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1. 发明专利

JP2012092111A Apparatus and method for maintaining and/or restoring viability of organ 有权
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：JP2012092111A
公开(公告)日：2012-05-17
申请号：JP2011256847
申请日：2011-11-24
申请人： Organ Recovery Systems Inc , オーガンリカヴァリーシステムズインコーポレイテッド
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： PROBLEM TO BE SOLVED: To provide an organ perfusion apparatus and method for storing organs for storage and/or transport of the organs.SOLUTION: The method includes perfusing the organ at hypothermic and/or normothermic temperatures, after hypothermic organ flushing. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pressurized medical fluid reservoir 10, to prevent overpressurization and to enable emergency flow cut-off. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. As a result, damage to vascular endothelial lining and to organ tissue in general are prevented or reduced. Viability of the organ may be automatically monitored by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled by using a control program.
摘要翻译：要解决的问题：提供一种器官灌注装置和方法，用于存储器官的储存和/或运输器官。解决方案：该方法包括在低温器官冲洗后在低温和/或正常体温下灌注器官。通过用正常体温温度下的医用流体灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过加压医疗液体储存器10来控制，以防止过压并且使得能够进行紧急流动切断。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。结果，防止或减少对血管内皮衬里和器官组织的损伤。可以通过监测医用液体灌注液的特性来自动监测器官的活力。灌注过程可以通过使用控制程序自动控制。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2012092113A Apparatus and method for maintaining and/or restoring viability of organ 审中-公开
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：JP2012092113A
公开(公告)日：2012-05-17
申请号：JP2011256852
申请日：2011-11-24
申请人： Organ Recovery Systems Inc , オーガンリカヴァリーシステムズインコーポレイテッド
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： PROBLEM TO BE SOLVED: To provide an organ perfusion apparatus and a method for monitoring, sustaining and/or restoring viability of organs and storing the organs for storage and/or transport.SOLUTION: The method includes perfusing the organ at hypothermic and/or normothermic temperatures, after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pressurized medical fluid reservoir 10. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to prevent or reduce damage to vascular endothelial lining and to organ tissue in general. The viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate.
摘要翻译：要解决的问题：提供器官灌注装置和用于监测，维持和/或恢复器官的活力并存储用于储存和/或运输的器官的方法。解决方案：该方法包括在器官运输和/或储存的低温器官冲洗后，以低体温和/或正常体温温度灌注器官。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压优选地通过设置在置于器官中的管的端部中的传感器由加压的医用流体储存器10来控制。医用流体可以从具有低压的中间容器防止或减少对血管内皮衬里和器官组织的损伤。优选通过监测医用液体灌注液的特性来自动监测器官的活力。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2012092112A Apparatus and method for maintaining and/or restoring viability of organ 审中-公开
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：JP2012092112A
公开(公告)日：2012-05-17
申请号：JP2011256851
申请日：2011-11-24
申请人： Organ Recovery Systems Inc , オーガンリカヴァリーシステムズインコーポレイテッド
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , A61F7/10 , A61F7/12 , A61L27/00 , A61M1/02 , A61M1/36 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： PROBLEM TO BE SOLVED: To provide an organ perfusion apparatus and a method for monitoring, sustaining and/or restoring viability of organs, and for storing the organs for storage and/or transport.SOLUTION: The method includes perfusing the organ at hypothermic and/or normothermic temperatures, after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid at normothermic temperatures. In perfusion, organ perfusion pressure is controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pressurized medical fluid reservoir 10. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization and to prevent or reduce damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored by monitoring characteristics of the medical fluid perfusate.
摘要翻译：要解决的问题：提供器官灌注装置和用于监测，维持和/或恢复器官活力并存储用于储存和/或运输的器官的方法。解决方案：该方法包括在器官运输和/或储存的低温器官冲洗后，以低体温和/或正常体温温度灌注器官。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力响应于设置在置于器官中的管的端部中的传感器被加压的医用流体储存器10控制。医用流体可以从具有低压头的中间容器进料到器官中避免器官过度加压，并防止或减少对血管内皮衬里和器官组织的损害。可以通过监测医用液体灌注液的特性来自动监测器官的活力。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2012092114A Apparatus and method for maintaining and/or restoring viability of organ 有权
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：JP2012092114A
公开(公告)日：2012-05-17
申请号：JP2011256854
申请日：2011-11-24
申请人： Organ Recovery Systems Inc , オーガンリカヴァリーシステムズインコーポレイテッド
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： PROBLEM TO BE SOLVED: To provide an organ perfusion apparatus and a method for monitoring, sustaining and/or restoring viability of organs and storing the organs for storage and/or transport.SOLUTION: The method includes perfusing the organ at hypothermic and/or normothermic temperatures, after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pressurized medical fluid reservoir 10. The damage to vascular endothelial lining and to organ tissue in general is prevented or reduced by evading the overpressurization of the organs. The viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate.
摘要翻译：要解决的问题：提供器官灌注装置和用于监测，维持和/或恢复器官的活力并存储用于储存和/或运输的器官的方法。解决方案：该方法包括在器官运输和/或储存的低温器官冲洗后，以低体温和/或正常体温温度灌注器官。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力优选地通过设置在置于器官中的管的端部中的传感器由加压的医用液体储存器10进行控制。一般来说，防止或减少对血管内皮衬里和器官组织的损伤逃避器官超压。优选通过监测医用液体灌注液的特性来自动监测器官的活力。版权所有（C）2012，JPO＆INPIT

5. 发明申请

WO2004089235A2 METHODS AND APPARATUS FOR PERFUSION, DIAGNOSIS, STORAGE AND/OR TRANSPORT OF AN ORGAN OR TISSUE 审中-公开
标题翻译：用于组织或组织的灌注，诊断，储存和/或运输的方法和装置
公开(公告)号：WO2004089235A2
公开(公告)日：2004-10-21
申请号：PCT/US2004/010182
申请日：2004-04-02
申请人： ORGAN RECOVERY SYSTEMS, INC. , WRIGHT, David, Walter , BRASSIL, John , SCHEIN, Douglas , GARLAND, Jeffrey, C. , TRAVIS, Lee, Williams
发明人： WRIGHT, David, Walter , BRASSIL, John , SCHEIN, Douglas , GARLAND, Jeffrey, C. , TRAVIS, Lee, Williams
IPC分类号： A61B19/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247 , Y10S435/809
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied. The apparatus and methods further include the cassette with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces. The apparatus and methods further include a tube frame removably connected to the cassette and configured to hold a plurality of tubes in a position to be connected to tubes in the portable housing.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该装置和方法包括具有一个或多个开口的器官盒，其被配置为允许管道穿过开口并连接到盒内的器官或组织，并且包括压力控制装置，以允许便携式外壳内的压力变化。该装置和方法还包括具有传热表面的盒，其布置成在所述运送器中的冷却源和传热表面之间传递热量。该装置和方法还包括可移除地连接到盒子并被配置为将多个管子保持在与便携式外壳中的管连接的位置的管框架。

6. 发明申请

WO0226034A3 APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS 审中-公开
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：WO0226034A3
公开(公告)日：2003-03-20
申请号：PCT/US0126591
申请日：2001-08-27
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore vability of organs and preserver organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygeneted cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubuing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization preventing and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of th emedical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官和保存器官的存储和/或运输的可行性。其他装置包括器官输送器，器官盒和器官诊断装置。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体（例如含氧交叉血红蛋白基碳酸氢盐医疗液体）灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力优选地响应于设置在放置在器官中的管道末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压防止和紧急流量截止。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。防止过度加压防止或减少对血管内皮衬里和器官组织的损害。可以自动监测器官的生存能力，优选通过监测体液灌注液的特性。可以使用控制程序自动控制灌注过程。

7. 发明申请

WO2006060709A2 BIOLOGICAL PATHWAYS IN PROGENITOR CELLS 审中-公开
标题翻译：前列腺细胞中的生物学途径
公开(公告)号：WO2006060709A2
公开(公告)日：2006-06-08
申请号：PCT/US2005043725
申请日：2005-12-02
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： PARENTEAU NANCY L
IPC分类号： G01N33/50
CPC分类号： C12Q1/6888 , C12Q2600/158 , G01N33/5023 , G01N33/5073
摘要： The disclosure relates to methods of identifying biological processes associated with non-fetal progenitor cells, and of identifying molecules and factors that regulate or modulate these processes, and is useful in fields including regenerative medicine (tissue regeneration), transplantation, and cancer research.
摘要翻译：本公开涉及鉴定与非胎儿祖细胞相关的生物学过程的方法，以及鉴定调节或调节这些过程的分子和因子的方法，并且在包括再生医学（组织再生），移植和癌症研究的领域中是有用的。

8. 发明申请

WO2006033674A1 APPARATUS AND METHOD FOR PERFUSION AND DETERMINING THE VIABILITY OF AN ORGAN 审中-公开
标题翻译：用于灌注和确定有机物的可能性的装置和方法
公开(公告)号：WO2006033674A1
公开(公告)日：2006-03-30
申请号：PCT/US2005/016057
申请日：2005-05-09
申请人： ORGAN RECOVERY SYSTEMS, INC.
发明人： BRASSIL, John , BAICU, Simona
IPC分类号： A01N1/02 , A61B5/02 , A61B5/04
CPC分类号： A61B5/14525 , A01N1/02 , A01N1/0247 , A61B5/413
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. During the period in which the organ is preserved and/or maintained, the organ may be additionally be perfused to obtain data regarding the fluid and/or organ. The data may then be used to ultimately provide information regarding the perfusion efficacy and allow for altering of the perfusion parameters.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。在保存和/或维持器官的期间，可以另外灌注器官以获得关于流体和/或器官的数据。然后可以使用数据来最终提供关于灌注功效的信息并允许改变灌注参数。

9. 发明申请

WO2004089235A3 METHODS AND APPARATUS FOR PERFUSION, DIAGNOSIS, STORAGE AND/OR TRANSPORT OF AN ORGAN OR TISSUE 审中-公开
标题翻译：用于组织或组织的灌注，诊断，储存和/或运输的方法和装置
公开(公告)号：WO2004089235A3
公开(公告)日：2005-06-23
申请号：PCT/US2004010182
申请日：2004-04-02
申请人： ORGAN RECOVERY SYSTEMS INC , WRIGHT DAVID WALTER , BRASSIL JOHN , SCHEIN DOUGLAS , GARLAND JEFFREY C , TRAVIS LEE WILLIAMS
发明人： WRIGHT DAVID WALTER , BRASSIL JOHN , SCHEIN DOUGLAS , GARLAND JEFFREY C , TRAVIS LEE WILLIAMS
IPC分类号： A01N1/02 , B65D81/18 , B65D85/02
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247 , Y10S435/809
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserve organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The apparatus and methods include the organ cassette with one or more openings configured to allow tubing to pass through the openings and be connected to the organ or tissue within the cassette, and including a pressure control device to allow pressure inside the portable housing to be varied. The apparatus and methods further include the cassette with heat transfer surfaces arranged to transfer heat between a cooling source in said transporter and the heat transfer surfaces. The apparatus and methods further include a tube frame removably connected to the cassette and configured to hold a plurality of tubes in a position to be connected to tubes in the portable housing.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官的活力并保存器官用于储存和/或运输。其他装置包括器官输送器，器官盒和器官诊断装置。该装置和方法包括具有一个或多个开口的器官盒，其被配置为允许管道穿过开口并连接到盒内的器官或组织，并且包括压力控制装置，以允许便携式外壳内的压力变化。该装置和方法还包括具有传热表面的盒，其布置成在所述运送器中的冷却源和传热表面之间传递热量。该装置和方法还包括可移除地连接到盒子并被配置为将多个管子保持在与便携式外壳中的管连接的位置的管框架。

10. 发明申请

WO0154495A9 SYSTEM FOR ORGAN AND TISSUE PRESERVATION AND HYPOTHERMIC BLOOD SUBSTITUTION 审中-公开
标题翻译：用于组织和组织保存的系统和高血压血液替代品
公开(公告)号：WO0154495A9
公开(公告)日：2002-10-24
申请号：PCT/US0102237
申请日：2001-01-24
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： TAYLOR MICHAEL J
IPC分类号： A01N1/02
CPC分类号： A01N1/02 , A01N1/0221 , Y10S514/832
摘要： A unified solution system for organ and/or tissue preservation and/or hypothermic blood substitution can be used to prepare multiple solutions for use in various stages of organ procurement, preservation and transplantation and bloodless surgery procedures. The base electrolyte solution may comprise an (hyperkalemic) intracellular or extracellular base solution to which various additives are added depending on the specific stages of the preservation or transplantation procedure. Base and additives can be stored in separate containers in a single package or kit.
摘要翻译：用于器官和/或组织保存和/或低温血液置换的统一解决方案可用于制备用于器官采购，保存和移植以及无血管手术程序的各个阶段的多种解决方案。基础电解质溶液可以包含根据保存或移植程序的特定阶段而添加各种添加剂的（高钾血症）细胞内或细胞外基质溶液。基料和添加剂可以存放在单个包装或试剂盒中的不同容器中。

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