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1. 发明申请

US20110224291A1 SKIN EXTERNAL COMPOSITION FOR INHIBITING EPIDERMAL HYPERPROLIFERATION AND ALLEVIATING INFLAMMATORY SKIN DISEASES CONTAINING ORTHODIHYDROXYISOFLAVONE DERIVATIVES 审中-公开
标题翻译：皮肤外用组合物，用于抑制皮下超高效和清除含有异羟肟酸衍生物的炎症性皮肤病
公开(公告)号：US20110224291A1
公开(公告)日：2011-09-15
申请号：US13129645
申请日：2009-11-17
申请人： Jun Seong Park , Hye Yoon Park , Dong Hyun Kim , Sang Min Lee , Dong Wook Shin , Shin Hyoung Kim , Min Soo Noh , Duck Hee Kim , Han Kon Kim
发明人： Jun Seong Park , Hye Yoon Park , Dong Hyun Kim , Sang Min Lee , Dong Wook Shin , Shin Hyoung Kim , Min Soo Noh , Duck Hee Kim , Han Kon Kim
IPC分类号： A61K31/352 , C07D311/36 , A61P17/00
CPC分类号： A61K31/352 , A61K9/0014 , A61K31/366
摘要： Disclosed herein is a skin external composition for inhibiting epidermal hyperproliferation and alleviating inflammatory skin diseases, which contains ortho-dihydroxyisoflavone derivatives as an active ingredient. Specifically, the skin external external composition contains the ortho-dihydroxyisoflavone derivatives, 4′,6,7-trihydroxyisoflavone, 3′,4′,7-trihydroxyisoflavone or a mixture thereof, and thus increases the expression of DKK3 protein and FZD1 protein, which appropriately control Wnt signaling, thereby inhibiting epidermal hyperproliferation and alleviating inflammatory skin diseases caused by epidermal hyperproliferation.
摘要翻译：本文公开了一种皮肤外用组合物，其用于抑制表皮过度增殖并减轻含有邻二羟基异黄酮衍生物作为活性成分的炎性皮肤病。具体地说，皮肤外用组合物含有邻二羟基异黄酮衍生物，4'，6,7-三羟基异黄酮，3'，4'，7-三羟基异黄酮或其混合物，从而增加了DKK3蛋白和FZD1蛋白的表达，适当控制Wnt信号，从而抑制表皮过度增殖并减轻由表皮过度增生引起的炎性皮肤病。

2. 发明申请

US20110212455A1 METHOD OF SCREENING MATERIAL FOR IMPROVING SKIN FUNCTIONS 审中-公开
标题翻译：筛选用于改善皮肤功能的材料的方法
公开(公告)号：US20110212455A1
公开(公告)日：2011-09-01
申请号：US13094059
申请日：2011-04-26
申请人： Min Soo NOH , Hyeon Ju YEO , Seon Mi PARK , Dong Wook SHIN , Hyoung Ho LEE , Han-Kon KIM
发明人： Min Soo NOH , Hyeon Ju YEO , Seon Mi PARK , Dong Wook SHIN , Hyoung Ho LEE , Han-Kon KIM
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： A method of screening a material for improving skin functions includes: (a) treating a skin cell with a candidate material; (b) detecting a change in a relative expression level of membrane-associated protein 17 (MAP17) gene; and (c) selecting a candidate material inducing the change in the expression level of the gene as a material for improving skin functions.That is to say, a material for improving skin functions is screened using MAP17 gene as a marker, on the basis of the change in the expression level of the MAP17 gene. A material for improving skin functions, which is useful in improving skin barrier function, promoting skin moisturization, preventing skin aging, or ameliorating skin troubles, may be effectively screened.
摘要翻译：筛选用于改善皮肤功能的材料的方法包括：（a）用候选材料处理皮肤细胞; （b）检测膜相关蛋白17（MAP17）基因的相对表达水平的变化; 和（c）选择诱导基因表达水平变化的候选物质作为改善皮肤功能的材料。也就是说，基于MAP17基因的表达水平的变化，使用MAP17基因作为标记来筛选用于改善皮肤功能的材料。可以有效地筛选用于改善皮肤功能的材料，其可用于改善皮肤屏障功能，促进皮肤保湿，防止皮肤老化或改善皮肤麻烦。

3. 发明申请

US20100120042A1 METHOD OF SCREENING MATERIAL FOR IMPROVING SKIN FUNCTIONS 审中-公开
标题翻译：筛选用于改善皮肤功能的材料的方法
公开(公告)号：US20100120042A1
公开(公告)日：2010-05-13
申请号：US12575944
申请日：2009-10-08
申请人： Minsoo NOH , Hyeonju Yeo , Seon Mi Park , Dong Wook Shin , Hyoung Ho Lee , Han-Kon Kim
发明人： Minsoo NOH , Hyeonju Yeo , Seon Mi Park , Dong Wook Shin , Hyoung Ho Lee , Han-Kon Kim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/158
摘要： A method of screening a material for improving skin functions includes: (a) treating a skin cell with a candidate material; (b) detecting a change in a relative expression level of membrane-associated protein 17 (MAP17) gene; and (c) selecting a candidate material inducing the change in the expression level of the gene as a material for improving skin functions. That is to say, a material for improving skin functions is screened using MAP17 gene as a marker, on the basis of the change in the expression level of the MAP17 gene. A material for improving skin functions, which is useful in improving skin barrier function, promoting skin moisturization, preventing skin aging, or ameliorating skin troubles, may be effectively screened.
摘要翻译：筛选用于改善皮肤功能的材料的方法包括：（a）用候选材料处理皮肤细胞; （b）检测膜相关蛋白17（MAP17）基因的相对表达水平的变化; 和（c）选择诱导基因表达水平变化的候选物质作为改善皮肤功能的材料。也就是说，基于MAP17基因的表达水平的变化，使用MAP17基因作为标记来筛选用于改善皮肤功能的材料。可以有效地筛选用于改善皮肤功能的材料，其可用于改善皮肤屏障功能，促进皮肤保湿，防止皮肤老化或改善皮肤麻烦。

4. 发明授权

US07620434B2 Apparatus and method for detecting hook switch of a mobile communication terminal 有权
标题翻译：一种用于检测移动通信终端的挂钩开关的装置和方法
公开(公告)号：US07620434B2
公开(公告)日：2009-11-17
申请号：US11556139
申请日：2006-11-02
申请人： Dong-Wook Shin
发明人： Dong-Wook Shin
IPC分类号： H04M1/00
CPC分类号： H04M1/6058 , H04M1/82
摘要： A method for preventing malfunction of a mobile communication terminal when a headset is used is provided. The method includes detecting an ON state of a hook switch according to pre-set options and outputting a first detect signal. The method further includes determining that a headset has been inserted into the mobile communication terminal and outputting a second detect signal.
摘要翻译：提供一种用于在使用耳机时防止移动通信终端的故障的方法。该方法包括根据预设选项检测挂机开关的接通状态并输出第一检测信号。该方法还包括确定头戴式耳机已被插入移动通信终端并输出第二检测信号。

5. 发明申请

US20060258609A1 Method for inhibition of lipogenesis by regulating PRP19 expression 审中-公开
标题翻译：通过调节PRP19表达抑制脂肪生成的方法
公开(公告)号：US20060258609A1
公开(公告)日：2006-11-16
申请号：US11430131
申请日：2006-05-09
申请人： Si-Young Cho , Eui-Seok Shin , Pil-Joon Park , Dong-Wook Shin , Hui-Kyoung Chang , Dae-Gun Kim , Hyoung-Ho Lee , Jeong-Ho Lee , Tae-Ryong Lee , Ih-Seop Chang
发明人： Si-Young Cho , Eui-Seok Shin , Pil-Joon Park , Dong-Wook Shin , Hui-Kyoung Chang , Dae-Gun Kim , Hyoung-Ho Lee , Jeong-Ho Lee , Tae-Ryong Lee , Ih-Seop Chang
IPC分类号： A61K48/00 , C12N15/09
CPC分类号： A61K48/00
摘要： The downregulation of PRP 19 (precursor RNA processing 19) protein expression results in effectively reducing the expression of SCD1 (stearyl CoA desaturase-1), the key lipogenic enzyme, and its down-stream triacylglycerol synthesis enzymes, DGAT-1 (diacyglycerol acyltransferase-1) and GPAT (glycerol-phosphate acyltransferase), as well as the intracellular content of neutral lipids, the major target for treating obesity.
摘要翻译： PRP19（前体RNA加工19）蛋白质表达的下调导致有效降低SCD1（硬脂酰CoA去饱和酶-1），关键脂肪生成酶及其下游三酰基甘油合成酶DGAT-1（二酰甘油酰基转移酶 - 1）和GPAT（甘油 - 磷酸酰基转移酶），以及中性脂质的细胞内含量，这是治疗肥胖症的主要目标。

6. 发明授权

US06384390B1 Apparatus for forming thin film using microwave and method therefor 有权
标题翻译：使用微波形成薄膜的设备及其方法
公开(公告)号：US06384390B1
公开(公告)日：2002-05-07
申请号：US09663418
申请日：2000-09-15
申请人： Sun-tae Jung , Dong-wook Shin , Hyoun-soo Kim
发明人： Sun-tae Jung , Dong-wook Shin , Hyoun-soo Kim
IPC分类号： H05B664
CPC分类号： H01L21/67248 , C23C16/453 , C23C16/56 , H01L21/02164 , H01L21/02271 , H01L21/02345 , H01L21/02356 , H01L21/316 , H01L21/31612 , H01L21/67115
摘要： An apparatus for forming a thin film using microwave and a method therefor are provided. The apparatus for forming a thin film on a wafer by densifying predetermined soot on a wafer, when the wafer and the soot form a sample, includes a microwave sintering furnace for sealing the sample and exposing the sample to microwave, thus sintering the sample, a sintering furnace atmosphere maker for controlling the state, being the atmosphere of air inside the microwave sintering furnace, a temperature sensor/controller for sensing a temperature inside the microwave sintering furnace, comparing the temperature with a predetermined reference temperature, and outputting an error temperature, and a microwave power source for generating microwave of a predetermined temperature with reference to the error temperature output from the temperature sensor/controller and applying the microwave to the microwave sintering furnace. It is possible to rapidly form a film of a fine and uniform structure by densification using microwave.
摘要翻译：提供一种使用微波形成薄膜的装置及其方法。当晶片和烟灰形成样品时，通过致密化晶片上的预定烟灰来在晶片上形成薄膜的装置包括用于密封样品并将样品暴露于微波的微波烧结炉，从而烧结样品，用于控制状态的烧结炉气氛制造商，微波烧结炉内的空气气氛，用于感测微波烧结炉内的温度的温度传感器/控制器，将温度与预定的参考温度进行比较，并输出误差温度，以及微波电源，用于根据从温度传感器/控制器输出的误差温度产生预定温度的微波，并将微波施加到微波烧结炉。可以通过使用微波的致密化快速形成精细且均匀结构的膜。

7. 发明授权

US6148125A Ge-Ga-S-based glass composition having light amplifying characteristic and apparatus for optical communications using the same 失效
标题翻译：具有光放大特性的Ge-Ga-S系玻璃组合物及使用其的光通信装置
公开(公告)号：US6148125A
公开(公告)日：2000-11-14
申请号：US185734
申请日：1998-11-04
申请人： Jong Heo , Yong-beom Shin , Se-ho Park , Dong-wook Shin , Hyoun-soo Kim
发明人： Jong Heo , Yong-beom Shin , Se-ho Park , Dong-wook Shin , Hyoun-soo Kim
IPC分类号： C03C3/00 , C03C3/32 , H01S3/16 , H01S3/17 , G02B6/26
CPC分类号： H01S3/17 , C03C3/323 , H01S3/1603 , H01S3/1613
摘要： A Ge--Ga--S-based glass composition having light amplifying characteristics and an apparatus for optical communications using the glass composition are provided. The present invention includes a sulfur-poor Ge--Ga--S based host glass which includes less S than compositions on the composition line of GeS.sub.2 --G.sub.2 S.sub.3 on the ternary phase diagram of Ge--Ga--S, and a rare earth active material doped on the host glass for luminescence and light amplification. Ga of no more than about 10 mol % is included in the host glass. Also, Pr.sup.3+ ions are used as the rare earth active material. Furthermore, for stable vitrification and a blue shift of a short wavelength absorption band, a vitrification stabilizer such as Br and I is added to the host glass. Also, the present invention includes an apparatus for performing optical communications such as a light amplifier using optical fiber comprised of the glass composition including the S-poor Ge--Ga--S host glass which includes less S than a glass on a composition line of GeS.sub.2 --Ga.sub.2 S.sub.3 and the rare earth active material doped on the host glass for the light amplification.
摘要翻译：提供了具有光放大特性的Ge-Ga-S系玻璃组合物和使用该玻璃组合物的光通信装置。本发明包括在Ge-Ga-S三元相图上包含比GeS2-G2S3组成线上的组合少的S的贫硫Ge-Ga-S基主体玻璃，以及掺杂在主机玻璃用于发光和光放大。不超过约10mol％的Ga包含在主体玻璃中。此外，Pr3 +离子用作稀土活性物质。此外，为了稳定的玻璃化和短波长吸收带的蓝移，将玻璃化稳定剂如Br和I加入到主体玻璃中。此外，本发明还包括一种用于执行光通信的装置，例如使用由玻璃组合物构成的光放大器的装置，所述玻璃组合物包括S型不良Ge-Ga-S主体玻璃，该玻璃组合物在GeS2的组成线上包括少于玻璃的S -Ga 2 S 3和掺杂在主体玻璃上的稀土活性材料用于光放大。

8. 发明申请

US20070099607A1 APPARATUS AND METHOD FOR DETECTING HOOK SWITCH OF A MOBILE COMMUNICATION TERMINAL 有权
标题翻译：用于检测移动通信终端的开关的装置和方法
公开(公告)号：US20070099607A1
公开(公告)日：2007-05-03
申请号：US11556139
申请日：2006-11-02
申请人： Dong-Wook Shin
发明人： Dong-Wook Shin
IPC分类号： H04Q7/20
CPC分类号： H04M1/6058 , H04M1/82
摘要： A method for transmitting information for a Multimedia Broadcast/Multicast Service (MBMS) capable of receiving a specific MBMS service without any difficulty in a when a terminal subscribed to the specific MBMS service moves from an to the, in which when the terminal moves from the to the, the terminal or the transmits to the state information of a terminal-related MBMS service which the is providing, and the provides the MBMS service to the terminal by setting a dedicated channel with the terminal.
摘要翻译：用于在订购特定MBMS服务的终端何时移动的情况下能够接收特定MBMS服务的多媒体广播/组播服务（MBMS）的信息的发送方法从终端移动到向终端发送或者发送正在提供的与终端相关的MBMS业务的状态信息，并且通过与终端设置专用信道来向终端提供MBMS服务。

9. 发明申请

US20140170122A1 ADULT STEM CELLS DERIVED FROM HUMAN SKIN DERMIS 审中-公开
标题翻译：从人类皮肤细胞衍生的成年干细胞
公开(公告)号：US20140170122A1
公开(公告)日：2014-06-19
申请号：US14240330
申请日：2012-08-24
申请人： Joong Hyun Shim , Seung Ha Yang , Tae Ryong Lee , Hak Hee Kang , Dong Wook Shin
发明人： Joong Hyun Shim , Seung Ha Yang , Tae Ryong Lee , Hak Hee Kang , Dong Wook Shin
IPC分类号： C12N5/0775 , A61K35/28
CPC分类号： C12N5/0668 , A61K35/28 , A61K35/32 , A61K35/35 , A61K35/36 , C12N5/0625 , C12N2533/54 , C12Q1/6881 , C12Q2600/158 , G01N33/74 , G01N2333/475 , G01N2333/485 , G01N2333/49 , G01N2333/50
摘要： Provided in the present invention are adult stem cells derived from human skin dermis, and a method for isolating same. Further provided in the present invention are osteoblastic cells and adipocytes differentiated from the adult stem cells derived from human skin dermis, and a differentiation method therefor. Further provided in the present invention is a composition for osteogenesis or lipogenesis containing the stem cells, osteoblastic cells, or adipocytes. The isolation method of the present invention enables the adult stem cells derived from human skin dermis to be obtained in an easy and simple manner at a high yield rate. Genes and growth factors which are specifically expressed in the adult stem cells derived from human skin dermis isolated using the method can be separated, identified, and used later.
摘要翻译：本发明中提供的是源自人皮肤真皮的成体干细胞及其分离方法。本发明还提供了从源于人皮肤真皮的成体干细胞分化的成骨细胞和脂肪细胞及其分化方法。本发明还提供了含有干细胞，成骨细胞或脂肪细胞的成骨或脂肪生成组合物。本发明的分离方法能够以高产率以容易且简单的方式获得源自人皮肤真皮的成体干细胞。在使用该方法分离的来自人皮肤真皮的成体干细胞中特异性表达的基因和生长因子可以被分离，鉴定和使用。

10. 发明申请

US20130236904A1 METHOD FOR SCREENING FOR MATERIALS FOR PROMOTING THE DIFFERENTIATION OF SKIN CELLS 审中-公开
标题翻译：筛选用于促进皮肤细胞分化的材料的方法
公开(公告)号：US20130236904A1
公开(公告)日：2013-09-12
申请号：US13988270
申请日：2011-11-18
申请人： Hyun Choi , Yeun Kyung Kim , Seung Ha Yang , Tae Ryong Lee , Min Soo Noh , Dong Wook Shin
发明人： Hyun Choi , Yeun Kyung Kim , Seung Ha Yang , Tae Ryong Lee , Min Soo Noh , Dong Wook Shin
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6881 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158
摘要： The present invention relates to a method for screening for materials for promoting the differentiation of skin cells, comprising: a step of treating skin cells with a test material; and a step of checking the relative degree of the expression of the DUOX 1 gene in the skin cells treated with the test material in the previous step. The present invention also relates to a kit for screening for materials for promoting the differentiation of skin cells, comprising a device for checking the relative degree of expression of the DUOX 1 gene in skin cells. The present invention also relates to a composition which contains, as an active ingredient, a material for increasing the expression of the DUOX 1 gene to promote the differentiation of skin cells, moisturize the skin, improve skin barrier function, or alleviate or treat symptoms of atopic dermatitis.
摘要翻译：本发明涉及一种用于筛选促进皮肤细胞分化的材料的方法，包括：用试验材料处理皮肤细胞的步骤; 以及检查在前一步骤中用试验材料处理的皮肤细胞中DUOX1基因表达的相对程度的步骤。本发明还涉及用于筛选用于促进皮肤细胞分化的材料的试剂盒，其包括用于检查皮肤细胞中DUOX1基因的相对表达程度的装置。本发明还涉及含有作为活性成分的用于增加DUOX1基因表达以促进皮肤细胞分化，增湿皮肤，改善皮肤屏障功能或缓解或治疗特应性皮炎。

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