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1. 发明授权

US06449584B1 Measurement signal processing method 失效
标题翻译：测量信号处理方法
公开(公告)号：US06449584B1
公开(公告)日：2002-09-10
申请号：US09435816
申请日：1999-11-08
申请人： Michel J. Bertrand , Dimo Zidarov
发明人： Michel J. Bertrand , Dimo Zidarov
IPC分类号： G06F1500
CPC分类号： G06F17/10
摘要： A method of processing data representing intensity values of a measurement signal as a function of a discrete variable such as time, which signal being characterized by series of peaks mixed with a substantially regular background noise, provides efficient noise attenuation and peak detection capabilities. When applied to a two-dimensional system, the method comprises an initial step of forming an intensity histogram vector representing a frequency distribution from the intensity values, which intensity histogram vector having N frequency vector components associated with corresponding N intensity sub-ranges within a maximum range extending from a minimum intensity value to a maximum intensity value. This initial step is followed by a step of zeroing a portion of the data corresponding to the intensity values which are below an intensity threshold value derived from shape characteristics of the distribution. Then, the intensity threshold value is subtracted from each remaining portion of the data to obtain processed data representing the measurement signal in which each peak exhibits an enhanced signal-to-noise ratio. The method is also applicable to multi-dimensional measurement systems involving more than one variable, such as chromatography/mass spectrometry measurement techniques.
摘要翻译：处理表示作为离散变量（诸如时间）的函数的测量信号的强度值的数据的方法，所述时间是以与基本上规则的背景噪声混合的一系列峰值为特征的信号，提供有效的噪声衰减和峰值检测能力。当应用于二维系统时，该方法包括从强度值形成表示频率分布的强度直方图向量的初始步骤，该强度直方图向量具有与最大值内的相应N个强度子范围相关联的N个频率矢量分量的强度直方图向量范围从最小强度值延伸到最大强度值。该初始步骤之后是对与由分布的形状特征导出的强度阈值以下的强度值相对应的数据的一部分归零的步骤。然后，从数据的每个剩余部分中减去强度阈值，以获得表示每个峰值表现出增强的信噪比的测量信号的处理数据。该方法也适用于涉及多个变量的多维测量系统，如色谱/质谱测量技术。

2. 发明授权

US06661178B1 Metastable atom bombardment source 失效
标题翻译：亚稳原子轰击源
公开(公告)号：US06661178B1
公开(公告)日：2003-12-09
申请号：US09723221
申请日：2000-11-28
申请人： Michel J. Bertrand , Olivier Peraldi
发明人： Michel J. Bertrand , Olivier Peraldi
IPC分类号： H01J724
CPC分类号： H01J49/102 , H01J27/04
摘要： The metastable atom bombardment source provides a charged particle free beam of metastable species that can be used to bombard and ionize organic and inorganic substances in a gas phase. The metastable atoms are produced by inducing a discharge in a gas (rare gases or small molecules). The discharge is curved between the cathode and anode, with the cathode located in a medium pressure zone and the anode located off-axis in a low pressure zone. A nozzle located between the cathode and the anode provides a collimated beam of metastable atoms of low kinetic energy that is directed at an ion volume containing the substances to be analyzed. By selecting the energy of the metastable state, selective fragmentation of molecules, particularly large molecular weight molecules, can be carried out.
摘要翻译：亚稳态原子轰击源提供了一种可带电粒子的亚稳态物质束，可用于轰击和离子化气相中的有机和无机物质。亚稳态原子通过在气体（稀有气体或小分子）中的排放而产生。放电在阴极和阳极之间弯曲，阴极位于中压区域，阳极位于低压区域的轴外。位于阴极和阳极之间的喷嘴提供准直的低动能的亚稳态原子束，其指向含有待分析物质的离子体积。通过选择亚稳态的能量，可以进行分子，特别是大分子量分子的选择性碎裂。

3. 发明授权

US06627881B1 Time-of-flight bacteria analyser using metastable source ionization 失效
标题翻译：使用亚稳态源电离的飞行时间细菌分析仪
公开(公告)号：US06627881B1
公开(公告)日：2003-09-30
申请号：US09722612
申请日：2000-11-28
申请人： Michel J. Bertrand , Olivier Peraldi
发明人： Michel J. Bertrand , Olivier Peraldi
IPC分类号： B01D4400
CPC分类号： H01J49/40 , H01J49/0472 , H01J49/061
摘要： For analyzing micro-organisms and other high-molecular weight species, a sample of the substance to be analyzed is prepared, placed in a pyrolyzer where it is pyrolyzed with a selected temperature program to provide pyrolyzed product of a high-dalton mass range. The product is ionized using metastable atoms which results in efficient ionization with little fragmentation. The metastable atoms are generated using a generator that provides a beam of metastable atoms which is basically free from ions. The ionized product is then analyzed using a high acquisition rate mass analyzer, such as a time-of-flight (TOF) analyzer.
摘要翻译：为了分析微生物和其他高分子量物质，准备待分析物质的样品，放置在热解器中，在其中用选定的温度程序进行热解，以提供高达尔顿质量范围的热解产物。该产物使用亚稳原子进行离子化，导致高效电离，几乎不碎裂。使用提供基本上不含离子的亚稳态原子束的发生器产生亚稳态原子。然后使用高采集速率质量分析仪（例如飞行时间（TOF）分析仪）分析电离产物。

4. 发明授权

US6124675A Metastable atom bombardment source 失效
标题翻译：亚稳原子轰击源
公开(公告)号：US6124675A
公开(公告)日：2000-09-26
申请号：US88079
申请日：1998-06-01
申请人： Michel J. Bertrand , Denis Faubert , Olivier Peraldi , Andre L'Heureux
发明人： Michel J. Bertrand , Denis Faubert , Olivier Peraldi , Andre L'Heureux
IPC分类号： H01J49/14 , H01J49/04 , H01J49/16 , H01J7/24
CPC分类号： H01J49/102 , H01J27/04
摘要： The metastable atom bombardment source provides a charged particle free beam of metastable species that can be used to bombard and ionize organic and inorganic substances in a gas phase. The metastable atoms are produced by inducing a discharge in a gas (rare gases or small molecules). The discharge is curved between the cathode and anode, with the cathode located in a medium pressure zone and the anode located off-axis in a low pressure zone; A nozzle located between the cathode and the anode provides a collimated beam of metastable atoms of low kinetic energy that is directed at an ion volume containing the substances to be analyzed.
摘要翻译：亚稳态原子轰击源提供了一种可带电粒子的亚稳态物质束，可用于轰击和离子化气相中的有机和无机物质。亚稳态原子通过在气体（稀有气体或小分子）中的排放而产生。放电在阴极和阳极之间弯曲，阴极位于中压区域，阳极位于低压区域的轴外; 位于阴极和阳极之间的喷嘴提供准直的低动能的亚稳态原子束，其指向含有待分析物质的离子体积。

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