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1. 发明申请

WO2004009120A1 HYBRID OF ITRACONAZOLE, CYCLOSPORINE OR CARVEDILOL WITH A LAYERED SILICATE AND A PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：具有层状硅酸盐的异烟肼，环磷酰胺或卡维地洛的混合物及其制备方法
公开(公告)号：WO2004009120A1
公开(公告)日：2004-01-29
申请号：PCT/KR2003/001449
申请日：2003-07-22
申请人： NANOHYBRID CO., LTD. , PARK, Tae-Un , JUNG, Hyun , KIM, Hyun-Mi , CHOY, Jin-Ho , LEE, Chi-Won
发明人： PARK, Tae-Un , JUNG, Hyun , KIM, Hyun-Mi , CHOY, Jin-Ho , LEE, Chi-Won
IPC分类号： A61K47/02
CPC分类号： A61K31/403 , A61K9/143 , A61K31/496 , A61K38/13
摘要： The present invention provides the hybrids wherein itraconazole, cyclosporine or carvedilol are intercalated into the interlayers and/or absorbed onto the surfaces of layered silicates. The hybrids according to the present invention enable the maximization of bioavailability of drugs by dissolving the drugs from the layered silicates. Furthermore, the present invention provides the preparing methods of the hybrids. The process comprises: (1) dispersing a layered silicate in an aqueous solution to form an aqueous solution containing the layered silicate; (2) dissolving a drug in a organic solvent to form an organic solution containing the drug, the organic solvent having a solubility higher than that in the aqueous solution; and (3) mixing and hybridizing in the inerrface of the aqueous solution containing the layered silicate and the organic phase solution containing the drug in order to intercalate the drug into the interlayers of the layered silicate and/or to absorb the drug onto the surface of the layered silicate.
摘要翻译：本发明提供了伊曲康唑，环孢菌素或卡维地洛插入中间层和/或吸收到层状硅酸盐表面上的杂交体。根据本发明的杂交体能够通过从层状硅酸盐中溶解药物使药物的生物利用度最大化。此外，本发明提供了杂种的制备方法。该方法包括：（1）将层状硅酸盐分散在水溶液中以形成含有层状硅酸盐的水溶液; （2）将药物溶解在有机溶剂中以形成含有药物的有机溶液，所述有机溶剂的溶解度高于所述水溶液中的溶解度; 和（3）在含有层状硅酸盐的水溶液和含有药物的有机相溶液的表面中混合和杂交，以将药物插入层状硅酸盐的夹层中和/或将药物吸收到层状硅酸盐。

2. 发明申请

WO2005044722A1 METHOD FOR FORMING ZNO NANO-ARRAY AND ZNO NANOWALL FOR UV LASER ON SILICON SUBSTRATE 审中-公开
标题翻译：用于在硅基板上形成紫外线激光的ZNO纳米阵列和氮纳米管的方法
公开(公告)号：WO2005044722A1
公开(公告)日：2005-05-19
申请号：PCT/KR2004/002866
申请日：2004-11-06
申请人： NANOHYBRID CO., LTD. , CHOY, Jin-Ho , JANG, Eue-Soon , WON, Jung-Hee
发明人： CHOY, Jin-Ho , JANG, Eue-Soon , WON, Jung-Hee
IPC分类号： B82B3/00
CPC分类号： H01S5/347 , B82Y20/00 , B82Y30/00 , C30B7/10 , C30B29/16 , C30B29/62 , H01S5/021 , H01S5/341
摘要： Provided are low-temperature formation methods of a perfectly oriented ZnO nanorod array and a new-type ZnO nanowall array having a new crystal growth rate, morphology, and orientation, from ZnO nanoparticles coated on a substrate. The method of forming the ZnO nanorod array includes synthesizing ZnO nanoparticles, coating on a substrate the ZnO nanoparticles serving both as a buffer layer and a seed layer, and growing the ZnO nanoparticles into crystals in a nutrient solution containing Zn nitrate, Zn acetate, or a derivative thereof, and hexamethylenetetramine. The method of forming the ZnO nanowall array includes synthesizing ZnO nanoparticles,to coating on a substrate the ZnO nanoparticles serving both as a buffer layer and a seed layer, and growing the ZnO nanoparticles into crystals in a nutrient solution containing Zn acetate or its derivative and sodium citrate.
摘要翻译：提供了完全取向的ZnO纳米棒阵列的低温形成方法和具有新的晶体生长速率，形态和取向的新型ZnO纳米壁阵列，其由涂覆在基底上的ZnO纳米颗粒组成。形成ZnO纳米棒阵列的方法包括合成ZnO纳米颗粒，在衬底上涂覆用作缓冲层和种子层的ZnO纳米颗粒，并将ZnO纳米颗粒在含有硝酸锌，乙酸锌或其衍生物和六亚甲基四胺。形成ZnO纳米壁阵列的方法包括合成ZnO纳米颗粒，在衬底上涂覆用作缓冲层和种子层的ZnO纳米颗粒，并将ZnO纳米颗粒在含有乙酸锌或其衍生物的营养溶液中生长成晶体，以及柠檬酸钠。

3. 发明申请

WO2006091009A1 PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER COMPRISING LMH-RA COMPLEX 审中-公开
标题翻译：用于治疗包含LMH-RA复合物的癌症的药物组合物
公开(公告)号：WO2006091009A1
公开(公告)日：2006-08-31
申请号：PCT/KR2006/000600
申请日：2006-02-22
申请人： NANOHYBRID CO., LTD. , CHOY, Jin-ho , PARK, Taeun , KIM, Sang-tae , SON, You-hwan
发明人： CHOY, Jin-ho , PARK, Taeun , KIM, Sang-tae , SON, You-hwan
IPC分类号： A61K31/07 , A61P35/00
CPC分类号： A61K33/24 , A61K31/203 , A61K33/08 , A61K33/26 , A61K33/30 , A61K2300/00
摘要： Provided is a pharmaceutical composition for the treatment of liver cancer, including a layered metal hydroxide-retinoic acid (LMH-RA) hybrid as a novel drug delivery system which shows few side effects of retinoic acid, good drug stability, sustained drug release, and improved drug delivery efficiency.
摘要翻译：提供了用于治疗肝癌的药物组合物，包括层状金属氢氧化物视黄酸（LMH-RA）杂合物作为新型药物递送系统，其显示视黄酸的副作用很小，药物稳定性好，持续的药物释放和提高药物输送效率。

4. 发明申请

WO2005067979A1 AHYBRID OF ITRACONAZOLE WITH A LAYERED SILICATE 审中-公开
标题翻译：具有层状硅酸盐的异烟肼的混合物
公开(公告)号：WO2005067979A1
公开(公告)日：2005-07-28
申请号：PCT/KR2005/000181
申请日：2005-01-20
申请人： NANOHYBRID CO., LTD. , JUNG, Hyun , PARK, Taeun , CHOY, Jin-Ho
发明人： JUNG, Hyun , PARK, Taeun , CHOY, Jin-Ho
IPC分类号： A61K47/48
CPC分类号： A61K31/41 , A61K47/52
摘要： A hybrid of an itraconazole with a silicate obtained through an interface reaction between an aqueous dispersion of a Iayered silicate and a solution containing an itraconazole dissolved in a water-insoluble organic solvent, wherein the amount of the layered silicate in the hybrid is 0.01 % to 10% by weight, is provided.
摘要翻译：伊曲康唑与硅酸盐的水分散体与溶解在水不溶性有机溶剂中的伊曲康唑的溶液之间的界面反应得到的硅酸盐的混合物，其中混合物中层状硅酸盐的量为0.01％〜 10重量％。

5. 发明申请

WO2006129893A1 INJECTABLE DRUG CARRIER COMPRISING LAYERED DOUBLE HYDROXIDE 审中-公开
标题翻译：包含层状双氢氧化物的注射式药物载体
公开(公告)号：WO2006129893A1
公开(公告)日：2006-12-07
申请号：PCT/KR2005/001667
申请日：2005-06-03
申请人： NANOHYBRID CO., LTD. , PARK, Taeun , CHOY, Jin-Ho , OH, Jae-Min , JUNG, Ji-Sun
发明人： PARK, Taeun , CHOY, Jin-Ho , OH, Jae-Min , JUNG, Ji-Sun
IPC分类号： A61K47/02
CPC分类号： A61K9/0019 , A61K9/143 , A61K47/02
摘要： Provided is an injectable drug carrier including a non-toxic Layered Double Hydroxide (LDH) and a pharmaceutically acceptable excipients. Provided is also a method of preparing the injectable drug carrier, the method including: synthesizing LDH with various compositions and controlling the size and shape of the LDH at a level that the LDH has no adverse effect in vivo . A solution obtained by dispersing the LDH in a solvent is injected in vivo . According to the method, nano-size LDH that does not affect a blood vessel in vivo can be synthesized. The LDH thus synthesized has no adverse effect in vivo even at a concentration of 400 mg/kg, and thus can contribute to establishment of a drug delivery system capable of improving the delivery efficiency of a specific drug.
摘要翻译：提供了包含无毒层状双氢氧化物（LDH）和药学上可接受的赋形剂的可注射药物载体。还提供了一种制备可注射药物载体的方法，该方法包括：以各种组成合成LDH，并以LDH在体内没有不利影响的水平控制LDH的大小和形状。将LDH分散在溶剂中得到的溶液体内注射。根据该方法，可以合成不影响体内血管的纳米级LDH。如此合成的LDH即使在400mg / kg的浓度下也不会在体内产生不利影响，因此有助于建立能够提高特定药物的输送效率的药物输送系统。

6. 发明申请

WO2005018679A1 A HYBRID OF FREE-BASE AMLODIPINE WITH A LAYERED SILICATE AND A PROCESS FOR PREPARING THE SAME 审中-公开
标题翻译：具有层状硅酸盐的自由基亚麻酸混合物及其制备方法
公开(公告)号：WO2005018679A1
公开(公告)日：2005-03-03
申请号：PCT/KR2004/002115
申请日：2004-08-21
申请人： NANOHYBRID CO., LTD. , CHOY, Jin-Ho , PARK, Tae-Un , HUH, Hyun-Sue
发明人： CHOY, Jin-Ho , PARK, Tae-Un , HUH, Hyun-Sue
IPC分类号： A61K47/48
CPC分类号： A61K9/1635 , A61K9/143
摘要： Provided are a hybrid having a free base amlodipine intercalated in a layered silicate and a process for preparing the same. The hybrid of a free base amlodipine with a layered silicate is easily dispersible in an aqueous solution and has a wide range of elution rate of amlodipine, i.e., 50 - 97 %, and thus, the amlodipine can be controlled to a concentration suitable for absorption by the human body. The hybrid can be useful as a material for an oral amlodipine preparation.
摘要翻译：提供了嵌入层状硅酸盐中的游离碱性氨氯地平的混合物及其制备方法。游离碱性氨氯地平与层状硅酸盐的混合物易于分散在水溶液中，并且具有宽范围的氨氯地平的洗脱速率，即50-97％，因此，氨氯地平可以控制到适于吸收的浓度由人体。杂交体可用作口服氨氯地平制剂的材料。

7. 发明申请

WO2009134042A3 ARBORESCENT OLIGOPEPTIDE-CONTAINING CYCLOTRIPHOSPHAZENE, PREPARATION METHOD THEREOF AND DRUG DELIVERY SYSTEM CONTAINING THE SAME 审中-公开
标题翻译：含ARBORESCENT OLIGEPEPTID的环磷酰胺，其制备方法及含有其的药物递送系统
公开(公告)号：WO2009134042A3
公开(公告)日：2010-02-11
申请号：PCT/KR2009002190
申请日：2009-04-27
申请人： NANOHYBRID CO LTD , SOHN YOUN SOO , JUN YONG JOO , CHOI SUNG MO
发明人： SOHN YOUN SOO , JUN YONG JOO , CHOI SUNG MO
IPC分类号： C07F9/22 , A61K47/24 , C07F9/659
CPC分类号： A61K47/24 , A61K9/0024 , C07F9/65815
摘要： The present invention provides a cyclotriphosphazene of Chemical formula 1 where an arborescent tetrapeptide is introduced to a cyclotriphosphazene together with a hydrophilic polyethyleneglycol, a preparation method thereof and a drug delivery system containing the same. The compound according to the present invention may form a strong hydrogel even at an extremely low concentration, for example, 2w/w% or lower. Moreover, the hydrogel produced from the compound of the present invention is useful as a drug delivery system for sustained release of drug, especially, a protein drug, since such a hydrogel has a biodegradability and a temperature sensitivity, can be prepared with ease, avoids inactivation of protein, and exhibits a sustained release property without a massive release of drugs.
摘要翻译：本发明提供了一种化学式1的环三磷腈，其中将芳族四肽与亲水性聚乙二醇一起引入环三磷腈，其制备方法和含有它们的药物递送系统。根据本发明的化合物即使在极低浓度下也可形成强水凝胶，例如2w / w％以下。此外，由本发明化合物制备的水凝胶可用作药物缓释药物，特别是蛋白质药物的药物递送系统，因为这种水凝胶具有生物降解性和温度敏感性，可以容易地制备，避免了蛋白质失活，并且具有持续释放的性质而没有大量释放药物。

8. 发明申请

WO2008130121A1 TUMOR SELECTIVE AND BIODEGRADABLE CYCLOTRIPHOSPHAZENE-PLATINUM(II) CONJUGATE ANTICANCER AGENT, AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：肿瘤选择性和生物可降解的环磷酰胺铂（II）偶联抗原剂及其制备方法
公开(公告)号：WO2008130121A1
公开(公告)日：2008-10-30
申请号：PCT/KR2008/002068
申请日：2008-04-11
申请人： NANOHYBRID CO., LTD. , SOHN, Youn-Soo , YU, Ji-Young , JUN, Yong-Joo
发明人： SOHN, Youn-Soo , YU, Ji-Young , JUN, Yong-Joo
IPC分类号： C07F17/02
CPC分类号： C07F15/0093
摘要： Disclosed are a novel cyclotriphosphazene-platinum(II) complex conjugate anticancer agent, showing high selectivity to tumor tissues due to the enhanced permeability and retention effect in tumor tissues and a preparation method thereof.
摘要翻译：公开了一种新型的环三磷腈 - 铂（II）络合物共轭抗癌剂，其由于增加肿瘤组织中的通透性和保留作用而显示出对肿瘤组织的高选择性及其制备方法。

9. 发明申请

WO2006088337A1 A BASE FORMING DRUG-LAYERED SILICATE HYBRID CONTAINING BASIC POLYMER AND ITS SYNTHESIS METHOD 审中-公开
标题翻译：一种形成含有层状硅酸盐混合物的基础聚合物及其合成方法
公开(公告)号：WO2006088337A1
公开(公告)日：2006-08-24
申请号：PCT/KR2006/000579
申请日：2006-02-21
申请人： NANOHYBRID CO., LTD. , CHOY, Jin-Ho , PARK, Taeun , LEE, Yoon-joo , KIM, Dong-Youn , PARK, Jin-Kuen
发明人： CHOY, Jin-Ho , PARK, Taeun , LEE, Yoon-joo , KIM, Dong-Youn , PARK, Jin-Kuen
IPC分类号： A61K47/48
CPC分类号： A61K31/4525 , A61K9/1611 , A61K9/1635 , A61K31/137 , A61K31/445
摘要： Provided are a hybrid of a poorly soluble basic drug and a layered silicate, including a water-soluble basic polymer, and a method of preparing the same. The water-soluble basic polymer may be an aminoalkylmethacrylate copolymer (e.g., Eudragit E 100: a copolymer composed of 1: 2:1 ratio of butyl methacrylate, (2,2-dimethylaminoethyl) methacrylate, and methyl methacrylate, Degussa) or polyvinylacetal diethylaminoacetate (AEA). In an oral formulation including the hybrid, a short-term dissolution of the poorly soluble drug can be increased to 90%, thereby increasing drug bioavailability.
摘要翻译：提供了一种难溶性碱性药物和层状硅酸盐，包括水溶性碱性聚合物的混合物及其制备方法。水溶性碱性聚合物可以是甲基丙烯酸氨基烷基酯共聚物（例如，Eudragit E 100：由甲基丙烯酸丁酯，（2,2-二甲基氨基乙基）甲基丙烯酸酯和甲基丙烯酸甲酯，Degussa的比例为1:2:1的聚合物）或聚乙烯醇缩二乙基氨基乙酸酯（AEA）。在包含杂交体的口服制剂中，难溶性药物的短期溶解可以提高到90％，从而提高药物生物利用度。

10. 发明申请

WO2003011233A1 COSMETIC RAW MATERIAL HAVING IMPROVED PROPERTIES AND PROCESSES FOR PREPARING THE SAME 审中-公开
标题翻译：具有改进性能的化妆品原料及其制备方法
公开(公告)号：WO2003011233A1
公开(公告)日：2003-02-13
申请号：PCT/KR2002/001410
申请日：2002-07-26
申请人： NANOHYBRID CO., LTD. , CHOY, Jin-Ho , HAN, Yang-Su , HWANG, Sung-Ho , LEE, Chi-Won
发明人： CHOY, Jin-Ho , HAN, Yang-Su , HWANG, Sung-Ho , LEE, Chi-Won
IPC分类号： A61K7/00
CPC分类号： A61K8/492 , A61K8/02 , A61K8/25 , A61K8/26 , A61K8/27 , A61K8/365 , A61K8/368 , A61K8/498 , A61K8/671 , A61K8/678 , A61K2800/56 , A61Q17/04 , A61Q19/00 , A61Q19/02 , A61Q19/08 , Y10T428/2982 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2998
摘要： The present invention provides a hybrid material comprised of an active component for raw materials for cosmetics and a layered metal hydroxide, showing good stability, low toxicity, low irritation, good sustained release and good dispersibility. The present invention provides a method for preparing the hybrid material, using the coprecipitation method, the ion-exchange method or the adsorption method, depending on properties of the active component for raw materials for cosmetics. The method may further comprise a step of coating the surface of the hybrid material after preparation of the hybrid material. The present invention provides cosmectics comprising the above hybrid material.
摘要翻译：本发明提供由化妆品原料的活性成分和层状金属氢氧化物构成的混合材料，显示出良好的稳定性，低毒性，低刺激性，良好的缓释性和良好的分散性。本发明提供一种使用共沉淀法，离子交换法或吸附法制备杂化材料的方法，这取决于化妆品原料的活性成分的性质。该方法还可以包括在制备混合材料之后涂覆混合材料的表面的步骤。本发明提供了包含上述混合材料的宇宙学。

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