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1. 发明公开

EP1743027A1 MUTANT PNEUMOLYSIN PROTEINS 失效转让
标题翻译： MUTANTE PNEUMOLYSIN-PROTEINE
公开(公告)号：EP1743027A1
公开(公告)日：2007-01-17
申请号：EP05742528.2
申请日：2005-05-09
申请人： Kirkham, Lea-Ann , Mitchell, Timothy, John
发明人： Kirkham, Lea-Ann , Mitchell, Timothy, John
IPC分类号： C12N15/31 , C07K14/315 , A61K39/09 , C12N5/10
CPC分类号： C07K14/3156 , A61K39/00 , C07K16/1275 , C07K2317/92
摘要： The invention relates to immunogenic compositions comprising mutant Streptococcus pneumoniae pneumolysin proteins. The invention further relates to such proteins and nucleic acids encoding these proteins. In particular embodiments, the invention is directed to an isolated mutant pneumolysin (PLY) protein, wherein the mutant PLY protein differs from the wild type PLY protein by the presence of a mutation within the region of amino acids 144 to 161 of the wild type sequence, such that the toxicity of the mutant is reduced relative to that of the wild-type protein. In particular embodiments, the mutant PLY protein differs from the wild type protein by the substitution or deletion of amino acids within this region, including the deletion of two adjacent amino acids within the region of amino acids 144 to 151 of the wild type sequence.

2. 发明公开

EP2032158A2 ADJUVANT COMPOSITIONS 审中-公开
标题翻译：佐剂组合物
公开(公告)号：EP2032158A2
公开(公告)日：2009-03-11
申请号：EP07733246.8
申请日：2007-06-15
申请人： Mitchell, Timothy John , Kirkham, Lea-Ann , Cowan, Graeme James , Douce, Gillian
发明人： Mitchell, Timothy John , Kirkham, Lea-Ann , Cowan, Graeme James , Douce, Gillian
IPC分类号： A61K39/00 , A61K48/00 , A61K39/09
CPC分类号： A61K39/00 , A61K39/0001 , A61K39/092 , A61K2039/53 , A61K2039/57 , A61K2039/6068
摘要： The invention relates to the use of bacterial cytolysin proteins, such as pneumolysin, as adjuvants for stimulating or enhancing immune responses against co-administered target antigens. Desirably, the target antigen is provided as a fusion protein with the cytolysin. The inventors have found that cytolysins may be particularly effective for stimulation of mucosal immune responses against the target antigen.

3. 发明专利

ES2427978T3 Proteínas mutantes de neumolisina 未知
公开(公告)号：ES2427978T3
公开(公告)日：2013-11-05
申请号：ES05742528
申请日：2005-05-09
申请人： KIRKHAM LEA ANN , MITCHELL TIMOTHY JOHN , UNIV GLASGOW
发明人： KIRKHAM LEA-ANN , MITCHELL TIMOTHY JOHN
IPC分类号： C12N15/31 , A61K39/00 , A61K39/09 , C07K14/315 , C07K16/12 , C12N5/10
摘要： Una proteína neumolisina (PLY) mutante aislada, en la que la proteína PLY mutante tiene al menos el 80% de identidad de secuencia con la proteína PLY nativa que tiene la secuencia mostrada en la figura 1 y difiere de dicha proteína PLY nativa en la presencia de una deleción de uno o más aminoácidos dentro de la región de aminoácidos 144 a 151 de la secuencia nativa, de modo que la toxicidad del mutante se reduce en relación con la proteína nativa.

4. 发明专利

CA2566344A1 MUTANT PNEUMOLYSIN PROTEINS 未知
公开(公告)号：CA2566344A1
公开(公告)日：2005-11-17
申请号：CA2566344
申请日：2005-05-09
申请人： MITCHELL TIMOTHY JOHN , KIRKHAM LEA-ANN
发明人： MITCHELL TIMOTHY JOHN , KIRKHAM LEA-ANN
IPC分类号： C12N15/31 , A61K39/00 , A61K39/09 , C07K14/315 , C07K16/12 , C12N5/10
摘要： The invention relates to immunogenic compositions comprising mutant Streptococcus pneumoniae pneumolysin proteins. The invention further relates to such proteins and nucleic acids encoding these proteins. In particular embodiments, the invention is directed to an isolated mutant pneumolysin (PLY) protein, wherein the mutant PLY protein differs from the wild-type PLY protein of SEQ ID NO:1 presence of a mutation within the region of amino acids 144 to 161 of the wild type such that the toxicity of the mutant is reduced relative to that of the wild-type protein. In particular embodiments, the mutant PLY protein differs from the wild-type protein by the substitution or deletion of amino acids including the deletion of two adjacent amino acids within the region of amino acids 144 to 151 of the wild-type sequence.

6. 发明专利

CA2566344C MUTANT PNEUMOLYSIN PROTEINS 未知
公开(公告)号：CA2566344C
公开(公告)日：2015-07-07
申请号：CA2566344
申请日：2005-05-09
申请人： KIRKHAM LEA-ANN , MITCHELL TIMOTHY JOHN
发明人： KIRKHAM LEA-ANN , MITCHELL TIMOTHY JOHN
IPC分类号： C12N15/31 , A61K39/00 , A61K39/09 , C07K14/315 , C07K16/12 , C12N5/10
摘要： The invention relates to immunogenic compositions comprising mutant Streptococcus pneumoniae pneumolysin proteins. The invention further relates to such proteins and nucleic acids encoding these proteins. In particular embodiments, the invention is directed to an isolated mutant pneumolysin (PLY) protein, wherein the mutant PLY protein differs from the wild type PLY protein by the presence of a mutation within the region of amino acids 144 to 161 of the wild type sequence, such that the toxicity of the mutant is reduced relative to that of the wild-type protein. In particular embodiments, the mutant PLY protein differs from the wild type protein by the substitution or deletion of amino acids within this region, including the deletion of two adjacent amino acids within the region of amino acids 144 to 151 of the wild type sequence.

7. 发明专利

HU900433D0 PNEUMOLYSIN MUTANTS 未知
公开(公告)号：HU900433D0
公开(公告)日：1991-08-28
申请号：HU43389
申请日：1989-12-15
申请人： PATON JAMES CLELAND , HANSMAN DAVID JOHN , BOULNOIS GRAHAM JOHN , ANDREW PETER WILLIAM , MITCHELL TIMOTHY JOHN , WALKER JOHN ARTHUR
发明人： PATON JAMES CLELAND , HANSMAN DAVID JOHN , BOULNOIS GRAHAM JOHN , ANDREW PETER WILLIAM , MITCHELL TIMOTHY JOHN , WALKER JOHN ARTHUR

8. 发明申请

WO2007144647A3 ADJUVANT COMPOSITIONS 审中-公开
标题翻译：补充剂组合物
公开(公告)号：WO2007144647A3
公开(公告)日：2009-02-05
申请号：PCT/GB2007002242
申请日：2007-06-15
申请人： MITCHELL TIMOTHY JOHN , KIRKHAM LEA-ANN , COWAN GRAEME JAMES , DOUCE GILLIAN
发明人： MITCHELL TIMOTHY JOHN , KIRKHAM LEA-ANN , COWAN GRAEME JAMES , DOUCE GILLIAN
IPC分类号： A61K39/00 , A61K39/09 , A61K48/00
CPC分类号： A61K39/00 , A61K39/0001 , A61K39/092 , A61K2039/53 , A61K2039/57 , A61K2039/6068
摘要： The invention relates to the use of bacterial cytolysin proteins, such as pneumolysin, as adjuvants for stimulating or enhancing immune responses against co-administered target antigens. Desirably, the target antigen is provided as a fusion protein with the cytolysin. The inventors have found that cytolysins may be particularly effective for stimulation of mucosal immune responses against the target antigen.
摘要翻译：本发明涉及细菌细胞溶解素蛋白（例如气溶炎蛋白）作为辅助剂用于刺激或增强针对共同施用的靶抗原的免疫应答的用途。期望地，靶抗原作为与细胞溶解素的融合蛋白提供。本发明人已经发现细胞溶蛋白可能对刺激针对靶抗原的粘膜免疫应答特别有效。

9. 发明申请

WO2005108419A1 MUTANT CHOLESTEROL-BINDING CYTOLYSIN PROTEINS 审中-公开
公开(公告)号：WO2005108419A1
公开(公告)日：2005-11-17
申请号：PCT/GB2005/001774
申请日：2005-05-09
申请人： KIRKHAM, Lea-Ann , MITCHELL, Timothy, John , COWAN, Graeme, James, Macfarlane
发明人： KIRKHAM, Lea-Ann , MITCHELL, Timothy, John , COWAN, Graeme, James, Macfarlane
IPC分类号： C07K14/195
CPC分类号： C07K14/3156 , A61K2039/6087
摘要： The invention relates to immunogenic compositions comprising mutant cytolysin proteins. The invention further relates to such proteins and nucleic acids encoding these proteins. In particular embodiments, the invention is directed to an isolated mutant cytolysin protein, wherein the mutant protein differs from the wild type protein by the deletion of one or more amino acids within the region corresponding to amino acids 144 to 161 of the wild type pneumolysin sequence. In certain embodiments, the mutant protein differs from the wild type protein by the deletion of one or more amino acids within the region corresponding to amino acids 144 to 151 of the wild type pneumolysin sequence. In particular embodiments, the mutant protein differs from the wild type protein by the deletion of two adjacent amino acids within the region corresponding to amino acids 144 to 151 of the wild type pneumolysin sequence.
摘要翻译：本发明涉及包含突变细胞溶解素蛋白质的免疫原性组合物。本发明进一步涉及这些蛋白质和编码这些蛋白质的核酸。在具体实施方案中，本发明涉及分离的突变细胞溶蛋白蛋白，其中突变蛋白与野生型肺炎溶血素序列的氨基酸144至161的区域中缺失一个或多个氨基酸不同于野生型蛋白质。在某些实施方案中，突变蛋白与野生型肺炎溶菌素序列的氨基酸144至151对应的区域中的一个或多个氨基酸的缺失与野生型蛋白质不同。在具体实施方案中，突变蛋白与野生型肺炎溶菌素序列的氨基酸144至151的区域内的两个相邻氨基酸的缺失不同于野生型蛋白质。

10. 发明申请

WO1990006951A1 PNEUMOLYSIN MUTANTS AND PNEUMOCOCCAL VACCINES MADE THEREFROM 审中-公开
标题翻译： PNEUMOLYSIN MUTANTS和PNEUMOCOCCAL VACCINES制作
公开(公告)号：WO1990006951A1
公开(公告)日：1990-06-28
申请号：PCT/AU1989000539
申请日：1989-12-15
申请人： PATON, James, Cleland , HANSMAN, David, John , BOULNOIS, Graham, John , ANDREW, Peter, William , MITCHELL, Timothy, John , WALKER, John, Arthur
IPC分类号： C07K13/00
CPC分类号： C07K14/3156 , A61K39/00 , Y02A50/472
摘要： Mutants of pneumolysin that are non-toxic by reason of amino acid substitutions have been constructed. These mutants elicit an immune response in animals that is reactive to wild-type pneumolysin. The invention also encompasses vaccines for humans based on these mutants, including vaccines comprising conjugates with pneumococcal capsular polysaccharides.
摘要翻译：已经构建了因氨基酸取代而无毒的肺炎球菌突变体。这些突变体在与野生型肺炎溶菌素反应的动物中引起免疫应答。本发明还包括基于这些突变体的人的疫苗，包括包含与肺炎球菌荚膜多糖的缀合物的疫苗。

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