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    • 2. 发明申请
    • METHODS, COMPOSITIONS AND DEVICES, INCLUDING MICROFLUIDIC DEVICES, COMPRISING COATED HYDROPHOBIC SURFACES
    • 方法,组合物和装置,包括微流体装置,包装涂覆的疏水性表面
    • WO2006015306A3
    • 2008-10-16
    • PCT/US2005027225
    • 2005-07-29
    • PREDICANT BIOSCIENCES INCCHAPMAN ROBERT GZHAO MINGQINI JINGBOOSSE LUC JSTULTS JOHN TYANG SAYRUDOLF ROGER
    • CHAPMAN ROBERT GZHAO MINGQINI JINGBOOSSE LUC JSTULTS JOHN TYANG SAYRUDOLF ROGER
    • B32B9/04B05D1/36B05D7/00
    • G01N33/6848B01L3/5027H01J49/0018H01J49/165
    • Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating layer and the hydrophobic surface is not required. Subsequent layers may then interact chemically or non-chemically with at least a portion of the first coating layer and/or region. Such coated surfaces may be part of a device or apparatus, including microfluidic devices. Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include a substrate having at least one microchannel, a cover arranged on a surface of the microchannel, and at least one electrical potential source. Some embodiments include a microchannel widened at an outlet. Other embodiments position the electrical potential source along a surface of the cover. Still other embodiments include a well in which an electrode and a membrane are disposed. The various embodiments provide stable electrospray ionization of substances from a microfluidic device to a mass spectrometer.
    • 公开了用于涂覆至少一部分疏水表面的方法,包括塑料或其它聚合物的表面。 这种方法包括使用与疏水表面相互作用的第一涂层和/或区域,尽管不需要在第一涂层和疏水表面之间形成化学键。 然后随后的层可以与第一涂层和/或区域的至少一部分化学或非化学相互作用。 这种涂覆的表面可以是包括微流体装置的装置或装置的一部分。 微流体装置向质谱仪提供物质。 微流体装置包括具有至少一个微通道的衬底,布置在微通道表面上的盖和至少一个电势源。 一些实施例包括在出口处加宽的微通道。 其他实施例将电势源沿着盖的表面定位。 其他实施例包括其中设置电极和膜的阱。 各种实施方案提供物质从微流体装置到质谱仪的稳定的电喷雾电离。
    • 7. 发明申请
    • METHODS, COMPOSITIONS AND DEVICES, INCLUDING MICROFLUIDIC DEVICES, COMPRISING COATED HYDROPHOBIC SURFACES
    • 方法,组合物和装置,包括微流体装置,包装涂覆的疏水性表面
    • WO2006015306A2
    • 2006-02-09
    • PCT/US2005/027225
    • 2005-07-29
    • PREDICANT BIOSCIENCES, INC.CHAPMAN, Robert, G.ZHAO, MingqiNI, JingBOOSSE, Luc, J.STULTS, John, T.YANG, SayRUDOLF, Roger
    • CHAPMAN, Robert, G.ZHAO, MingqiNI, JingBOOSSE, Luc, J.STULTS, John, T.YANG, SayRUDOLF, Roger
    • H01J49/00
    • G01N33/6848B01L3/5027H01J49/0018H01J49/165
    • Methods are disclosed for coating at least a portion of a hydrophobic surface, including the surfaces of plastics or other polymers. Such methods include the use of a first coating layer and/or region that interacts with the hydrophobic surface, although the formation of a chemical bond between the first coating layer and the hydrophobic surface is not required. Subsequent layers may then interact chemically or non-chemically with at least a portion of the first coating layer and/or region. Such coated surfaces may be part of a device or apparatus, including microfluidic devices. Microfluidic devices provide substances to a mass spectrometer. The microfluidic devices include a substrate having at least one microchannel, a cover arranged on a surface of the microchannel, and at least one electrical potential source. Some embodiments include a microchannel widened at an outlet. Other embodiments position the electrical potential source along a surface of the cover. Still other embodiments include a well in which an electrode and a membrane are disposed. The various embodiments provide stable electrospray ionization of substances from a microfluidic device to a mass spectrometer.
    • 公开了用于涂覆至少一部分疏水表面的方法,包括塑料或其它聚合物的表面。 这种方法包括使用与疏水表面相互作用的第一涂层和/或区域,尽管不需要在第一涂层和疏水表面之间形成化学键。 然后随后的层可以与第一涂层和/或区域的至少一部分化学或非化学相互作用。 这种涂覆的表面可以是包括微流体装置的装置或装置的一部分。 微流体装置向质谱仪提供物质。 微流体装置包括具有至少一个微通道的衬底,布置在微通道表面上的盖和至少一个电势源。 一些实施例包括在出口处加宽的微通道。 其他实施例将电势源沿着盖的表面定位。 其他实施例包括其中设置电极和膜的阱。 各种实施方案提供物质从微流体装置到质谱仪的稳定的电喷雾电离。