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1. 发明授权

US06566545B2 Menthol derivatives and process for preparing the same 有权
标题翻译：薄荷醇衍生物及其制备方法
公开(公告)号：US06566545B2
公开(公告)日：2003-05-20
申请号：US10226129
申请日：2002-08-23
申请人： Jae Won Yoo , Duck Hee Kim , Seong Joon Moon , Min Soo Noh , Soo Hyun Kim , Su Sun An , Jin Seon Lee
发明人： Jae Won Yoo , Duck Hee Kim , Seong Joon Moon , Min Soo Noh , Soo Hyun Kim , Su Sun An , Jin Seon Lee
IPC分类号： C07F902
CPC分类号： C07F9/117 , A61K8/55 , A61K2800/75 , A61Q17/00 , A61Q19/00 , A61Q19/08
摘要： The present invention provides a menthol derivative represented by the following Formula 1 and a method for preparing the menthol derivative. The menthol derivative represented by the Formula 1 is prepared by reacting menthol and phosphorous oxychloride with an equivalence ratio of 1:1˜1.3 in an organic solvent in the presence of organic base to obtain dichloro[5-methyl-2(mehtylethyl)cylclohexyloxy]phosphino-1-one; and reacting above obtained dichloro[5-methyl-2(mehtylethyl)cylclohexyloxy]phosphino-1-one with 3-amino propanol in the organic solvent in the presence of the organic; then hydrolyzing and crystallizing the product with polar organic solvent.
摘要翻译：本发明提供由下式1表示的薄荷醇衍生物和制备薄荷醇衍生物的方法。式1表示的薄荷醇衍生物是通过在有机碱存在下，在有机溶剂中，使薄荷醇和三氯氧化磷与当量比为1:1-1.3的反应制备，得到二氯[5-甲基-2-（甲基乙基）环己基氧基] 膦基-1-酮; 并在有机溶剂存在下使上述得到的二氯[5-甲基-2-（甲基乙基）环己基氧基]膦基-1-酮与3-氨基丙醇在有机溶剂中反应; 然后用极性有机溶剂水解和结晶产物。

2. 发明授权

US5707892A Method for fabricating a semiconductor laser diode 失效
标题翻译：制造半导体激光二极管的方法
公开(公告)号：US5707892A
公开(公告)日：1998-01-13
申请号：US560714
申请日：1995-11-20
申请人： Tae Kyung Yoo , Meoung Whan Cho , Ju Ok Seo , Shi Jong Leem , Min Soo Noh
发明人： Tae Kyung Yoo , Meoung Whan Cho , Ju Ok Seo , Shi Jong Leem , Min Soo Noh
IPC分类号： H01S5/00 , H01S5/10 , H01S5/16 , H01S5/22 , H01S5/227 , H01L21/20
CPC分类号： H01S5/227 , H01S5/164 , H01S2304/06 , H01S5/22 , H01S5/2275
摘要： A method for fabricating a semiconductor laser diode includes the steps of forming a double hetero structured semiconductor layer on a substrate, forming a dielectric layer on the double hetero structured semiconductor layer, selectively etching the dielectric layer to expose a portion of the double hetero structured semiconductor layer, selectively removing the exposed semiconductor layer using the dielectric layer as a mask by liquid phase etching, and re growing a semiconductor layer on the etched portion by liquid phase epitaxy.
摘要翻译：一种制造半导体激光二极管的方法包括以下步骤：在衬底上形成双异质结构半导体层，在双异质结构半导体层上形成电介质层，选择性地蚀刻电介质层以暴露双异质结构半导体的一部分层，通过液相蚀刻使用电介质层作为掩模选择性地去除暴露的半导体层，并且通过液相外延再生长在蚀刻部分上的半导体层。

3. 发明申请

US20130236904A1 METHOD FOR SCREENING FOR MATERIALS FOR PROMOTING THE DIFFERENTIATION OF SKIN CELLS 审中-公开
标题翻译：筛选用于促进皮肤细胞分化的材料的方法
公开(公告)号：US20130236904A1
公开(公告)日：2013-09-12
申请号：US13988270
申请日：2011-11-18
申请人： Hyun Choi , Yeun Kyung Kim , Seung Ha Yang , Tae Ryong Lee , Min Soo Noh , Dong Wook Shin
发明人： Hyun Choi , Yeun Kyung Kim , Seung Ha Yang , Tae Ryong Lee , Min Soo Noh , Dong Wook Shin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158
摘要： The present invention relates to a method for screening for materials for promoting the differentiation of skin cells, comprising: a step of treating skin cells with a test material; and a step of checking the relative degree of the expression of the DUOX 1 gene in the skin cells treated with the test material in the previous step. The present invention also relates to a kit for screening for materials for promoting the differentiation of skin cells, comprising a device for checking the relative degree of expression of the DUOX 1 gene in skin cells. The present invention also relates to a composition which contains, as an active ingredient, a material for increasing the expression of the DUOX 1 gene to promote the differentiation of skin cells, moisturize the skin, improve skin barrier function, or alleviate or treat symptoms of atopic dermatitis.
摘要翻译：本发明涉及一种用于筛选促进皮肤细胞分化的材料的方法，包括：用试验材料处理皮肤细胞的步骤; 以及检查在前一步骤中用试验材料处理的皮肤细胞中DUOX1基因表达的相对程度的步骤。本发明还涉及用于筛选用于促进皮肤细胞分化的材料的试剂盒，其包括用于检查皮肤细胞中DUOX1基因的相对表达程度的装置。本发明还涉及含有作为活性成分的用于增加DUOX1基因表达以促进皮肤细胞分化，增湿皮肤，改善皮肤屏障功能或缓解或治疗特应性皮炎。

4. 发明授权

US07356235B2 Light guide plate for surface light-emitting device and method of manufacturing the same 失效
标题翻译：表面发光装置用导光板及其制造方法
公开(公告)号：US07356235B2
公开(公告)日：2008-04-08
申请号：US11159206
申请日：2005-06-23
申请人： Chul Chae Choi , Min Soo Noh , Hyun Ho Oh , Chan Ho Park
发明人： Chul Chae Choi , Min Soo Noh , Hyun Ho Oh , Chan Ho Park
IPC分类号： G02B6/10
CPC分类号： G02B6/0038 , G02B6/005 , G02B6/0065
摘要： A light guide plate for a surface light-emitting device and a method of manufacturing the same are disclosed wherein the light guide plate is constructed in the form of an optical waveguide including an upper cladding film, core films formed with V-cut grooves, and a lower cladding film, so that since the upper and lower cladding films with a relatively low refractive index are respectively located on upper and lower surfaces of the core films, external foreign substances cannot penetrate into the core films, and the core films are not brought into contact with other components, whereby optical transmission properties are not changed and brightness can be also enhanced, and since the V-cut grooves are formed or both the V-cut grooves and optical waveguides are formed at the same time by means of a simple hot embossing process, the manufacturing costs can be saved.
摘要翻译：公开了一种用于表面发光器件的导光板及其制造方法，其中导光板被构造为包括上包层膜的光波导，形成有V切槽的芯膜，以及下包层膜，因为折射率相对较低的上包层和下包层膜分别位于芯膜的上表面和下表面上，外部异物不能渗透到芯膜中，并且芯膜不被带入与其他部件接触，由此光传输性能不变，并且还可以提高亮度，并且由于形成V切槽，或者通过简单的方式同时形成V形槽和光波导热压花工艺，可节省制造成本。

5. 发明授权

US06340694B1 Diarylbenzopyran derivatives as cyclooxygenase-2 inhibitors 有权
标题翻译：二芳基苯并吡喃衍生物作为环加氧酶-2抑制剂
公开(公告)号：US06340694B1
公开(公告)日：2002-01-22
申请号：US09763146
申请日：2001-02-20
申请人： Yung Hyup Joo , Chang Hoon Lee , Min-Soo Noh , Jun-Yong Ha , Jin Kyu Choi , Kyung Min Lim , Jin Kwan Kim , Seon-Hwa Kang
发明人： Yung Hyup Joo , Chang Hoon Lee , Min-Soo Noh , Jun-Yong Ha , Jin Kyu Choi , Kyung Min Lim , Jin Kwan Kim , Seon-Hwa Kang
IPC分类号： A61K314433
CPC分类号： C07D405/04 , C07D311/26 , C07D409/04
摘要： The diarylbenzopyran derivatives represented by formula I, and the pharmaceutically acceptable salts thereof, are disclosed. The composition comprising the compound of formula I, or a pharmaceutically acceptable salt thereof, shows an excellent selective inhibition of cyclooxygenase-2.
摘要翻译：公开了由式I表示的二芳基苯并吡喃衍生物及其药学上可接受的盐。包含式I化合物或其药学上可接受的盐的组合物显示对环氧合酶-2的优异的选择性抑制。

6. 发明申请

US20110224291A1 SKIN EXTERNAL COMPOSITION FOR INHIBITING EPIDERMAL HYPERPROLIFERATION AND ALLEVIATING INFLAMMATORY SKIN DISEASES CONTAINING ORTHODIHYDROXYISOFLAVONE DERIVATIVES 审中-公开
标题翻译：皮肤外用组合物，用于抑制皮下超高效和清除含有异羟肟酸衍生物的炎症性皮肤病
公开(公告)号：US20110224291A1
公开(公告)日：2011-09-15
申请号：US13129645
申请日：2009-11-17
申请人： Jun Seong Park , Hye Yoon Park , Dong Hyun Kim , Sang Min Lee , Dong Wook Shin , Shin Hyoung Kim , Min Soo Noh , Duck Hee Kim , Han Kon Kim
发明人： Jun Seong Park , Hye Yoon Park , Dong Hyun Kim , Sang Min Lee , Dong Wook Shin , Shin Hyoung Kim , Min Soo Noh , Duck Hee Kim , Han Kon Kim
IPC分类号： A61K31/352 , C07D311/36 , A61P17/00
CPC分类号： A61K31/352 , A61K9/0014 , A61K31/366
摘要： Disclosed herein is a skin external composition for inhibiting epidermal hyperproliferation and alleviating inflammatory skin diseases, which contains ortho-dihydroxyisoflavone derivatives as an active ingredient. Specifically, the skin external external composition contains the ortho-dihydroxyisoflavone derivatives, 4′,6,7-trihydroxyisoflavone, 3′,4′,7-trihydroxyisoflavone or a mixture thereof, and thus increases the expression of DKK3 protein and FZD1 protein, which appropriately control Wnt signaling, thereby inhibiting epidermal hyperproliferation and alleviating inflammatory skin diseases caused by epidermal hyperproliferation.
摘要翻译：本文公开了一种皮肤外用组合物，其用于抑制表皮过度增殖并减轻含有邻二羟基异黄酮衍生物作为活性成分的炎性皮肤病。具体地说，皮肤外用组合物含有邻二羟基异黄酮衍生物，4'，6,7-三羟基异黄酮，3'，4'，7-三羟基异黄酮或其混合物，从而增加了DKK3蛋白和FZD1蛋白的表达，适当控制Wnt信号，从而抑制表皮过度增殖并减轻由表皮过度增生引起的炎性皮肤病。

7. 发明申请

US20110212455A1 METHOD OF SCREENING MATERIAL FOR IMPROVING SKIN FUNCTIONS 审中-公开
标题翻译：筛选用于改善皮肤功能的材料的方法
公开(公告)号：US20110212455A1
公开(公告)日：2011-09-01
申请号：US13094059
申请日：2011-04-26
申请人： Min Soo NOH , Hyeon Ju YEO , Seon Mi PARK , Dong Wook SHIN , Hyoung Ho LEE , Han-Kon KIM
发明人： Min Soo NOH , Hyeon Ju YEO , Seon Mi PARK , Dong Wook SHIN , Hyoung Ho LEE , Han-Kon KIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： A method of screening a material for improving skin functions includes: (a) treating a skin cell with a candidate material; (b) detecting a change in a relative expression level of membrane-associated protein 17 (MAP17) gene; and (c) selecting a candidate material inducing the change in the expression level of the gene as a material for improving skin functions.That is to say, a material for improving skin functions is screened using MAP17 gene as a marker, on the basis of the change in the expression level of the MAP17 gene. A material for improving skin functions, which is useful in improving skin barrier function, promoting skin moisturization, preventing skin aging, or ameliorating skin troubles, may be effectively screened.
摘要翻译：筛选用于改善皮肤功能的材料的方法包括：（a）用候选材料处理皮肤细胞; （b）检测膜相关蛋白17（MAP17）基因的相对表达水平的变化; 和（c）选择诱导基因表达水平变化的候选物质作为改善皮肤功能的材料。也就是说，基于MAP17基因的表达水平的变化，使用MAP17基因作为标记来筛选用于改善皮肤功能的材料。可以有效地筛选用于改善皮肤功能的材料，其可用于改善皮肤屏障功能，促进皮肤保湿，防止皮肤老化或改善皮肤麻烦。

8. 发明授权

US07867712B2 Nucleic acid sequences associated with cell states 有权
标题翻译：与细胞状态相关的核酸序列
公开(公告)号：US07867712B2
公开(公告)日：2011-01-11
申请号：US12063182
申请日：2006-08-08
申请人： James L. Sherley , Min-Soo Noh
发明人： James L. Sherley , Min-Soo Noh
IPC分类号： C12Q1/68 , G01N33/53 , C12P19/34
CPC分类号： C12Q1/6883 , C12Q2600/158
摘要： The present invention is directed to nucleic acid sequences whose expression is associated with different cell states, including nucleic acid sequences whose expression is induced at least 100-fold, or alternatively upregulated, in cells exhibiting asymmetric self-renewal relative to other cells. The invention is also directed to nucleic acid sequences whose expression is induced at least 100-fold, or alternatively upregulated, in cells exhibiting symmetric self-renewal relative to other cells.
摘要翻译：本发明涉及其表达与不同细胞状态相关的核酸序列，包括在其相对于其他细胞显示不对称自我更新的细胞中，其表达被诱导至少100倍或可选地上调的核酸序列。本发明还涉及其表达在相对于其他细胞显示对称自我更新的细胞中被诱导至少100倍或可选地上调的核酸序列。

9. 发明申请

US20080283869A1 METHOD FOR MANUFACTURING SEMICONDUCTOR LIGHT EMITTING DEVICE 有权
标题翻译：制造半导体发光器件的方法
公开(公告)号：US20080283869A1
公开(公告)日：2008-11-20
申请号：US12120311
申请日：2008-05-14
申请人： Min Soo Noh , Hyun Chul Ko
发明人： Min Soo Noh , Hyun Chul Ko
IPC分类号： H01S5/00 , H01L33/00
CPC分类号： H01S5/32341 , H01L33/0079 , H01S5/0202 , H01S5/0213 , H01S5/0215 , H01S5/0217 , H01S5/0218 , H01S5/22 , H01S5/3211
摘要： A method for manufacturing a semiconductor light emitting device, which is capable of providing high characteristic homogeneity and reproducibility, is disclosed. The disclosed method includes forming a buffer layer over a substrate, selectively growing a nitride crystal layer on the buffer layer, forming a nitride semiconductor layer having a multilayer structure over the nitride crystal layer, forming a first electrode on the nitride semiconductor layer, attaching an auxiliary substrate to the first electrode, separating the substrate from the nitride crystal layer, forming a second electrode on the nitride crystal layer exposed in accordance with the separation of the substrate, and removing the auxiliary substrate from the first electrode.
摘要翻译：公开了能够提供高特性均匀性和再现性的半导体发光器件的制造方法。所公开的方法包括在衬底上形成缓冲层，在缓冲层上选择性地生长氮化物晶体层，在氮化物晶体层上形成具有多层结构的氮化物半导体层，在氮化物半导体层上形成第一电极，将辅助衬底分离到第一电极，将衬底与氮化物晶体层分离，在根据衬底的分离暴露的氮化物晶体层上形成第二电极，并从第一电极移除辅助衬底。

10. 发明授权

US08242483B2 Method for manufacturing semiconductor light emitting device 有权
标题翻译：半导体发光元件的制造方法
公开(公告)号：US08242483B2
公开(公告)日：2012-08-14
申请号：US12120311
申请日：2008-05-14
申请人： Min Soo Noh , Hyun Chul Ko
发明人： Min Soo Noh , Hyun Chul Ko
IPC分类号： H01L33/20 , H01S5/20
CPC分类号： H01S5/32341 , H01L33/0079 , H01S5/0202 , H01S5/0213 , H01S5/0215 , H01S5/0217 , H01S5/0218 , H01S5/22 , H01S5/3211
摘要： A method for manufacturing a semiconductor light emitting device, which is capable of providing high characteristic homogeneity and reproducibility, is disclosed. The disclosed method includes forming a buffer layer over a substrate, selectively growing a nitride crystal layer on the buffer layer, forming a nitride semiconductor layer having a multilayer structure over the nitride crystal layer, forming a first electrode on the nitride semiconductor layer, attaching an auxiliary substrate to the first electrode, separating the substrate from the nitride crystal layer, forming a second electrode on the nitride crystal layer exposed in accordance with the separation of the substrate, and removing the auxiliary substrate from the first electrode.
摘要翻译：公开了能够提供高特性均匀性和再现性的半导体发光器件的制造方法。所公开的方法包括在衬底上形成缓冲层，在缓冲层上选择性地生长氮化物晶体层，在氮化物晶体层上形成具有多层结构的氮化物半导体层，在氮化物半导体层上形成第一电极，将辅助衬底分离到第一电极，将衬底与氮化物晶体层分离，在根据衬底的分离暴露的氮化物晶体层上形成第二电极，并从第一电极移除辅助衬底。

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