法。本发明还涉及疫苗用于针对由流感病毒引起的感染进行痤疮或治疗性免疫的用途。

10. 发明申请

WO2008135719A2 PARTICLE CASSETTES AND PROCESSES THEREFOR 审中-公开
标题翻译：颗粒体系及其工艺
公开(公告)号：WO2008135719A2
公开(公告)日：2008-11-13
申请号：PCT/GB2008001483
申请日：2008-04-25
申请人： POWDERJECT RES LTD , BATES NIGEL ROBERT , PRICE PHILIP THOMAS
发明人： BATES NIGEL ROBERT , PRICE PHILIP THOMAS
IPC分类号： A61M5/30 , A61M5/24 , B65B9/04 , B65B11/50
CPC分类号： A61M5/204 , A61M5/2053 , A61M5/2459 , A61M5/3015 , A61M5/31 , A61M2005/3128 , A61M2207/00 , A61M2207/10 , B65B7/2814 , B65B15/02 , B65B55/08 , Y10T29/49826 , Y10T156/1089 , Y10T428/1352 , Y10T428/24149 , Y10T428/24157
摘要： An article for use in manufacturing particle cassettes comprising one or more single pieces of membrane having a plurality of gas flow passages bonded thereto. The article allows convenient manufacture of particle cassettes. Two such articles may be employed to provide a finished particle cassette and a production line in which a plurality of gas flow passages are conveyed on a single membrane is disclosed.
摘要翻译：一种用于制造颗粒盒的制品，包括一个或多个具有多个与其结合的气流通道的膜片。该文章允许方便地制造颗粒盒。可以使用两个这样的制品来提供成品粒子盒，并且在单个膜上输送多个气体流动通道的生产线。

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