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1. 发明授权

US08365693B2 Single cam phaser camshaft 有权
标题翻译：单凸轮移相凸轮轴
公开(公告)号：US08365693B2
公开(公告)日：2013-02-05
申请号：US12863747
申请日：2008-12-18
申请人： Timothy Mark Lancefield , Nicholas James Lawrence , Ian Methley , Richard Alwyn Owen
发明人： Timothy Mark Lancefield , Nicholas James Lawrence , Ian Methley , Richard Alwyn Owen
IPC分类号： F01L1/04
CPC分类号： F01L1/34413 , F01L1/047 , F01L2001/0473 , F01L2103/00 , Y10T29/49293
摘要： A camshaft assembly is disclosed which comprises an inner shaft (12), an outer tube (14) surrounding and rotatable relative to the inner shaft (12), and two groups of cam lobes mounted on the outer tube, the first group of cam lobes being fast in rotation with the outer tube, and each cam (10) lobe (18) of the second group being rotatably mounted on the outer surface of the tube (14) and connected for rotation with the inner shaft (12) by means of one or more drive members (50) passing through circumferentially elongated slots in the outer tube. In the invention, each drive member comprises a (15) drive component (50d) engaged with fixed alignment in the cam lobe (18) and a separate fastener (50b) that is rotatable to clamp the drive component against a flat surface on the inner shaft (12), each drive member (50) being constructed such that during the tightening of the fastener (50b) no relative (20) sliding movement is required at the interface between the drive component (50d) and the inner shaft (12).
摘要翻译：公开了一种凸轮轴组件，其包括内轴（12），围绕内轴（12）并且可旋转的外管（14），以及安装在外管上的两组凸轮凸角，第一组凸轮凸角与外管快速旋转，并且第二组的每个凸轮（10）叶片（18）可旋转地安装在管（14）的外表面上，并且通过以下方式连接以与内轴（12）一起旋转：一个或多个驱动构件（50）穿过外管中的周向细长的槽。在本发明中，每个驱动构件包括在凸轮凸角（18）中与固定对准接合的（15）驱动部件（50d）和可旋转的单独的紧固件（50b），以将驱动部件夹紧在内部的平坦表面上每个驱动构件（50）被构造成使得在紧固件（50b）的紧固期间，在驱动部件（50d）和内轴（12）之间的界面处不需要相对（20）的滑动运动，。

2. 发明授权

US08316807B2 Engine valve system with variable lift and duration 有权
标题翻译：发动机阀门系统具有可变升程和持续时间
公开(公告)号：US08316807B2
公开(公告)日：2012-11-27
申请号：US12896996
申请日：2010-10-04
申请人： Ian Methley , Nicholas James Lawrence
发明人： Ian Methley , Nicholas James Lawrence
IPC分类号： F01L1/34
CPC分类号： F01L13/0047 , F01L1/18 , F01L1/20 , F01L1/2405
摘要： An improvement is disclosed for an engine valve system with variable lift and duration of the type that includes two cams mounted coaxially, a summation rocker coupled to cam followers in contact with both cams and movable in proportion to the instantaneous sum of the lifts of the respective cams, and a valve actuating rocker pivotably coupled to the summation rocker and serving to open an engine valve in dependence upon the movement of the summation rocker. In the invention, at least one of the couplings of the summation rocker with the cam followers and with the valve actuating rocker incorporates an adjustable eccentric which is rotatable to enable the clearance within the valve system to be set.
摘要翻译：公开了一种用于具有可变提升和持续时间的发动机气门系统的改进，该发动机气门系统包括同轴安装的两个凸轮，与两个凸轮接触的凸轮随动件联接的相加摇杆，并且可相对于相应的升降机的瞬时总和成比例地移动凸轮以及可枢转地联接到求和摇杆的阀致动摇杆，并用于根据求和摇杆的运动来打开发动机气门。在本发明中，总和摇杆与凸轮从动件和阀致动摇杆的联接器中的至少一个联接器包括可调节的偏心轮，其可旋转以使阀系统内的间隙能够被设定。

3. 发明申请

US20100184851A1 INHIBITION OF CELL PROLIFERATION 审中-公开
标题翻译：抑制细胞增殖
公开(公告)号：US20100184851A1
公开(公告)日：2010-07-22
申请号：US12551262
申请日：2009-08-31
申请人： Said M. Sebti , Srikumar Chellappan , Nicholas James Lawrence
发明人： Said M. Sebti , Srikumar Chellappan , Nicholas James Lawrence
IPC分类号： A61K31/155 , C07C335/32 , C07D317/60 , A61K31/36 , A61P35/00 , C12N5/00
CPC分类号： C07D317/56 , A61K31/155 , A61K31/36 , C07C335/32 , C07C335/38 , G01N33/5748 , G01N2500/02
摘要： Compounds of formula (I) and (II) are provided as modulators of Rb:Raf-1 interactions which are potent, selective disruptors of Rb:Raf-1 binding. Therapeutic methods of using the compounds, for example for treating or ameliorating a cell proliferation disorder such as cancer, are provided.
摘要翻译：提供式（I）和（II）的化合物作为Rb：Raf-1相互作用的调节剂，其是Rb：Raf-1结合的有效的选择性破坏剂。提供了使用化合物的治疗方法，例如用于治疗或改善细胞增殖病症如癌症。

4. 发明申请

US20100132640A1 CAMSHAFT ASSEMBLY 有权
标题翻译： CAMSHAFT大会
公开(公告)号：US20100132640A1
公开(公告)日：2010-06-03
申请号：US11816692
申请日：2006-03-13
申请人： Ian Methley , Richard Alwyn Owen , Nicholas James Lawrence , Timothy Mark Lancefield
发明人： Ian Methley , Richard Alwyn Owen , Nicholas James Lawrence , Timothy Mark Lancefield
IPC分类号： F01L1/04 , B23P11/00
CPC分类号： F01L1/047 , F01L1/344 , F01L2001/0473 , Y10T29/49293 , Y10T29/49948 , Y10T74/2101
摘要： A camshaft assembly is disclosed which comprises an inner shaft, an outer tube surrounding and rotatable relative to the inner shaft, and two groups of cam lobes mounted on the outer tube, the first group of cam lobes being fast in rotation with the outer tube, the second group being rotatably mounted on the outer surface of the tube and connected for rotation with the inner shaft. The connection between the second group of cam lobes and the inner shaft is effected by means of driving members whose positions are adjustable in order to compensate for significant manufacturing inaccuracies between the inner shaft and its associated group of cam lobes.
摘要翻译：公开了一种凸轮轴组件，其包括内轴，围绕内轴可旋转的外管和安装在外管上的两组凸轮凸角，第一组凸轮凸轮与外管快速旋转，第二组可旋转地安装在管的外表面上并与内轴一起旋转。第二组凸轮凸角与内轴之间的连接通过位置可调的驱动构件来实现，以补偿内轴与其相关联的凸轮凸轮组之间的显着制造不准确。

5. 发明授权

US07210440B2 Camshaft assembly 有权
标题翻译：凸轮轴总成
公开(公告)号：US07210440B2
公开(公告)日：2007-05-01
申请号：US11372764
申请日：2006-03-10
申请人： Nicholas James Lawrence , Richard Alwyn Owen , Timothy Mark Lancefield , Ian Methley
发明人： Nicholas James Lawrence , Richard Alwyn Owen , Timothy Mark Lancefield , Ian Methley
IPC分类号： F01L1/04
CPC分类号： F01L1/047 , F01L1/34413 , F01L2001/0473 , F01L2001/0476 , F01L2001/34483 , F01L2820/041 , Y10T74/2101
摘要： A camshaft assembly includes an inner shaft, an outer tube surrounding and rotatable relative to the inner shaft, and two groups of cam lobes mounted on the outer tube. The first group of cam lobes is fast in rotation with the outer tube and the second group is rotatably mounted on the outer tube and connected for rotation with the inner shaft by means of pins that pass with clearance through slots in the outer tube. A spring is incorporated in the camshaft assembly to bias the inner shaft relative to the outer tube towards one extreme of its angular range.
摘要翻译：凸轮轴组件包括内轴，围绕内轴可旋转的外管和安装在外管上的两组凸轮凸角。第一组凸轮凸轮与外管快速旋转，第二组可旋转地安装在外管上，并且通过穿过外管中的狭缝的销穿过的销连接以与内轴一起旋转。弹簧组合在凸轮轴组件中，以将内轴相对于外管偏压到其角度范围的一个极限。

6. 发明授权

US07134411B2 Valve operating mechanism 有权
公开(公告)号：US07134411B2
公开(公告)日：2006-11-14
申请号：US11284725
申请日：2005-11-21
申请人： Timothy Mark Lancefield , Nicholas James Lawrence , Ian Methley , Mark Andrew Richard Walton
发明人： Timothy Mark Lancefield , Nicholas James Lawrence , Ian Methley , Mark Andrew Richard Walton
IPC分类号： F01L1/18
CPC分类号： F01L1/146 , F01L1/182 , F01L1/267 , F01L1/46 , F01L13/0047 , F01L2001/054 , F01L2105/00
摘要： A valve operating mechanism is described for an internal combustion engine in which at least one valve (14) of an engine cylinder is operated by two cams (10,12). The cams (10,12) have respective cam followers (38,36) which are resiliently biased to remain in contact with the cams (10,12) at all times and which act on the valve (14) by way of a summation linkage (20,24) in such a manner that the displacement of the valve (14) at any instant is determined by a combination of the displacements of the two cam followers (38,36). In the invention, movement of each of the two cam followers (38,36) is transmitted to the summation linkage (20,24) by way of a respective one of two pushrods (28,30).

7. 发明授权

US08642278B2 Inhibition of cell proliferation 有权
标题翻译：抑制细胞增殖
公开(公告)号：US08642278B2
公开(公告)日：2014-02-04
申请号：US11562903
申请日：2006-11-22
申请人： Said M. Sebti , Srikumar Chellappan , Nicholas James Lawrence
发明人： Said M. Sebti , Srikumar Chellappan , Nicholas James Lawrence
IPC分类号： A61K31/155 , A61K31/215 , A61K31/34 , A61K31/41 , A61K31/415 , A61K31/425 , A61K31/44 , A61K31/47 , A61K31/675 , C07D233/00 , C07D249/12
CPC分类号： C07C323/45 , C07C279/06 , C07C335/32 , C07D213/53 , C07D215/12 , C07D233/30 , C07D233/84 , C07D235/28 , C07D249/12 , C07D249/14 , C07D277/40 , C07D277/42 , C07D317/56 , C07D317/58
摘要： The disclosed modulators of Rb:Raf-1 interactions are potent, selective disruptors of Rb:Raf-1 binding, with IC50 values ranging from 80 nM to 500 nM. Further, these compounds are surprisingly effective in inhibiting a wide variety of cancer cells, including osteosarcoma, epithelial lung carcinoma, non-small cell lung carcinoma, three different pancreatic cancer cell lines, two different glioblastoma cell lines, metastatic breast cancer, melanoma, and prostate cancer. Moreover, the disclosed compounds effectively disrupt angiogenesis and significantly inhibited tumors in nude mice derived from human epithelial lung carcinoma tumors. Accordingly, the disclosed compounds, pharmaceutical compositions comprising the compounds, methods of inhibiting cell proliferation, methods of treating subjects with cancer, and methods of preparing the disclosed compounds are provided.
摘要翻译：所公开的Rb：Raf-1相互作用的调节剂是Rb：Raf-1结合的有效的选择性破坏剂，IC 50值范围为80nM至500nM。此外，这些化合物令人惊奇地有效地抑制多种癌细胞，包括骨肉瘤，上皮性肺癌，非小细胞肺癌，三种不同的胰腺癌细胞系，两种不同的胶质母细胞瘤细胞系，转移性乳腺癌，黑素瘤和前列腺癌。此外，所公开的化合物有效地破坏了血管发生，并显着抑制了源自人上皮性肺癌肿瘤的裸鼠中的肿瘤。因此，提供了所公开的化合物，包含该化合物的药物组合物，抑制细胞增殖的方法，治疗患有癌症的受试者的方法以及制备所公开的化合物的方法。

8. 发明申请

US20120034186A1 INDOLINE SCAFFOLD SHP-2 INHIBITORS AND METHOD OF TREATING CANCER 有权
标题翻译： INDOLINE SCAFFOLD SHP-2抑制剂和治疗癌症的方法
公开(公告)号：US20120034186A1
公开(公告)日：2012-02-09
申请号：US13274699
申请日：2011-10-17
申请人： Jie Wu , Nicholas James Lawrence , Said M. Sebti , Harshani Rithma Lawrence
发明人： Jie Wu , Nicholas James Lawrence , Said M. Sebti , Harshani Rithma Lawrence
IPC分类号： A61K38/21 , A61P35/00 , C07D209/40 , A61K31/404 , C07D403/04 , A61K31/497
CPC分类号： C07D209/34 , C07D209/12 , C07D209/40 , C07D215/36
摘要： Protein tyrosine phosphatase (PTP) Shp2 is a non-receptor PTP that involved in cell signaling and regulation of cell proliferation, differentiation, and migration. Shp2 mediates activation of kinases that are involved in the pathogenesis of human carcinoma. A high throughput screen identified compounds that inhibit the PTP Shp2. Several compounds were identified that selectively inhibit Shp2 over Shp1 with low to sub-micromolar activity. Also disclosed are methods of inhibiting a protein tyrosine phosphatase in a cell and treating cancer through selective inhibition of Shp2.
摘要翻译：蛋白酪氨酸磷酸酶（PTP）Shp2是参与细胞信号传导和调节细胞增殖，分化和迁移的非受体PTP。 Shp2介导参与人类癌症发病机制的激酶活化。高通量筛选鉴定抑制PTP Shp2的化合物。鉴定出几种化合物选择性地抑制Shp2超过Shp1，具有低至亚微摩尔的活性。还公开了抑制细胞中的蛋白质酪氨酸磷酸酶并通过选择性抑制Shp2治疗癌症的方法。

9. 发明授权

US07958859B2 Camshaft assembly 有权
标题翻译：凸轮轴总成
公开(公告)号：US07958859B2
公开(公告)日：2011-06-14
申请号：US11816692
申请日：2006-03-13
申请人： Ian Methley , Richard Alwyn Owen , Nicholas James Lawrence , Timothy Mark Lancefield
发明人： Ian Methley , Richard Alwyn Owen , Nicholas James Lawrence , Timothy Mark Lancefield
IPC分类号： F01L1/04
CPC分类号： F01L1/047 , F01L1/344 , F01L2001/0473 , Y10T29/49293 , Y10T29/49948 , Y10T74/2101
摘要： A camshaft assembly is disclosed which comprises an inner shaft, an outer tube surrounding and rotatable relative to the inner shaft, and two groups of cam lobes mounted on the outer tube, the first group of cam lobes being fast in rotation with the outer tube, the second group being rotatably mounted on the outer surface of the tube and connected for rotation with the inner shaft. The connection between the second group of cam lobes and the inner shaft is effected by means of driving members whose positions are adjustable in order to compensate for significant manufacturing inaccuracies between the inner shaft and its associated group of cam lobes.
摘要翻译：公开了一种凸轮轴组件，其包括内轴，围绕内轴可旋转的外管和安装在外管上的两组凸轮凸角，第一组凸轮凸轮与外管快速旋转，第二组可旋转地安装在管的外表面上并与内轴一起旋转。第二组凸轮凸角与内轴之间的连接通过位置可调的驱动构件来实现，以补偿内轴与其相关联的凸轮凸轮组之间的显着制造不准确。

10. 发明授权

US07819099B2 Rotary hydraulic coupling 有权
标题翻译：旋转液压联轴器
公开(公告)号：US07819099B2
公开(公告)日：2010-10-26
申请号：US12062667
申请日：2008-04-04
申请人： Nicholas James Lawrence , Ian Methley , Timothy Mark Lancefield
发明人： Nicholas James Lawrence , Ian Methley , Timothy Mark Lancefield
IPC分类号： F01L1/34
CPC分类号： F01L1/047 , F01L1/3442
摘要： A rotary hydraulic coupling is described for use in an engine having a camshaft, a hydraulic phaser for driving the camshaft, and an oil feed manifold secured to the body of the engine and incorporating oil galleries for supplying oil to the phaser. The rotary coupling, which serves to connect the oil galleries of the oil feed manifold to rotating oil ducts which lead to hydraulic working chambers within the phaser, comprises a cylindrical first element rotatably received within and sealed relative to an annular second element, each of the first and second elements having bores that communicate with annular grooves in a mating surface of at least one of the two elements to establish fluid flow communication between the bores in the two elements, the bores in the first element being connected to axially extending oil passages formed within the first element. In the invention, the first element is formed of an outer tube and an inner spool, and the axially extending oil passages in the first element are formed by channels and/or holes in the inner spool.
摘要翻译：描述了用于具有凸轮轴，用于驱动凸轮轴的液压相位器和固定到发动机主体的供油歧管的发动机的旋转液压联轴器，并且包括用于向相位器供油的油画廊。用于将供油歧管的油画廊与导向相移器内的液压工作室的旋转油道连接的旋转联轴器包括可旋转地接收在环形第二元件内并相对于环形第二元件密封的圆柱形第一元件，第一和第二元件具有孔，其与两个元件中的至少一个元件的配合表面中的环形槽连通，以在两个元件中的孔之间建立流体流动连通，第一元件中的孔与形成的轴向延伸的油通道连接在第一个元素内。在本发明中，第一元件由外管和内卷轴形成，并且第一元件中的轴向延伸的油通道由内卷轴中的通道和/或孔形成。

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