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1. 发明申请

WO2012108672A3 REVERSE TRANSCRIPTASE HAVING IMPROVED THERMOSTABILITY 审中-公开
标题翻译：逆转录酶具有改善的热稳定性
公开(公告)号：WO2012108672A3
公开(公告)日：2012-12-20
申请号：PCT/KR2012000894
申请日：2012-02-07
申请人： BIONEER CORP , PARK HAN OH , YANG SUNG JUN , JOO SUNG MO , HWANG BYOUNG OH
发明人： PARK HAN OH , YANG SUNG JUN , JOO SUNG MO , HWANG BYOUNG OH
IPC分类号： C12N9/12 , C12N15/54 , C12N15/63
CPC分类号： C12N9/1276 , C12N1/20 , C12N9/12 , C12N15/70 , C12P19/34 , Y02P20/52
摘要： The present invention relates to a reverse transcriptase having improved thermostability, more precisely a mutant reverse transcriptase with improved thermostability by substitution of one or more amino acids selected from the group consisting of the 63rd glutamine (Q63), the 264th lysine (K264), the 295th lysine (K295), the 306th threonine (T306), the 346th glutamic acid (E346), the 408th proline (P408), the 438th histidine (H438), and the 454th asparagin (N454) of the amino acid sequence of M-MLV originated reverse transcriptase represented by SEQ. ID. NO: 1 with other amino acids. The mutant reverse transcriptase of the present invention demonstrates excellent thermostability, compared with the wild type reverse transcriptase. Therefore, it is advantageous to obtain the target cDNA with stable reverse transcription activity even in the presence of RNA that can form the stable secondary structure at a high temperature.
摘要翻译：本发明涉及具有改善的热稳定性的逆转录酶，更准确地说是通过取代选自第63位谷氨酰胺（Q63），第264位赖氨酸（K264），第63位赖氨酸 M-氨基酸序列的第295位赖氨酸（K295），第306位苏氨酸（T306），第346位谷氨酸（E346），第408位脯氨酸（P408），第438位组氨酸（H438）和第454位天冬酰胺（N454） MLV来源于SEQ.ID.No.1所示的逆转录酶。 ID。 NO：1与其他氨基酸。与野生型逆转录酶相比，本发明的突变逆转录酶显示出优异的热稳定性。因此，即使在能够在高温下形成稳定的二级结构的RNA的存在下获得具有稳定逆转录活性的靶cDNA也是有利的。

2. 发明申请

WO2012157955A2 OIL PURIFICATION METHOD AND APPARATUS WITH POROUS MEMBRANE 审中-公开
标题翻译：油多孔方法和装置
公开(公告)号：WO2012157955A2
公开(公告)日：2012-11-22
申请号：PCT/KR2012/003836
申请日：2012-05-16
申请人： BIONEER CORPORATION , PARK, Han Oh , KIM, Jae Ha , KIM, Jun Pyo
发明人： PARK, Han Oh , KIM, Jae Ha , KIM, Jun Pyo
CPC分类号： B01D69/12 , B01D71/021 , B01D71/022 , B01D71/024 , B01D2311/04 , C10M175/0091 , B01D2311/103
摘要： Provided is a method of purifying oil by which nano particles are effectively removed from the oil. According to the oil purifying method, oil is effectively purified at a high temperature using a carbon nanostructure-metal or -metal oxide composite nano porous membrane composed of a carbon nanostructure-metal composite.
摘要翻译：提供了一种净化油的方法，通过该方法可以有效地从油中除去纳米颗粒。根据油净化方法，使用由碳纳米结构金属复合材料构成的碳纳米结构金属或金属氧化物复合纳米多孔膜，在高温下有效地纯化油。

3. 发明申请

WO2012023722A3 LOW HEAT CAPACITY COMPOSITE FOR THERMAL CYCLER 审中-公开
标题翻译：用于热循环的低热容复合材料
公开(公告)号：WO2012023722A3
公开(公告)日：2012-05-24
申请号：PCT/KR2011005756
申请日：2011-08-08
申请人： BIONEER CORP , PARK HAN OH , KIM JAE HA
发明人： PARK HAN OH , KIM JAE HA
IPC分类号： C09K5/14 , B01L7/00 , C22C26/00
CPC分类号： B01L7/52 , B22F2998/10 , B22F2999/00 , C09K5/14 , C22C1/0416 , C22C1/0425 , C22C1/0466 , C22C1/0483 , C22C13/00 , C22C13/02 , C22C26/00 , C22C1/1084 , B22F3/14 , B22F3/18 , C22C1/02
摘要： Provided is a low heat capacity composite for a thermal cycler. The low heat capacity composite of the present invention is a low heat capacity composite for a thermal cycler capable of overcoming difficulty in manufacture and reproducibility due to uniqueness of the existing PCR thermal cycler only. The low heat capacity composite of the present invention can reduce the cost of raw material and retain excellent heat property due to the improvement in low heat capacity and physical and mechanical properties, thereby remarkably shortening PCR reaction time and saving energy when used as a thermal block for a thermal cycler.
摘要翻译：提供了用于热循环仪的低热容复合材料。本发明的低热容复合材料是用于热循环仪的低热容复合材料，其能够仅克服现有的PCR热循环仪的唯一性，从而克服制造难度和重复性。本发明的低热容复合材料可以降低原料的成本，并且由于低热容量和物理机械性能的改善而保持优异的热性能，从而显着缩短PCR反应时间并在用作热块时节省能量用于热循环仪。

4. 发明申请

WO2010131916A3 SIRNA CONJUGATE AND PREPARATION METHOD THEREOF 审中-公开
标题翻译： SIRNA结合物及其制备方法
公开(公告)号：WO2010131916A3
公开(公告)日：2011-04-07
申请号：PCT/KR2010003039
申请日：2010-05-13
申请人： BIONEER CORP , HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C12N15/87
CPC分类号： A61K47/48215 , A61K9/1075 , A61K47/34 , A61K47/60 , B82Y5/00 , C07F7/0836 , C07H21/02 , C08G65/3356 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/30 , C12N2320/51 , Y10S977/773 , Y10S977/906
摘要： The present invention relates to an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalentely bonding siRNA and a polymeric compound for improving the biostability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the biostability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relatively low concentration. Therefore, the conjugate can advantageously be used not only as an siRNA treatment tool for cancers and other infectious diseases, but also as a novel type siRNA delivery system.
摘要翻译：本发明涉及siRNA-聚合物缀合物及其制备方法，更具体地说，涉及通过共价键合siRNA和用于提高siRNA生物稳定性的高分子化合物形成的杂合共轭体的制备方法，杂交缀合物。本发明的缀合物可以改善siRNA的生物稳定性，从而实现将治疗性siRNA有效地递送到细胞中，并且即使以较低浓度的小剂量也显示出siRNA的活性。因此，缀合物不仅可以有效地用作癌症和其他感染性疾病的siRNA治疗工具，而且可以用作新型的siRNA递送系统。

5. 发明申请

WO2010104345A3 APPARATUS FOR INTEGRATED REAL-TIME NUCLEIC ACID ANALYSIS, AND METHOD FOR DETECTING A TARGET NUCLEIC ACID USING SAME 审中-公开
标题翻译：用于综合实时核酸分析的装置和使用其检测目标核酸的方法
公开(公告)号：WO2010104345A3
公开(公告)日：2011-01-13
申请号：PCT/KR2010001530
申请日：2010-03-11
申请人： BIONEER CORP , KIM YU-JEONG , KOO WAN-LIM , KIM JONG-HOON , JANG DAE-JIN , SEO JIN-CHEOL , KIM SEONG-YOUL , PARK HAE-JOON , PARK HAN OH
发明人： KIM YU-JEONG , KOO WAN-LIM , KIM JONG-HOON , JANG DAE-JIN , SEO JIN-CHEOL , KIM SEONG-YOUL , PARK HAE-JOON , PARK HAN OH
IPC分类号： C12Q1/68 , C12M1/38 , C12N15/09
CPC分类号： B03C1/01 , B03C1/288 , B03C1/30 , C12Q1/6844 , G01N35/0098 , Y02A90/26 , C12Q2561/113 , C12Q2537/143
摘要： The present invention relates to an integrated real-time nucleic acid analysis apparatus and to a method using same. More particularly, the present invention relates to an integrated real-time nucleic acid analysis apparatus which performs a qualitative analysis and a quantitative analysis at the same time on genes corresponding to a plurality of biological samples of various types, and to a method for detecting a target nucleic acid using same. The integrated real-time nucleic acid analysis apparatus and the method for detecting a target nucleic acid using same according to the present invention perform just a single test on a variety of targets, requested for a variety of analytes, in a quick and accurate manner, and thus can be efficiently used in a hospital or the like where diagnoses for diseases are required.
摘要翻译：本发明涉及一种综合实时核酸分析装置及其使用方法。更具体地，本发明涉及一种对与多种生物样品相对应的基因同时进行定性分析和定量分析的综合实时核酸分析装置，以及一种检测方法靶核酸使用相同的。综合实时核酸分析装置和根据本发明的用于检测目标核酸的方法仅以对快速和准确的方式对各种分析物要求的各种靶标进行单次测试，因此能够有效地用于需要诊断疾病的医院等中。

6. 发明申请

WO2009102171A2 SILICA MAGNETIC PARTICLES HAVING A SPHERICAL FORM AND A PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：具有球形的二氧化硅磁性颗粒及其制备方法
公开(公告)号：WO2009102171A2
公开(公告)日：2009-08-20
申请号：PCT/KR2009000718
申请日：2009-02-13
申请人： BIONEER CORP , KIM JAE-HA , PARK JONG-GWANG , KIM JONG-HOON , PARK HAN-OH
发明人： KIM JAE-HA , PARK JONG-GWANG , KIM JONG-HOON , PARK HAN-OH
IPC分类号： C01B33/18 , C01B33/12 , C04B35/14
CPC分类号： C01B33/126
摘要： The present invention relates to silica magnetic particles having a spherical form and a process for preparing the same. The silica magnetic particles prepared according to the present invention, which are silica particles that includes the magnetic particles and additionally have the functional group on the surfaces, has an advantage that the particle size distribution is uniform. Further, the silica magnetic particles prepared according to the present invention can be used as a reagent for separating biomaterials and a reagent for detecting biomaterials.
摘要翻译：本发明涉及具有球形的二氧化硅磁性颗粒及其制备方法。根据本发明制备的二氧化硅磁性颗粒是包含磁性颗粒并且在表面上另外具有官能团的二氧化硅颗粒，其具有颗粒尺寸分布均匀的优点。此外，根据本发明制备的二氧化硅磁性颗粒可以用作用于分离生物材料的试剂和用于检测生物材料的试剂。

7. 发明申请

WO2009045067A2 PRIMERS FOR PCR AMPLIFICATION COMPRISING ABASIC PARTS WITHIN THE PRIMER SEQUENCES 审中-公开
标题翻译：用于在放大器序列中包含ABASIC部分的PCR扩增的引物
公开(公告)号：WO2009045067A2
公开(公告)日：2009-04-09
申请号：PCT/KR2008/005821
申请日：2008-10-02
申请人： BIONEER CORPORATION , KIM, Hyun Bae , KIM, Seong Youl , GIL, Jun Mo , PARK, Hae Joon , PARK, Han Oh
发明人： KIM, Hyun Bae , KIM, Seong Youl , GIL, Jun Mo , PARK, Hae Joon , PARK, Han Oh
IPC分类号： C12Q1/68
CPC分类号： C12Q1/686 , C12Q2525/119
摘要： The present invention relates to primers for PCR amplification comprising abasic parts within the primer sequences and a method for PCR amplification using the same. More precisely, the present invention relates to primers capable of amplifying different templates and having abasic parts complementary to mutated site or polymorphic site of template DNA and a method for PCR amplification comprising the steps of mixing the composition for PCR amplification comprising the primers with nucleic acid template; and performing PCR with the mixture. The primers for PCR amplification of the present invention contain abasic parts not having specific coding information in their nucleotide sequences, so that they can amplify different templates having mutated sites at the same time.
摘要翻译：本发明涉及用于PCR扩增的引物，其包括引物序列内的无碱部分和使用其的PCR扩增方法。更确切地说，本发明涉及能够扩增不同模板并具有与模板DNA的突变位点或多态位点互补的脱碱基的引物，以及用于PCR扩增的方法，其包括将包含引物的PCR扩增组合物与核酸模板; 并用混合物进行PCR。用于本发明的PCR扩增的引物含有在其核苷酸序列中不具有特定编码信息的脱碱基，从而可以同时扩增具有突变位点的不同模板。

8. 发明申请

WO2009002034A3 REAL-TIME PCR MONITORING APPARATUS 审中-公开
标题翻译：实时PCR监测装置
公开(公告)号：WO2009002034A3
公开(公告)日：2008-12-31
申请号：PCT/KR2008/003408
申请日：2008-06-17
申请人： BIONEER CORPORATION , PARK, Hanee , CHOI, il kyu , PARK, Han Oh
发明人： PARK, Hanee , CHOI, il kyu , PARK, Han Oh
IPC分类号： C12Q1/68
摘要： The present invention relates to a real-time PCR monitoring apparatus for real-time monitoring production of reaction product produced during the reaction while performing nucleic acid amplification such as PCR for various kinds of trace samples. Specifically, the present invention relates to an apparatus for real-time monitoring biochemical reaction for efficiently dividing interference between an excitation light and a fluorescence, which includes a polarizer, a polarizing beam splitter, a polarization converter and so on.
摘要翻译：本发明涉及一种实时PCR监测装置，用于实时监测反应过程中产生的反应产物的生产，同时对各种痕量样品进行核酸扩增如PCR。具体而言，本发明涉及一种用于实时监测生物化学反应的装置，用于有效地分隔激发光和荧光之间的干涉，其包括偏振器，偏振分束器，偏振转换器等。

9. 发明申请

WO2008156270A2 GOLD-COATED STENT COATED/PLATED THE CHEMICALS AND OLIGONUCLEOTIDE BINDING GOLD-COATED STENT AND PROCESS FOR PRODUCING THE SAME 审中-公开
标题翻译：镀金属涂层/涂覆化学品和低聚物结合金涂层的固定体及其制造方法
公开(公告)号：WO2008156270A2
公开(公告)日：2008-12-24
申请号：PCT/KR2008003385
申请日：2008-06-16
申请人： BIONEER CORP , PARK HAN-OH , LEE JAE-DON , LEE SAM-YONG , JUNG EUN-JUNG
发明人： PARK HAN-OH , LEE JAE-DON , LEE SAM-YONG , JUNG EUN-JUNG
IPC分类号： A61L27/28
CPC分类号： A61L31/088 , A61L31/10 , A61L2400/18
摘要： The present invention relates to a gold-plated stent and its preparation method. More specifically, it relates to a gold- plated stent that is coated with various chemical materials such as 2-aminoalkanethiol, epihalogenhydrin, and diamine compounds in a sequence and also oligonucleotide gold-plated stent, which is prepared by binding oligonucleotide, a biomaterial, to the gold- plated stent coated with said chemicals. The oligonucleotide gold-plated stent of the present invention has an advantages of raising the local concentration in injured parts and minimizing the toxicity overall the body, so it can be used for prevention of restenosis after angioplasty.
摘要翻译：本发明涉及镀金支架及其制备方法。更具体地说，涉及一种金相支架，其以序列方式涂覆有各种化学物质如2-氨基烷硫醇，表卤代醇和二胺化合物，还涉及寡核苷酸金镀支架，其通过结合寡核苷酸，生物材料，到涂有所述化学品的镀金支架上。本发明的寡核苷酸镀金支架具有提高受伤部位局部浓度，使体内毒性最小化的优点，因此可用于预防血管成形术后的再狭窄。

10. 发明申请

WO2007108621A1 SIRNA FOR INHIBITING NF-KB/RELA EXPRESSION 审中-公开
标题翻译： SIRNA抑制NF-KB / RELA表达
公开(公告)号：WO2007108621A1
公开(公告)日：2007-09-27
申请号：PCT/KR2007/001319
申请日：2007-03-17
申请人： BIONEER CORPORATION , CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim , KIM, Seon Hoe , KIM, Ji Young , LEE, Eun Ju , LEE, Mi Young , KIM, Young Joo , LEE, Ui Jin , HAN, Chang Whan
发明人： CHOI, Young Chul , PARK, Han Oh , CHOUNG, So Rim , KIM, Seon Hoe , KIM, Ji Young , LEE, Eun Ju , LEE, Mi Young , KIM, Young Joo , LEE, Ui Jin , HAN, Chang Whan
IPC分类号： C12N15/11 , A61K48/00
CPC分类号： C12N15/113 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/346 , C12N2310/3521
摘要： The present invention relates to siRNA for inhibiting NF-κB/RelA and a pharmaceutical composition for treating rheumatoid arthritis. The pharmaceutical composition for treating rheumatoid arthritis of present invention comprises an active ingredient of siRNA which binds with mRNA transcribed from a gene coding for NF-κB/RelA to inhibit NF-κB/RelA expression in a cell. The pharmaceutical composition for treating rheumatoid arthritis can directly inhibit NF-κB/RelA expression in the gene level as well as induce the death of abnormally proliferated synovial cells, which makes possible its practical application for the treatment of rheumatoid arthritis in a more efficient manner.
摘要翻译：本发明涉及用于抑制NF-κB/ RelA的siRNA和用于治疗类风湿性关节炎的药物组合物。用于治疗本发明类风湿性关节炎的药物组合物包含与编码NF-κB/ RelA的基因转录的mRNA结合以抑制细胞中NF-κB/ RelA表达的siRNA活性成分。用于治疗类风湿性关节炎的药物组合物可以直接抑制基因水平的NF-κB/ RelA表达，并诱导异常增殖的滑膜细胞死亡，这使其成为可能以更有效的方式治疗类风湿性关节炎的实际应用。

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