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1. 发明授权

US08357396B2 Intrabuccally rapidly disintegrating tablet and a production method of the tablets 有权
公开(公告)号：US08357396B2
公开(公告)日：2013-01-22
申请号：US13282271
申请日：2011-10-26
申请人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
发明人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
IPC分类号： A61K9/20
CPC分类号： A61K9/2095 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2027
摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.

2. 发明申请

US20060159759A1 Tablet containing water-absorbing amino acid 审中-公开
标题翻译：片剂含吸水氨基酸
公开(公告)号：US20060159759A1
公开(公告)日：2006-07-20
申请号：US10546439
申请日：2004-03-05
申请人： Motohiro Ohta , Kiyoshi Morimoto , Muneko Kuboyama , Hirokazu Yoshimoto , Hideo Kawabe
发明人： Motohiro Ohta , Kiyoshi Morimoto , Muneko Kuboyama , Hirokazu Yoshimoto , Hideo Kawabe
IPC分类号： A61K9/24 , A61K31/198
CPC分类号： A61K31/401 , A23L33/175 , A23L33/30 , A61K9/0058 , A61K9/1617 , A61K31/198
摘要： The present invention provides a tablet which comprises a water-absorbent amino acid and a coating agent which is soluble in ethanol and hardly soluble in water. The tablet of the present invention is useful as amino acid preparations for sports, dieting, or pharmaceuticals, and also useful as nutritional supplements, pharmaceuticals and the like in order to supply nutritious of amino acids effective to human health maintenance, or enhance physiological activity of human tissues.
摘要翻译：本发明提供一种片剂，其包含吸水性氨基酸和可溶于乙醇且几乎不溶于水的包衣剂。本发明的片剂可用作运动，节食或药物的氨基酸制剂，并且还可用作营养补充剂，药物等，以提供对人体健康维持有效的氨基酸营养素，或增强生理活性人体组织。

3. 发明申请

US20050147666A1 Tablets quickly disintegrating in oral cavity 审中-公开
标题翻译：片剂在口腔内迅速崩解
公开(公告)号：US20050147666A1
公开(公告)日：2005-07-07
申请号：US10506349
申请日：2003-03-06
申请人： Motohiro Ohta , Yuji Iwase , Naohiro Saito , Kiyoshi Morimoto
发明人： Motohiro Ohta , Yuji Iwase , Naohiro Saito , Kiyoshi Morimoto
IPC分类号： A61K9/00 , A61K9/20 , A61K31/22 , A61P3/06
CPC分类号： A61K31/22 , A61K9/0056 , A61K9/2018
摘要： According to the present invention, provided are an intraorally rapidly disintegrable tablet which comprises D-mannitol and a disintegrator in addition to fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent; a process for producing an intraorally rapidly disintegrable tablet which comprises mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, and subjecting the material to compression molding; and an intraorally rapidly disintegrable tablet which is prepared by mixing D-mannitol and a disintegrator with fine granules prepared by granulating a mixture of a water-soluble pharmacologically active ingredient and an adsorbent to yield a material for compression molding, subjecting the material to compression molding.
摘要翻译：根据本发明，提供了除了通过将水溶性药理活性成分和吸附剂的混合物制粒而制备的细颗粒以外还含有D-甘露糖醇和崩解剂的口腔内快速崩解片剂，一种生产口腔内快速崩解片剂的方法，其包括将D-甘露糖醇和崩解剂与通过将水溶性药理学活性成分和吸附剂的混合物制粒而制备的细粒混合，得到压缩成型材料，压缩成型; 以及通过将D-甘露糖醇和崩解剂与通过将水溶性药理活性成分和吸附剂的混合物制粒而制备的细颗粒混合而制备的口腔内快速崩解片剂，得到压缩成型材料，将其压缩成型。

4. 发明授权

US06432534B1 Process for the production of tablets and tablets 有权
标题翻译：生产片剂和片剂的方法
公开(公告)号：US06432534B1
公开(公告)日：2002-08-13
申请号：US09555660
申请日：2000-09-14
申请人： Eiji Hayakawa , Motohiro Ohta , Hiroyuki Morimoto , Kiyoshi Morimoto , Yasushi Watanabe , Kunio Ito , Sanji Tokuno
发明人： Eiji Hayakawa , Motohiro Ohta , Hiroyuki Morimoto , Kiyoshi Morimoto , Yasushi Watanabe , Kunio Ito , Sanji Tokuno
IPC分类号： B32B516
CPC分类号： A61J3/10 , B30B11/08 , B30B15/0011 , Y10T428/2991
摘要： A method for producing tablet including active component, diluting agent, and lubricant by means of a tabletting machine provided with punches and dies, comprising steps of; preparing molding material including active component, diluting anent, and a part of lubricant; applying most of the remaining amount of the lubricant on surfaces of the punches and a surface of the die; and tabletting the molding material by means of the punches on which surfaces the lubricant is applied and the die on which surface the lubricant is applied
摘要翻译：一种通过设置有冲头和模具的压片机生产包含活性成分，稀释剂和润滑剂的片剂的方法，包括以下步骤：制备包括活性组分，稀释剂和润滑剂的一部分的成型材料; 将大部分剩余量的润滑剂施加到冲头的表面和模具的表面上; 并通过施加润滑剂的表面的冲头和施加润滑剂的表面的模具对成型材料进行压片

5. 发明授权

US5565212A Process for producing compositions for ruminants 失效
标题翻译：制备反刍动物组合物的方法
公开(公告)号：US5565212A
公开(公告)日：1996-10-15
申请号：US405458
申请日：1995-03-16
申请人： Yorozu Yokomori , Toshikazu Murayama , Tomoaki Masada , Motohiro Ohta , Masaki Azuma , Yoshio Yumiba
发明人： Yorozu Yokomori , Toshikazu Murayama , Tomoaki Masada , Motohiro Ohta , Masaki Azuma , Yoshio Yumiba
IPC分类号： A23K1/16 , A23K1/00 , A23K1/18 , A61K9/28 , A61K9/50
CPC分类号： A61K9/5036 , A23K40/35 , A61K9/501 , A61K9/5015 , A61K9/5026 , A61K9/5042 , A61K9/5047
摘要： Disclosed is a process for producing a composition for ruminants, which is characterized in that a nucleus containing a physiologically active substance is coated with a coating material prepared by suspending in water (i) an emulsion comprising water and at least one hydrophobic substance hardly soluble in water and (ii) a slurry containing at least one polymer soluble in water of pH 5.0 or below and insoluble in water of pH over 5.0 In the process, an aqueous suspension is used for coating instead of a meterial dissolved in an organic solvent.
摘要翻译：本发明公开了一种反刍动物用组合物的制造方法，其特征在于，含有生理活性物质的细胞核涂覆有通过在水中悬浮而制备的涂料（i）包含水和至少一种难溶于水和（ii）含有至少一种可溶于pH 5.0或以下的水的聚合物并且不溶于pH超过5.0的水的浆料。在该方法中，使用水性悬浮液代替溶解在有机溶剂中的水溶液。

6. 发明授权

US5080917A Oral compositions for ruminants 失效
标题翻译：口服组合物
公开(公告)号：US5080917A
公开(公告)日：1992-01-14
申请号：US333170
申请日：1989-04-03
申请人： Kunio Itoh , Kiyoshi Sugiyama , Motohiro Ohta
发明人： Kunio Itoh , Kiyoshi Sugiyama , Motohiro Ohta
IPC分类号： A23K1/00 , A61K9/50 , A61K9/52
CPC分类号： A61K9/5047 , A23K40/35 , A61K9/5015 , A61K9/5026 , Y10S426/807
摘要： A coating agent for delaying the release of a physiologically active substance to be administered per os to ruminants, said coating comprising a veterinary acceptable water-soluble, synthetic high molecular compound and ethylcellulose, said coating agent being stable in the first stomach or rumen of ruminants and capable of being effectively disintegrated for subsequent absorption in the 4th stomach of ruminants, characterized in that said coating agent further comprises at least one substance which is miscible with both of said high molecular weight compound and ethylcellulose and is insoluble in water.Said coating agent forms a coat which protects the active substance from degradation in the first stomach of a ruminant at a pH of about 5.5 and rapidly breaks down in the 4th stomach at a pH of about 3, thereby releasing the active ingredient for absorption by the animal.The coating agent and the actives coated therewith and their preparation are described.

7. 发明申请

US20120135076A1 INTRABUCCALLY RAPIDLY DISINTEGRATING TABLET AND A PRODUCTION METHOD OF THE TABLETS 有权
标题翻译：快速消毒片和片剂的生产方法
公开(公告)号：US20120135076A1
公开(公告)日：2012-05-31
申请号：US13282271
申请日：2011-10-26
申请人： Motohiro OHTA , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
发明人： Motohiro OHTA , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
IPC分类号： A61K9/20 , B02C23/00
CPC分类号： A61K9/2095 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2027
摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.
摘要翻译：通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。

8. 发明授权

US08071128B2 Intrabuccally rapidly disintegrating tablet and a production method of the tablets 有权
标题翻译：片剂快速崩解片剂及其制备方法
公开(公告)号：US08071128B2
公开(公告)日：2011-12-06
申请号：US10356641
申请日：2003-06-20
申请人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
发明人： Motohiro Ohta , Eiji Hayakawa , Kunio Ito , Sanji Tokuno , Kiyoshi Morimoto , Yasushi Watanabe
IPC分类号： A61K9/20
CPC分类号： A61K9/2095 , A61J3/10 , A61K9/0056 , A61K9/2018 , A61K9/2027
摘要： An intrabuccally rapidly disintegrating tablet which is manufactured by a simple method, has an enough practical hardness and is rapidly disintegrated in the buccal cavity and its production method. The intrabuccally rapidly disintegrating tablet is produced by growing a powder material into a granulated material with a fixed particle diameter, the powder material including a sugar alcohol or a saccharide as main ingredient, each of which is first particle having an average particle diameter of not more than 30 μm, by mixing thus obtained granulated material with an active ingredient and a disintegrant, and by compressing the mixture into a predetermined shape.
摘要翻译：通过简单的方法制造的口腔内快速崩解片剂具有足够的实用硬度并且在口腔中快速崩解及其制备方法。通过将粉末材料生长成具有固定粒径的造粒材料，粉末材料包括作为主要成分的糖醇或糖类的粉末材料，其平均粒径不大于通过将由此获得的造粒材料与活性成分和崩解剂混合，并将混合物压缩成预定形状。

9. 发明申请

US20060039967A1 Amino acid-containing chewable 审中-公开
标题翻译：含氨基酸的咀嚼物
公开(公告)号：US20060039967A1
公开(公告)日：2006-02-23
申请号：US10522946
申请日：2003-08-08
申请人： Motohiro Ohta , Kiyoshi Morimoto , Muneko Kuboyama , Hirokazu Yoshimoto , Hideo Kawabe , Takeshi Shibasaki
发明人： Motohiro Ohta , Kiyoshi Morimoto , Muneko Kuboyama , Hirokazu Yoshimoto , Hideo Kawabe , Takeshi Shibasaki
IPC分类号： A61K9/20 , A61K31/198
CPC分类号： A61K9/0056 , A23L33/175 , A61K9/2018 , A61K9/2054 , A61K31/198
摘要： The present invention provides a chewable tablet having an improved oral disintegration property, which is easily chewed and capable of containing a large amount of an amino acid depending on need, more specifically, a chewable tablet comprising an amino acid and an oral disintegration promoting agent.
摘要翻译：本发明提供具有改善的口腔崩解性的咀嚼片，其易于咀嚼并且能够根据需要含有大量的氨基酸，更具体地说，包含氨基酸和口腔崩解促进剂的咀嚼片。

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