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1. 发明申请

WO2003070760A2 ANTI-Aβ ANTIBODIES AND THEIR USE 审中-公开
标题翻译：抗Aβ抗体及其用途
公开(公告)号：WO2003070760A2
公开(公告)日：2003-08-28
申请号：PCT/EP2003/001759
申请日：2003-02-20
申请人： F. HOFFMANN-LA ROCHE AG , MORPHOSYS AG , BARDROFF, Michael , BOHRMANN, Bernd , BROCKHAUS, Manfred , HUBER, Walter , KRETZSCHMAR, Titus , LÖHNING, Corinna , LOETSCHER, Hansruedi , NORDSTEDT, Christer , ROTHE, Christine
发明人： BARDROFF, Michael , BOHRMANN, Bernd , BROCKHAUS, Manfred , HUBER, Walter , KRETZSCHMAR, Titus , LÖHNING, Corinna , LOETSCHER, Hansruedi , NORDSTEDT, Christer , ROTHE, Christine
IPC分类号： C07K14/47
CPC分类号： C07K16/18 , A61K39/0007 , A61K2039/505 , C07K14/4711 , G01N33/6896
摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.
摘要翻译：本发明涉及能够特异性识别R-A4肽的两个区域的抗体分子，其中第一区域包含如SEQ ID NO：1所示的氨基酸序列AEFRHDSGY或其片段，其中第二区域包含氨基酸酸序列VHHQKLVFFAEDVG，如SEQ ID NO：2所示或其片段。此外，公开了编码本发明抗体分子的核酸分子和包含所述核酸分子的载体和宿主。此外，本发明提供包含本发明化合物以及本发明的抗体分子，核酸分子，载体或宿主的特定用途的组合物，优选药物或诊断组合物。

2. 发明申请

WO2005051998A3 ANTIBODIES BINDING TO A C-TERMINAL FRAGMENT OF APOLIPOPROTEIN E 审中-公开
标题翻译：抗体与APOLIPOPROTEIN C端子片段的结合E
公开(公告)号：WO2005051998A3
公开(公告)日：2007-07-26
申请号：PCT/EP2004013426
申请日：2004-11-26
申请人： ASTRAZENECA AB , DYAX CORP , NORDSTEDT CHRISTER , GOLDSCHMIDT TOM , HENDERIKX MARIA , HOET RENE , HOOGENBOOM HENDRICUS , HUFTON SIMON , ANDERSSON CHRISTIN V , LINDQUIST JOHANNA , SUNNEMARK DAN , LEONOV SERGY
发明人： NORDSTEDT CHRISTER , GOLDSCHMIDT TOM , HENDERIKX MARIA , HOET RENE , HOOGENBOOM HENDRICUS , HUFTON SIMON , ANDERSSON CHRISTIN V , LINDQUIST JOHANNA , SUNNEMARK DAN , LEONOV SERGY
IPC分类号： C07K16/18 , A61K39/395 , C12N5/10 , C12N15/13 , C12N15/63 , G01N33/68
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/92 , C07K2319/00
摘要： A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
摘要翻译：人抗体片段，该抗体或片段：（i）与具有载脂蛋白E（ApoE-CTD）的C-末端结构域的SEQ ID NO：1所示的氨基酸序列的多肽或a 的一部分和（ii）与人斑块结合。

3. 发明申请

WO1997001098A1 PROCESS FOR DETECTION, QUANTIFICATION AND/OR IDENTIFICATION OF A PEPTIDE 审中-公开
标题翻译：肽的检测，定量和/或鉴定方法
公开(公告)号：WO1997001098A1
公开(公告)日：1997-01-09
申请号：PCT/SE1996000780
申请日：1996-06-14
申请人： PHARMACIA & UPJOHN AB , KARLSTRÖM, Anders , NORDSTEDT, Christer , THYBERG, Johan
发明人： PHARMACIA & UPJOHN AB
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , B01J2219/005 , B01J2219/00574 , B01J2219/00596 , B01J2219/00725 , C07K1/047 , C40B40/10 , G01N33/6845
摘要： The invention relates to a process for detection, quantification and/or identification of a peptide which comprises the steps of labelling a peptide library on beads with a radioactive or light emittant substance, mixing with photographic media, spreading out the obtained slurry on a dish, incubation, developing and isolation of single labelled beads.
摘要翻译：本发明涉及一种用于检测，定量和/或鉴定肽的方法，其包括以下步骤：用放射性或轻度发射物质在珠粒上标记肽文库，与照相培养基混合，将得到的浆液分散在培养皿上，培养，培养和分离单个标记的珠粒。

4. 发明申请

WO2005051998A2 ANTIBODIES 审中-公开
标题翻译：抗体
公开(公告)号：WO2005051998A2
公开(公告)日：2005-06-09
申请号：PCT/EP2004/013426
申请日：2004-11-26
申请人： ASTRAZENECA AB , DYAX CORP. , NORDSTEDT, Christer , GOLDSCHMIDT, Tom , HENDERIKX, Maria , HOET, René , HOOGENBOOM, Hendricus , HUFTON, Simon , ANDERSSON, Christin, V. , LINDQUIST, Johanna , SUNNEMARK, Dan , LEONOV, Sergy
发明人： NORDSTEDT, Christer , GOLDSCHMIDT, Tom , HENDERIKX, Maria , HOET, René , HOOGENBOOM, Hendricus , HUFTON, Simon , ANDERSSON, Christin, V. , LINDQUIST, Johanna , SUNNEMARK, Dan , LEONOV, Sergy
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/92 , C07K2319/00
摘要： A human antibody fragment, which antibody or fragment: (i) binds to a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 of the C-terminal domain of Apolipoprotein E (ApoE-CTD) or the amino acid sequence of a part thereof; and (ii) binds to human plaques.
摘要翻译：人抗体片段，该抗体或片段：（i）与具有载脂蛋白E（ApoE-CTD）的C-末端结构域的SEQ ID NO：1所示的氨基酸序列的多肽或a 的一部分和（ii）与人斑块结合。

5. 发明申请

WO2003070760A3 ANTI-AMYLOID BETA ANTIBODIES AND THEIR USE 审中-公开
公开(公告)号：WO2003070760A3
公开(公告)日：2003-08-28
申请号：PCT/EP2003/001759
申请日：2003-02-20
申请人： F. HOFFMANN-LA ROCHE AG , MORPHOSYS AG , BARDROFF, Michael , BOHRMANN, Bernd , BROCKHAUS, Manfred , HUBER, Walter , KRETZSCHMAR, Titus , LÖHNING, Corinna , LOETSCHER, Hansruedi , NORDSTEDT, Christer , ROTHE, Christine
发明人： BARDROFF, Michael , BOHRMANN, Bernd , BROCKHAUS, Manfred , HUBER, Walter , KRETZSCHMAR, Titus , LÖHNING, Corinna , LOETSCHER, Hansruedi , NORDSTEDT, Christer , ROTHE, Christine
IPC分类号： C07K14/47
摘要： The present invention relates to antibody molecules capable of specifically recognizing two regions of the R-A4 peptide, wherein the first region comprises the amino acid sequence AEFRHDSGY as shown in SEQ ID NO: 1 or a fragment thereof and wherein the second region comprises the amino acid sequence VHHQKLVFFAEDVG as shown in SEQ ID NO: 2 or a fragment thereof. Furthermore, nucleic acid molecules encoding the inventive antibody molecules and vectors and hosts comprising said nucleic acid molecules are disclosed. In addition, the present invention provides for compositions, preferably pharmaceutical or diagnostic compositions, comprising the compounds of the invention as well as for specific uses of the antibody molecules, nucleic acid molecules, vectors or hosts of the invention.

6. 发明申请

WO1997021728A1 PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID 'beta' 审中-公开
标题翻译：肽结合AMYLOID beta的KLVFF序列
公开(公告)号：WO1997021728A1
公开(公告)日：1997-06-19
申请号：PCT/SE1996001621
申请日：1996-12-09
申请人： KAROLINSKA INNOVATIONS AB , NORDSTEDT, Christer , NÄSLUND, Jan , THYBERG, Johan , TJERNBERG, Lars, O. , TERENIUS, Lars
发明人： KAROLINSKA INNOVATIONS AB
IPC分类号： C07K14/47
CPC分类号： C07K5/0821 , A61K38/00 , C07K5/0808 , C07K5/0815 , C07K5/0819 , C07K5/101 , C07K5/1019 , C07K5/1021 , C07K5/1024 , C07K14/4711 , G01N33/6896 , G01N2800/2821
摘要： The invention relates to compounds of formula (I) or (II), which are of interest especially for inhibition of polymerization of amyloid beta peptide, as model substances for synthesis of amyloid beta peptide-ligands, as tools for the identification of other organic compounds with similar functional properties and/or as ligands for detection of amyloid deposits using e.g. positron emission tomography (PET). Formula (II) is: R1 - A' - Y' - Leu - X' - Z' - B' - R2, in which X' means any group or amino acid imparting to the compound according to formula (I) the ability to bind to the KLVFF-sequence in amyloid beta peptide, or two amino acids imparting the same ability, but with the proviso that one is not proline; Y' means any amino acid; Z' means any non-acidic amino acid; A' means a direct bond or an alpha -amino acid bonded at the carboxyl terminal of the alpha -carboxy group or a di-, tri-, tetra- or pentapeptide bonded at the carboxyl terminal of the alpha -carboxy group; B' means a direct bond or an alpha -amino acid bonded at the alpha -nitrogen or a di-, tri-, tetra- or pentapeptide bonded at the alpha -nitrogen of the N-terminal alpha -amino acid; R1 is H or -CO-R3 bonded at the alpha -aminogroup of A'; R2 is H, -OR4 or NR5R6, all bonded to the alpha -carboxyl group of the alpha -carboxyterminal of B'; R3 and R4 are straight or branched carbon chain of 1-4 carbon atoms; R5 and R6 are independently H, alkyl, cycloalkyl, aryl or substituted aryl or together are -(CH2)n-, where n is 4-5; and R1 and R2 together can form a hydrocarbon ring or heterocyclic ring; all alpha -amino acids being either D- or L-isomers.
摘要翻译：本发明涉及式（I）或（II）化合物，其特别用于抑制淀粉样蛋白β肽的聚合作为淀粉样蛋白β肽配体的合成的模型物质，作为用于鉴定其它有机化合物的工具具有类似的功能性质和/或用于检测淀粉样沉积物的配体正电子发射断层扫描（PET）。式（II）是：R1-A'-Y'-Leu-X'-Z'-B'-R2，其中X'表示赋予根据式（I）的化合物的任何基团或氨基酸，结合淀粉样蛋白β肽中的KLVFF序列或赋予相同能力的两个氨基酸，但条件是一个不是脯氨酸; Y'表示任何氨基酸; Z'表示任何非酸性氨基酸; A'是指在α-羧基的羧基末端键合的直接键或α-氨基酸，或在α-羧基的羧基末端键合的二，三，四或五肽; B'是指在α-氮键合的直接键或α-氨基酸，或在N-末端α-氨基酸的α-氮上键合的二 - ，三 - ，四 - 或五肽; R1是在A'的α-氨基团键合的H或-CO-R3; R2是H，-OR4或NR5R6，均与B'的α-羧基末端的α-羧基键合; R3和R4是1-4个碳原子的直链或支链碳链; R 5和R 6独立地为H，烷基，环烷基，芳基或取代的芳基，或一起为 - （CH 2）n - ，其中n为4-5; 并且R 1和R 2可以一起形成烃环或杂环; 所有α-氨基酸是D-或L-异构体。

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