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1. 发明申请

WO2010131916A3 SIRNA CONJUGATE AND PREPARATION METHOD THEREOF 审中-公开
标题翻译： SIRNA结合物及其制备方法
公开(公告)号：WO2010131916A3
公开(公告)日：2011-04-07
申请号：PCT/KR2010003039
申请日：2010-05-13
申请人： BIONEER CORP , HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C12N15/87
CPC分类号： A61K47/48215 , A61K9/1075 , A61K47/34 , A61K47/60 , B82Y5/00 , C07F7/0836 , C07H21/02 , C08G65/3356 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/30 , C12N2320/51 , Y10S977/773 , Y10S977/906
摘要： The present invention relates to an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalentely bonding siRNA and a polymeric compound for improving the biostability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the biostability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relatively low concentration. Therefore, the conjugate can advantageously be used not only as an siRNA treatment tool for cancers and other infectious diseases, but also as a novel type siRNA delivery system.
摘要翻译：本发明涉及siRNA-聚合物缀合物及其制备方法，更具体地说，涉及通过共价键合siRNA和用于提高siRNA生物稳定性的高分子化合物形成的杂合共轭体的制备方法，杂交缀合物。本发明的缀合物可以改善siRNA的生物稳定性，从而实现将治疗性siRNA有效地递送到细胞中，并且即使以较低浓度的小剂量也显示出siRNA的活性。因此，缀合物不仅可以有效地用作癌症和其他感染性疾病的siRNA治疗工具，而且可以用作新型的siRNA递送系统。

2. 发明申请

WO2010095879A3 SIRNA TO BE BOUND TO TRANSCRIPTS OF APOPTOSIS-RELATED GENES, AND COMPOSITIONS FOR TREATING CANCER USING SAME 审中-公开
标题翻译： SIRNA受寄生虫病相关基因的转录和用于治疗癌症的组合物
公开(公告)号：WO2010095879A3
公开(公告)日：2011-02-24
申请号：PCT/KR2010001031
申请日：2010-02-19
申请人： BIONEER CORP , HAN BO RAM , KIM SEONG-YOUL , PARK HAN OH
发明人： HAN BO RAM , KIM SEONG-YOUL , PARK HAN OH
IPC分类号： C12N15/11 , A61K48/00 , A61P35/00
CPC分类号： C12N15/113 , C12N2310/14
摘要： The present invention relates to siRNA to be bound to transcripts of apoptosis-related genes, and to compositions for treating cancer using same. More particularly, the present invention relates to siRNA which is bound to the mRNA of TRAF7 (tumor necrosis factor receptor associated factor) genes or TAB2 (TAK1 binding protein 2) genes to inhibit the expression of said genes, thus leading to cancer cell-specific apoptosis and to compositions for treating cancer containing said siRNA as an active ingredient. The siRNA and the compositions containing same according to the present invention induce cancer cell-specific apoptosis, and therefore, can be used as effective anticancer therapeutic agents which cause no damage to normal cells.
摘要翻译：本发明涉及要结合凋亡相关基因的转录物的siRNA，以及使用其的治疗癌症的组合物。更具体地，本发明涉及与TRAF7（肿瘤坏死因子受体相关因子）基因或TAB2（TAK1结合蛋白2）基因的mRNA结合以抑制所述基因的表达的siRNA，从而导致癌细胞特异性凋亡和用于治疗含有所述siRNA作为活性成分的癌症的组合物。根据本发明的siRNA和含有该组合物的组合物诱导癌细胞特异性凋亡，因此可以用作对正常细胞不造成损伤的有效的抗癌治疗剂。

3. 发明公开

KR20120067254A Cutting burger holder 审中-公开
标题翻译：切割刀架
公开(公告)号：KR20120067254A
公开(公告)日：2012-06-25
申请号：KR20100128740
申请日：2010-12-15
申请人： HAN BO RAM
发明人： HAN BO RAM
IPC分类号： A47J47/16 , B65D5/54
CPC分类号： B65D85/36 , A47J47/16
摘要： PURPOSE: A hamburger holder having a cutting line is provided to use regardless of size by cutting the holder according to the size, and to apply to not only hamburger but also other breads like sandwich by manufacturing various sizes and shapes. CONSTITUTION: A hamburger holder having a cutting line comprises covers and straps. The covers are formed into a shape of a disc corresponding to hamburger size. The straps connect the disc-shaped covers. The holder can tear off depending on the size and manufacture various shapes and sizes, thereby applying other breads like sandwich.
摘要翻译：目的：提供具有切割线的汉堡包支架，不管尺寸如何，通过根据尺寸切割保持器而使用，并且通过制造各种尺寸和形状不仅适用于汉堡包，还适用于像三明治的其他面包。构成：具有切割线的汉堡包支架包括盖和带。盖子形成为对应于汉堡包尺寸的圆盘的形状。带子连接盘形盖。保持器可以根据尺寸撕裂并制造各种形状和尺寸，从而应用其他面包如三明治。

4. 发明专利

CA2761749C SIRNA CONJUGATE AND PREPARATION METHOD THEREOF 未知
公开(公告)号：CA2761749C
公开(公告)日：2017-09-05
申请号：CA2761749
申请日：2010-05-13
申请人： BIONEER CORP
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： C12N15/113 , A61K31/7105 , C07H21/00 , C07H21/02 , C08G65/32 , C12N15/11 , C12N15/87
摘要： Provided are an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalently bonding siRNA and a polymeric compound for improving the in vivo stability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the in vivo stability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relative low concentration. Therefore, the conjugate can advantageously be used as not only an siRNA treatment tool for cancers and other infectious disease, but also a novel type siRNA delivery system.

5. 发明专利

AU2010248239B2 siRNA conjugate and preparation method thereof 未知
公开(公告)号：AU2010248239B2
公开(公告)日：2015-01-22
申请号：AU2010248239
申请日：2010-05-13
申请人： BIONEER CORP
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C12N15/87
摘要： The present invention relates to an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalentely bonding siRNA and a polymeric compound for improving the biostability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the biostability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relatively low concentration. Therefore, the conjugate can advantageously be used not only as an siRNA treatment tool for cancers and other infectious diseases, but also as a novel type siRNA delivery system.

6. 发明专利

CA2761749A1 SIRNA CONJUGATE AND PREPARATION METHOD THEREOF 未知
公开(公告)号：CA2761749A1
公开(公告)日：2010-11-18
申请号：CA2761749
申请日：2010-05-13
申请人： BIONEER CORP
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C12N15/87
摘要： The present invention relates to an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalentely bonding siRNA and a polymeric compound for improving the biostability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the biostability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relatively low concentration. Therefore, the conjugate can advantageously be used not only as an siRNA treatment tool for cancers and other infectious diseases, but also as a novel type siRNA delivery system.

7. 发明专利

BRPI1012141A2 conjugado de sirna e método de preparação do mesmo 未知
公开(公告)号：BRPI1012141A2
公开(公告)日：2016-03-29
申请号：BRPI1012141
申请日：2010-05-13
申请人： BIONEER CORP
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： C07H21/02 , A61K48/00 , C12N15/11 , C12N15/87
摘要： conjugado de sirma e método de preparação do mesmo. são providos um conjugado de sirna-polímero e um método para preparação do mesmo e mais especificamente, um conjugado híbrido formado por ligação covalente de sirna e um composto polimérico para aperfeiçoar a estabilidade in vivo de sirna e um método de preparação do conjugado híbrido. o conjugado da presente invenção pode aperfeiçoar a estabilidade in vivo de sirna, pelo que, obtendo uma liberação eficiente de sirna terapêutico nas células e exibindo a atividade de sirna mesmo com uma dose pequena de uma concentração relativa baixa. portanto, o conjugado pode ser usado vantajosamente não apenas como uma ferramenta para tratamento com sirna dos cânceres e outras doenças infecciosas, porém também um novo tipo de sistema de liberação de sirna.

8. 发明专利

AU2015200143A1 SIRNA CONJUGATE AND PREPARATION METHOD THEREOF 未知
公开(公告)号：AU2015200143A1
公开(公告)日：2015-02-05
申请号：AU2015200143
申请日：2015-01-13
申请人： BIONEER CORP
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C12N15/87
摘要： The present invention relates to an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalentely bonding siRNA and a polymeric compound for improving the biostability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the biostability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relatively low concentration. Therefore, the conjugate can advantageously be used not only as an siRNA treatment tool for cancers and other infectious diseases, but also as a novel type siRNA delivery system.

9. 发明专利

CA2871888A1 SIRNA CONJUGATE AND PREPARATION METHOD THEREOF 未知
公开(公告)号：CA2871888A1
公开(公告)日：2010-11-18
申请号：CA2871888
申请日：2010-05-13
申请人： BIONEER CORP
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： A61K47/48 , A61K48/00 , C07H21/00 , C12N15/113 , C12N15/87
摘要： Provided are an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalently bonding siRNA and a polymeric compound for improving the in vivo stability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the in vivo stability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relative low concentration. Therefore, the conjugate can advantageously be used as not only an siRNA treatment tool for cancers and other infectious disease, but also a novel type siRNA delivery system.

10. 发明公开

EP2463371A4 SIRNA CONJUGATE AND PREPARATION METHOD THEREOF 有权
标题翻译： -siRNA缀合物及其制备方法
公开(公告)号：EP2463371A4
公开(公告)日：2013-01-16
申请号：EP10775118
申请日：2010-05-13
申请人： BIONEER CORP
发明人： HAN BO RAM , PARK HAN OH , SHIN MI SIK , LEE SAM YOUNG
IPC分类号： C12N15/11 , A61K48/00 , C07H21/02 , C12N15/87
CPC分类号： A61K47/48215 , A61K9/1075 , A61K47/34 , A61K47/60 , B82Y5/00 , C07F7/0836 , C07H21/02 , C08G65/3356 , C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/351 , C12N2310/3515 , C12N2320/30 , C12N2320/51 , Y10S977/773 , Y10S977/906

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