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1. 发明申请

US20230087473A1 COMPOSITION OF SUSPOEMULSION FORMULATION OF ANTHELMINTIC DRUGS WITH ESSENTIAL OILS FOR NASO-PULMONARY ADMINISTRATION 有权
公开(公告)号：US20230087473A1
公开(公告)日：2023-03-23
申请号：US17481730
申请日：2021-09-22
申请人： HEMANT N. JOSHI , Neelam Sharma
发明人： HEMANT N. JOSHI , Neelam Sharma
IPC分类号： A61K9/107 , A61K45/06 , A61K9/00 , A61K31/4184 , A61K31/166 , A61K31/7048
摘要： A suspo-emulsion dosage form of anthelmintic drug such as Ivermectin or niclosamide with essential oils was proposed to be used for administration to the nasal cavity and lungs. The suspo-emulsion formulation is to be administered using a suitable medical device. The composition may be used to treat or prevent viral infections such as Covid-19.

2. 发明申请

US20130078323A1 ADAPTOGENIC ACTIVITY OF LABISIA PUMILA EXTRACT 审中-公开
标题翻译：青蒿素提取物的自发活性
公开(公告)号：US20130078323A1
公开(公告)日：2013-03-28
申请号：US13378932
申请日：2009-06-16
申请人： Sarang Bani , Anjali Pandey , Kiranjeet Kour , Prashant Singh Chauhan , Balkrishan Chandan , Neelam Sharma , Kuldeep Singh , Surrinder Koul , Bishan Dutt Gupta , Payarelal Sangwan , Devinder Kumar Gupta , Shankar Lal , Rajendran Marnickavasagar
发明人： Sarang Bani , Anjali Pandey , Kiranjeet Kour , Prashant Singh Chauhan , Balkrishan Chandan , Neelam Sharma , Kuldeep Singh , Surrinder Koul , Bishan Dutt Gupta , Payarelal Sangwan , Devinder Kumar Gupta , Shankar Lal , Rajendran Marnickavasagar
IPC分类号： A61K36/185
CPC分类号： A61K36/185
摘要： The present invention provides a process of extracting the leaves of Labisia pumila with water into a free flowing powder using accelerated solvent system and drying. The invention also relates to the immunopotentiating effects of the extract against stress. The extract has effects on fatigue, hypoxia time, potentiation of swimming endurance, bod weight, weight of the thymus and spleen and levels of CD244+ NK cells, CD4+ and CD8+ T cells, expression of ThI cytokines IL-2 and IFN-gamma, corticosterone, glutathione, alanine aminotransferase and lipid peroxidation levels.
摘要翻译：本发明提供了一种使用加速溶剂体系和干燥将水分提取成自由流动粉末的Labisia pumila的叶子的方法。本发明还涉及提取物抗压力的免疫增强作用。提取物对疲劳，缺氧时间，游泳耐力的增强，体重，胸腺和脾的重量以及CD244 + NK细胞，CD4 +和CD8 + T细胞的水平，Th1细胞因子IL-2和IFN-γ的表达，皮质酮的影响，谷胱甘肽，丙氨酸氨基转移酶和脂质过氧化水平。

3. 发明授权

US07794753B2 Synergistic hepatoprotective composition and a method thereof 有权
标题翻译：协同肝保护组合物及其方法
公开(公告)号：US07794753B2
公开(公告)日：2010-09-14
申请号：US10402151
申请日：2003-03-31
申请人： Vishwa Nath Gupta , Krishan Avtar Suri , Bishan Datt Gupta , Bupinder Singh Jaggi , Naresh Kumar Satti , Bal Krishan Chandan , Neelam Sharma , Vikram Bhardwaj , Om Parkash Suri , Ghulam Nabi Qazi , Jyotsna Suri , Madalsa Bargotra
发明人： Vishwa Nath Gupta , Krishan Avtar Suri , Bishan Datt Gupta , Bupinder Singh Jaggi , Naresh Kumar Satti , Bal Krishan Chandan , Neelam Sharma , Vikram Bhardwaj , Om Parkash Suri , Ghulam Nabi Qazi , Jyotsna Suri , Madalsa Bargotra
IPC分类号： A61K9/14 , A61K31/20
CPC分类号： A61K31/20 , A61K9/141 , A61K31/365 , A61K2300/00
摘要： The present invention relates to a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) in the ratio ranging between 1:7 to 7:1 (w/w), useful in hepatoprotection; and a process for the preparation of a synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP) useful in hepatoprotection, said process comprising steps of grounding the particles of the t-TCA and AP into fine particles, mixing the fine particles in ratio ranging between 1:7 to 7:1 (w/w), and grinding the mixture to obtain formulation, and also, a method of hepatoprotection of a subject using the synergistic formulation comprising trans-tetracos-15-enoic acid (t-TCA) and andrographolide (AP), said method comprising the steps of administering the formulation to the subject.
摘要翻译：本发明涉及包含反式二十四碳-15-辛酸（t-TCA）和穿心莲内酯（AP）的协同制剂，其比例范围为1:7至7:1（w / w），可用于肝保护; 以及用于制备包含可用于肝保护的反式二十四碳-15-辛酸（t-TCA）和穿心莲内酯（AP））的协同制剂的方法，所述方法包括以下步骤：将t-TCA和AP的颗粒接合到细颗粒，以1:7至7:1（w / w）的比例混合细颗粒，并研磨混合物以获得制剂，以及使用包含反式二十四烷酸的协同制剂对受试者进行肝保护的方法， 15-辛酸（t-TCA）和穿心莲内酯（AP），所述方法包括以下步骤：将该制剂给予受试者。

4. 发明申请

US20050192251A1 Water soluble bioactive fraction isolated from gum resin exudate of Boswellia serrata, process for isolation thereof composition containing said fraction and use thereof 审中-公开
$Water soluble bioactive fraction isolated from gum resin exudate of Boswellia serrata, process for isolation thereof composition containing said fraction and use thereof$
标题翻译：从乳香浆树胶渗出液中分离的水溶性生物活性成分，其含有所述级分的组分的分离方法及其用途
公开(公告)号：US20050192251A1
公开(公告)日：2005-09-01
申请号：US11115823
申请日：2005-04-27
申请人： Sunil Banerjee , Om Gupta , Subhash Taneja , Bishan Gupta , Vijay Sethi , Avtar Anand , Lila Manhas , Rajinder Gupta , Sarang Bani , Surjeet Singh , Neelam Sharma , Sukhdev Handa
发明人： Sunil Banerjee , Om Gupta , Subhash Taneja , Bishan Gupta , Vijay Sethi , Avtar Anand , Lila Manhas , Rajinder Gupta , Sarang Bani , Surjeet Singh , Neelam Sharma , Sukhdev Handa
IPC分类号： A61K31/736 , C08B37/00
CPC分类号： A61K31/736 , C08B37/006
摘要： The present invention relates to a water-soluble bioactive fraction obtained from the gum resin exudate of Boswellia serrata and to a process for the preparation thereof. The present invention also relates to a process for the isolation of a water soluble bioactive fraction containing a mixture of potassium and calcium salts of polysaccharides composed of units of arabinose, galactose and D-glucuronic acid, having marked anti-inflammatory and anti-arthritic activities from the gum resin exudate of Boswellia serrata and to the use thereof in the treatment of arthritis in the form of a pharmaceutical composition containing the bioactive fraction.
摘要翻译：本发明涉及由浆状乳杆菌的树胶渗出液获得的水溶性生物活性成分及其制备方法。本发明还涉及一种分离含有由阿拉伯糖，半乳糖和D-葡萄糖醛酸单元组成的多糖的钾盐和钙盐混合物的水溶性生物活性级分的方法，具有明显的抗炎和抗关节炎活性来自浆状乳杆菌的树胶渗出液，以及其用于治疗关节炎的用途，其为包含生物活性级分的药物组合物的形式。

5. 发明申请

US20080242944A1 METHOD AND SYSTEM FOR FACILITATING ERROR FREE SCAN ADMINISTRATION 审中-公开
标题翻译：促进错误免费扫描管理的方法和系统
公开(公告)号：US20080242944A1
公开(公告)日：2008-10-02
申请号：US11693861
申请日：2007-03-30
申请人： Neelam Sharma
发明人： Neelam Sharma
IPC分类号： A61B5/00
CPC分类号： A61B5/411 , A61B5/117 , G06K7/10851 , G16H10/65 , G16H40/20
摘要： A method and system for facilitating error free scan is disclosed herein. The system for preventing wrong scan administration to a patient comprises: an identifier associated with a patient for identifying at least one patient parameter. The patient parameter may be configured to indicate patient information such as pregnancy or the presence of metallic implants. An interrogator is provided for automatically interrogating the identifier to obtain the at least one patient parameter during one or more predefined stages when the patient is in proximity of a scanner. A controller is operatively coupled to the interrogator for generating a wrong scan signal based on the communicated information.
摘要翻译：本文公开了一种便于无错误扫描的方法和系统。用于防止对患者的错误扫描管理的系统包括：与患者相关联的识别至少一个患者参数的标识符。患者参数可以被配置为指示患者信息，例如怀孕或金属植入物的存在。提供了询问器，用于当患者处于扫描仪附近时，在一个或多个预定阶段期间自动询问标识符以获得至少一个患者参数。控制器可操作地耦合到询问器，用于基于传送的信息产生错误的扫描信号。

6. 发明申请

US20200268651A1 STABLE VITAMIN B12 LIQUID FORMULATIONS 审中-公开
公开(公告)号：US20200268651A1
公开(公告)日：2020-08-27
申请号：US16282713
申请日：2019-02-22
申请人： Hemant N. Joshi , Neelam Sharma
发明人： Hemant N. Joshi , Neelam Sharma
IPC分类号： A61K9/00 , A61K9/48 , A61K9/50 , A61K31/155 , A61K31/55 , A61K31/341 , A61K31/714
摘要： An aqueous solution of vitamin B12 can be stabilized by the synergistic effect of HPMC, carrageenan and potassium acetate. This property is used to develop four formulations—1. A solution used to prepare B12 loaded capsule shell matrix, 2. vitamin B12 injectable formulation, 3. vitamin B12 nasal formulation and 4. Vitamin B12 oral solution formulation.

7. 发明授权

US06989162B2 Hepatoprotective agent of plant origin and a process thereof 有权
标题翻译：植物来源的肝保护剂及其制备方法
公开(公告)号：US06989162B2
公开(公告)日：2006-01-24
申请号：US10403700
申请日：2003-03-31
申请人： Ghulam Nabi Qazi , Om Parkash Suri , Kasturi Lal Bedi , Krishan Avtar Suri , Bishan Datt Gupta , Bupinder Singh Jaggi , Bal Krishan Kapahi , Naresh Kumar Satti , Musarat Amina , Bal Krishan Chandan , Neelam Sharma , Gurdarshan Singh
发明人： Ghulam Nabi Qazi , Om Parkash Suri , Kasturi Lal Bedi , Krishan Avtar Suri , Bishan Datt Gupta , Bupinder Singh Jaggi , Bal Krishan Kapahi , Naresh Kumar Satti , Musarat Amina , Bal Krishan Chandan , Neelam Sharma , Gurdarshan Singh
IPC分类号： A61K35/78 , A61K31/70 , A61K31/33 , A61K31/555 , A61K31/05
CPC分类号： A61K36/53 , Y10S514/893
摘要： A process of isolation of pure Acteoside of high hepatoprotection from plant Colerbrookea oppositifolia, said process comprising steps of drying aerial parts of the plant, grounding the dried parts into powder, percolating the powder with water or ethanol for 3-4 times to obtain an extract, filtering the extract for clearing of suspended particles to obtain supernatant, drying the supernatant at about 45 to 55° C. to obtain a residue, fractionating the residue with chloroform, ethyl acetate, and butanol successively, subjecting butanol fraction to adsorption chromatography of SiO2 after adding methanol to the fraction, charging the adsorbed fraction to glass column, eluting the column with solvents of increasing polarity of methanol:chloroform to obtain further fractions and repeating the process one more time, subjecting the fractions to column chromatography to obtain fractions, concentrating the fractions under reduced pressure to obtain acteoside as residue; and a method of effectively hepatoprotecting a subject using pure Acteoside from plant Colerbrookea oppositifolia, said method comprising steps of administering appropriate low-dose of the acteoside to the subject.
摘要翻译：从植物Colerbrookea oppositifolia中分离出高保护酶的纯Acteoside的过程，所述方法包括干燥植物的地上部分，将干燥部分粉碎成粉末，用水或乙醇渗滤粉末3-4次以获得提取物过滤提取物以清除悬浮颗粒以获得上清液，在约45至55℃下干燥上清液，得到残余物，依次用氯仿，乙酸乙酯和丁醇分馏残余物，将丁醇级分进行吸附层析在将甲醇加入到级分中后，将吸附的级分装入玻璃柱，用极性升高的甲醇：氯仿溶剂洗脱柱，得到更多的级分并重复该过程一次，进行柱色谱分离，得到级分，减压浓缩，得到作为残留物的acteoside; 该方法包括以下步骤：向受试者施用合适的低剂量的acteoside。

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