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1. 发明申请

WO2005108419A1 MUTANT CHOLESTEROL-BINDING CYTOLYSIN PROTEINS 审中-公开
公开(公告)号：WO2005108419A1
公开(公告)日：2005-11-17
申请号：PCT/GB2005/001774
申请日：2005-05-09
申请人： KIRKHAM, Lea-Ann , MITCHELL, Timothy, John , COWAN, Graeme, James, Macfarlane
发明人： KIRKHAM, Lea-Ann , MITCHELL, Timothy, John , COWAN, Graeme, James, Macfarlane
IPC分类号： C07K14/195
CPC分类号： C07K14/3156 , A61K2039/6087
摘要： The invention relates to immunogenic compositions comprising mutant cytolysin proteins. The invention further relates to such proteins and nucleic acids encoding these proteins. In particular embodiments, the invention is directed to an isolated mutant cytolysin protein, wherein the mutant protein differs from the wild type protein by the deletion of one or more amino acids within the region corresponding to amino acids 144 to 161 of the wild type pneumolysin sequence. In certain embodiments, the mutant protein differs from the wild type protein by the deletion of one or more amino acids within the region corresponding to amino acids 144 to 151 of the wild type pneumolysin sequence. In particular embodiments, the mutant protein differs from the wild type protein by the deletion of two adjacent amino acids within the region corresponding to amino acids 144 to 151 of the wild type pneumolysin sequence.
摘要翻译：本发明涉及包含突变细胞溶解素蛋白质的免疫原性组合物。本发明进一步涉及这些蛋白质和编码这些蛋白质的核酸。在具体实施方案中，本发明涉及分离的突变细胞溶蛋白蛋白，其中突变蛋白与野生型肺炎溶血素序列的氨基酸144至161的区域中缺失一个或多个氨基酸不同于野生型蛋白质。在某些实施方案中，突变蛋白与野生型肺炎溶菌素序列的氨基酸144至151对应的区域中的一个或多个氨基酸的缺失与野生型蛋白质不同。在具体实施方案中，突变蛋白与野生型肺炎溶菌素序列的氨基酸144至151的区域内的两个相邻氨基酸的缺失不同于野生型蛋白质。

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