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1. 发明申请

WO2012082776A3 METHOD AND DEVICE FOR HOLOGRAPHIC OPTO-FLUIDIC MICROSCOPY 审中-公开
公开(公告)号：WO2012082776A3
公开(公告)日：2012-06-21
申请号：PCT/US2011/064701
申请日：2011-12-13
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , OZCAN, Aydogan , BISHARA, Waheb
发明人： OZCAN, Aydogan , BISHARA, Waheb
IPC分类号： G01B9/021 , G01B9/04 , G01N21/85
摘要： A method and system of imaging a moving object within a microfluidic environment includes illuminating a first side of a flow cell configured to carry the moving object within a flow of carrier fluid with an illumination source emitting at least partially coherent light, the at least partially coherent light passing through an aperture prior to illuminating the flow cell. A plurality of lower resolution frame images of the moving object are acquired with an image sensor disposed on an opposing side of the flow cell, wherein the image sensor is angled relative to a direction of flow of the moving object within the carrier fluid. A higher resolution image is reconstructed of the moving object based at least in part on the plurality of lower resolution frame images.

2. 发明申请

WO2007084959A1 SYSTEMS AND METHODS FOR PROVIDING MIRROR TUNNEL MICROSCOPY 审中-公开
标题翻译：用于提供镜面隧道显微镜的系统和方法
公开(公告)号：WO2007084959A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/060717
申请日：2007-01-18
申请人： THE GENERAL HOSPITAL CORPORATION , TEARNEY, Guillermo, J. , BOUMA, Brett, E. , OZCAN, Aydogan
发明人： TEARNEY, Guillermo, J. , BOUMA, Brett, E. , OZCAN, Aydogan
IPC分类号： G02B27/46 , G02B27/08 , G02B21/36
CPC分类号： G02B27/08 , G01J3/36 , G02B17/006 , G02B21/00 , G02B21/367 , G02B27/46
摘要： Exemplary apparatus and method for obtaining information associated with at least one image of at least one portion of a sample can be provided. For example, at least one first electro¬ magnetic radiation can be provided from the at least one portion (e.g., using a first electro-magnetic radiation guiding arrangement which is configured to provide). A plurality of spatial frequency bands of the image associated with the first electro-magnetic radiation can be generated. Further, at least one second electro-magnetic radiation which is associated with the spatial frequency bands of the image can be received (e.g., using a second arrangement), and the image can be reconstructed based on the spatial frequency bands.
摘要翻译：可以提供用于获得与样品的至少一部分的至少一个图像相关联的信息的示例性装置和方法。例如，可以从至少一个部分（例如，使用配置为提供的第一电磁辐射引导装置）提供至少一个第一电磁辐射。可以产生与第一电磁辐射相关联的图像的多个空间频带。此外，可以接收与图像的空间频带相关联的至少一个第二电磁辐射（例如，使用第二布置），并且可以基于空间频带重建图像。

3. 发明申请

WO2004019018A3 METHOD OF MEASURING NONLINEARITY SPATIAL PROFILES OF SAMPLES AND TEMPORAL PROFILES OF OPTICAL PULSES 审中-公开
公开(公告)号：WO2004019018A3
公开(公告)日：2004-03-04
申请号：PCT/US2003/026311
申请日：2003-08-21
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , OZCAN, Aydogan , DIGONNET, Michel, J.F. , KINO, Gordon, S.
发明人： OZCAN, Aydogan , DIGONNET, Michel, J.F. , KINO, Gordon, S.
IPC分类号： G01N21/63
摘要： A method for measuring a physical function forms a symmetric composite function by combining the physical function with a reference function. The method obtains a Fourier transform of the symmetric composite function. The method calculates an inverse Fourier transform of the obtained Fourier transform, wherein the calculated inverse Fourier transform provides information regarding the physical function. The physical function can be a nonlinearity profile of a sample with at least one sample surface. The physical function can alternatively by a sample temporal waveform of a sample optical pulse.

4. 发明申请

WO2012094523A2 LENS-FREE TOMOGRAPHIC IMAGING DEVICES AND METHODS 审中-公开
标题翻译：无透镜层析成像装置和方法
公开(公告)号：WO2012094523A2
公开(公告)日：2012-07-12
申请号：PCT/US2012/020366
申请日：2012-01-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , OZCAN, Aydogan , ISIKMAN, Serhan Omer , BISHARA, Waheb
发明人： OZCAN, Aydogan , ISIKMAN, Serhan Omer , BISHARA, Waheb
IPC分类号： G01B9/02 , G01B11/24
CPC分类号： G01B9/02047 , G01B9/02041 , G01B9/02091 , G01N21/453 , G01N21/4795 , G02B21/0008 , G02B21/06 , G02B21/367 , G03H1/0005 , G03H1/02 , G03H1/0443 , G03H1/0866 , G03H1/265 , G03H2001/005 , G03H2001/0212 , G03H2001/0447 , G03H2001/046 , G03H2210/30 , G03H2210/62 , G03H2222/24 , G03H2222/34 , G03H2223/16 , G03H2227/02 , G03H2227/03 , G03H2240/56
摘要： A system for three dimensional imaging of an object contained within a sample includes an image sensor, a sample holder configured to hold the sample, the sample holder disposed adjacent to the image sensor, and an illumination source comprising partially coherent light. The illumination source is configured to illuminate the sample through at least one of an aperture, fiber-optic cable, or optical waveguide interposed between the illumination source and the sample holder, wherein the illumination source is configured to illuminate the sample through a plurality of different angles.
摘要翻译：用于对包含在样本内的对象进行三维成像的系统包括图像传感器，被配置为保持样本的样本保持器，被设置为与图像传感器相邻的样本保持器以及照明源，该照明源包括部分相干光。该照明源被配置为通过介于照明源和样本保持器之间的孔径，光纤电缆或光波导中的至少一个来照射样本，其中照明源被配置为通过多个不同的角度。

5. 发明申请

WO2013119266A1 PORTABLE RAPID DIAGNOSTIC TEST READER 审中-公开
标题翻译：便携式快速诊断测试读取器
公开(公告)号：WO2013119266A1
公开(公告)日：2013-08-15
申请号：PCT/US2012/040282
申请日：2012-05-31
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , OZCAN, Aydogan , MUDANYALI, Onur , DIMITROV, Stoyan , SIKORA, Uzair , PADMANABHAN, Swati , NAVRUZ, Isa
发明人： OZCAN, Aydogan , MUDANYALI, Onur , DIMITROV, Stoyan , SIKORA, Uzair , PADMANABHAN, Swati , NAVRUZ, Isa
IPC分类号： G01N21/64 , H04B1/38
CPC分类号： G06F19/3487 , B01L2300/0825 , G01N21/01 , G01N21/645 , G01N21/8483 , G01N33/543 , G01N33/56905 , G01N33/5695 , G01N33/56988 , G01N2021/0118 , G01N2021/7786 , G01N2021/825 , G01N2021/8488 , G01N2201/0221 , G01N2201/062 , G01N2201/0634 , G06F17/30424 , G06F19/00 , G06K7/10732 , G06K7/10831 , G16H15/00 , Y02A90/22 , Y02A90/24 , Y02A90/26
摘要： A portable rapid diagnostic test reader system includes a mobile phone having a camera and one or more processors contained within the mobile phone and a modular housing configured to mount to the mobile phone. The modular housing including a receptacle configured to receive a sample tray holding a rapid diagnostic test. At least one illumination source is disposed in the modular housing and located on one side of the rapid diagnostic test. An optical demagnifier is disposed in the modular housing interposed between the rapid diagnostic test and the mobile phone camera.
摘要翻译：便携式快速诊断测试读取器系统包括具有照相机的移动电话和包含在移动电话内的一个或多个处理器以及被配置为安装到移动电话的模块化外壳。模块化壳体包括被配置成容纳保持快速诊断测试的样品托盘的插座。至少一个照明源设置在模块化壳体中并且位于快速诊断测试的一侧。光学消音器设置在插入快速诊断测试和移动电话摄像机之间的模块化壳体中。

6. 发明申请

WO2012054351A3 MICROSCOPY METHOD AND SYSTEM INCORPORATING NANOFEATURES 审中-公开
标题翻译：显微镜方法和系统纳入纳米技术
公开(公告)号：WO2012054351A3
公开(公告)日：2012-06-28
申请号：PCT/US2011056439
申请日：2011-10-14
申请人： UNIV CALIFORNIA , OZCAN AYDOGAN
发明人： OZCAN AYDOGAN
IPC分类号： G01B9/04 , G01N33/483
CPC分类号： H01L27/14625 , B82Y15/00 , G01B21/00 , G01N21/253 , G01N21/41
摘要： A lensfree imaging and sensing device includes an image sensor comprising an array of pixels and a substantially optically transparent layer disposed above the image sensor. Nano-sized features that support surface plasmon waves are populated on the substantially optically transparent layer separating the image sensor from the nano-sized features. The nano-sized features may include apertures through a substantially optically opaque layer (e.g., metal layer) or they may include antennas. An illumination source is provided that is configured to illuminate a sample. At least one processor is operatively coupled to the image sensor. Changes to the detected transmission pattern at the image sensor are used to sense conditions at or near the surface containing the nano-sized features. Conditions may include binding events or other changes to the index of refraction occurring near the surface of the device.
摘要翻译：无镜头成像和感测装置包括包含像素阵列的图像传感器和设置在图像传感器上方的基本光学透明层。支持表面等离子体振子波的纳米尺寸特征填充在将图像传感器与纳米尺寸特征分离的基本上光学透明的层上。纳米尺寸的特征可以包括穿过基本光学不透明层（例如，金属层）的孔或者它们可以包括天线。提供配置成照亮样品的照明源。至少一个处理器可操作地耦合到图像传感器。在图像传感器处对检测到的透射图案的改变用于感测包含纳米尺寸特征的表面处或附近的状况。条件可以包括绑定事件或对设备表面附近发生的折射率的其他改变。

7. 发明申请

WO2012082776A2 METHOD AND DEVICE FOR HOLOGRAPHIC OPTO-FLUIDIC MICROSCOPY 审中-公开
标题翻译：用于全息光透镜显微镜的方法和装置
公开(公告)号：WO2012082776A2
公开(公告)日：2012-06-21
申请号：PCT/US2011064701
申请日：2011-12-13
申请人： UNIV CALIFORNIA , OZCAN AYDOGAN , BISHARA WAHEB
发明人： OZCAN AYDOGAN , BISHARA WAHEB
IPC分类号： G01B9/021 , G01B9/04 , G01N21/85
CPC分类号： G06K9/00127 , G01N15/1429 , G01N15/1434 , G01N15/1463 , G01N2015/1006 , G01N2015/1075 , G01N2015/1454 , G03H1/0443 , G03H2001/0447 , G03H2001/0816 , G03H2001/0825 , G03H2001/2655 , G06K9/0014 , G06T7/0012 , G06T2207/10016 , G06T2207/10056 , G06T2207/30242
摘要： A method and system of imaging a moving object within a microfluidic environment includes illuminating a first side of a flow cell configured to carry the moving object within a flow of carrier fluid with an illumination source emitting at least partially coherent light, the at least partially coherent light passing through an aperture prior to illuminating the flow cell. A plurality of lower resolution frame images of the moving object are acquired with an image sensor disposed on an opposing side of the flow cell, wherein the image sensor is angled relative to a direction of flow of the moving object within the carrier fluid. A higher resolution image is reconstructed of the moving object based at least in part on the plurality of lower resolution frame images.
摘要翻译：一种使微流体环境内的移动物体成像的方法和系统包括：照射流动池的第一侧，所述流动池被配置成用载流流体携带移动物体，其中照射源发射至少部分相干光，所述至少部分相干在照射流动池之前穿过孔的光。利用设置在流动池的相对侧上的图像传感器来获取运动物体的多个较低分辨率帧图像，其中图像传感器相对于运载流体内的运动物体的流动方向成角度。至少部分地基于所述多个较低分辨率帧图像来重构运动对象的较高分辨率图像。

8. 发明申请

WO2006102056A1 METHOD OF RETRIEVING PHASE AND MAGNITUDE OF WEAK ULTRA-SHORT OPTICAL PULSES USING A STRONGER UNKNOWN PULSE 审中-公开
标题翻译：使用强烈的未知脉冲检测弱光超短脉冲相的相位和幅度的方法
公开(公告)号：WO2006102056A1
公开(公告)日：2006-09-28
申请号：PCT/US2006/009675
申请日：2006-03-17
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY , OZCAN, Aydogan , DIGONNET, Michel, J., F. , KINO, Gordon, S.
发明人： OZCAN, Aydogan , DIGONNET, Michel, J., F. , KINO, Gordon, S.
IPC分类号： G01J11/00
CPC分类号： G04F13/02 , G01J11/00
摘要： A method determines a complex electric field temporal profile of an optical pulse. The method includes providing a measured magnitude of the Fourier transform of a complex electric field temporal profile of a pulse sequence comprising the optical pulse and a dummy pulse. The method further includes providing an estimated phase term of the Fourier transform of the complex electric field temporal profile of the pulse sequence. The method further includes multiplying the measured magnitude and the estimated phase term to generate an estimated Fourier transform of the complex electric field temporal profile of the pulse sequence. The method further includes calculating an inverse Fourier transform of the estimated Fourier transform, wherein the inverse Fourier transform is a function of time. The method further includes calculating an estimated complex electric field temporal profile of the pulse sequence by applying at least one constraint to the inverse Fourier transform.
摘要翻译：一种方法确定光脉冲的复电场时间分布。该方法包括提供包括光脉冲和伪脉冲的脉冲序列的复电场时间分布的傅立叶变换的测量幅度。该方法还包括提供脉冲序列的复电场时间曲线的傅立叶变换的估计相位项。该方法还包括将测量的幅度和估计的相位项相乘以产生脉冲序列的复电场时间曲线的估计傅里叶变换。该方法还包括计算估计傅立叶变换的傅立叶逆变换，其中逆傅里叶变换是时间的函数。该方法还包括通过对傅里叶逆变换应用至少一个约束来计算脉冲序列的估计复电场时间分布。

9. 发明申请

WO2004019018A2 METHOD OF MEASURING A PHYSICAL FUNCTION USING A COMPOSITE FUNCTION WHICH INCLUDES THE PHYSICAL FUNCTION AND AN ARBITRARY REFERENCE FUNCTION 审中-公开
标题翻译：使用包含物理功能和仲裁参考功能的复合函数来测量物理功能的方法
公开(公告)号：WO2004019018A2
公开(公告)日：2004-03-04
申请号：PCT/US0326311
申请日：2003-08-21
申请人： UNIV LELAND STANFORD JUNIOR , OZCAN AYDOGAN , DIGONNET MICHEL J F , KINO GORDON S
发明人： OZCAN AYDOGAN , DIGONNET MICHEL J F , KINO GORDON S
IPC分类号： G01J11/00 , G01N21/63
CPC分类号： G01N21/21 , G01J11/00 , G01N21/4788 , G01N21/636 , G01N2021/4723 , G01N2021/4735
摘要： A method for measuring a physical function forms a symmetric composite function by combining the physical function with a reference function. The method obtains a Fourier transform of the symmetric composite function. The method calculates an inverse Fourier transform of the obtained Fourier transform, wherein the calculated inverse Fourier transform provides information regarding the physical function. The physical function can be a nonlinearity profile of a sample with at least one sample surface. The physical function can alternatively by a sample temporal waveform of a sample optical pulse.
摘要翻译：用于测量物理功能的方法通过将物理功能与参考功能组合来形成对称复合函数。该方法获得对称复合函数的傅立叶变换。该方法计算所获得的傅立叶变换的傅立叶逆变换，其中所计算的傅里叶逆变换提供关于物理功能的信息。物理功能可以是具有至少一个样品表面的样品的非线性分布。物理功能可以替代地通过采样光脉冲的采样时间波形。

10. 发明申请

WO2013019640A1 LENSFREE HOLOGRAPHIC MICROSCOPY USING WETTING FILMS 审中-公开
标题翻译： LENSFREE HOLOGRAPHIC MICROSCOPY WITH WETTING FILMS
公开(公告)号：WO2013019640A1
公开(公告)日：2013-02-07
申请号：PCT/US2012/048601
申请日：2012-07-27
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , OZCAN, Aydogan , BISHARA, Waheb , MUDANYALI, Onur
发明人： OZCAN, Aydogan , BISHARA, Waheb , MUDANYALI, Onur
IPC分类号： G01N21/00 , G01N33/483 , G01B9/04
CPC分类号： G01B9/021 , G02B21/367 , G03H1/0443 , G03H1/0866 , G03H2001/0447 , G03H2240/56 , G06K9/00134 , G06T7/0012
摘要： A method of imaging a sample includes forming a monolayer wetting layer over a sample containing objects therein. A plurality of lower resolution images are obtained of the sample interposed between an illumination source and an image sensor, wherein each lower resolution image is obtained at discrete spatial locations. The plurality of lower resolution images of the sample are converted into a higher resolution image. One or more of an amplitude image and a phase image are reconstructed of the objects contained within the sample.
摘要翻译：成像样品的方法包括在其中含有物体的样品上形成单层润湿层。获得插入在照明源和图像传感器之间的样本的多个较低分辨率图像，其中在离散空间位置处获得每个较低分辨率图像。样本的多个较低分辨率图像被转换成更高分辨率的图像。对包含在样本内的对象重建振幅图像和相位图像中的一个或多个。

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