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1. 发明专利

JP2005160596A Pretreatment method and application of biomaterial 有权
标题翻译：预处理方法和生物材料的应用
公开(公告)号：JP2005160596A
公开(公告)日：2005-06-23
申请号：JP2003400924
申请日：2003-11-28
申请人： Naoki Ishiguro , National Institute Of Advanced Industrial & Technology , Fumiaki Sugiura , 文昭杉浦 , 独立行政法人産業技術総合研究所 , 直樹石黒
发明人： TERAOKA HIROSHI , ISHIGURO NAOKI , SUGIURA FUMIAKI
IPC分类号： A61L27/00 , C12N5/07 , C12N5/0735 , C12N5/074 , C12N5/0775 , C12N5/0789
摘要： PROBLEM TO BE SOLVED: To provide a new pretreatment method and application of biomaterial contributing to regeneration medical treatment and cell medical treatment. SOLUTION: A method for preparing an artificial bone unit containing cells pretreated so as to be able to be applied to a living body by agitatably mixing micromoldings into the suspension liquid of cells capable of expressing a hard tissue forming relating function is characterized of (1)preparing a cell suspension liquid of a predetermined cell concentration using the cells, (2)mixing a plurality of micromoldings into the cell suspension liquid to make the micromoldings trap the cells within the suspension liquid, (3)stationarily placing the micromoldings trapping the cells in a culturing environment or a cell differentiation environment, (4)forming micromoldings or cell complex bodies by culturing until a part or whole of the cells trapped by the micromoldings forms cell aggregated masses, and (5)preparing the artificial bone unit containing the cells capable of being applied in the living body by the above (1) to (4). And the artificial bone unit containing the cells is also disclosed. COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供一种新的预处理方法和有助于再生医疗和细胞治疗的生物材料的应用。解决方案：一种制备人造骨单元的方法，其特征在于，含有预处理细胞以能够通过将微胶囊搅拌混合到能够表达硬组织形成相关功能的细胞的悬浮液中而应用于生物体的人造骨单元的特征在于（1）使用所述细胞制备预定细胞浓度的细胞悬浮液，（2）将多个微胶囊混合到细胞悬浮液中，使微胶囊捕获悬浮液中的细胞，（3）静置放置微胶束捕获在培养环境或细胞分化环境中的细胞，（4）通过培养形成微型胶原或细胞复合体，直到被微胶囊捕获的细胞的一部分或全部形成细胞凝集物质，和（5）制备含有能够通过上述（1）〜（4）将生物体施用于细胞的细胞。还公开了含有细胞的人造骨单元。版权所有（C）2005，JPO＆NCIPI

2. 发明专利

JP2005170816A Material for restoring cartilage, and method for producing the same 审中-公开
标题翻译：复原材料及其生产方法
公开(公告)号：JP2005170816A
公开(公告)日：2005-06-30
申请号：JP2003410953
申请日：2003-12-09
申请人： Naoki Ishiguro , Seiji Kondo , Shinji Mishima , Hiroto Mitsuyama , 真爾三嶋 , 浩人光山 , 直樹石黒 , 精司近藤
发明人： ISHIGURO NAOKI , MITSUYAMA HIROTO , KONDO SEIJI , MISHIMA SHINJI
IPC分类号： A61L27/00 , A61K31/245 , A61K35/12 , A61K35/16 , A61K38/43 , A61P19/04
摘要： PROBLEM TO BE SOLVED: To provide a material which can early and safely restore cartilage, and to provide a method for producing the same. SOLUTION: The material for restoring cartilages comprises cartilage cells prepared from a patient to be transplanted, platelet-rich plasma, about 4 mg/mL of fibrinogen, and an anti-plasmin agent (nafamostat mesilate). COPYRIGHT: (C)2005,JPO&NCIPI
摘要翻译：要解决的问题：提供可以早期和安全地恢复软骨的材料，并提供其制造方法。解决方案：用于恢复软骨的材料包括从待移植的患者制备的软骨细胞，富含血小板的血浆，约4mg / mL的纤维蛋白原和抗纤维蛋白溶解剂（甲磺酸奈马莫司他）。版权所有（C）2005，JPO＆NCIPI

3. 发明专利

JP2004329458A Biomaterial aggregate/cement complex, and cement cured body 有权
公开(公告)号：JP2004329458A
公开(公告)日：2004-11-25
申请号：JP2003127616
申请日：2003-05-02
申请人： Naoki Ishiguro , Yukihiro Matsuyama , National Institute Of Advanced Industrial & Technology , 幸弘松山 , 独立行政法人産業技術総合研究所 , 直樹石黒
发明人： TERAOKA HIROSHI , ISHIGURO NAOKI , MATSUYAMA YUKIHIRO
IPC分类号： A61L27/00 , A61F2/28 , A61L24/00 , A61L24/02 , A61L24/04
CPC分类号： A61L24/0042 , A61L24/0005 , A61L24/02 , A61L24/04
摘要： PROBLEM TO BE SOLVED: To provide a biomaterial aggregate/cement complex, and a cement cured body, or the like. SOLUTION: In the aggregate particle/cement complex containing biocompatible material aggregate particles, (1) the aggregate particles are made of calcium phosphate ceramics or biodegradable plastics; (2) the particle diameter of the aggregate is from 151 μm to 5 mm; (3) the quantity of contained aggregate particles in the cement is from 51 to 90 vol%; and (4) the cement is a self-curing type calcium phosphate cement. An infusion/filler for organisms is made of the aggregate particle/cement complex. A tube-filled object consists of the infusion/filler filled in a tube whose one end or both ends are closed. An infusion filling material spouting device consists of an outlet formed in a part of the tube-filled object. The cement cured body is made by hydrating and curing the cement part of the aggregate particle/cement complex. A method for controlling mechanical characteristics of the self-curing type calcium phosphate cement hydrating/curing body is adding the biomaterial aggregate particles to the self-curing type calcium phosphate cement by 51-90 vol%. COPYRIGHT: (C)2005,JPO&NCIPI

4. 发明授权

US06703409B2 2′-Halo-3′,5′-dialkoxyphen-1′-yl-imino-2-imidazolidine and the use thereof as a drug 有权
标题翻译： 2'-Halo-3'，5'-二烷氧基苯基-1'-基 - 亚氨基-2-咪唑烷及其作为药物的用途
公开(公告)号：US06703409B2
公开(公告)日：2004-03-09
申请号：US10351486
申请日：2003-01-24
申请人： Franz Esser , Pascale Pouzet , Naoki Ishiguro , Hisato Kitagawa , Ikunobu Muramatsu
发明人： Franz Esser , Pascale Pouzet , Naoki Ishiguro , Hisato Kitagawa , Ikunobu Muramatsu
IPC分类号： A61K314168
CPC分类号： C07D233/50
摘要： The present invention relates to 2′-halo-3′,5′-dialkoxyphen-1′-yl-imino-2-imidazolidine, the tautomeric 2′-halo-3′,5′-dialkoxyanilino-2-imidazoline and/or the pharmacologically acceptable salts thereof and their use as pharmaceutical compositions.
摘要翻译：本发明涉及2'-卤代-3'，5'-二烷氧基苯基-1'-基 - 亚氨基-2-咪唑烷，互变异构2'-卤代-3'，5'-二烷氧基苯胺基 - 咪唑啉和/或其药理学上可接受的盐及其作为药物组合物的用途。

5. 发明申请

US20090011059A1 Ginger Extract For Inhibiting Human Drug Transporters 审中-公开
标题翻译：姜提取物抑制人类药物转运蛋白
公开(公告)号：US20090011059A1
公开(公告)日：2009-01-08
申请号：US12158423
申请日：2006-12-20
申请人： Naoki Ishiguro , Wataru Kishimoto , Thomas Ebner , Willy Roth
发明人： Naoki Ishiguro , Wataru Kishimoto , Thomas Ebner , Willy Roth
IPC分类号： A61K36/906 , A61K31/121 , A61K31/122 , A61K31/216 , A61K31/225 , A61K31/075 , A61K31/341
CPC分类号： A61K36/9068 , A61K9/1635 , A61K9/1641 , A61K9/1652 , A61K9/2077 , A61K9/4858 , A61K9/4866 , A61K9/5047 , A61K9/5084 , A61K31/085 , A61K31/09 , A61K31/12 , A61K31/121 , A61K31/215 , A61K31/341 , A61K45/06 , A61K47/46 , A61K2300/00
摘要： The present invention relates to the use of a ginger extract on its own or in combination with pharmaceutical compositions for inhibiting human drug transporters for positively influencing the oral bioavailability and pharmacokinetics of active substances.
摘要翻译：本发明涉及姜提取物本身或与用于抑制人类药物转运蛋白的药物组合物的组合以积极影响活性物质的口服生物利用度和药代动力学的用途。

6. 发明授权

US06660772B2 Use of 2-amino-1-(4-hydroxy-2-methanesulfonamidophenyl)ethanol for treating urinary incontinence 有权
公开(公告)号：US06660772B2
公开(公告)日：2003-12-09
申请号：US10060492
申请日：2002-01-30
申请人： Pascale Pouzet , Franz Esser , Hisato Kitagawa , Naoki Ishiguro , Ikunobu Muramatsu
发明人： Pascale Pouzet , Franz Esser , Hisato Kitagawa , Naoki Ishiguro , Ikunobu Muramatsu
IPC分类号： A61K514605
CPC分类号： A61K31/18
摘要： A method of treating urinary incontinence in a patient in need thereof, the method comprising administering to the patient an effective amount of 2-amino-1-(4-hydroxy-2-methanesulfonamidophenyl)ethanol or a pharmacologically acceptable salt thereof, and pharmaceutical compositions.

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