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1. 发明申请

WO1993019085A1 NOVEL ANTLER-DERIVED BONE GROWTH FACTORS 审中-公开
标题翻译：新型安非他酮衍生的骨生长因子
公开(公告)号：WO1993019085A1
公开(公告)日：1993-09-30
申请号：PCT/US1993002435
申请日：1993-03-18
申请人： OSTEOSA, INC. , MUNDY, Gregory, R. , GUTIERREZ, Gloria, E. , GARRETT, Ian, R. , SABATINI, Massimo , IZBICKA, Elzbieta , BURGESS, Wilson , CRUMLEY, Gregg, R. , MORSE, Clarence, C. , ARNETT, TImothy, R.
发明人： OSTEOSA, INC.
IPC分类号： C07K03/12
CPC分类号： C07K14/65 , A61K38/00 , C07K14/51 , C07K16/22
摘要： The present invention relates to the development of bone growth factors as therapeutics for the prevention and treatment of pathological conditions involving bone tissue. The present invention provides biologically active proteinaceous factors comprising polypeptides containing the amino acid sequence M-A-G-L-G-D-E-F-G-D, [SEQ ID NO: 1], (X) F E T L F G A/V E D V I/D A L Q F V C G D, [SEQ ID NO: 2], or A-Y-I-P-I-E-T-L-E-G-I/G-E-L-V-D/Q-T-G/L-Q-F, [SEQ ID NO: 3], or biologically active fragments or sequence analogues thereof. Among the biological properties of the proteinaceous materials of the present invention is the capability to promote the growth and/or differentiation of osteoblastic cells.
摘要翻译：本发明涉及作为预防和治疗涉及骨组织的病理状况的治疗剂的骨生长因子的发展。本发明提供包含含有氨基酸序列MAGLGDEFGD，[SEQ ID NO：1]，（X）FETLFGA / VEDVI / DALQFVCGD，[SEQ ID NO：2]或AYIPIETLEGI / GELVD / QTG / LQF的多肽的生物活性蛋白质因子，[SEQ ID NO：3]或其生物活性片段或序列类似物。本发明的蛋白质材料的生物学特性是促进成骨细胞生长和/或分化的能力。

2. 发明专利

CA2113828A1 OSTEOCLAST GROWTH REGULATORY FACTOR 未知
公开(公告)号：CA2113828A1
公开(公告)日：1993-02-04
申请号：CA2113828
申请日：1992-07-23
申请人： OSTEOSA INC
发明人： MUNDY GREGORY R , BURGESS WILSON H , YONEDA TOSHIYUKA
IPC分类号： A61K38/00 , C07K7/08 , C07K14/51 , C07K16/22 , C12N15/13 , C12P21/08 , A61K38/10 , C12N5/12 , A61K39/395
摘要： 2113828 9301827 PCTABS00019 The present invention relates to a novel osteoclast growth regulatory factor, hereinafter referred to as "osteoclastpoietic factor (OPF)", which stimulates the formation of osteoclast bone cells, a process of preparing same, therapeutic and diagnostic uses thereof, antibodies to and antagonists of OPF, and assays for OPF, all of which relate to the development of therapeutics for the prevention and treatment of diseases involving bone tissue, for example, osteoporosis, paget's disease and osteopetrosis.

3. 发明申请

WO1997000318A1 OSTEOCLAST GROWTH REGULATORY FACTOR 审中-公开
标题翻译： OSTEOCLAST生长调节因子
公开(公告)号：WO1997000318A1
公开(公告)日：1997-01-03
申请号：PCT/US1996009127
申请日：1996-06-04
申请人： OSTEOSA INC.
发明人： OSTEOSA INC. , ROODMAN, G., David , REGGY, Sakamuri, V. , MUNDY, Gregory, R.
IPC分类号： C12N15/11
CPC分类号： C07K16/22 , A61K38/00 , C07K14/51
摘要： The present invention relates to a novel osteoclast growth regulatory factor, "osteoclast stimulating factor (OSF)", which stimulates the growth and/or differentiation of osteoclast cells, methods of preparing OSF, therapeutic and diagnostic uses thereof, nucleic acid sequences encoding all or part of OSF, antibodies to and antagonists of OSF, and assays for OSF, and provides therapeutics for the prevention and treatment of diseases involving bone tissue including osteoporosis, Paget's disease, and osteopetrosis.
摘要翻译：本发明涉及一种破骨细胞生长调节因子“破骨细胞刺激因子（OSF）”，其刺激破骨细胞的生长和/或分化，制备OSF的方法，其治疗和诊断用途，编码全部或 OSF的一部分，OSF的抗体和拮抗剂，以及OSF的测定，并提供用于预防和治疗包括骨质疏松症，佩吉特氏病和骨硬化症在内的骨组织的疾病的治疗剂。

4. 发明申请

WO1996019501A1 MODULATORS OF BONE CELL FUNCTION AND USES THEREOF 审中-公开
标题翻译：骨细胞功能调节剂及其用途
公开(公告)号：WO1996019501A1
公开(公告)日：1996-06-27
申请号：PCT/US1995016826
申请日：1995-12-19
申请人： OSTEOSA INC. , YONEDA, Toshiyuki , IZBICKA, Elzbieta , MUNDY, Gregory, R.
发明人： OSTEOSA INC.
IPC分类号： C07K16/40
CPC分类号： C12N9/6448 , A61K38/00 , C07K14/51 , C07K16/22
摘要： A pancreas-derived factor has been identified which lowers serum calcium and inhibits bone resorption, and also stimulates proliferation of MG-63 osteoblast-like cells. The factor has been purified to homogeneity from porcine pancreas and obtained definitive amino acid sequence has been obtained (SEQ ID NO:1). This factor bears homology to a human pancreatic elastase, elastase IIIB. Experiments with recombinant human pancreatic elastase IIIB as well as neutralizing antibodies to human pancreatic elastase IIIB demonstrate that the biological effects of native PX are mimicked by those of recombinant human elastase IIIB both in vitro and in vivo. Numerous diagnostic and therapeutic applications are contemplated, including drug screening assays, test kits for diagnosing and monitoring conditions characterized by changes in bone cell population, and compositions and methods for treating undesirable bone resorption or accretion.
摘要翻译：已经鉴定出胰腺衍生因子，其降低血清钙并抑制骨吸收，并且还刺激MG-63成骨细胞样细胞的增殖。该因子已经从猪胰腺纯化至均质，并获得了确定的氨基酸序列（SEQ ID NO：1）。该因子与人胰腺弹性蛋白酶弹性蛋白酶IIIB具有同源性。重组人胰腺弹性蛋白酶IIIB的实验以及人胰腺弹性蛋白酶IIIB的中和抗体证实，天然PX的生物学效应由体外和体内重组人弹性蛋白酶IIIB的生物学效应模拟。涵盖了许多诊断和治疗应用，包括药物筛选测定，用于诊断和监测以骨细胞群体变化为特征的病症的测试试剂盒，以及用于治疗不期望的骨吸收或增生的组合物和方法。

5. 发明专利

CA2184916C USE OF FIBROBLAST GROWTH FACTORS TO STIMULATE BONE GROWTH 未知
公开(公告)号：CA2184916C
公开(公告)日：2008-05-13
申请号：CA2184916
申请日：1995-03-06
申请人： OSTEOSA INC , RHONE POULENC RORER INC
发明人： DUNSTAN COLIN R , IZBICKA ELZBIETA , MUNDY GREGORY , BURGESS WILSON , JAYE MICHAEL C
IPC分类号： A61K38/18 , G01B21/20 , A61K31/727 , A61K38/00 , A61K38/22 , A61K45/00 , A61P1/02 , A61P5/00 , A61P19/08 , A61P19/10 , A61P43/00 , C07K14/50 , C12P21/02 , G01N21/35 , G01N21/85 , G01N33/10
摘要： The present invention provides therapeutic compositions for the prevention a nd treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pathological conditions involving bone tissue, for example, osteoporosis, Paget's disease , osteopetrosis, and periodontal disease and fracture repair, and healing of bone defects by administering FGF-I to an animal or human in need of said treatment.

6. 发明专利

AU5985996A Osteoclast growth regulatory factor 未知
公开(公告)号：AU5985996A
公开(公告)日：1997-01-15
申请号：AU5985996
申请日：1996-06-04
申请人： OSTEOSA INC
发明人： ROODMAN G DAVID , REDDY SAKAMURI V , MUNDY GREGORY R
IPC分类号： A61K38/00 , C07K14/51 , C12N15/11 , A61K38/16 , A61K38/18 , C07K14/47 , C07K14/475 , C07K16/00 , C07K16/22 , C12N15/16 , C12N15/18

7. 发明专利

AU2157695A Use of fibroblast growth factors to stimulate bone growth 未知
公开(公告)号：AU2157695A
公开(公告)日：1995-09-25
申请号：AU2157695
申请日：1995-03-06
申请人： OSTEOSA INC , RHONE POULENC RORER PHARMACEUTICALS INC
发明人： DUNSTAN COLIN R , IZBICKA ELZBIETA , MUNDY GREGORY , BURGESS WILSON , JAYE MICHAEL C
IPC分类号： G01B21/20 , A61K38/00 , A61K38/18 , A61K38/22 , A61K45/00 , A61P1/02 , A61P5/00 , A61P19/08 , A61P19/10 , A61P43/00 , C07K14/50 , C12P21/02 , G01N21/35 , G01N21/85 , G01N33/10 , A61K45/05
摘要： The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pathological conditions involving bone tissue, for example, osteoporosis, Paget's disease, osteopetrosis, and periodontal disease and fracture repair, and healing of bone defects by administering FGF-1 to an animal or human in need of treatment.

8. 发明专利

CA2132219A1 NOVEL ANTLER-DERIVED BONE GROWTH FACTORS 未知
公开(公告)号：CA2132219A1
公开(公告)日：1993-09-30
申请号：CA2132219
申请日：1993-03-18
申请人： OSTEOSA INC
发明人： MUNDY GREGORY R , GUTIERREZ GLORIA E , GARRETT IAN R , SABATINI MASSIMO , IZBICKA ELZBIETA , BURGESS WILSON , CRUMLEY GREGG R , MORSE CLARENCE C , ARNETT TIMOTHY R
IPC分类号： C12N15/09 , A61K35/32 , A61K38/00 , A61K38/22 , A61K39/395 , A61P3/00 , A61P43/00 , C07K1/16 , C07K1/20 , C07K1/22 , C07K14/51 , C07K14/65 , C07K16/00 , C07K16/22 , C12P21/02 , C12N15/18 , A61K38/04 , A61K38/18 , C07K7/06 , C07K7/08
摘要： 2132219 9319085 PCTABS00025 The present invention relates to the development of bone growth factors as therapeutics for the prevention and treatment of pathological conditions involving bone tissue. The present invention provides biologically active proteinaceous factors comprising polypeptides containing the amino acid sequence M-A-G-L-G-D-E-F-G-D, ¢SEQ ID NO: 1!, (X) F E T L F G A/V E D V I/D A L Q F V C G D, ¢SEQ ID NO: 2!, or A-Y-I-P-I-E-T-L-E-G-I/G-E-L-V-D/Q-T-G/L-Q-F, ¢SEQ ID NO: 3!, or biologically active fragments or sequence analogues thereof. Among the biological properties of the proteinaceous materials of the present invention is the capability to promote the growth and/or differentiation of osteoblastic cells.

9. 发明申请

WO1996038167A1 USE OF FIBROBLAST GROWTH FACTORS TO STIMULATE BONE GROWTH 审中-公开
标题翻译：使用成纤维细胞生长因子刺激骨骼生长
公开(公告)号：WO1996038167A1
公开(公告)日：1996-12-05
申请号：PCT/US1996007920
申请日：1996-05-29
申请人： OSTEOSA, INC. , RHONE-POULENC RORER PHARMACEUTICALS INC. , DUNSTAN, Colin, R. , IZBICKA, Elizbieta , MUNDY, Gregory , BURGESS, Wilson , JAYE, Michael, C.
发明人： OSTEOSA, INC. , RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： A61K38/18
CPC分类号： C07K14/50 , A61K9/0019 , A61K9/0063 , A61K9/08 , A61K38/1825 , A61L27/227 , A61L27/54 , A61L2300/414 , A61L2430/02 , C07K14/501 , Y10S530/84
摘要： The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pathological conditions involving bone tissue, for example, osteoporosis, Paget's disease, osteopetrosis, and periodontal disease and fracture rapair, and healing of bone defects by administering FGF-1 to an animal or human in need of said treatment.
摘要翻译：本发明提供了用于预防和治疗涉及骨和牙齿组织的病理状况的治疗组合物。本发明还提供一种促进骨修复和/或生长的方法，用于治疗涉及骨组织的病理状况，例如骨质疏松症，佩吉特氏病，骨硬化症，牙周病和骨折性关节炎，以及通过施用FGF来治疗骨缺损 -1对需要所述治疗的动物或人。

10. 发明申请

WO1995024211A1 USE OF FIBROBLAST GROWTH FACTORS TO STIMULATE BONE GROWTH 审中-公开
标题翻译：使用成纤维细胞生长因子刺激骨骼生长
公开(公告)号：WO1995024211A1
公开(公告)日：1995-09-14
申请号：PCT/US1995002847
申请日：1995-03-06
申请人： OSTEOSA, INC. , RHONE-POULENC RORER PHARMACEUTICALS INC. , DUNSTAN, Colin, R. , IZBICKA, Elzbieta , MUNDY, Gregory , BURGESS, Wilson , JAYE, Michael, C.
发明人： OSTEOSA, INC. , RHONE-POULENC RORER PHARMACEUTICALS INC.
IPC分类号： A61K38/18
CPC分类号： C07K14/501 , A61K38/1825 , C07K14/50 , G01N21/85 , G01N33/10 , Y10S530/84
摘要： The present invention provides therapeutic compositions for the prevention and treatment of pathological conditions involving bone and dental tissue. The present invention also provides a method to promote bone repair and/or growth for the treatment of pathological conditions involving bone tissue, for example, osteoporosis, Paget's disease, osteopetrosis, and periodontal disease and fracture repair, and healing of bone defects by administering FGF-1 to an animal or human in need of said treatment.
摘要翻译：本发明提供了用于预防和治疗涉及骨和牙齿组织的病理状况的治疗组合物。本发明还提供一种促进骨修复和/或生长的方法，用于治疗涉及骨组织的病理状况，例如骨质疏松症，佩吉特氏病，骨硬化症，牙周病和骨折修复，以及通过施用FGF来治疗骨缺损 -1对需要所述治疗的动物或人。

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