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1. 发明专利

IL292762A Novel insulin analogues and uses thereof 未知
公开(公告)号：IL292762A
公开(公告)日：2022-07-01
申请号：IL29276222
申请日：2022-05-03
申请人： NOVO NORDISK AS , HUBALEK FRANTISEK , NORRMAN MATHIAS , OLSEN HELLE BIRK , MADSEN PETER , KJELDSEN THOMAS B?RGLUM , STURIS JEPPE
发明人： HUBALEK FRANTISEK , NORRMAN MATHIAS , OLSEN HELLE BIRK , MADSEN PETER , KJELDSEN THOMAS B?RGLUM , STURIS JEPPE
IPC分类号： A61K31/455 , A61K38/28 , A61K47/10 , A61K47/22 , C07K14/62
摘要： The present invention is in the therapeutic field of drugs for medical conditions relating to diabetes. More specifically the invention relates to insulin analogues of human insulin. The invention provides pharmaceutical compositions comprising such insulin analogues and the uses if the such analogues for the treatment or prevention of medical conditions relating to diabetes.

2. 发明申请

WO2006053906A1 SOLUBLE, STABLE INSULIN-CONTAINING FORMULATIONS WITH A PROTAMINE SALT 审中-公开
标题翻译：可溶性，稳定的含胰岛素的胰蛋白胨盐配方
公开(公告)号：WO2006053906A1
公开(公告)日：2006-05-26
申请号：PCT/EP2005/056105
申请日：2005-11-21
申请人： NOVO NORDISK A/S , OLSEN, Helle, Birk , KAARSHOLM, Niels, Christian , BALSCHMIDT, Per
发明人： OLSEN, Helle, Birk , KAARSHOLM, Niels, Christian , BALSCHMIDT, Per
IPC分类号： A61K38/28 , A61K38/17
CPC分类号： A61K38/28 , A61K9/0019 , A61K47/42
摘要： The present invention relates to pharmaceutical formulations comprising insulin, an insulin analog, an insulin derivative, or a combination of any of the foregoing, and a salt of protamine, to methods of preparing such formulations, and to uses of such formulations in the treatment of diseases and conditions for which use of the insulin peptide(s) contained in such formulations is indicated. The present invention further relates to methods for increasing the stability and/or solubility of insulin in insulin-containing formulations at a pH less than 7.0 by adding a salt of protamine to the insulin-containing formulations.
摘要翻译：本发明涉及包含胰岛素，胰岛素类似物，胰岛素衍生物，或前述任何一种的组合物和鱼精蛋白盐的药物制剂，以及制备这些制剂的方法，以及这些制剂在治疗中的应用指示使用这些制剂中所含的胰岛素肽的疾病和病症。本发明还涉及通过向含有胰岛素的制剂中加入鱼精蛋白盐来增加胰岛素在含胰岛素制剂中的pH小于7.0的稳定性和/或溶解度的方法。

3. 发明申请

WO2012080320A1 FAST-ACTING INSULIN IN COMBINATION WITH LONG-ACTING INSULIN 审中-公开
标题翻译：快速胰岛素与长效胰岛素组合
公开(公告)号：WO2012080320A1
公开(公告)日：2012-06-21
申请号：PCT/EP2011/072739
申请日：2011-12-14
申请人： NOVO NORDISK A/S , HAVELUND, Svend , RIBEL-MADSEN, Ulla , JONASSEN, Ib , OLSEN, Helle Birk
发明人： HAVELUND, Svend , RIBEL-MADSEN, Ulla , JONASSEN, Ib , OLSEN, Helle Birk
IPC分类号： A61K38/28 , A61K47/16 , A61K47/18 , A61P3/10
CPC分类号： A61K38/28 , A61K9/0019 , A61K31/198 , A61K31/455 , A61K47/10 , A61K47/183 , A61K47/22 , A61K2300/00
摘要： Insulin preparations comprising a long-acting insulin compound, a fast-acting insulin compound, a nicotinic compound and an amino acid.
摘要翻译：包含长效胰岛素化合物，速效胰岛素化合物，烟碱化合物和氨基酸的胰岛素制剂。

4. 发明申请

WO2010149772A1 PREPARATION COMPRISING INSULIN, NICOTINAMIDE AND AN AMINO ACID 审中-公开
标题翻译：包含胰岛素，尼古丁和氨基酸的制剂
公开(公告)号：WO2010149772A1
公开(公告)日：2010-12-29
申请号：PCT/EP2010/059069
申请日：2010-06-25
申请人： NOVO NORDISK A/S , OLSEN, Helle, Birk , HAVELUND, Svend , RIBEL, Ulla , STURIS, Jeppe , NAVER, Helle , SCHLEIN, Morten , LUDVIGSEN, Svend
发明人： OLSEN, Helle, Birk , HAVELUND, Svend , RIBEL, Ulla , STURIS, Jeppe , NAVER, Helle , SCHLEIN, Morten , LUDVIGSEN, Svend
IPC分类号： A61K38/28 , A61K31/465 , A61K47/18 , A61P3/10 , A61K45/06
CPC分类号： A61K38/28 , A61K9/0019 , A61K31/198 , A61K31/455 , A61K31/465 , A61K45/06 , A61K47/02 , A61K47/183 , A61K47/22 , A61K2300/00
摘要： Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
摘要翻译：包含胰岛素化合物或两种或更多种胰岛素化合物，烟碱化合物和氨基酸的混合物的胰岛素制剂。

5. 发明申请

WO2009021956A2 RAPID ACTING INSULIN ANALOGUES 审中-公开
标题翻译：快速行动胰岛素类似物
公开(公告)号：WO2009021956A2
公开(公告)日：2009-02-19
申请号：PCT/EP2008/060597
申请日：2008-08-12
申请人： NOVO NORDISK A/S , OLSEN, Helle, Birk , KJELDSEN, Thomas, Børglum , BALSCHMIDT, Per , GLENDORF, Tine , HAVELUND, Svend
发明人： OLSEN, Helle, Birk , KJELDSEN, Thomas, Børglum , BALSCHMIDT, Per , GLENDORF, Tine , HAVELUND, Svend
IPC分类号： C07K14/62
CPC分类号： C07K14/62
摘要： The invention is related to fast acting insulin analogues which can form soluble mixtures (pre-mixed or self-mixed) with long acting insulin analogues. The fast action is achieved through monomerizing substitutions/deletions in the C-terminus of the B-chain of human insulin and the mixability with long acting insulin analogues is achieved through a substitution of the Zn-binding His in position B10 of human insulin with lie, VaI, Ala or Phe. In one embodiment the invention is related to fast acting insulin analogues in which at least one of the natural amino acid residues in position B22-B30 in the human B-chain has been substituted with another amino acid residue having the effect of promoting formation of the monomeric form of insulin, the His amino acid residue in position 10 in the B-chain is substituted with lie, VaI, Ala or Phe and wherein further one or more of the amino acid residues in position B22-B30 optionally have been deleted.
摘要翻译：本发明涉及可与长效胰岛素类似物形成可溶性混合物（预混合或自混合）的快速作用胰岛素类似物。快速作用是通过在人胰岛素的B链的C末端进行单体化取代/缺失来实现的，并且通过用位于人胰岛素B10位置的Zn结合His取代长效胰岛素类似物的混合物来实现，Val，Ala或Phe。在一个实施方案中，本发明涉及快速作用的胰岛素类似物，其中人B链中位置B22-B30中的至少一个天然氨基酸残基已经被另一个氨基酸残基取代，其具有促进形成单体形式的胰岛素，B链中10位的His氨基酸残基被取代为Val，Ala或Phe，并且其中还有一个或多个位置B22-B30的氨基酸残基被缺失。

6. 发明申请

WO2004080480A1 PHARMACEUTICAL PREPARATIONS COMPRISING ACID-STABILISED INSULIN 审中-公开
标题翻译：包含酸稳定胰岛素的药物制剂
公开(公告)号：WO2004080480A1
公开(公告)日：2004-09-23
申请号：PCT/DK2004/000158
申请日：2004-03-11
申请人： NOVO NORDISK A/S , ØSTERGAARD, Søren , OLSEN, Helle, Birk , KAARSHOLM, Niels, C. , MADSEN, Peter , JAKOBSEN, Palle , LUDVIGSEN, Svend , SCHLUCKEBIER, Gerd , STEENSGAARD, Dorte, Bjerre , PETERSEN, Anders, Klarskov
发明人： ØSTERGAARD, Søren , OLSEN, Helle, Birk , KAARSHOLM, Niels, C. , MADSEN, Peter , JAKOBSEN, Palle , LUDVIGSEN, Svend , SCHLUCKEBIER, Gerd , STEENSGAARD, Dorte, Bjerre , PETERSEN, Anders, Klarskov
IPC分类号： A61K38/28
CPC分类号： A61K45/06 , A61K33/30 , A61K38/28 , A61K47/34 , C07D215/38 , C07D233/96 , C07D239/26 , C07D249/06 , C07D249/18 , C07D257/04 , C07D277/20 , C07D277/62 , C07D307/80 , C07D307/81 , C07D317/54 , C07D401/04 , C07D401/12 , C07D403/06 , C07D405/10 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/14 , C07D471/04 , C07D513/04 , C07K14/62 , A61K2300/00
摘要： Novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer that are capable of prolonging the action of insulin preparations are disclosed.
摘要翻译：公开了能够延长胰岛素制剂作用的R状态胰岛素六聚体的HisB10 Zn 2+位点的新配体。

7. 发明申请

WO2007135117A2 SOLUBLE, STABLE INSULIN-CONTAINING FORMULATIONS 审中-公开
标题翻译：可溶性，稳定的含胰岛素的制剂
公开(公告)号：WO2007135117A2
公开(公告)日：2007-11-29
申请号：PCT/EP2007/054862
申请日：2007-05-21
申请人： NOVO NORDISK A/S , OLSEN, Helle, Birk , KAARSHOLM, Niels, Christian , JAKOBSEN, Palle , BALSCHMIDT, Per
发明人： OLSEN, Helle, Birk , KAARSHOLM, Niels, Christian , JAKOBSEN, Palle , BALSCHMIDT, Per
IPC分类号： A61K38/28 , A61K38/03
CPC分类号： A61K38/03 , A61K38/28 , A61K2300/00
摘要： The present invention relates to pharmaceutical formulations comprising insulin, an insulin analog, an insulin derivative, or a combination of any of the foregoing, and a salt of positively charged peptides, to methods of preparing such formulations, and to uses of such formulations in the treatment of diseases and conditions for which use of the insulin peptide(s) contained in such formulations is indicated. The present invention further relates to methods for increasing the stability and/or solubility of insulin in insulin-containing formulations at a pH less than 7.0 by adding a salt of salt of positively charged peptides to the insulin-containing formulations.
摘要翻译：本发明涉及包含胰岛素，胰岛素类似物，胰岛素衍生物或任何前述物质的组合的药物制剂，以及带正电荷的肽的盐，制备这些制剂的方法，以及这些制剂在指出了使用这些制剂中所含的胰岛素肽的疾病和病症的治疗。本发明还涉及通过向含胰岛素的制剂中加入带正电荷的肽的盐，来增加胰岛素在pH小于7.0的制剂中的稳定性和/或溶解度的方法。

8. 发明申请

WO2006005683A1 PHAMACEUTICAL PREPARATIONS COMPRISING INSULIN 审中-公开
标题翻译：包含胰岛素的药物制剂
公开(公告)号：WO2006005683A1
公开(公告)日：2006-01-19
申请号：PCT/EP2005/053070
申请日：2005-06-29
申请人： NOVO NORDISK A/S , OLSEN, Helle, Birk , KAARSHOLM, Niels, Christian , MADSEN, Peter , BALSCHMIDT, Per
发明人： OLSEN, Helle, Birk , KAARSHOLM, Niels, Christian , MADSEN, Peter , BALSCHMIDT, Per
IPC分类号： A61K38/28
CPC分类号： A61K45/06 , A61K33/30 , A61K38/28 , A61K2300/00
摘要： Novel preparations comprising ligands for the HisB10 Zn 2+ sites of the R-state insulin hexamer wherein the ligand is extended by protamine that are capable of prolonging the action of insulin preparations.
摘要翻译：包含R状态胰岛素六聚体的HisB10 Zn 2+ 2 +位点配体的新型制剂，其中配体通过精蛋白延长，其能够延长胰岛素制剂的作用。

9. 发明申请

WO2004056347A2 STABILISED INSULIN COMPOSITIONS 审中-公开
标题翻译：包含胰岛素和胰高血糖素的胆固醇的药物组合物
公开(公告)号：WO2004056347A2
公开(公告)日：2004-07-08
申请号：PCT/DK2003/000931
申请日：2003-12-22
申请人： NOVO NORDISK A/S , KAARSHOLM, Niels, Christian , MADSEN, Peter , SCHLEIN, Morten , OLSEN, Helle, Birk , HAVELUND, Svend , STEENSGAARD, Dorte, Bjerre , LUDVIGSEN, Svend , JAKOBSEN, Palle , PETERSEN, Anders, Klarskov , SCHLUCKEBIER, Gerd
发明人： KAARSHOLM, Niels, Christian , MADSEN, Peter , SCHLEIN, Morten , OLSEN, Helle, Birk , HAVELUND, Svend , STEENSGAARD, Dorte, Bjerre , LUDVIGSEN, Svend , JAKOBSEN, Palle , PETERSEN, Anders, Klarskov , SCHLUCKEBIER, Gerd
IPC分类号： A61K31/00
CPC分类号： C07D403/04 , A61K31/416 , A61K31/4192 , A61K38/28 , C07D249/06 , C07D249/18 , C07D277/34 , C07D413/12 , C07D417/12 , C07K14/62 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising insulin and novel ligands for the His B10 Zn 2+ sites of the R-state insulin hexamer. The resulting preparations have improved physical and chemical stability.
摘要翻译：本发明提供包含胰岛素和R状态胰岛素六聚体的His Zn 2+位点的新配体的药物组合物。所得制剂具有改善的物理和化学稳定性。

10. 发明申请

WO2012080362A1 PREPARATION COMPRISING INSULIN, NICOTINAMIDE AND AN AMINO ACID 审中-公开
标题翻译：包括胰岛素，尼古丁和氨基酸的制剂
公开(公告)号：WO2012080362A1
公开(公告)日：2012-06-21
申请号：PCT/EP2011/072809
申请日：2011-12-14
申请人： NOVO NORDISK A/S , OLSEN, Helle Birk , HAVELUND, Svend , RIBEL-MADSEN, Ulla , STURIS, Jeppe , NAVER, Helle , SCHLEIN, Morten , LUDVIGSEN, Svend
发明人： OLSEN, Helle Birk , HAVELUND, Svend , RIBEL-MADSEN, Ulla , STURIS, Jeppe , NAVER, Helle , SCHLEIN, Morten , LUDVIGSEN, Svend
IPC分类号： A61K47/16 , A61K47/18 , A61K38/28 , A61K31/198 , A61K31/465 , A61P3/10
CPC分类号： A61K33/30 , A61K9/0019 , A61K31/198 , A61K31/465 , A61K38/28 , A61K47/183 , A61K47/22 , A61K2300/00
摘要： Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
摘要翻译：包含胰岛素化合物或两种或更多种胰岛素化合物，烟碱化合物和氨基酸的混合物的胰岛素制剂。

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