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1. 发明专利

GB201121157D0 Sample processor 未知
公开(公告)号：GB201121157D0
公开(公告)日：2012-01-18
申请号：GB201121157
申请日：2011-12-08
申请人： NAYLOR STUART , DANIELS GRAEME

2. 发明申请

WO2008059252A9 METHODS AND COMPOSITION FRO T CELL RECEPTORS WHICH RECOGNIZE 5T4 ANTIGEN 审中-公开
标题翻译：识别5T4抗原的方法和组合物FRO T细胞受体
公开(公告)号：WO2008059252A9
公开(公告)日：2008-09-18
申请号：PCT/GB2007004361
申请日：2007-11-15
申请人： OXFORD BIOMEDICA LTD , MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
发明人： MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
IPC分类号： C12Q1/68
CPC分类号： C07K14/4748
摘要： The present invention relates to the use of peptide epitopes of 5T4 antigen in the identification and isolation of T cell receptors which recognize 5T4 antigen.
摘要翻译：本发明涉及5T4抗原的肽表位在识别和分离识别5T4抗原的T细胞受体中的用途。

3. 发明申请

WO2004031390A1 VECTOR SYSTEM 审中-公开
标题翻译：矢量系统
公开(公告)号：WO2004031390A1
公开(公告)日：2004-04-15
申请号：PCT/GB2003/004260
申请日：2003-10-03
申请人： OXFORD BIOMEDICA (UK) LIMITED , MAZARAKIS, Nicholas , AZZOUZ, Mimoun , BINLEY, Katie , NAYLOR, Stuart , KINGSMAN, Susan
发明人： MAZARAKIS, Nicholas , AZZOUZ, Mimoun , BINLEY, Katie , NAYLOR, Stuart , KINGSMAN, Susan
IPC分类号： C12N15/49
CPC分类号： C12N15/86 , A61K39/00 , A61K48/00 , A61K2121/00 , A61K2123/00 , C12N2740/15043 , C12N2740/15045 , C12N2810/6054 , C12N2810/6081
摘要： Use of a vector system to transduce a target site, wherein the vector system travels to the target site by diffusion, and wherein the vector system is or comprises at least part of a rabies G envelope protein or a mutant, variant, homologue or fragment thereof, or a CVS envelope protein or a mutant, variant, homologue or fragment thereof, and further wherein the target site is at least part of the central nervous system.
摘要翻译：使用载体系统转导靶位点，其中载体系统通过扩散行进到靶位点，并且其中载体系统是或包含狂犬病G包膜蛋白或突变体，变体，同源物或其片段的至少一部分，或CVS包膜蛋白或其突变体，变体，同源物或其片段，并且其中所述靶位点是所述中枢神经系统的至少一部分。

4. 发明申请

WO9915684A9 EXPRESSION OF GENES IN HEMATOPOIETIC STEM CELLS IN HISCHAEMIC CONDITIONS 审中-公开
标题翻译： HEMATOPOIETIC干细胞中基因表达在病理条件中的表达
公开(公告)号：WO9915684A9
公开(公告)日：1999-09-16
申请号：PCT/GB9802885
申请日：1998-09-23
申请人： OXFORD BIOMEDICA LTD , LEWIS CLAIRE , BINLEY KATIE MARY , BEBBINGTON CHRIS , NAYLOR STUART
发明人： LEWIS CLAIRE , BINLEY KATIE MARY , BEBBINGTON CHRIS , NAYLOR STUART
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K48/00 , A61P25/00 , A61P35/00 , C07K14/145 , C07K14/155 , C12N5/10 , C12N7/00 , C12N15/63 , C12N15/861 , C12N15/867 , C12Q1/02 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N15/63 , C12N2710/10343 , C12N2740/15022 , C12N2740/15043 , C12N2740/15052 , C12N2760/20122 , C12N2810/40 , C12N2810/60 , C12N2810/6054 , C12N2830/002
摘要： A modified haematopoeitic stem cell (MHSC) is described. The MHSC comprises at least one expressable nucleotide sequence of interest (NOI) wherein the or each NOI is operably linked to one or more ischaemia like response element (ILRE).
摘要翻译：描述了经修饰的血液造影干细胞（MHSC）。 MHSC包含至少一种可表达的目的核苷酸序列（NOI），其中所述或每个NOI可操作地连接至一种或多种缺血样反应元件（ILRE）。

5. 发明申请

WO03018621A8 GENES 审中-公开
标题翻译：基因
公开(公告)号：WO03018621A8
公开(公告)日：2004-02-19
申请号：PCT/GB0203892
申请日：2002-08-23
申请人： OXFORD BIOMEDICA LTD , KINGSMAN SUSAN MARY , WHITE JONATHAN , WARD NEIL RAYMOND , HARRIS ROBERT ALAN , NAYLOR STUART , MUNDY CHRISTOPHER ROBERT
发明人： KINGSMAN SUSAN MARY , WHITE JONATHAN , WARD NEIL RAYMOND , HARRIS ROBERT ALAN , NAYLOR STUART , MUNDY CHRISTOPHER ROBERT
IPC分类号： C07K14/47 , C07K14/00 , A61K38/17 , C12N15/09 , C12N15/63
CPC分类号： C07K14/47

6. 发明申请

WO2002083728A2 SPLICE VARIANT 审中-公开
公开(公告)号：WO2002083728A2
公开(公告)日：2002-10-24
申请号：PCT/GB2002/001662
申请日：2002-04-08
申请人： OXFORD BIOMEDICA (UK) LIMITED , WHITE, Jonathan , HARRIS, Robert, Alan , KAN, On , MUNDY, Christopher, Robert , WARD, Neil, Raymond , KINGSMAN, Susan, Mary , NAYLOR, Stuart , RAYNER, William, Nigel , BINLEY, Katie, Mary
发明人： WHITE, Jonathan , HARRIS, Robert, Alan , KAN, On , MUNDY, Christopher, Robert , WARD, Neil, Raymond , KINGSMAN, Susan, Mary , NAYLOR, Stuart , RAYNER, William, Nigel , BINLEY, Katie, Mary
IPC分类号： C07K14/47
CPC分类号： C07K14/47 , A61K38/00
摘要： This invention relates to a novel isoform of the EGLN3 gene and the product of this gene, that has been implicated in certain disease states. This novel isoform lacks an internal stretch of nucleotides form the wild type gene, probably due to an alternative splicing event. Both the full length EGLN3 protein and EGLN3 splice variant have been shown to be biologically active. Overexpression of both these isoforms reduce HIF-mediated gene expression through HRE reporters, thus demonstrating their role in the HIF signalling pathway. The suppression effect of the EGLN3 splice variant appears to be stronger than that of the full length EGLN3 protein.
摘要翻译：本发明涉及EGLN3基因的新型同工型和该基因的产物，其涉及某些疾病状态。这种新型异构体缺乏形成野生型基因的内部核苷酸段，这可能是由于可选的剪接事件。全长EGLN3蛋白和EGLN3剪接变体都显示出具有生物活性。这些同种型的过度表达通过HRE记录降低了HIF介导的基因表达，从而证明了它们在HIF信号通路中的作用。 EGLN3剪接变体的抑制作用似乎比全长EGLN3蛋白质更强。

7. 发明申请

WO2011001178A1 APPARATUS FOR PURGING CONTAINERS FOR STORING SENSITIVE MATERIALS 审中-公开
标题翻译：用于储存敏感材料的容器的装置
公开(公告)号：WO2011001178A1
公开(公告)日：2011-01-06
申请号：PCT/GB2010051083
申请日：2010-06-30
申请人： ROYLAN DEVELOPMENTS LTD , NAYLOR STUART
发明人： NAYLOR STUART
IPC分类号： F17D1/04
CPC分类号： F17D1/04 , H01L21/67393
摘要： Apparatus for purging containers for the storage of sensitive materials is described. It includes means to connect a source of compressed purge gas to a purge gas inlet (2) on a container (1), including a pneumatically operated valve (6) adapted to allow purge gas to pass from the source to the inlet and a timing device (9) associated with the valve (6) and adapted to turn off the gas flow after a given time, and including means to vary the time between commencement and cessation of gas flow. The timing device is preferably one which operates on a pneumatic or clockwork basis, enabling the apparatus to operate without any electrical power supply, driven by the purge gas pressure alone. This enables the construction of a simple reliable unit, at a cost even enabling the unit to be incorporated into the container itself if desired. The use of a pneumatically operated valve enables portable apparatus to be designed with low power use if it includes e.g. electronic sensors to measure a property of the purge gas being exhausted from the container.
摘要翻译：描述了用于清洁用于存储敏感材料的容器的装置。其包括将压缩的净化气体源连接到容器（1）上的吹扫气体入口（2）的装置，所述吹扫气体入口（2）包括气动操作的阀（6），其适于使吹扫气体从所述源传送到所述入口，与阀（6）相关联并适于在给定时间之后关闭气流的装置（9），并且包括改变气体流量的开始和停止之间的时间的装置。定时装置优选是以气动或发条为基础运行的定时装置，使得装置能够在没有任何电力供应的情况下操作，仅由吹扫气体压力驱动。这使得能够构造简单可靠的单元，但是如果需要，甚至能够将该单元结合到容器本身中。使用气动阀使得便携式设备可以被设计成具有低功率使用，如果它包括例如用于测量从容器中排出的净化气体的性质的电子传感器。

8. 发明申请

WO2008059252A3 METHODS AND COMPOSITION FRO T CELL RECEPTORS WHICH RECOGNIZE 5T4 ANTIGEN 审中-公开
公开(公告)号：WO2008059252A3
公开(公告)日：2008-12-04
申请号：PCT/GB2007004361
申请日：2007-11-15
申请人： OXFORD BIOMEDICA LTD , MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
发明人： MYERS KEVIN , REDCHENKO IRINA , SHINGLER WILLIAM , HARROP RICHARD , NAYLOR STUART , KINGSMAN ALAN , KINGSMAN SUSAN
IPC分类号： C07K14/47
CPC分类号： C07K14/4748
摘要： The present invention relates to the use of peptide epitopes of 5T4 antigen in the identification and isolation of T cell receptors which recognize 5T4 antigen.

9. 发明申请

WO9915684A2 METHOD 审中-公开
标题翻译：方法
公开(公告)号：WO9915684A2
公开(公告)日：1999-04-01
申请号：PCT/GB9802885
申请日：1998-09-23
申请人： OXFORD BIOMEDICA LTD , LEWIS CLAIRE , BINLEY KATIE MARY , BEBBINGTON CHRIS , NAYLOR STUART
发明人： LEWIS CLAIRE , BINLEY KATIE MARY , BEBBINGTON CHRIS , NAYLOR STUART
IPC分类号： C12N15/09 , A61K35/12 , A61K35/76 , A61K48/00 , A61P25/00 , A61P35/00 , C07K14/145 , C07K14/155 , C12N5/10 , C12N7/00 , C12N15/63 , C12N15/861 , C12N15/867 , C12Q1/02 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , C07K14/005 , C12N15/63 , C12N2710/10343 , C12N2740/15022 , C12N2740/15043 , C12N2740/15052 , C12N2760/20122 , C12N2810/40 , C12N2810/60 , C12N2810/6054 , C12N2830/002
摘要： A modified haematopoeitic stem cell (MHSC) is described. The MHSC comprises at least one expressable nucleotide sequence of interest (NOI) wherein the or each NOI is operably linked to one or more ischaemia like response element (ILRE).
摘要翻译：描述了经修饰的血液造影干细胞（MHSC）。 MHSC包含至少一种可表达的目的核苷酸序列（NOI），其中所述或每个NOI可操作地连接至一种或多种缺血样反应元件（ILRE）。

10. 发明申请

WO2011001178A4 APPARATUS FOR PURGING CONTAINERS FOR STORING SENSITIVE MATERIALS 审中-公开
公开(公告)号：WO2011001178A4
公开(公告)日：2011-01-06
申请号：PCT/GB2010/051083
申请日：2010-06-30
申请人： ROYLAN DEVELOPMENTS LIMITED , NAYLOR, Stuart
发明人： NAYLOR, Stuart
IPC分类号： F17D1/04
摘要： Apparatus for purging containers for the storage of sensitive materials is described. It includes means to connect a source of compressed purge gas to a purge gas inlet (2) on a container (1), including a pneumatically operated valve (6) adapted to allow purge gas to pass from the source to the inlet and a timing device (9) associated with the valve (6) and adapted to turn off the gas flow after a given time, and including means to vary the time between commencement and cessation of gas flow. The timing device is preferably one which operates on a pneumatic or clockwork basis, enabling the apparatus to operate without any electrical power supply, driven by the purge gas pressure alone. This enables the construction of a simple reliable unit, at a cost even enabling the unit to be incorporated into the container itself if desired. The use of a pneumatically operated valve enables portable apparatus to be designed with low power use if it includes e.g. electronic sensors to measure a property of the purge gas being exhausted from the container.

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