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    • 2. 发明授权
    • Process for synthesis of 11C-labeled methyl iodide and apparatus
    • 合成11C标记甲基碘的方法及仪器
    • US5278875A
    • 1994-01-11
    • US913696
    • 1992-07-16
    • Yoshiki FujisawaShigeki YamazakiHideyuki NakagawaNaoko Takahashi
    • Yoshiki FujisawaShigeki YamazakiHideyuki NakagawaNaoko Takahashi
    • C07B59/00G21G1/10
    • C07B59/001
    • In a process for the synthesis of .sup.11 C-labeled methyl iodide which comprises producing .sup.11 CO.sub.2 by the irradiation of a proton beam, supplying .sup.11 CO.sub.2 gas to a collector of .sup.11 CO.sub.2 gas, bubbling .sup.11 CO.sub.2 gas into a reducing agent solution to reduce .sup.11 CO.sub.2, removing the reducing agent solution by evaporation, synthesizing .sup.11 CH.sub.3 I from the reduced product of .sup.11 CO.sub.2, and recovering .sup.11 CH.sub.3 I by distillation, the termination point of the .sup.11 CO.sub.2 gas supply, the termination point of the bubbling, the termination point of the evaporation of the reducing agent solution or the termination point of the distillation of .sup.11 CH.sub.3 I is decided by a radiation sensor provided in the vicinity of the reaction vessel or a transfer tube connecting the target box wherein .sup.11 CO.sub.2 gas is generated or a temperature sensor provided in an exhaust tube of the reaction vessel. The synthesizing time is shortened, and the yield of .sup.11 CH.sub.3 I is improved by improving the utilization of .sup.11 CO.sub.2 gas and the recovery of .sup.11 CH.sub.3 I of which the half-life is very short.
    • 在合成11C标记的甲基碘的方法中,其包括通过照射质子束产生11CO 2,向11CO 2气体的收集器提供11CO 2气体,将11CO 2气体鼓泡到还原剂溶液中以还原11CO2,除去还原剂 通过蒸发合成11CH3I,通过蒸馏合成11CH3I,通过蒸馏回收11CH 3 I,11CO 2气体供应的终止点,起泡终止点,还原剂溶液的蒸发终止点或终止点 11CH3I的蒸馏由设置在反应容器附近的辐射传感器或连接其上产生11CO 2气体的目标箱的转移管或设置在反应容器的排气管中的温度传感器决定。 合成时间缩短,提高11CO2气的利用率和11CH3I的半衰期非常短的11CH3I的回收率提高了11CH3I的产率。