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1. 发明申请

WO2009027105A2 METHOD OF PROVIDING PATIENT SPECIFIC IMMUNE RESPONSE IN AMYLOIDOSES AND PROTEIN AGGREGATION DISORDERS 审中-公开
标题翻译：提供AMYLOIDIDES和蛋白质聚集障碍患者特异性免疫应答的方法
公开(公告)号：WO2009027105A2
公开(公告)日：2009-03-05
申请号：PCT/EP2008007127
申请日：2008-09-01
申请人： NEURIMMUNE THERAPEUTICS AG , HENCO KARSTEN , NITSCH ROGER , GRIMM JAN , ZELLER ANJA , MAIER MARCEL
发明人： HENCO KARSTEN , NITSCH ROGER , GRIMM JAN , ZELLER ANJA , MAIER MARCEL
IPC分类号： A61K31/7088 , A61K39/39 , A61P25/28
CPC分类号： A61K39/0007 , A61K31/7088 , A61K39/39 , A61K2039/53 , A61K2039/545 , A61K2039/55511 , A61K2039/55561 , A61K2039/57 , A61K2039/575 , C12N15/117 , G01N33/6896 , G01N2333/4709
摘要： A novel treatment of Alzheimer's disease and other disorders involving protein misfolding or aggregation is provided by enhancing or sustaining an antibody response against predominantly directed against pathological protein aggregates or neo-epitopes present on pathogenic forms of said protein or protein complex. Furthermore, therapeutic methods are described, wherein ex vivo stimulated antigen-selected peripheral blood lymphocytes are regrafted into the cognate donor.
摘要翻译：通过增强或维持针对主要针对存在于所述蛋白质或蛋白质复合物的致病形式的病理蛋白聚集体或新表位的抗体应答来提供对阿尔茨海默氏病和涉及蛋白质错误折叠或聚集的其它病症的新颖治疗。此外，描述了治疗方法，其中离体刺激的抗原选择的外周血淋巴细胞被移植到同源供体中。

2. 发明申请

WO2008068024A3 MEANS AND METHODS FOR ISOLATING AND DETERMINING NOVEL TARGETS FOR THE TREATMENT OF NEURODEGENERATIVE, NEUROLOGICAL OR NEUROPSYCHIATRIC DISORDERS AND COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：用于分离和确定治疗神经损伤，神经病学或神经病学疾病的新目标的方法和方法及包含其的组合物
公开(公告)号：WO2008068024A3
公开(公告)日：2008-07-24
申请号：PCT/EP2007010631
申请日：2007-12-06
申请人： UNIV ZUERICH , KOHLI BERNHARD , KONIETZKO UWE , NITSCH ROGER , GRIMM JAN
发明人： KOHLI BERNHARD , KONIETZKO UWE , NITSCH ROGER , GRIMM JAN
IPC分类号： G01N33/68 , C12N15/85
CPC分类号： G01N33/6896 , A01K67/0275 , A01K2217/05 , A01K2217/206 , A01K2227/105 , A01K2267/0312 , A01K2267/0337 , C07K14/4711 , C07K2319/22 , C12N15/8509 , C12N2830/008
摘要： A novel method of identifying and obtaining molecules interacting with neurodegenerative, neurological or neuropsychiatric disorder-associated proteins is provided, which is suitable for drug screening and drug development. Furthermore, drugs and drug targets for the therapeutic intervention of neurodegenerative, neurological or neuropsychiatric disorders, in particular Alzheimer's disease are described.
摘要翻译：提供了一种识别和获得与神经变性，神经系统或神经精神障碍相关蛋白相互作用的分子的新方法，其适用于药物筛选和药物开发。此外，描述了用于神经变性，神经系统或神经精神障碍，特别是阿尔茨海默氏病的治疗性干预的药物和药物靶标。

4. 发明申请

WO0025138A3 METHODS OF DIAGNOSING OR PROGNOSING ALZHEIMER'S DISEASE 审中-公开
标题翻译：诊断或预防阿尔茨海默病的方法
公开(公告)号：WO0025138A3
公开(公告)日：2000-08-24
申请号：PCT/EP9908023
申请日：1999-10-22
申请人： NITSCH ROGER , GROWDON JOHN
发明人： NITSCH ROGER , GROWDON JOHN
IPC分类号： G01N33/50 , A61K38/46 , A61K38/55 , A61K45/00 , A61K48/00 , A61P25/28 , C12N15/09 , C12Q1/37 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/68
CPC分类号： G01N33/6896 , G01N2333/8139 , G01N2800/2821
摘要： A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising: determining a level, or an activity, or both said level and said activity, of transcription product and/or a translation product of (i) a cystatin C gene or (ii) a polymorphic variant of a cystatin C gene in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of said transcription product and/or said translation product to a reference value representing a known disease or health status, thereby diagnosing or prognosing Alzheimer's disease in said subject, or determining whether said subject is at increased risk of developing Alzheimer's disease.
摘要翻译：一种用于诊断或预测受试者中的阿尔茨海默氏病的方法，或确定受试者是否处于发展中的阿尔茨海默氏病的风险增加的方法，包括：测定转录产物和/或其他疾病的水平或活性，或所述水平和所述活性（i）半胱氨酸蛋白酶抑制剂C基因或（ii）来自所述受试者的样品中半胱氨酸蛋白酶抑制剂C基因的多态性变体的翻译产物; 以及将所述转录产物和/或所述翻译产物的所述水平或所述活性，或所述水平和所述活性两者与代表已知疾病或健康状况的参考值进行比较，从而诊断或预测所述受试者的阿尔茨海默氏病，或确定所述受试者是否处于发展为阿尔茨海默氏病的风险增加。

5. 发明专利

AU1153300A Methods of diagnosing or prognosing alzheimer's disease 未知
公开(公告)号：AU1153300A
公开(公告)日：2000-05-15
申请号：AU1153300
申请日：1999-10-22
申请人： NITSCH ROGER
发明人： NITSCH ROGER , GROWDON JOHN
IPC分类号： G01N33/50 , A61K38/46 , A61K38/55 , A61K45/00 , A61K48/00 , A61P25/28 , C12N15/09 , C12Q1/37 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/68
摘要： A method for diagnosing or prognosing Alzheimer's disease in a subject, or determining whether a subject is at increased risk of developing Alzheimer's disease, comprising: determining a level, or an activity, or both said level and said activity, of transcription product and/or a translation product of (i) a cystatin C gene or (ii) a polymorphic variant of a cystatin C gene in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of said transcription product and/or said translation product to a reference value representing a known disease or health status, thereby diagnosing or prognosing Alzheimer's disease in said subject, or determining whether said subject is at increased risk of developing Alzheimer's disease.

6. 发明申请

WO2008151841A3 TREATMENT FOR ALZHEIMER' S DISEASE 审中-公开
标题翻译：治疗阿尔茨海默病
公开(公告)号：WO2008151841A3
公开(公告)日：2009-04-09
申请号：PCT/EP2008004834
申请日：2008-06-16
申请人： UNIV ZUERICH , GRIMM JAN , NITSCH ROGER , CHEN FENG
发明人： GRIMM JAN , NITSCH ROGER , CHEN FENG
IPC分类号： A61K38/18 , A61K48/00 , A61P25/00
CPC分类号： A61K38/1816
摘要： Provided are novel drugs and methods in the treatment as well as diagnosis of neurological disorders such as Alzheimer's disease and amyloid-beta pathology/amyloidosis. More specifically, the use of erythropoietin and analogs thereof for the treatment of Aß peptide related brain impairments is described. Furthermore, the use of claudin-5 and variants thereof as biomarker for Alzheimer's disease and for the progression of Alzheimer's disease, respectively, is provided.
摘要翻译：提供了治疗中的新型药物和方法以及诸如阿尔茨海默病和淀粉样蛋白β病理学/淀粉样变性之类的神经障碍的诊断。更具体地，描述了促红细胞生成素及其类似物用于治疗Aβ肽相关脑损伤的用途。此外，提供了分别使用claudin-5及其变体作为阿尔茨海默病的生物标志物和阿尔茨海默氏病的进展。

7. 发明申请

WO0225279A3 USE OF AMYLOID PRECURSOR PROTEIN FOR TREATING BRAIN AMYLOIDOSIS 审中-公开
标题翻译：使用淀粉样蛋白前体蛋白治疗脑损伤
公开(公告)号：WO0225279A3
公开(公告)日：2002-07-04
申请号：PCT/EP0110816
申请日：2001-09-19
申请人： EVOTEC NEUROSCIENCES GMBH , UNIV ZUERICH , NITSCH ROGER , MOHAJERI HASAN , WOLLMER AXEL , POHLNER JOHANNES
发明人： NITSCH ROGER , MOHAJERI HASAN , WOLLMER AXEL , POHLNER JOHANNES
IPC分类号： A61K38/17 , A61P25/28 , G01N33/50
CPC分类号： A61K38/1709
摘要： The present invention discloses the use of (i) a fragment of the amyloid precursor protein (APP); or, (ii) a derivative of (i); or, (iii) a functional mimetic of (i) or (ii), in the preparation of a medicament for modulating CNS levels and/or activity of a member of the neprilysin family.
摘要翻译：本发明公开了（i）淀粉样蛋白前体蛋白片段（APP）的用途; 或（ii）（i）的衍生物; 或（iii）（i）或（ii）的功能模拟物在制备调节neprilysin家族成员的CNS水平和/或活性的药物中的用途。

8. 发明申请

WO2010004434A3 METHOD OF PROMOTING NEUROGENESIS 审中-公开
标题翻译：促进神经发生的方法
公开(公告)号：WO2010004434A3
公开(公告)日：2010-08-26
申请号：PCT/IB2009006666
申请日：2009-07-09
申请人： UNIV ZUERICH , NITSCH ROGER , LINDVALL OLLE , BISCARO BARBARA , EKDAHL CHRISTINE
发明人： NITSCH ROGER , LINDVALL OLLE , BISCARO BARBARA , EKDAHL CHRISTINE
IPC分类号： C07K16/18 , A61K39/395
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/74
摘要： The present description relates generally to methods of using Abeta binding molecules including, for example, antibodies and antibody fragments that recognize Abeta. The description provides methods of promoting neurogenesis, angiogenesis, synaptic activity and/or dendritic arborization using Abeta binding molecules. The description also provides methods of treating various diseases, disorder, injuries and conditions associated with amyloid plaques or the accumulation of Abeta.
摘要翻译：本说明书一般涉及使用Abeta结合分子的方法，包括例如识别Abeta的抗体和抗体片段。该描述提供了使用Abeta结合分子促进神经发生，血管生成，突触活性和/或树突状结构的方法。该描述还提供了治疗与淀粉样蛋白斑块相关的各种疾病，病症，损伤和病症或Abeta积累的方法。

9. 发明申请

WO0116364A2 METHODS OF DIAGNOSING OR PROGNOSTICATING AGE-RELATED MACULAR DEGENERATION 审中-公开
标题翻译：诊断或预后相关性变异的方法
公开(公告)号：WO0116364A2
公开(公告)日：2001-03-08
申请号：PCT/EP0008554
申请日：2000-09-01
申请人： EVOTEC NEUROSCIENCES GMBH , RICHARD GIESBERT , NITSCH ROGER
发明人： RICHARD GIESBERT , NITSCH ROGER
IPC分类号： C07K14/81 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/8139 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： A method for diagnosing or prognosing age-related macular degeneration in a subject, or determining whether a subject is at increased risk of developing age-related macular degeneration or monitoring the progression of age-related macular degeneration in a subject, comprising: determining a level, or an activity, or both said level and said activity, of at least one substance which is selected from the group consisting of a transcription product of a Cystatin C gene, a translation product of a Cystatin C gene, a fragment of said translation product, an amyloid protein, and a transcription product of a gene coding for an amyloid protein in a sample from said subject; and comparing said level, or said activity, or both said level and said activity, of at least one of said substances to a reference value representing a known disease or health status, thereby diagnosing or prognosing said age-related macular degeneration in said subject, or determining whether said subject is at increased risk of developing age-related macular degeneration or monitoring the progression of said age-related macular degeneration in said subject.
摘要翻译：用于诊断或预测受试者中年龄相关性黄斑变性的方法，或确定受试者是否处于发展年龄相关性黄斑变性的风险增加或监测受试者中年龄相关性黄斑变性的进展的方法，包括：确定水平，或活性，或所述水平和所述活性两者，选自Cystatin C基因的转录产物，半胱氨酸蛋白酶抑制蛋白C基因的翻译产物，所述翻译产物的片段的至少一种物质，淀粉样蛋白，以及来自所述受试者的样品中编码淀粉样蛋白的基因的转录产物; 以及将所述物质的至少一种的所述水平或所述活性或所述水平和所述活性两者比较为代表已知疾病或健康状况的参考值，从而诊断或预测所述受试者中所述年龄相关性黄斑变性，或确定所述受试者是否处于发展年龄相关性黄斑变性的风险增加或监测所述受试者中所述年龄相关性黄斑变性的进展。

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