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1. 发明专利

JP2012092113A Apparatus and method for maintaining and/or restoring viability of organ 审中-公开
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：JP2012092113A
公开(公告)日：2012-05-17
申请号：JP2011256852
申请日：2011-11-24
申请人： Organ Recovery Systems Inc , オーガンリカヴァリーシステムズインコーポレイテッド
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： PROBLEM TO BE SOLVED: To provide an organ perfusion apparatus and a method for monitoring, sustaining and/or restoring viability of organs and storing the organs for storage and/or transport.SOLUTION: The method includes perfusing the organ at hypothermic and/or normothermic temperatures, after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pressurized medical fluid reservoir 10. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to prevent or reduce damage to vascular endothelial lining and to organ tissue in general. The viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate.
摘要翻译：要解决的问题：提供器官灌注装置和用于监测，维持和/或恢复器官的活力并存储用于储存和/或运输的器官的方法。解决方案：该方法包括在器官运输和/或储存的低温器官冲洗后，以低体温和/或正常体温温度灌注器官。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压优选地通过设置在置于器官中的管的端部中的传感器由加压的医用流体储存器10来控制。医用流体可以从具有低压的中间容器防止或减少对血管内皮衬里和器官组织的损伤。优选通过监测医用液体灌注液的特性来自动监测器官的活力。版权所有（C）2012，JPO＆INPIT

2. 发明专利

JP2012092111A Apparatus and method for maintaining and/or restoring viability of organ 有权
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：JP2012092111A
公开(公告)日：2012-05-17
申请号：JP2011256847
申请日：2011-11-24
申请人： Organ Recovery Systems Inc , オーガンリカヴァリーシステムズインコーポレイテッド
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： PROBLEM TO BE SOLVED: To provide an organ perfusion apparatus and method for storing organs for storage and/or transport of the organs.SOLUTION: The method includes perfusing the organ at hypothermic and/or normothermic temperatures, after hypothermic organ flushing. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pressurized medical fluid reservoir 10, to prevent overpressurization and to enable emergency flow cut-off. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. As a result, damage to vascular endothelial lining and to organ tissue in general are prevented or reduced. Viability of the organ may be automatically monitored by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled by using a control program.
摘要翻译：要解决的问题：提供一种器官灌注装置和方法，用于存储器官的储存和/或运输器官。解决方案：该方法包括在低温器官冲洗后在低温和/或正常体温下灌注器官。通过用正常体温温度下的医用流体灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力优选地响应于设置在置于器官中的管的末端中的传感器，通过加压医疗液体储存器10来控制，以防止过压并且使得能够进行紧急流动切断。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。结果，防止或减少对血管内皮衬里和器官组织的损伤。可以通过监测医用液体灌注液的特性来自动监测器官的活力。灌注过程可以通过使用控制程序自动控制。版权所有（C）2012，JPO＆INPIT

3. 发明专利

JP2012092112A Apparatus and method for maintaining and/or restoring viability of organ 审中-公开
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：JP2012092112A
公开(公告)日：2012-05-17
申请号：JP2011256851
申请日：2011-11-24
申请人： Organ Recovery Systems Inc , オーガンリカヴァリーシステムズインコーポレイテッド
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , A61F7/10 , A61F7/12 , A61L27/00 , A61M1/02 , A61M1/36 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： PROBLEM TO BE SOLVED: To provide an organ perfusion apparatus and a method for monitoring, sustaining and/or restoring viability of organs, and for storing the organs for storage and/or transport.SOLUTION: The method includes perfusing the organ at hypothermic and/or normothermic temperatures, after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid at normothermic temperatures. In perfusion, organ perfusion pressure is controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pressurized medical fluid reservoir 10. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization and to prevent or reduce damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored by monitoring characteristics of the medical fluid perfusate.
摘要翻译：要解决的问题：提供器官灌注装置和用于监测，维持和/或恢复器官活力并存储用于储存和/或运输的器官的方法。解决方案：该方法包括在器官运输和/或储存的低温器官冲洗后，以低体温和/或正常体温温度灌注器官。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力响应于设置在置于器官中的管的端部中的传感器被加压的医用流体储存器10控制。医用流体可以从具有低压头的中间容器进料到器官中避免器官过度加压，并防止或减少对血管内皮衬里和器官组织的损害。可以通过监测医用液体灌注液的特性来自动监测器官的活力。版权所有（C）2012，JPO＆INPIT

4. 发明专利

JP2012092114A Apparatus and method for maintaining and/or restoring viability of organ 有权
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：JP2012092114A
公开(公告)日：2012-05-17
申请号：JP2011256854
申请日：2011-11-24
申请人： Organ Recovery Systems Inc , オーガンリカヴァリーシステムズインコーポレイテッド
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： PROBLEM TO BE SOLVED: To provide an organ perfusion apparatus and a method for monitoring, sustaining and/or restoring viability of organs and storing the organs for storage and/or transport.SOLUTION: The method includes perfusing the organ at hypothermic and/or normothermic temperatures, after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubing placed in the organ, by a pressurized medical fluid reservoir 10. The damage to vascular endothelial lining and to organ tissue in general is prevented or reduced by evading the overpressurization of the organs. The viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate.
摘要翻译：要解决的问题：提供器官灌注装置和用于监测，维持和/或恢复器官的活力并存储用于储存和/或运输的器官的方法。解决方案：该方法包括在器官运输和/或储存的低温器官冲洗后，以低体温和/或正常体温温度灌注器官。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力优选地通过设置在置于器官中的管的端部中的传感器由加压的医用液体储存器10进行控制。一般来说，防止或减少对血管内皮衬里和器官组织的损伤逃避器官超压。优选通过监测医用液体灌注液的特性来自动监测器官的活力。版权所有（C）2012，JPO＆INPIT

5. 发明申请

WO0226034A3 APPARATUS AND METHOD FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS 审中-公开
标题翻译：维护和/或恢复机构可行性的装置和方法
公开(公告)号：WO0226034A3
公开(公告)日：2003-03-20
申请号：PCT/US0126591
申请日：2001-08-27
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore vability of organs and preserver organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygeneted cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubuing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization preventing and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of th emedical fluid perfusate. The perfusion process can be automatically controlled using a control program.
摘要翻译：器官灌注装置和方法监测，维持和/或恢复器官和保存器官的存储和/或运输的可行性。其他装置包括器官输送器，器官盒和器官诊断装置。该方法包括在低温和/或正常体温温度下灌注器官，优选在用于器官运输和/或储存的低温器官冲洗之后。该方法可以在先前或随后的器官的静态或灌注低温暴露下进行。通过用正常体温温度下的医用流体（例如含氧交叉血红蛋白基碳酸氢盐医疗液体）灌注器官来恢复高能量核苷酸（例如ATP）水平来恢复器官活力。在灌注中，器官灌注压力优选地响应于设置在放置在器官中的管道末端中的传感器，通过气动加压的医用液体储存器进行控制，提供灌注压力微调，超压防止和紧急流量截止。在低体温模式中，器官用液体灌注，优选地是含有抗氧化剂的简单晶体溶液，间歇地或以缓慢的连续流动。可以从具有低压头的中间容器将药液输送到器官中，以避免器官过压。防止过度加压防止或减少对血管内皮衬里和器官组织的损害。可以自动监测器官的生存能力，优选通过监测体液灌注液的特性。可以使用控制程序自动控制灌注过程。

6. 发明申请

WO0178504A2 NOVEL WARMING METHOD OF CRYOPRESERVED SPECIMENS 审中-公开
标题翻译： CRYOPRESVED样品的新型加温方法
公开(公告)号：WO0178504A2
公开(公告)日：2001-10-25
申请号：PCT/US0112464
申请日：2001-04-17
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： CAMPBELL LIA HANSON , BROCKBANK KELVIN G M , TAYLOR MICHAEL J
IPC分类号： A01N1/02 , C12N5/02
CPC分类号： A01N1/0284 , A01N1/02 , A01N1/0205
摘要： A two stage method of thawing cells from a cryopreserved state includes first warming the cells from a cryopreservation temperature to a transition temperature of at least -30 DEG C in a first, slow-warming stage by exposing the cells to an atmosphere having a temperature of less than 30 DEG C, and once the cells have obtained the transition temperature, subsequently further warming the cells from the transition temperature by exposing the cells to a temperature of least 32 DEG C in a second, rapid-warming stage. After the cells obtain the transition temperature in the first stage, the cells may be equilibrated at the transition temperature for a period of time prior to conducting the second stage warming. The method is particularly useful in warming cryopreserved cells attached to a fixed substrate. A thermal conduction device in association with the cryopreserved cells may also be used to further assist in the warming procedure.
摘要翻译：从低温保存状态解冻细胞的两阶段方法包括在第一个缓慢升温阶段中将细胞从冷冻保存温度升温至至少-30℃的转变温度，将细胞暴露于温度为小于30℃，并且一旦细胞获得转变温度，随后在第二次快速升温阶段中将细胞暴露于至少32℃的温度，从而使细胞从转变温度进一步升温。细胞获得第一阶段的转变温度之后，可以在进行第二阶段升温之前将细胞在转变温度下平衡一段时间。该方法特别适用于连接至固定底物的冷冻保存细胞。与冷冻保存细胞相关联的导热装置也可用于进一步帮助加温过程。

7. 发明公开

EP1317175A2 APPARATUS FOR MAINTAINING AND/OR RESTORING VIABILITY OF ORGANS 有权
标题翻译：设备维护和/或恢复器官的活力
公开(公告)号：EP1317175A2
公开(公告)日：2003-06-11
申请号：EP01966245
申请日：2001-08-27
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： OWEN DONALD R , KRAVITZ DAVID C , BRASSIL JOHN , BROCKBANK KELVIN G M , BURROUGHS ANDREW , ISAACS DICKON , STEIBEL DENNIS J , FRASER RICHARD , HARRIS STANLEY , SCHEIN DOUGLAS
IPC分类号： A01N1/02 , C12M3/00
CPC分类号： A01N1/0273 , A01N1/02 , A01N1/0247
摘要： An organ perfusion apparatus and method monitor, sustain and/or restore viability of organs and preserver organs for storage and/or transport. Other apparatus include an organ transporter, an organ cassette and an organ diagnostic device. The method includes perfusing the organ at hypothermic and/or normothermic temperatures, preferably after hypothermic organ flushing for organ transport and/or storage. The method can be practiced with prior or subsequent static or perfusion hypothermic exposure of the organ. Organ viability is restored by restoring high energy nucleotide (e.g., ATP) levels by perfusing the organ with a medical fluid, such as an oxygeneted cross-linked hemoglobin-based bicarbonate medical fluid, at normothermic temperatures. In perfusion, organ perfusion pressure is preferably controlled in response to a sensor disposed in an end of tubuing placed in the organ, by a pneumatically pressurized medical fluid reservoir, providing perfusion pressure fine tuning, overpressurization preventing and emergency flow cut-off. In the hypothermic mode, the organ is perfused with a medical fluid, preferably a simple crystalloid solution containing antioxidants, intermittently or in slow continuous flow. The medical fluid may be fed into the organ from an intermediary tank having a low pressure head to avoid organ overpressurization. Preventing overpressurization prevents or reduces damage to vascular endothelial lining and to organ tissue in general. Viability of the organ may be automatically monitored, preferably by monitoring characteristics of the medical fluid perfusate. The perfusion process can be automatically controlled using a control program.

8. 发明专利

AU4230200A Method of cryopreservation of blood vessels by vitrification 未知
公开(公告)号：AU4230200A
公开(公告)日：2000-11-14
申请号：AU4230200
申请日：2000-04-12
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： KHIRABADI BIJAN S , SONG YING C , BROCKBANK KELVIN G M
IPC分类号： A01N1/02 , A61K35/12 , A61K35/44 , A01N1/00 , C12N5/00

9. 发明专利

CA2405404A1 NOVEL WARMING METHOD OF CRYOPRESERVED SPECIMENS 未知
公开(公告)号：CA2405404A1
公开(公告)日：2001-10-25
申请号：CA2405404
申请日：2001-04-17
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： BROCKBANK KELVIN G M , CAMPBELL LIA HANSON , TAYLOR MICHAEL J
IPC分类号： A01N1/02 , C12N5/02
摘要： A two stage method of thawing cells from a cryopreserved state includes firs t warming the cells from a cryopreservation temperature to a transition temperature of at least -30~C in a first, slow-warming stage by exposing the cells to an atmosphere having a temperature of less than 30~C, and once the cells have obtained the transition temperature, subsequently further warming the cells from the transition temperature by exposing the cells to a temperature of least 32~C in a second, rapid-warming stage. After the cells obtain the transition temperature in the first stage, the cells may be equilibrated at the transition temperature for a period of time prior to conducting the second stage warming. The method is particularly useful in warming cryopreserved cells attached to a fixed substrate. A thermal conduction device in association with the cryopreserved cells may also be us ed to further assist in the warming procedure.

10. 发明专利

AT282955T 未知
公开(公告)号：AT282955T
公开(公告)日：2004-12-15
申请号：AT01928590
申请日：2001-04-17
申请人： ORGAN RECOVERY SYSTEMS INC
发明人： CAMPBELL LIA HANSON , BROCKBANK KELVIN G M , TAYLOR MICHAEL J
IPC分类号： A01N1/02 , C12N5/02
摘要： A two stage method of thawing cells from a cryopreserved state includes first warming the cells from a cryopreservation temperature to a transition temperature of at least -30° C. in a first, slow-warming stage by exposing the cells to an atmosphere having a temperature of less than 30° C., and once the cells have obtained the transition temperature, subsequently further warming the cells from the transition temperature by exposing the cells to a temperature of at least 32° C. in a second, rapid-warming stage. After the cells obtain the transition temperature in the first stage, the cells may be equilibrated at the transition temperature for a period of time prior to conducting the second stage warming. The method is particularly useful in warming cryopreserved cells attached to a fixed substrate. A thermal conduction device in association with the cryopreserved cells may also be used to further assist in the warming procedure.

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