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1. 发明申请

US20060191848A1 Integrated separation of organic substances from an aqueous bio-process mixture 审中-公开
标题翻译：有机物质与水生物过程混合物的综合分离
公开(公告)号：US20060191848A1
公开(公告)日：2006-08-31
申请号：US10513894
申请日：2003-05-02
申请人： Nicole Ruffer , Christian Wandrey , Ralf Takors
发明人： Nicole Ruffer , Christian Wandrey , Ralf Takors
IPC分类号： C02F9/00
CPC分类号： B01D11/048 , B01D11/0488
摘要： The present invention relates to a process for integrated removal of one or more organic substances present in an aqueous bioprocess mixture, which comprise at least one positively charged and/or chargeable nitrogen-containing group, by means of reactive extraction in at least one step, in which process at least one liquid-liquid centrifuge is used for said reactive extraction and said organic substances are re-extracted from the extractant into an aqueous phase. More specifically, the bioprocess mixture directed to the liquid-liquid centrifuges is rendered cell-free and protein-free, before being directed into the first centrifuge. Furthermore, the invention relates to such a process in which an aqueous bioprocess mixture is continuously removed from a bioreactor, led, with an extractant, into a liquid-liquid centrifuge, extracted by means of said extractant, with an organic phase being obtained which contains the substance to be extracted from the fermentation mixture. Said substance may be re-extracted in a cycle via a second liquid-liquid centrifuge, resulting subsequently in a concentrated aqueous solution of the extracted substance, and the organic phase being recycled into the first liquid-liquid centrifuge.
摘要翻译：本发明涉及通过在至少一个步骤中的反应性萃取来整合去除存在于含水生物过程混合物中的一种或多种有机物质的方法，所述含水生物过程混合物包含至少一个带正电荷和/或带电荷的含氮基团，在该方法中，使用至少一种液 - 液离心机用于所述反应萃取，并且将所述有机物质从萃取剂中再萃取到水相中。更具体地，在被引导到第一离心机之前，被引导到液体 - 液体离心机的生物过程混合物被赋予无细胞和无蛋白质。此外，本发明涉及这样的方法，其中将水性生物过程混合物从生物反应器中连续地从生物反应器中取出，并用萃取剂引入到液体离心机中，通过所述萃取剂提取，得到的有机相包含从发酵混合物中提取的物质。所述物质可以经由第二液 - 液离心机在循环中再提取，随后产生萃取物质的浓缩水溶液，并将有机相再循环到第一液 - 液离心机中。

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