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1. 发明公开

EP1024364A1 Methods of diagnosing or prognosing Alzheimer's disease 审中-公开
标题翻译： Methoden zur诊断on阿尔茨海默病
公开(公告)号：EP1024364A1
公开(公告)日：2000-08-02
申请号：EP99101377.2
申请日：1999-01-26
申请人： Nitsch, Roger M., Prof. Dr.
发明人： Nitsch, Roger M., Prof. Dr , Growdon, John H., Dr.
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/8139 , G01N2800/2821
摘要： A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising:
determining a level, or an activity, or both said level and said activity, of at least one substance which is selected from the group consisting of cystatin C, a variant thereof, a transcription product of a cystatin C gene, and a variant thereof, in a sample from said subject; and
comparing said level, or said activity, or both said level and said activity, of at least one of said substances to a reference value representing a known disease or health status,
thereby diagnosing or prognosing said Alzheimer's disease in said subject, or determining whether said subject is at increased risk of developing Alzheimer's disease.
摘要翻译：一种用于在受试者中诊断或预后阿尔茨海默氏病的方法，或确定受试者是否处于发展中的阿尔茨海默氏病的风险增加的方法，包括：确定至少一种物质的水平或活性，或所述水平和所述活性，在所述受试者的样品中选自半胱氨酸蛋白酶抑制剂C，其变体，半胱氨酸蛋白酶抑制剂C基因的转录产物及其变体; 以及将所述物质的至少一种的所述水平或所述活性或所述活性或所述活性两者比较为代表已知疾病或健康状况的参考值，从而诊断或预测所述受试者的所述阿尔茨海默病，或者确定是否所述受试者处于发展阿尔茨海默氏病的风险增加。

2. 发明公开

EP1129191A1 METHODS OF DIAGNOSING OR TREATING NEUROLOGICAL DISEASES 有权
标题翻译：方法进行诊断和治疗神经系统疾病
公开(公告)号：EP1129191A1
公开(公告)日：2001-09-05
申请号：EP99960975.3
申请日：1999-11-12
申请人： Nitsch, Roger , Greeve, Isabell
发明人： Nitsch, Roger , Greeve, Isabell
IPC分类号： C12N15/12 , C07K14/47 , C12Q1/68 , G01N33/68 , A61K38/17
CPC分类号： C07K14/4711 , G01N33/6896
摘要： The invention discloses an isolated nucleic acid molecule encoding a protein molecule, the function of which is to protect cells against degeneration and/or cell death, wherein the amino acid sequence of the protein comprises the sequence shown in SEQ ID NO. 2 or functional variant thereof.

3. 发明公开

EP1002862A1 Methods of diagnosing or treating neurological diseases 审中-公开
标题翻译：一种用于神经疾病的诊断或治疗方法
公开(公告)号：EP1002862A1
公开(公告)日：2000-05-24
申请号：EP98121478.6
申请日：1998-11-12
申请人： Nitsch, Roger M., Prof. Dr.
发明人： The designation of the inventor has not yet been filed
IPC分类号： C12N15/12 , C07K14/47 , C12Q1/68 , G01N33/68 , A61K38/17
CPC分类号： C07K14/4711 , G01N33/6896
摘要： An isolated nucleic acid molecule encoding a protein molecule shown in SEQ ID No. 1.
摘要翻译：编码蛋白质分子在SEQ ID所示的分离的核酸分子号第一

4. 发明公开

EP1123509A2 METHODS OF DIAGNOSING OR PROGNOSING ALZHEIMER'S DISEASE 有权
标题翻译：的诊断或预测阿尔茨海默氏病的方法
公开(公告)号：EP1123509A2
公开(公告)日：2001-08-16
申请号：EP99971091.6
申请日：1999-10-22
申请人： Nitsch, Roger
发明人： NITSCH, Roger , GROWDON, John
IPC分类号： G01N33/68
CPC分类号： G01N33/6896 , G01N2333/8139 , G01N2800/2821
摘要： A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising: determining a level, or an activity, or both said level and said activity, of transcription product and/or a translation product of (i) a cystatin C gene or (ii) a polymorphic variant of a cystatin C gene in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of said transcription product and/or said translation product to a reference value representing a known disease or health status, thereby diagnosing or prognosing Alzheimer's disease in said subject, or determining whether said subject is at increased risk of developing Alzheimer's disease.

6. 发明专利

IL217923D0 METHOD OF PROVIDING DISEASE-SPECIFIC BINDING MOLECULES AND TARGETS 未知
公开(公告)号：IL217923D0
公开(公告)日：2012-03-29
申请号：IL21792312
申请日：2012-02-02
申请人： UNIV ZUERICH , NITSCH ROGER , HOCK CHRISTOPH , ESSLINGER CHRISTOPH , TISSOT KATHRIN , GRIMM JAN , KNOBLOCH MARLEN
IPC分类号： A61K39/00 , C07K20060101

7. 发明专利

AU1153300A Methods of diagnosing or prognosing alzheimer's disease 未知
公开(公告)号：AU1153300A
公开(公告)日：2000-05-15
申请号：AU1153300
申请日：1999-10-22
申请人： NITSCH ROGER
发明人： NITSCH ROGER , GROWDON JOHN
IPC分类号： G01N33/50 , A61K38/46 , A61K38/55 , A61K45/00 , A61K48/00 , A61P25/28 , C12N15/09 , C12Q1/37 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/68
摘要： A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising: determining a level, or an activity, or both said level and said activity, of transcription product and/or a translation product of (i) a cystatin C gene or (ii) a polymorphic variant of a cystatin C gene in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of said transcription product and/or said translation product to a reference value representing a known disease or health status, thereby diagnosing or prognosing Alzheimer's disease in said subject, or determining whether said subject is at increased risk of developing Alzheimer's disease.

8. 发明申请

WO2009027105A2 METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS 审中-公开
标题翻译：提供AMYLOIDIDES和蛋白质聚集障碍患者特异性免疫应答的方法
公开(公告)号：WO2009027105A2
公开(公告)日：2009-03-05
申请号：PCT/EP2008007127
申请日：2008-09-01
申请人： NEURIMMUNE THERAPEUTICS AG , HENCO KARSTEN , NITSCH ROGER , GRIMM JAN , ZELLER ANJA , MAIER MARCEL
发明人： HENCO KARSTEN , NITSCH ROGER , GRIMM JAN , ZELLER ANJA , MAIER MARCEL
IPC分类号： A61K31/7088 , A61K39/39 , A61P25/28
CPC分类号： A61K39/0007 , A61K31/7088 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/575 , C12N15/117 , G01N33/6896 , G01N2333/4709
摘要： A novel treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.
摘要翻译：通过增强或维持针对主要针对存在于所述蛋白质或蛋白质复合物的致病形式的病理蛋白聚集体或新表位的抗体应答来提供对阿尔茨海默氏病和涉及蛋白质错误折叠或聚集的其它病症的新颖治疗。此外，描述了治疗方法，其中离体刺激的抗原选择的外周血淋巴细胞被移植到同源供体中。

9. 发明申请

WO2008110373A1 METHOD OF PROVIDING HUMAN TUMOR-SPECIFIC ANTIBODIES 审中-公开
标题翻译：提供人类肿瘤特异性抗体的方法
公开(公告)号：WO2008110373A1
公开(公告)日：2008-09-18
申请号：PCT/EP2008/002022
申请日：2008-03-13
申请人： UNIVERSITY OF ZURICH , ESSLINGER, Christoph , KUENZLE, Sandra , ABELA, Irene , NITSCH, Roger, M., D. , MOCH, Holger , GOEBELS, Norbert , JAEGER, Dirk , ZIPPELIUS, Alfred , KNUTH, Alexander
发明人： ESSLINGER, Christoph , KUENZLE, Sandra , ABELA, Irene , NITSCH, Roger, M., D. , MOCH, Holger , GOEBELS, Norbert , JAEGER, Dirk , ZIPPELIUS, Alfred , KNUTH, Alexander
IPC分类号： C07K16/00 , C07K16/30 , A61K39/395 , A61P35/00 , G01N33/53
CPC分类号： C07K16/30 , A61K45/06 , A61K49/0002 , C07K16/3053 , C07K2317/21
摘要： Provided are novel tumor-specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize tumor-associated antigens and that are obtained from a tumor patient who shows an at least partial clinical response or is symptom-free. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of tumors are described.
摘要翻译：提供了新的肿瘤特异性结合分子，特别是人抗体以及识别肿瘤相关抗原的片段，衍生物和变体，并且其是从显示至少部分临床反应或无症状的肿瘤患者获得的。此外，描述了包含这样的结合分子，抗体及其模拟物的药物组合物以及筛选新结合分子的方法，其可以是或可以不是抗体以及肿瘤治疗中的靶标。

10. 发明申请

WO2008068024A2 MEANS AND METHODS FOR ISOLATING AND DETERMINING NOVEL TARGETS FOR THE TREATMENT OF NEURODEGENERATIVE, NEUROLOGICAL OR NEUROPSYCHIATRIC DISORDERS AND COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：用于分离和确定用于治疗神经退行性疾病，神经病学或神经过敏性疾病的新颖靶的手段和方法以及包含其的组合物
公开(公告)号：WO2008068024A2
公开(公告)日：2008-06-12
申请号：PCT/EP2007/010631
申请日：2007-12-06
申请人： UNIVERSITÄT ZÜRICH , KOHLI, Bernhard , KONIETZKO, Uwe , NITSCH, Roger , GRIMM, Jan
发明人： KOHLI, Bernhard , KONIETZKO, Uwe , NITSCH, Roger , GRIMM, Jan
IPC分类号： G01N33/68 , C12N15/85
CPC分类号： G01N33/6896 , A01K67/0275 , A01K2217/05 , A01K2217/206 , A01K2227/105 , A01K2267/0312 , A01K2267/0337 , C07K14/4711 , C07K2319/22 , C12N15/8509 , C12N2830/008
摘要： A novel method of identifying and obtaining molecules interacting with neurodegenerative, neurological or neuropsychiatric disorder-associated proteins is provided, which is suitable for drug screening and drug development. Furthermore, drugs and drug targets for the therapeutic intervention of neurodegenerative, neurological or neuropsychiatric disorders, in particular Alzheimer's disease are described.
摘要翻译：提供了一种识别和获得与神经退行性疾病，神经病学或神经精神疾病相关蛋白相互作用的分子的新方法，其适用于药物筛选和药物开发。此外，描述了神经退行性疾病，神经疾病或神经精神疾病，特别是阿尔茨海默病的治疗性干预的药物和药物靶标。

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