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1. 发明专利

CA2241777A1 MAGNETIC FLUID MODIFICATION DEVICE AND USE 未知
公开(公告)号：CA2241777A1
公开(公告)日：1999-12-26
申请号：CA2241777
申请日：1998-06-26
申请人： OHWAKI KENJI , HAMASAKI KAZUNORI , MORI MATSUJI
发明人： OHWAKI KENJI , HAMASAKI KAZUNORI , MORI MATSUJI
IPC分类号： B01F3/04 , B01F13/08 , B01J19/08 , F23K5/08 , F02M19/03
摘要： To improve the affinity between a gas and a liquid, the liquid is passed through an enclosure where it contacts a portion of the magnets of a magnetic field generating device and passes through the magnetic field created by the magnets while a gas is in contact with the other portion of the magnets. A liquid level control device maintains and controls the liquid level so that the magnets simultaneously extend about equally into the gas and liquid with both contacting the magnets and being within the magnetic field created by the magnets. The gas in the enclosure increases the effectiveness that the magnetic field and magnets have on the liquid. The gas used in the enclosure can optionally subsequently be mixed with the liquid or another gas can be mixed with the liquid. Additional gases and liquids can be mixed together. The device and process associated with it can be used on different liquids and different gasses, including fuel mixed with air in a combustion process.

2. 发明申请

WO1996033973A1 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES 审中-公开
标题翻译： 1,4-取代的哌啶衍生物
公开(公告)号：WO1996033973A1
公开(公告)日：1996-10-31
申请号：PCT/JP1996001128
申请日：1996-04-25
申请人： BANYU PHARMACEUTICAL CO., LTD. , TSUCHIYA, Yoshimi , NOMOTO, Takashi , OHSAWA, Hirokazu , KAWAKAMI, Kumiko , OHWAKI, Kenji , NISHIKIBE, Masaru
发明人： BANYU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D211/46
CPC分类号： C07D401/12 , C07D211/46 , C07D211/58 , C07D405/12 , C07D409/12 , C07D417/12
摘要： Novel 1,4-disubstituted piperidine derivatives represented by general formula (I) and pharmaceutically acceptable salts thereof, wherein Ar represents phenyl wherein one or two arbitrary hydrogen atoms on its ring may be substituted by substituent(s) selected from the group consisting of halogeno and lower alkyl or an aromatic 5- or 6-membered heterocycle having one or two heteroatoms selected from the group consisting of oxygen, nitrogen and sulfur; R represents C3-6 cycloalkyl or C3-6 cycloalkenyl; R represents saturated or unsaturated aliphatic C5-15 hydrocarbon group; and X represents O or NH. The compounds have a selective antagonism against the muscarine M3 receptor and a high safety with little side effect. Thus they are useful in the treatment or prevention of respiratory diseases such as asthma, chronic respiratory obstruction and pulmonary fibrosis, urological diseases accompanied with urination disorders such as frequent urination, urgency of micturition and urinary incontinence and digestive diseases such as convulsion or motion hyperenergia of the digestive tracts and irritable large intestine.
摘要翻译：由通式（I）表示的新的1,4-二取代哌啶衍生物及其药学上可接受的盐，其中Ar表示苯基，其中其一个或两个任意的氢原子可以被选自以下的取代基取代：卤代和具有一个或两个选自氧，氮和硫的杂原子的低级烷基或芳族5-或6-元杂环; R 1表示C 3-6环烷基或C 3-6环烯基; R 2表示饱和或不饱和的脂族C 5-15烃基; X表示O或NH。这些化合物对毒蕈碱M3受体具有选择性拮抗作用，安全性高，副作用小。因此，它们可用于治疗或预防呼吸系统疾病如哮喘，慢性呼吸阻塞和肺纤维化，泌尿系统疾病伴随排尿障碍，例如尿频，排尿紧急和尿失禁以及消化系统疾病如惊厥或运动过敏消化道和易怒大肠。

3. 发明申请

WO1998005641A1 FLUORINATED 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES 审中-公开
标题翻译：氟化1,4-取代的哌啶衍生物
公开(公告)号：WO1998005641A1
公开(公告)日：1998-02-12
申请号：PCT/JP1997002600
申请日：1997-07-28
申请人： BANYU PHARMACEUTICAL CO., LTD. , TSUCHIYA, Yoshimi , NOMOTO, Takashi , OHSAWA, Hirokazu , KAWAKAMI, Kumiko , OHWAKI, Kenji , NISHIKIBE, Masaru
发明人： BANYU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D211/46
CPC分类号： C07D401/06 , C07D211/58 , C07D405/06 , C07D409/06
摘要： Novel fluorinated 1,4-disubstituted piperidine derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof, wherein Ar represents aryl or heteroaryl having 1 or 2 heteroatoms selected from the group consisting of nitrogen, oxygen and sulphur in which one to three hydrogen atoms on the aryl or heteroaryl ring may be substituted by lower alkyl, etc.; R represents C1-3 cycloalkyl in which one to four arbitrary hydrogen atoms may be substituted by fluorine; R represents saturated or unsaturated, aliphatic C5-15 hydrocarbon in which one to six arbitrary hydrogen atoms may be substituted by fluorine, aralkyl, arylalkenyl, or heteroarylalkyl or heteroarylalkenyl having one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, in which one to three hydrogen atoms on the aralkyl, arylalkenyl, heteroarylalkyl or heteroarylalkenyl ring may be substituted by lower alkyl, trifluoromethyl, cyano, hydroxy, nitro, lower alkoxycarbonyl, halogeno, lower alkoxy, amino, etc.; and X represents O or NH, provided that at least one of R and R has one or more fluorine atoms. Because of having selective muscarinic receptor antagonism and being excellent in oral activity, persistence of the action and dynamic in vivo, these compounds are useful as efficacious and safe remedies or preventives with little side effects for respiratory, urologic and digestive diseases.
摘要翻译：由通式（I）表示的新型氟化1,4-二取代哌啶衍生物或其药学上可接受的盐，其中Ar表示具有1或2个选自氮，氧和硫的杂原子的芳基或杂芳基，其中一至三个氢芳基或杂芳基环上的原子可以被低级烷基等取代; R 1表示其中一至四个任意氢原子可被氟取代的C 1-3环烷基; R 2表示饱和或不饱和的脂族C 5-15烃，其中一至六个任意氢原子可被氟，芳烷基，芳基烯基或具有一个或两个选自氮，氧的杂芳基烷基或杂芳基烯基取代和其中芳烷基，芳基烯基，杂芳基烷基或杂芳基烯基环上的一至三个氢原子可被低级烷基，三氟甲基，氰基，羟基，硝基，低级烷氧基羰基，卤代，低级烷氧基，氨基等取代的硫。并且X表示O或NH，条件是R 1和R 2中的至少一个具有一个或多个氟原子。由于具有选择性的毒蕈碱受体拮抗作用，口服活性优异，作用持久，体内动态，因此这些化合物作为呼吸系统，泌尿系统和消化系统疾病副作用少的有效和安全的补救措施或预防措施是有用的。

4. 发明申请

WO1997045414A1 1,4-DISUBSTITUTED PIPERIDINE DERIVATIVES 审中-公开
标题翻译： 1,4-取代的哌啶衍生物
公开(公告)号：WO1997045414A1
公开(公告)日：1997-12-04
申请号：PCT/JP1997001770
申请日：1997-05-27
申请人： BANYU PHARMACEUTICAL CO., LTD. , TSUCHIYA, Yoshimi , NOMOTO, Takashi , OHSAWA, Hirokazu , KAWAKAMI, Kumiko , OHWAKI, Kenji , NISHIKIBE, Masaru
发明人： BANYU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D211/58
CPC分类号： C07D211/58
摘要： 1,4-Disubstituted piperidine derivatives represented by general formula (I) and pharmaceutically acceptable salts thereof, wherein Ar represents heteroaryl having one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur and optionally fused to aryl or benzene (wherein each hydrogen on the aryl and heteroaryl rings may be substituted by lower alkyl, halogeno, lower alkoxy, amino or hydroxymethyl); R represents C3-6 cycloalkyl having one or two hydroxyl groups on the ring; R represents heteroarylalkyl having one or two heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur and optionally fused to saturated or unsaturated aliphatic C5-15 hydrocarbon, aralkyl, arylalkenyl or benzene (wherein each hydrogen on the aralkyl, arylalkenyl and heteroarylalkyl rings may be substituted by lower alkyl, halogeno, lower alkoxy, amino or hydroxymethyl); and X represents O or NH. Because of having a selective muscarine M3 receptor antagonism, these compounds are useful as safe remedies or preventives with little side effects for respiratory diseases such as asthma, chronic respiratory obstruction and pulmonary fibrosis; urologic diseases in association with urination disorders such as frequent urination, urgency of micturition and urinary incontinence; and digestive diseases such as irritable bowel syndrome and convulsion or motor hyperenergia of digestive tracts.
摘要翻译：由通式（I）表示的1,4-二取代哌啶衍生物及其药学上可接受的盐，其中Ar表示具有一个或两个选自氮，氧和硫并且任选地与芳基或苯稠合的杂原子的杂芳基（其中每个芳基和杂芳基环上的氢可以被低级烷基，卤代，低级烷氧基，氨基或羟甲基取代）; R 1表示在环上具有一个或两个羟基的C 3-6环烷基; R 2表示具有一个或两个选自氮，氧和硫的杂原子的杂芳基烷基，并且任选地与饱和或不饱和的脂族C 5-15烃，芳烷基，芳基烯基或苯稠合（其中芳烷基上的每个氢，芳烯基烯基和杂芳基烷基环可以被低级烷基，卤代，低级烷氧基，氨基或羟甲基取代）; X表示O或NH。由于具有选择性的毒蕈碱M3受体拮抗作用，这些化合物可用作对哮喘，慢性呼吸阻塞和肺纤维化等呼吸系统疾病具有副作用的安全补救措施或预防药物; 泌尿系统疾病与排尿障碍如排尿紧急，排尿紧急和尿失禁有关; 消化道疾病如肠易激综合征，消化道惊厥或运动过敏等。

5. 发明申请

WO1998004554A1 CHEMOKINE RECEPTOR ANTAGONISTS 审中-公开
标题翻译：化疗受体拮抗剂
公开(公告)号：WO1998004554A1
公开(公告)日：1998-02-05
申请号：PCT/JP1997002548
申请日：1997-07-23
申请人： BANYU PHARMACEUTICAL CO., LTD. , NAYA, Akira , OWADA, Yufu , SAEKI, Toshihiko , OHWAKI, Kenji , IWASAWA, Yoshikazu
发明人： BANYU PHARMACEUTICAL CO., LTD.
IPC分类号： C07D405/12
CPC分类号： C07D401/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/12 , C07D417/12 , C07D451/14
摘要： Compounds represented by general formula (I), pharmaceutically acceptable anion-exchange products thereof, or hydrates of both, wherein R and R are the same or different and each represents hydrogen, halogeno, lower alkyl, etc.; X represents oxygen, sulfur or CH; Y represents CH or nitrogen; and A represents 1-substituted-4-piperidinyl, etc. Because of having chemokine receptor antagonism, these compounds are useful as remedies for various diseases related to chemokine, such as acute inflammatory diseases, chronic inflammatory diseases, human acquired immunological deficiency syndrome, cancer, ischemic reflow disorders and/or arteriosclerosis.
摘要翻译：由通式（I）表示的化合物，其药学上可接受的阴离子交换产物或两者的水合物，其中R 1和R 2相同或不同，各自表示氢，卤代，低级烷基等; X表示氧，硫或CH; Y表示CH或氮; A代表1-取代-4-哌啶基等。由于具有趋化因子受体拮抗作用，这些化合物可用作与趋化因子有关的各种疾病的补救措施，如急性炎性疾病，慢性炎性疾病，人类获得性免疫缺陷综合症，癌症，缺血性回流障碍和/或动脉硬化。

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