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1. 发明申请

WO1997001098A1 PROCESS FOR DETECTION, QUANTIFICATION AND/OR IDENTIFICATION OF A PEPTIDE 审中-公开
标题翻译：肽的检测，定量和/或鉴定方法
公开(公告)号：WO1997001098A1
公开(公告)日：1997-01-09
申请号：PCT/SE1996000780
申请日：1996-06-14
申请人： PHARMACIA & UPJOHN AB , KARLSTRÖM, Anders , NORDSTEDT, Christer , THYBERG, Johan
发明人： PHARMACIA & UPJOHN AB
IPC分类号： G01N33/543
CPC分类号： C40B30/04 , B01J2219/005 , B01J2219/00574 , B01J2219/00596 , B01J2219/00725 , C07K1/047 , C40B40/10 , G01N33/6845
摘要： The invention relates to a process for detection, quantification and/or identification of a peptide which comprises the steps of labelling a peptide library on beads with a radioactive or light emittant substance, mixing with photographic media, spreading out the obtained slurry on a dish, incubation, developing and isolation of single labelled beads.
摘要翻译：本发明涉及一种用于检测，定量和/或鉴定肽的方法，其包括以下步骤：用放射性或轻度发射物质在珠粒上标记肽文库，与照相培养基混合，将得到的浆液分散在培养皿上，培养，培养和分离单个标记的珠粒。

2. 发明申请

WO1998028412A1 MODIFIED HUMAN FACTOR Xa 审中-公开
标题翻译：改性人体因子Xa
公开(公告)号：WO1998028412A1
公开(公告)日：1998-07-02
申请号：PCT/SE1997002160
申请日：1997-12-18
申请人： PHARMACIA & UPJOHN AB , CHMIELEWSKA, Joanna , LUNDQVIST, Tomas , MOSIALOU, Erifili , OGG, Derek
发明人： PHARMACIA & UPJOHN AB
IPC分类号： C12N09/64
CPC分类号： C12N9/6432 , A61K38/00 , C12Y304/21006
摘要： The present invention is directed to a modified coagulation factor Xa which has an improved capacity of forming crystals compared to its native form. Such crystals or crystalline composition are especially useful for studies in crystalline form of the active catalytic side of factor Xa when it is complexed to a specific affinity ligand with inhibiting characteristics.
摘要翻译：本发明涉及与其天然形式相比具有改进的形成晶体的能力的改性凝血因子Xa。当晶体或结晶组合物与具有抑制特性的特异性亲和配体络合时，这种晶体或结晶组合物特别可用于研究结晶形式的Xa的活性催化侧。

3. 发明申请

WO1997039952A1 IMPROVED MEDICAL CONTAINERS 审中-公开
标题翻译：改进医用容器
公开(公告)号：WO1997039952A1
公开(公告)日：1997-10-30
申请号：PCT/SE1997000682
申请日：1997-04-23
申请人： PHARMACIA & UPJOHN AB , ANDERSSON, Gunnar , MULLIGAN, Des
发明人： PHARMACIA & UPJOHN AB
IPC分类号： B65B55/02
CPC分类号： A61J1/10
摘要： A sealed container opening, intended for fluid communication with a container for storing medical fluids, comprising a tubular sleeve-formed part (22, 22A) having a resilient pierceable stopper (24, 24A) inserted in its mouth (21, 21A) and a covering sealing device (10, 10A). The sealed container opening contains the same autoclavable polyolefinic material as the container. All parts of said container opening, exposed to the fluid or fluid handling devices are sterilized in a signal process by means of steam transferred to these parts during its autoclavation. Saddle formed port systems attachable to a flexible container are also disclosed.
摘要翻译：一种用于与用于储存医用流体的容器流体连通的密封容器开口，包括一个管状套筒形成部分（22,2 22A），其具有插入其口部（21,21a）中的弹性可穿刺塞子（24,24A）和覆盖密封装置（10,10A）。密封的容器开口包含与容器相同的可高压灭菌的聚烯烃材料。暴露于流体或流体处理装置的所述容器开口的所有部分在信号过程中通过在其高压灭菌期间转移到这些部件的蒸汽进行灭菌。还公开了可附接到柔性容器的鞍形端口系统。

4. 发明申请

WO1997036929A1 MONOCLONAL ANTIBODIES BINDING HUMAN GROWTH HORMONE (hGH) 审中-公开
标题翻译：单克隆抗体结合人类生长激素（hGH）
公开(公告)号：WO1997036929A1
公开(公告)日：1997-10-09
申请号：PCT/SE1997000553
申请日：1997-03-27
申请人： PHARMACIA & UPJOHN AB , CONSEJO SUPERIOR DE INVESTIGACIONES , HANSSON, Yngve, Elof , KREMER BARON, Leonor , MARTINEZ ALONSO, Carlos , MELLADO GARCIA, José Mario , RODRIGUEZ FRADE, José Miguel
发明人： PHARMACIA & UPJOHN AB , CONSEJO SUPERIOR DE INVESTIGACIONES
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , C07K2317/73 , G01N33/74 , G01N2333/61
摘要： The invention relates to monoclonal antibody capable of specific binding to the molecular weight of 20 kDa variant of human growth hormone. This monoclonal antibody has no substantial binding to hGH of molecular weight 22 kDa. The invention also relates to the use of this monoclonal antibody for measurement of hGH 20K, especially in body fluids. The antibodies can be used for detection and quantification of hGH 20K, especially in serum.
摘要翻译：本发明涉及能够特异性结合人生长激素的20kDa变体的分子量的单克隆抗体。该单克隆抗体与分子量22kDa的hGH没有实质性结合。本发明还涉及该单克隆抗体用于测量hGH 20K，特别是在体液中的用途。抗体可用于检测和定量hGH 20K，特别是在血清中。

5. 发明申请

WO1997043436A1 A PROCESS FOR PRODUCING A RECOMBINANT POLYPEPTIDE INVOLVING THE ADDITION OF AN INHIBITOR OF METAL-DEPENDENT PROTEASES OR CHYMOTRYPSINS TO THE CELL CULTURE MEDIUM 审中-公开
标题翻译：生产涉及金属依赖性蛋白或乙酰胆碱酯酶抑制剂添加到细胞培养基中的重组多肽的方法
公开(公告)号：WO1997043436A1
公开(公告)日：1997-11-20
申请号：PCT/SE1997000783
申请日：1997-05-13
申请人： PHARMACIA & UPJOHN AB , ADAMSON, Lars , WALUM, Erik , DIXELIUS, Johan , LIMA LIE, Kristina
发明人： PHARMACIA & UPJOHN AB
IPC分类号： C12P21/02
CPC分类号： C07K14/755 , A61K38/00 , C12N15/67 , C12P21/02
摘要： The present invention relates to a process for reducing the detrimental influence of certain proteases on recombinant human protein and polypeptide molecules, by adding an inhibitor of metal-dependent proteases or chymotrypsins to the cell culture medium. The invention also relates to a cell culture medium for cultivating cells expressing and secreting a biologically active recombinant human polypeptide containing an inhibitor of metal-dependent proteases or chymotrypsins, or a combination thereof. The invention further relates to use of recombinant factor VIII which has been produced in a cell culture medium according to the present process for the manufacture of a medicament for administration to a patient having the symptoms of hemophilia A. Also, the invention relates to a method for treatment of hemophilia A by administration of a therapeutically effective amount of recombinant factor VIII which has been produced in a cell culture medium according to the present process.
摘要翻译：本发明涉及通过向细胞培养基中加入金属依赖性蛋白酶或糜蛋白酶抑制剂来减少某些蛋白酶对重组人蛋白质和多肽分子的不利影响的方法。本发明还涉及用于培养表达和分泌含有金属依赖性蛋白酶或糜蛋白酶抑制剂或其组合的生物活性重组人多肽的细胞的细胞培养基。本发明还涉及根据本方法在细胞培养基中产生的重组因子VIII的用途，用于制备用于给患有血友病A症状的患者施用的药物。本发明还涉及一种方法用于通过施用根据本方法在细胞培养基中产生的治疗有效量的重组因子VIII来治疗血友病A。

6. 发明申请

WO1997041858A1 PYRIDYL- AND PYRIMIDYL-PIPERAZINES IN THE TREATMENT OF SUBSTANCE ABUSE DISORDERS 审中-公开
标题翻译：吡咯并吡啶并吡啶在治疗物质滥用症中的作用
公开(公告)号：WO1997041858A1
公开(公告)日：1997-11-13
申请号：PCT/SE1997000673
申请日：1997-04-22
申请人： PHARMACIA & UPJOHN AB , BJÖRK, Anders
发明人： PHARMACIA & UPJOHN AB
IPC分类号： A61K31/495
CPC分类号： A61K31/506 , A61K31/496
摘要： Use of a compound of formula (I) and the pharmaceutically acceptable acid addition salts thereof, wherein R1 is either halogen or hydrogen and R2 is halogen; X is CH2, O or S; R3 and R4 are the same or different and selected from hydrogen or lower alkyl; n is 2 or 3; A is selected from the pyrimidyl- or pyridyl- groups (a), (b) or (c) wherein R5, R6 and R7 are as defined in the description; for the manufacture of a medicament for the relief or prevention of a withdrawal syndrome resulting from addiction to a drug or substance of abuse or for treatment thereof.
摘要翻译：式（I）化合物及其药学上可接受的酸加成盐的用途，其中R 1为卤素或氢，R 2为卤素; X是CH 2，O或S; R3和R4相同或不同，选自氢或低级烷基; n为2或3; A选自嘧啶基或吡啶基（a），（b）或（c），其中R5，R6和R7如说明书中所定义; 用于制造用于缓解或预防由于滥用药物或物质或其治疗而成瘾引起的戒断综合征的药物。

7. 发明申请

WO1997038709A1 USE OF GROWTH HORMONE 审中-公开
标题翻译：使用生长激素
公开(公告)号：WO1997038709A1
公开(公告)日：1997-10-23
申请号：PCT/SE1997000601
申请日：1997-04-10
申请人： PHARMACIA & UPJOHN AB , JOHANNSSON, Gudmundur , MÅRIN, Per , LÖNN, Lars , OTTOSSON, Malin , STENLÖF, Kaj , BJÖRNTORP, Per , SJÖSTRÖM, Lars , BENGTSSON, Bengt-Åke
发明人： PHARMACIA & UPJOHN AB
IPC分类号： A61K38/27
CPC分类号： A61K38/27
摘要： The invention relates to the use of growth hormone, preferably human growth hormone or analogues thereof for the manufacturing of a medicament for treatment of individuals with the Metabolic syndrome. They include individuals with abdominal/visceral obesity and its metabolic and circulatory consequences including insulin resistance, lipoprotein aberrations and hypertension. The medicament is also used to increase insulin sensitivity and for treatment and prevention of non-insulin dependent diabetes mellitus.
摘要翻译：本发明涉及生长激素，优选人生长激素或其类似物在制备用于治疗具有代谢综合征的个体的药物中的用途。它们包括具有腹部/内脏肥胖症的个体及其代谢和循环后果，包括胰岛素抵抗，脂蛋白异常和高血压。该药物还用于增加胰岛素敏感性和用于治疗和预防非胰岛素依赖性糖尿病。

8. 发明申请

WO1998024819A1 5-HYDROXYTRYPTOPHOL (5-HTOL) DERIVATIVES, ANTIBODIES, IMMUNOASSAYS AND DETECTION OF RECENT ALCOHOL CONSUMPTION 审中-公开
标题翻译： 5-羟基吡啶（5-HTOL）衍生物，抗体，免疫测定和检测最近的酒精消费
公开(公告)号：WO1998024819A1
公开(公告)日：1998-06-11
申请号：PCT/SE1997002035
申请日：1997-12-05
申请人： PHARMACIA & UPJOHN AB , BRANDT, Ragnhild , BECK, Olof , HELANDER, Anders , JÖNSSON, Rose-Marie , UNGER, Eric , BORG, Stefan , ÅKERBLOM, Eva
发明人： PHARMACIA & UPJOHN AB
IPC分类号： C07K16/44
CPC分类号： C07H17/02 , C07K16/44 , Y10T436/14 , Y10T436/145555 , Y10T436/17 , Y10T436/173845 , Y10T436/203332 , Y10T436/25
摘要： Antibody specific for a 5-HTOL compound. A glucuronide with 5-hydroxytryptophol (5-HTOL) characterized in that it comprises the structure of the beta -glucuronide between the 5-hydroxy group of 5-HTOL and D-glucopyranosiduronic acid. An immunoassay and a diagnostic method utilizing the immunoassay wherein a 5-hydroxytryptophol (5-HTOL) compound is determined by the use of an antibody specific for a 5-HTOL compound is used.
摘要翻译：针对5-HTOL化合物的抗体。具有5-羟基三苯乙醇（5-HTOL）的葡糖苷酸，其特征在于其包含5-羟基5-HTOL和D-吡喃葡萄糖苷二糖酸之间的β-葡萄糖醛酸苷结构。使用免疫测定法和诊断方法，其中使用5-羟色胺（5-HTOL）化合物通过使用对5-HTOL化合物特异的抗体来测定。

9. 发明申请

WO1998022124A1 USE OF GROWTH HORMONE SECRETAGOGUE COMPOUND FOR TREATING CARDIAC FAILURE OR RELATED VASCULAR DYSFUNCTION 审中-公开
标题翻译：使用生长激素分泌物化合物治疗心脏衰竭或相关血管性功能障碍
公开(公告)号：WO1998022124A1
公开(公告)日：1998-05-28
申请号：PCT/SE1997001957
申请日：1997-11-21
申请人： PHARMACIA & UPJOHN AB , BERTI, Ferruccio , DE GENNARO COLONNA, Vito , MÜLLER, Eugenio , ROSSONI, Giuseppe , BOGHEN, Muny , NILSSON, Magnus
发明人： PHARMACIA & UPJOHN AB
IPC分类号： A61K38/08
CPC分类号： A61K38/27 , A61K38/08 , A61K38/25 , A61K2300/00
摘要： The present invention relates to the use of growth hormone (GH) secretagogue compound or GH and Adrenocorticotropic hormone (ACTH) secretagogue compound for the manufacture of a medicament for treating cardiac failure or related vascular dysfunction.
摘要翻译：本发明涉及生长激素（GH）促分泌素化合物或GH和促肾上腺皮质激素（ACTH）促分泌素化合物在制备用于治疗心力衰竭或相关血管功能障碍的药物中的用途。

10. 发明申请

WO1998015477A1 DEVICE FOR DISPOSAL OF ARTICLES 审中-公开
标题翻译：处理文章的设备
公开(公告)号：WO1998015477A1
公开(公告)日：1998-04-16
申请号：PCT/SE1997001482
申请日：1997-09-05
申请人： PHARMACIA & UPJOHN AB , LEVANDER, Gustav
发明人： PHARMACIA & UPJOHN AB
IPC分类号： B65F01/00
CPC分类号： B65F1/10 , B65D31/14 , B65F1/0006
摘要： Device for disposal of articles (1) comprising a receptacle (2) for receiving the articles (1) and at least one introduction part (3), preferably formed as a channel, allowing introduction of the articles (1) into the receptacle (2), being integrated with the receptacle (2) in such a way that the articles (1) may only be taken out with difficulty from the receptacle (2) through the at least one introduction part (3). The device is especially useful for disposal of articles being contaminated with drugs or medicaments. Further the device is designed to fulfil child-resistant test requirements.
摘要翻译：用于处理物品（1）的装置，包括用于容纳物品（1）的容器（2）和优选形成为通道的至少一个引入部件（3），允许将物品（1）引入到容器（2）中）与容器（2）一体化，使得物品（1）可能难以从容器（2）穿过至少一个引入部分（3）而被取出。该设备对于处理被药物或药物污染的物品特别有用。此外，该设备旨在满足儿童防护测试要求。

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