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1. 发明专利

JP2007222176A Method and apparatus for preparing sample cartridge for particle acceleration device 有权
标题翻译：用于制备颗粒加速装置的样品盒的方法和装置
公开(公告)号：JP2007222176A
公开(公告)日：2007-09-06
申请号：JP2007102246
申请日：2007-04-09
申请人： Powderject Vaccines Inc , パウダージェクトバクシーンズ, インコーポレイテッド
发明人： MCCABE DENNIS E
IPC分类号： C12M1/00 , C12N15/00 , A61K39/00 , A61K48/00 , B05D1/00 , B05D7/22 , C12N15/89 , C12Q1/68
CPC分类号： B05D1/002 , B05D7/222 , C12N15/895
摘要： PROBLEM TO BE SOLVED: To provide a method and apparatus for introducing substance into the target cell, by particle-mediated delivery in the field of delivering particles.
SOLUTION: The invention relates to the method for deposition of particles into a length of tubing having longitudinal axis and a cured inner surface by a process which includes (a) a process preparing a uniform suspension of particles coated with biological substances in an evaporable liquid, (b) a process rotating the tubing centering the longitudinal axis in a first rotating speed, (c) a process introducing the suspension of the particles into the tubing while rotating the tubing in the first speed, (d) a process rotating the tubing to separate the particles from the evaporable liquid in a centrifugal separation method and dispersing the particles on the inner surface of the tubing, and (e) a process rotating the tubing and a gas is passed through the tubing to dry the particles that have been dispersed against the inner surface of the tubing.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供一种将物质引入靶细胞的方法和装置，通过粒子介导的递送颗粒领域的递送。解决方案：本发明涉及通过一种方法将颗粒沉积到具有纵向轴线和固化内表面的长度的管道中的方法，该方法包括（a）制备涂覆有生物物质的颗粒的均匀悬浮液的方法，（b）使以纵向轴线为中心的管道以第一旋转速度旋转的过程，（c）在以第一速度旋转管道的同时将颗粒的悬浮液引入管道中的过程，（d）所述管道以离心分离方法将颗粒与蒸发性液体分离并将颗粒分散在管道的内表面上，以及（e）使管道和气体旋转的过程通过管道以干燥具有被分散在管的内表面上。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2001213807A PARTICLE-MEDIATED TRANSFORMATION OF ANIMAL SOMATIC CELL 失效
公开(公告)号：JP2001213807A
公开(公告)日：2001-08-07
申请号：JP2000387953
申请日：2000-12-20
申请人： POWDERJECT VACCINES INC
发明人： BRILL WINSTON J , MCCABE DENNIS E , YANG NING-SUN
IPC分类号： C12N15/09 , A01K67/00 , A61K9/14 , A61K38/45 , A61K47/02 , A61K48/00 , C12M1/00 , C12M3/00 , C12N5/10 , C12N9/10 , C12N15/87 , C12N15/89
摘要： PROBLEM TO BE SOLVED: To hereditarily transform the somatic cells in the skin of living animals. SOLUTION: A medicament intended to hereditarily transform the somatic cells in the skin of living animals is provided. The above medicament contains inert, high-density support particles which, in turn, are coated with the copy of an extraneous gene construct and are each smaller in size than the somatic cell; wherein the extraneous gene construct contains a DNA sequence encoding a relevant protein and a proximity regulatory sequence effective for expressing the protein in the somatic cells.

3. 发明专利

JP2007259865A Gas-driving type particle-delivering device 有权
标题翻译：气体驱动型颗粒递送装置
公开(公告)号：JP2007259865A
公开(公告)日：2007-10-11
申请号：JP2007167027
申请日：2007-06-25
申请人： Powderject Vaccines Inc , パウダージェクトバクシーンズ, インコーポレイテッド
发明人： MCCABE DENNIS E , HEINZEN RICHARD J
IPC分类号： C12M1/00 , A61K48/00 , A61P43/00 , B05B7/10 , B05B7/14 , B24C5/04 , C12M1/04 , C12M1/36 , C12M3/00 , C12N15/00
CPC分类号： B24C11/005 , B24C5/04 , C12M35/00
摘要： PROBLEM TO BE SOLVED: To provide a device for delivering a substance to cells by a particle-mediating delivery technique. SOLUTION: This device for delivering particles to target cells or target tissues involves a body having an acceleration passage formed in the body and having an entrance and an exit; and a rotating flow element disposed in the acceleration passage and giving a rotation movement to a gas flow passing through the rotating flow element. COPYRIGHT: (C)2008,JPO&INPIT
摘要翻译：要解决的问题：提供通过粒子介导递送技术将物质递送到细胞的装置。解决方案：用于将颗粒递送到靶细胞或靶组织的装置涉及具有形成在体内并具有入口和出口的加速通道的主体; 以及旋转流动元件，其设置在所述加速通道中并且给通过所述旋转流动元件的气流提供旋转运动。版权所有（C）2008，JPO＆INPIT

4. 发明专利

JP2008253259A Gas-driven type particle delivery device 审中-公开
标题翻译：气体驱动型颗粒递送装置
公开(公告)号：JP2008253259A
公开(公告)日：2008-10-23
申请号：JP2008068314
申请日：2008-03-17
申请人： Powderject Vaccines Inc , パウダージェクトバクシーンズ,インコーポレイテッド
发明人： MCCABE DENNIS E , HEINZEN RICHARD J
IPC分类号： C12M1/00 , A61K38/00 , A61K38/22 , A61K48/00 , B05B7/10 , B05B7/14 , B24C5/04 , C12M1/36 , C12M3/00
CPC分类号： B24C11/005 , B24C5/04 , C12M35/00
摘要： PROBLEM TO BE SOLVED: To provide a device for delivering a substance into cells by a particle-mediating delivery technique.
SOLUTION: The device for delivering particles to target cells or target tissues involves a body having an acceleration passage formed in the body and having an entrance and an exit; and a rotating flow element disposed in the acceleration passage and giving a rotation movement to a gas flow passing through the rotating flow element.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供通过粒子介导递送技术将物质递送到细胞中的装置。解决方案：用于将颗粒递送到靶细胞或靶组织的装置涉及具有形成在体内并具有入口和出口的加速通道的主体; 以及旋转流动元件，其设置在所述加速通道中并且给通过所述旋转流动元件的气流提供旋转运动。版权所有（C）2009，JPO＆INPIT

5. 发明专利

TW200628611A 核酸構築體 NUCLEIC ACID CONSTRUCTS 审中-公开
简体标题：核酸构筑体 NUCLEIC ACID CONSTRUCTS
公开(公告)号：TW200628611A
公开(公告)日：2006-08-16
申请号：TW094112658
申请日：2005-04-20
申请人：袍德傑疫苗公司 POWDERJECT VACCINES, INC.
发明人：詹姆斯弗勒 FULLER, JAMES
IPC分类号： C12N , A61K
摘要：本發明係關於核酸構築體，其包括嵌合型啟動基因序列和適合插入密碼序列之選殖位置，其係以可操作之方式與該嵌合型啟動基因連接，其中該嵌合型啟動基因序列包括：(a)hCMV速發早期啟動基因序列；(b)hCMV主要速發早期基因的表現序列1和至少一部分的表現序列2；以及(c)提供異種插入序列，代替hCMV主要速發早期基因的插入序列A區域。
简体摘要：本发明系关于核酸构筑体，其包括嵌合型启动基因串行和适合插入密码串行之选殖位置，其系以可操作之方式与该嵌合型启动基因连接，其中该嵌合型启动基因串行包括：(a)hCMV速发早期启动基因串行；(b)hCMV主要速发早期基因的表现串行1和至少一部分的表现串行2；以及(c)提供异种插入串行，代替hCMV主要速发早期基因的插入串行A区域。

6. 发明申请

US20040213798A1 Spray-dried alum compositions 审中-公开
标题翻译：喷雾干燥的明矾组合物
公开(公告)号：US20040213798A1
公开(公告)日：2004-10-28
申请号：US10852740
申请日：2004-05-25
申请人： PowderJect Vaccines, Inc.
发明人： Yuh-Fun Maa , Lu Zhao , Steven J. Prestrelski
IPC分类号： A61K039/00
CPC分类号： A61K9/1694 , A61K9/0021
摘要： A gel-forming free-flowing powder suitable for use as a vaccine is prepared by spray-drying an aqueous suspension that contains an antigen adsorbed to an aluminum salt adjuvant, a saccharide, an amino acid or a salt thereof, and a colloidal substance. Processes for forming these powder compositions are also described, as well as methods of using the compositions in a vaccination procedure.
摘要翻译：通过喷雾干燥含有吸附在铝盐佐剂，糖类，氨基酸或其盐上的抗原和胶态物质的水性悬浮液来制备适合用作疫苗的凝胶形成自由流动粉末。还描述了用于形成这些粉末组合物的方法，以及在疫苗接种程序中使用该组合物的方法。

7. 发明申请

US20040109874A1 Induction of mucosal immunity by vaccination via the skin route 审中-公开
标题翻译：通过皮肤途径免疫接种诱导粘膜免疫
公开(公告)号：US20040109874A1
公开(公告)日：2004-06-10
申请号：US10724727
申请日：2003-12-02
申请人： PowderJect Vaccines, Inc.
发明人： Dexiang Chen , Sangeeta Bhargava , Deborah Fuller
IPC分类号： A61K039/12 , A61K039/02
CPC分类号： A61K39/05 , A61K39/12 , A61K39/145 , A61K39/39 , A61K2039/5252 , A61K2039/541 , A61K2039/543 , A61K2039/55544 , A61K2039/55561 , A61K2039/57 , A61K2039/70 , C12N2760/16134
摘要： Methods for generating an immune response at a mucosal surface are described. Compositions suitable for use in the methods for generating an immune response at a mucosal surface are also described. In addition, methods for treating or preventing a disease caused by the entry of a pathogen into the body of a subject via a mucosal surface are provided.
摘要翻译：描述了在粘膜表面产生免疫应答的方法。还描述了适用于在粘膜表面产生免疫应答的方法中的组合物。此外，提供了用于治疗或预防由病原体经由粘膜表面进入受试者体内引起的疾病的方法。

8. 发明申请

WO2005035779A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO2005035779A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/033391
申请日：2004-10-12
申请人： POWDERJECT VACCINES, INC , BRAUN, Ralph, Patrick , DONG, Lichun
发明人： BRAUN, Ralph, Patrick , DONG, Lichun
IPC分类号： C12Q
CPC分类号： A61K39/00 , A61K9/0019 , A61K9/167 , A61K39/12 , A61K39/145 , A61K39/21 , A61K39/245 , A61K39/292 , A61K2039/53 , A61K2039/54 , A61K2039/545 , A61K2039/55544 , A61K2039/57 , A61K2039/585 , C12N2710/16634 , C12N2710/20034 , C12N2730/10134 , C12N2740/16134 , C12N2740/16234 , C12N2740/16334 , C12N2760/16134 , Y02A50/386 , Y02A50/412 , Y02A50/423 , Y02A50/472
摘要： The invention relates to a method of eliciting a T cell response against a T cell epitope in a host mammalian subject, which method comprises : (i) a first immunisation that comprises at least two administrations which are from 1 to 14 days apart to the subject, wherein each administration comprises administering a nucleotide of interest (NOI) encoding the T cell epitope, and optionally (ii) a second immunisation that comprises at least one administration to the subject of (a) a NOI encoding the T cell epitope, or (b) a protein comprising the T cell epitope, wherein the time between the first administration of the first immunisation, and the first administration of the second immunisation, is from 21 to 365 days.
摘要翻译：本发明涉及一种针对宿主哺乳动物受试者中的T细胞表位引起T细胞应答的方法，该方法包括：（i）包含至少两次相对于受试者1至14天施用的第一次免疫其中每个施用包括施用编码T细胞表位的目标核苷酸（NOI），和任选地（ii）第二次免疫，其包含至少一次给予受试者的（a）编码T细胞表位的NOI或（ b）包含T细胞表位的蛋白质，其中第一次免疫的第一次施用与第一次免疫接种之间的时间为21至365天。

9. 发明申请

WO2005035771A2 NUCLEIC ACID CONSTRUCTS 审中-公开
标题翻译：核酸结构
公开(公告)号：WO2005035771A2
公开(公告)日：2005-04-21
申请号：PCT/GB2004/004279
申请日：2004-10-11
申请人： POWDERJECT VACCINES, INC. , POWDERMED LIMITED , FULLER, James
发明人： FULLER, James
IPC分类号： C12N15/85
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/53 , C07K14/4716 , C07K14/4741 , C07K14/62 , C12N15/85 , C12N2710/16622 , C12N2710/16722 , C12N2730/10122 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/60
摘要： A nucleic acid construct comprising a chimeric promoter sequence and a cloning site for insertion of a coding sequence in operable linkage with the chimeric promoter, wherein the chimeric promoter sequence comprises: (a) a hCMV immediate early promoter sequence; (b) exon 1 and at least a part of exon 2 of the hCMV major immediate early gene; and (c) a heterologous'intron provided in place of the intron A region of the hCMV major immediate early gene.
摘要翻译：核酸构建体，其包含嵌合启动子序列和用于插入与所述嵌合启动子可操作连接的编码序列的克隆位点，其中所述嵌合启动子序列包含：（a）hCMV立即早期启动子序列; （b）hCMV主要立即早期基因的外显子1和至少一部分外显子2; 和（c）代替hCMV主要立即早期基因的内含子A区提供的异源内含子。

10. 发明申请

WO2002094313A2 VACCINE COMPOSITION 审中-公开
标题翻译：疫苗组合物
公开(公告)号：WO2002094313A2
公开(公告)日：2002-11-28
申请号：PCT/GB2002/002336
申请日：2002-05-20
申请人： POWDERJECT VACCINES, INC. , POWDERJECT RESEARCH LIMITED
发明人： FULLER, Deborah , FULLER, James , HAYNES, Joel , SHIPLEY, Timothy
IPC分类号： A61K39/21
CPC分类号： C07K14/005 , A61K39/00 , A61K48/00 , A61K2039/5256 , A61K2039/53 , A61K2039/57 , C12N15/895 , C12N2730/10122 , C12N2740/15022 , C12N2740/16022 , C12N2740/16122 , C12N2740/16222 , C12N2740/16322 , C12N2750/14143
摘要： Recombinant nucleic acid molecules are described. The molecules have a first nucleic acid sequence encoding an antigen containing two or more cytolytic T lymphocyte (CTL) epitopes, wherein said epitopes are selected from the amino acid sequences of SEQ ID NOs: 1, 2, 3, 4, 5 and 6 and analogues of any thereof which can be recognised by a CD8+ T cell that recognises an epitope with the amino acid sequence of any one of SEQ ID NOs: 1, 2, 3, 4, 5 or 6. Peptides encoded by the molecules and vectors and compositions containing these molecules are also described. Methods of eliciting an immune response using these molecules are also described.
摘要翻译：描述重组核酸分子。分子具有编码含有两个或多个细胞溶解性T淋巴细胞（CTL）表位的抗原的第一核酸序列，其中所述表位选自SEQ ID NO：1,2,3,4,5和6的氨基酸序列，可以由识别具有SEQ ID NO：1,2,3,4,5或6中任一个的氨基酸序列的表位的CD8 + T细胞识别的任何的类似物。由分子和载体编码的肽和还描述了含有这些分子的组合物。还描述了使用这些分子引发免疫应答的方法。

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