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1. 发明申请

WO2009055313A1 COMPOSITIONS AND METHODS FOR DELIVERY OF GLYCOPEPTIDE ANTIBIOTICS TO MEDICAL DEVICE SURFACES 审中-公开
标题翻译：用于向医疗装置表面递送糖尿病抗生素的组合物和方法
公开(公告)号：WO2009055313A1
公开(公告)日：2009-04-30
申请号：PCT/US2008/080321
申请日：2008-10-17
申请人： AFFINERGY INC. , DARBY, Martyn, K. , SANFORD, Isaac, G. , BENSON, R., Edward , GRON, Hanne , HAMILTON, Paul, T. , NAIR, Shrikumar, A.
发明人： DARBY, Martyn, K. , SANFORD, Isaac, G. , BENSON, R., Edward , GRON, Hanne , HAMILTON, Paul, T. , NAIR, Shrikumar, A.
IPC分类号： A61K38/00
CPC分类号： C07K7/06 , A61L27/227 , A61L27/28 , A61L27/54 , A61L29/048 , A61L29/08 , A61L29/16 , A61L31/047 , A61L31/08 , A61L31/16 , A61L2300/252 , A61L2300/406 , C07K7/08 , C07K14/001 , C07K2319/00
摘要： The presently disclosed subject matter relates to peptides having binding affinity for glycopeptide antibiotics and methods and compositions for delivering glycopeptide antibiotic to the surface of medical devices. The peptide compositions can comprise a peptide having binding affinity for a surface material of a medical device that is coupled to the peptide having binding affinity for glycopeptide antibiotic. Also provided are methods of applying the peptide compositions to a medical device by contacting the peptide compositions with a surface of the medical device. In addition, kits are provided comprising the peptide compositions.
摘要翻译：目前公开的主题涉及对糖肽抗生素具有结合亲和力的肽以及将糖肽抗生素递送到医疗器械表面的方法和组合物。肽组合物可以包含对与对糖肽抗生素具有结合亲和力的肽偶联的医疗器械的表面材料具有结合亲和力的肽。还提供了通过使肽组合物与医疗装置的表面接触来将肽组合物应用于医疗装置的方法。此外，提供了包含肽组合物的试剂盒。

2. 发明申请

WO2012158169A1 METHODS AND COMPOSITIONS FOR TISSUE REPAIR 审中-公开
标题翻译：组织修复的方法和组合
公开(公告)号：WO2012158169A1
公开(公告)日：2012-11-22
申请号：PCT/US2011/037064
申请日：2011-05-18
申请人： AFFINERGY, INC. , DARBY, Martyn, Kerry , JUZUMIENE, Dalia, Isolda , SANFORD, Isaac, Gilliam , CULP, William, David, Jr. , CHEN, Yuchen , HODGES, Jonathan, Allen , KRAJEWSKA, Magdalena , NAIR, Shrikumar, Ambujakshan
发明人： DARBY, Martyn, Kerry , JUZUMIENE, Dalia, Isolda , SANFORD, Isaac, Gilliam , CULP, William, David, Jr. , CHEN, Yuchen , HODGES, Jonathan, Allen , KRAJEWSKA, Magdalena , NAIR, Shrikumar, Ambujakshan
IPC分类号： A61K38/08 , A61K38/10
CPC分类号： A61K38/08 , A61K35/14 , A61K35/28 , A61K38/014 , A61K38/10 , A61L27/54 , A61L2300/25 , A61L2400/18 , A61L2420/02
摘要： Compositions and methods for tissue repair are provided including cell binding peptides and BMP binding peptides. The cell binding peptides bind to one or more of stem cells and fibroblasts. The tissue for repair includes bone, tendon, muscle, connective tissue, ligament, cardiac tissue, bladder tissue, or dermis. Implantable devices for tissue repair are provided to which the cell and/or BMP binding peptides are attached, such as acellular extracellular matrix having attached binding peptide and bone graft material comprising a ceramic.
摘要翻译：提供组织修复的组合物和方法，包括细胞结合肽和BMP结合肽。细胞结合肽结合一种或多种干细胞和成纤维细胞。用于修复的组织包括骨，肌腱，肌肉，结缔组织，韧带，心脏组织，膀胱组织或真皮。提供用于组织修复的可植入装置，细胞和/或BMP结合肽所连接的装置，例如具有附着结合肽的细胞外细胞基质和包含陶瓷的骨移植材料。

3. 发明申请

WO2011063165A9 METHODS AND COMPOSITIONS FOR CAPTURE OF CELLS 审中-公开
标题翻译：用于获取细胞的方法和组合物
公开(公告)号：WO2011063165A9
公开(公告)日：2011-12-08
申请号：PCT/US2010057304
申请日：2010-11-18
申请人： AFFINERGY INC , SANFORD ISAAC GILLIAM , JUZUMIENE DALIA ISOLDA , DARBY MARTYN KERRY , NAIR SHRIKUMAR AMBUJAKSHAN , HODGES JONATHAN ALLEN
发明人： SANFORD ISAAC GILLIAM , JUZUMIENE DALIA ISOLDA , DARBY MARTYN KERRY , NAIR SHRIKUMAR AMBUJAKSHAN , HODGES JONATHAN ALLEN
IPC分类号： C07K14/00
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods are provided for capturing cells. Cell binding peptides are provided that bind to one or more of stem cells, fibroblasts, or endothelial cells. In the methods, a sample containing cells is contacted with a cell binding peptide attached to a substrate, and the cells present in the sample are captured onto the substrate through binding to the cell binding peptide.
摘要翻译：提供组合物和方法用于捕获细胞。提供结合一种或多种干细胞，成纤维细胞或内皮细胞的细胞结合肽。在该方法中，将含有细胞的样品与附着于底物的细胞结合肽接触，通过结合细胞结合肽将存在于样品中的细胞捕获到底物上。

4. 发明申请

WO2009120968A3 COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE 审中-公开
公开(公告)号：WO2009120968A3
公开(公告)日：2009-10-01
申请号：PCT/US2009/038573
申请日：2009-03-27
申请人： AFFINERGY INC. , ORGAMBIDE, Guy , ANWER, Mohmed , NAIR, Shrikumar, A. , HAMILTON, Paul, T.
发明人： ORGAMBIDE, Guy , ANWER, Mohmed , NAIR, Shrikumar, A. , HAMILTON, Paul, T.
IPC分类号： A61L33/00
摘要： The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.

5. 发明申请

WO03011115A3 PEPTIDE-BASED MULTIMERIC TARGETED CONTRAST AGENTS 审中-公开
标题翻译：基于肽的多靶点造影剂
公开(公告)号：WO03011115A3
公开(公告)日：2003-05-22
申请号：PCT/US0224261
申请日：2002-07-30
申请人： EPIX MEDICAL INC , ZHANG ZHAODA , CARAVAN PETER D , MCMURRY THOMAS J , KOLODZIEJ ANDREW , NAIR SHRIKUMAR , AMEDIO JOHN C , DUMAS STEPHANE , WANG XIFANG , SUN WEI-CHUAN , NIVOROZHKIN ALEXANDER L , KOERNER STEFFI K
发明人： ZHANG ZHAODA , CARAVAN PETER D , MCMURRY THOMAS J , KOLODZIEJ ANDREW , NAIR SHRIKUMAR , AMEDIO JOHN C , DUMAS STEPHANE , WANG XIFANG , SUN WEI-CHUAN , NIVOROZHKIN ALEXANDER L , KOERNER STEFFI K
IPC分类号： A61K49/00 , A61K47/48 , A61K49/08 , C07K5/117 , C07K7/06 , C07K7/08 , A61B5/055
CPC分类号： C07K7/08 , A61K47/64 , A61K49/0039 , A61K49/0041 , A61K49/0043 , A61K49/0056 , A61K49/085 , A61K49/122 , A61K49/124 , A61K49/14 , A61K51/088 , C07K1/1077 , C07K7/06
摘要： Peptides and peptide-targeted multimeric contrast agents are described, as well as methods of making and using the contrast agents.
摘要翻译：描述了肽和靶向肽的多聚体造影剂，以及制造和使用造影剂的方法。

6. 发明申请

WO0108712A2 TARGETING MULTIMERIC IMAGING AGENTS THROUGH MULTILOCUS BINDING 审中-公开
标题翻译：通过多重绑定来定位多元成像剂
公开(公告)号：WO0108712A2
公开(公告)日：2001-02-08
申请号：PCT/US0020536
申请日：2000-07-28
申请人： EPIX MEDICAL INC , LAUFFER RANDALL B , MCMURRY THOMAS J , DUMAS STEPHANE , KOLODZIEJ ANDREW , AMEDIO JOHN , CARAVAN PETER , ZHANG ZHAODA , NAIR SHRIKUMAR
发明人： LAUFFER RANDALL B , MCMURRY THOMAS J , DUMAS STEPHANE , KOLODZIEJ ANDREW , AMEDIO JOHN , CARAVAN PETER , ZHANG ZHAODA , NAIR SHRIKUMAR
IPC分类号： A61K49/04 , A61K49/00 , A61K49/06 , A61K49/08 , A61K49/14
CPC分类号： A61K49/0021 , A61K49/0032 , A61K49/0052 , A61K49/085 , A61K49/10 , A61K49/124 , A61K49/128 , A61K49/14
摘要： The present invention relates to contrast agents for diagnostic imaging. In particular, this invention relates to novel multimeric compounds which exhibit improved relaxivity properties upon binding to endogenous proteins or other physiologically relevant sites. The compounds consist of: a) two or more Image Enhancing Moieties (IEMs) (or signal-generating moiety) comprising multiple subunits; b) two or more Target Binding Moieties (TBMs), providing for in vivo localization and multimer rigidification; c) a scaffold framework for attachment of the above moieties; and d) optional linkers for attachment of the IEMs to scaffold. This invention also relates to pharmaceutical compositions comprising these compounds and to methods of using the compounds and compositions for contrast enhancement of diagnostic imaging.
摘要翻译：本发明涉及用于诊断成像的造影剂。特别地，本发明涉及新颖的多聚体化合物，其在结合内源蛋白质或其他生理学相关位点时表现出改善的松弛性能。该化合物包括：a）包含多个亚基的两个或更多个图像增强部分（IEM）（或产生信号的部分）; b）两个或多个目标结合部分（TBM），用于体内定位和多聚体硬化; c）用于连接上述部分的支架框架; 和d）用于将IEM连接到脚手架的可选接头。本发明还涉及包含这些化合物的药物组合物以及使用化合物和组合物用于诊断成像的对比度增强的方法。

7. 发明申请

WO2011063140A3 IMPLANTABLE BONE GRAFT MATERIALS 审中-公开
公开(公告)号：WO2011063140A3
公开(公告)日：2011-05-26
申请号：PCT/US2010/057266
申请日：2010-11-18
申请人： AFFINERGY, INC. , MELICAN, Mora, Carolynne , SANFORD, Isaac, Gilliam , HODGES, Jonathan, Allen , NAIR, Shrikumar, Ambujakshan , DARBY, Martyn, Kerry
发明人： MELICAN, Mora, Carolynne , SANFORD, Isaac, Gilliam , HODGES, Jonathan, Allen , NAIR, Shrikumar, Ambujakshan , DARBY, Martyn, Kerry
IPC分类号： A61F2/00 , A61K38/16
摘要： Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached stem cell binding peptide. The implantable bone graft materials are useful for promoting bone growth in a subject.

8. 发明申请

WO2011063140A2 IMPLANTABLE BONE GRAFT MATERIALS 审中-公开
标题翻译：可植入骨移植材料
公开(公告)号：WO2011063140A2
公开(公告)日：2011-05-26
申请号：PCT/US2010057266
申请日：2010-11-18
申请人： AFFINERGY INC , MELICAN MORA CAROLYNNE , SANFORD ISAAC GILLIAM , HODGES JONATHAN ALLEN , NAIR SHRIKUMAR AMBUJAKSHAN , DARBY MARTYN KERRY
发明人： MELICAN MORA CAROLYNNE , SANFORD ISAAC GILLIAM , HODGES JONATHAN ALLEN , NAIR SHRIKUMAR AMBUJAKSHAN , DARBY MARTYN KERRY
IPC分类号： A61F2/00 , A61K31/74 , A61K33/06 , A61K33/10 , A61K33/42
CPC分类号： A61K47/48992 , A61K9/0024 , A61K38/10 , A61K47/02 , A61K47/42 , A61K47/64 , A61K47/6957 , A61L27/425 , A61L27/427 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2430/02
摘要： Compositions and methods are provided for promoting bone growth. An implantable bone graft material is provided comprising a resorbable ceramic and a resorbable polymer, wherein the polymer comprises a covalently attached stem cell binding peptide. The implantable bone graft materials are useful for promoting bone growth in a subject.
摘要翻译：提供了用于促进骨生长的组合物和方法。提供了包含可再吸收陶瓷和可再吸收聚合物的可植入骨移植材料，其中所述聚合物包含共价连接的干细胞结合肽。可植入的骨移植材料可用于促进受试者的骨生长。

9. 发明申请

WO2009120968A2 COATING COMPOSITIONS HAVING IMPROVED PERFORMANCE 审中-公开
标题翻译：具有改进性能的涂料组合物
公开(公告)号：WO2009120968A2
公开(公告)日：2009-10-01
申请号：PCT/US2009038573
申请日：2009-03-27
申请人： AFFINERGY INC , ORGAMBIDE GUY , ANWER MOHMED , NAIR SHRIKUMAR A , HAMILTON PAUL T
发明人： ORGAMBIDE GUY , ANWER MOHMED , NAIR SHRIKUMAR A , HAMILTON PAUL T
IPC分类号： A61L27/54 , A61K38/16
CPC分类号： A61K38/16 , A61K2300/00
摘要： The presently disclosed subject matter provides compositions comprising a first substrate-binding domain (a peptide or a polymer) having binding affinity for a tissue or a medical device, a second substrate-binding domain having binding affinity for a target molecule, and the target molecule. In some embodiments, the first and second substrate-binding domains are covalently linked. The first and second substrate-binding domains are covalently coupled to at least one hydrophobic interaction tag, negatively charged interaction tag, or positively charged interaction tag. When the substrate-binding domains are combined and coated onto the tissue or medical device, the hydrophobic interaction tags interact with each other and the charged interaction tags interact with the oppositely charged interaction tags or the oppositely charged substrate binding polymers, to form a macromolecular network of non-covalently coupled substrate-binding domains to load the target molecule onto the tissue or medical device.
摘要翻译：目前公开的主题提供了包含对组织或医疗装置具有结合亲和力的第一底物结合结构域（肽或聚合物），对靶分子具有结合亲和力的第二底物结合结构域和靶分子。在一些实施方案中，第一和第二底物结合结构域共价连接。第一和第二底物结合结构域与至少一个疏水相互作用标签，带负电荷的相互作用标签或带正电荷的相互作用标签共价偶联。当底物结合结构域被组合并涂覆在组织或医疗装置上时，疏水性相互作用标签彼此相互作用，并且带电相互作用标签与相反电荷的相互作用标签或相反电荷的底物结合聚合物相互作用以形成大分子网络的非共价偶联的底物结合结构域以将靶分子加载到组织或医疗装置上。

10. 发明申请

WO2009032943A3 METHODS AND COMPOSITIONS FOR DELIVERY OF GROWTH FACTOR TO FIBROUS CONNECTIVE TISSUE 审中-公开
公开(公告)号：WO2009032943A3
公开(公告)日：2009-03-12
申请号：PCT/US2008/075282
申请日：2008-09-04
申请人： AFFINERGY, INC. , BUEHRER, Benjamin, Marcus , HAMILTON, Paul, Theodore , JUZUMIENE, Dalia, Izolda , NAIR, Shrikumar, Ambujakshan , CHEN, Yuchen
发明人： BUEHRER, Benjamin, Marcus , HAMILTON, Paul, Theodore , JUZUMIENE, Dalia, Izolda , NAIR, Shrikumar, Ambujakshan , CHEN, Yuchen
IPC分类号： A61F2/02 , A61K38/04
摘要： The presently disclosed subject matter relates to a peptide composition for non-covalently localizing fibrous connective tissue-inducing growth factor to a surface of an implant, the composition comprising a peptide having binding affinity for a surface material of an implant coupled to a peptide having binding affinity for a fibrous connective tissue-inducing growth factor. Methods are provided for delivering fibrous connective tissue-inducing growth factor GDF-7 in an amount effective to promote fibrous connective tissue repair and fibrous connective tissue formation. Also provided are methods of applying the peptide composition to an implant by contacting the composition with a surface of the implant; and kits comprising the compositions.

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