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1. 发明授权

US6063200A Three-dimensional micro fabrication device for filamentary substrates 失效
标题翻译：用于丝状基材的三维微型制造装置
公开(公告)号：US6063200A
公开(公告)日：2000-05-16
申请号：US21103
申请日：1998-02-10
申请人： Stephen C. Jacobsen , Michael R. McNeely , David L. Wells
发明人： Stephen C. Jacobsen , Michael R. McNeely , David L. Wells
IPC分类号： H01L21/203 , C23C14/50 , C23C14/56 , G03F7/24 , C23C16/54
CPC分类号： C23C14/505 , C23C14/562
摘要： A fixture apparatus for material deposition or processing on a long, flexible, nonplanar, filamentary substrate has a tubular member for holding the filamentary substrate rotatably disposed on a base. An opening is formed in the tubular member through which material is deposited on the surface of the filamentary substrate. Moveable tubes are each slidingly disposed in the tubular member on either side of the opening. The tubes and/or the tubular member hold the filamentary substrate on both sides of a deposition area on the substrate to maintain the straight configuration of the long, flexible, filamentary substrate. The tubes and/or tubular member also physically masks the filamentary substrate to prevent material deposition outside the deposition area on the substrate. The base has a circular path and a rotating member. A wheel is coupled to one side of the tubular member and is rotatably disposed on the circular path of the base. The other side of the tubular member is rotatable coupled to the rotating member of the base by a bearing. The rotating member causes the wheel to turn about a vertical axis in a circular path. The wheel is fixed to the tubular member causing the tubular member to rotate about a horizontal axis or longitudinal axis of the tubular member. As the rotating member turns and the wheel rolls, the tubular member the filamentary substrate is rotated about the two different axes to uniformly deposit material on the filament.
摘要翻译：用于在长的，柔性的，非平面的丝状基底上进行材料沉积或加工的固定装置具有用于保持可旋转地设置在基部上的丝状基底的管状构件。在管状构件中形成开口，通过该开口，材料通过该开口被沉积在丝状基底的表面上。可移动管各自滑动地布置在开口两侧的管状构件中。管和/或管状构件将丝状基底保持在基底上的沉积区域的两侧，以保持长的，柔性的丝状基底的直线构型。管和/或管状构件还物理地遮蔽丝状基底以防止材料沉积在基底上的沉积区域外部。底座具有圆形路径和旋转构件。轮联接到管状构件的一侧并且可旋转地设置在基座的圆形路径上。管状构件的另一侧通过轴承可旋转地联接到基座的旋转构件。旋转构件使得轮在圆形路径中绕垂直轴转动。轮被固定到管状构件，导致管状构件围绕管状构件的水平轴线或纵向轴线旋转。当旋转构件转动并且轮滚动时，管状构件，丝状基底围绕两个不同的轴线旋转以均匀地将材料沉积在细丝上。

2. 发明授权

US06607907B2 Air flow regulation in microfluidic circuits for pressure control and gaseous exchange 失效
公开(公告)号：US06607907B2
公开(公告)日：2003-08-19
申请号：US09855870
申请日：2001-05-15
申请人： Michael R. McNeely , Mark K. Spute
发明人： Michael R. McNeely , Mark K. Spute
IPC分类号： C12M136
CPC分类号： B01L3/5027 , B01J19/0093 , B01J2219/00783 , B01J2219/00873 , B01J2219/00891 , B01J2219/0095 , B01J2219/00963 , B01L3/50273 , B01L3/502738 , B01L5/00 , B01L7/02 , B01L7/52 , B01L2300/14 , B01L2400/0487 , B01L2400/06 , Y10T436/2575
摘要： A method and system are disclosed for manipulating the flow of gases into and out of a microfluidic circuit to regulate pressure within the circuit or to provide for the delivery of gases to or removal of gases from the circuit. Pressure within the microfluidic circuit may be increased or decreased to modify physical or chemical properties of fluid within the circuit, or to modify reaction kinetics. Gaseous reactants may be added to the circuit, and reaction products or excess reactant gases may be removed the circuit according to the invention. Warm or cool air or other gas may be flowed over liquid reactants within the circuit to perform a warming or cooling function. Various biochemical reactions or processes, including for example polymerase chain reaction (PCR) and ligand-receptor binding, may be performed with the use of the inventive method and system.

3. 发明授权

US6066361A Method for coating a filament 失效
标题翻译：丝线涂布方法
公开(公告)号：US6066361A
公开(公告)日：2000-05-23
申请号：US363543
申请日：1999-07-29
申请人： Stephen C. Jacobsen , Michael R. McNeely , David L. Wells
发明人： Stephen C. Jacobsen , Michael R. McNeely , David L. Wells
IPC分类号： H01L21/203 , C23C14/50 , C23C14/56 , G03F7/24 , B05D5/06
CPC分类号： C23C14/505 , C23C14/562
摘要： A method of coating a surface of a filament. In particular, the invention rotates a member (13) about a first axis (54), which will rotate a tubular member (16), which is rotatably coupled to the rotating member at an angle to the first axis, through a plane and about a longitudinal axis (56) of the tubular member that is co-planer to the plane. This is done to assist in the depositing of a uniform material onto the filament that extends through the tubular member and through a deposition area (40). It is important for the method to maintain the deposition area at an intersection of the first axis, longitudinal axis and plane, while the filament is being rotated in step. The method provides for adjusting the deposition area to expose a different length of the filament to the deposition of material thereon. Additionally, the method further comprises the steps of: un-winding a length of the filament that is in a feed basket coupled to one end of the tubular member; feeding the filament length through the tubular member; and collecting the filament length in a receiving basket that is coupled to another end of the tubular member. It is noted that there is a step of rotating a traction wheel, which is fixedly coupled about the tubular member at an end opposite to where the tubular member is rotatably coupled to the rotating member, about the longitudinal axis to cause the tubular member to rotate through the plane and about the co-planer longitudinal axis. Wherein the traction wheel runs along a top surface of a circular wall that is located equal distant about the first axis.
摘要翻译：一种涂覆细丝表面的方法。特别地，本发明使构件（13）围绕第一轴线（54）旋转，所述第一轴线（54）将旋转管状构件（16），所述管状构件（16）以与第一轴线成一定角度可旋转地联接到旋转构件，所述管状构件的与所述平面共同平面的纵向轴线（56）。这样做有助于将均匀的材料沉积到延伸穿过管状构件并通过沉积区域（40）的细丝上。该方法在第一轴，纵轴和平面的交点处保持沉积区域是重要的，同时灯丝在步骤中旋转。该方法提供了调节沉积区域以将不同长度的细丝暴露于其上的材料沉积。另外，该方法还包括以下步骤：将缠绕在与筒状构件的一端相连的进料篮中的长丝的长度不卷曲; 通过所述管状构件供给所述长丝; 以及将纤维长度收集在联接到管状构件的另一端的接收篮中。应注意的是，有一个转动牵引轮的步骤，该牵引轮围绕管状构件固定地围绕管状构件在相对于管状构件可旋转地联接到旋转构件的端部处围绕纵向轴线联接，以使管状构件旋转通过飞机和共平面纵轴。其中牵引轮沿着围绕第一轴线等距离的圆形壁的顶表面延伸。

4. 发明申请

US20100240022A1 Reagent preparation and valving design for liquid testing 审中-公开
标题翻译：液体试验的试剂制备和阀门设计
公开(公告)号：US20100240022A1
公开(公告)日：2010-09-23
申请号：US12308486
申请日：2007-06-22
申请人： Michael R. McNeely
发明人： Michael R. McNeely
IPC分类号： C12Q1/00 , C12M1/34 , F15D1/00 , F16K11/00
CPC分类号： B01L3/502738 , B01L3/5025 , B01L2200/0621 , B01L2200/16 , B01L2300/0681 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2400/0481 , B01L2400/0605 , B01L2400/0677 , B01L2400/0683 , B01L2400/0688 , Y10T137/0318 , Y10T137/87788
摘要： The technology described in this disclosure is a combination of controlled and precise ‘reagent delivery’ integrated together with controlled liquid flow through a sample processing device used for generating a desired chemical or biological reaction.
摘要翻译：本公开中描述的技术是将受控液体流与通过用于产生所需化学或生物反应的样品处理装置集成在一起的受控和精确的“试剂输送”的组合。

5. 发明授权

US06637463B1 Multi-channel microfluidic system design with balanced fluid flow distribution 失效
标题翻译：具有平衡流体流量分布的多通道微流体系统设计
公开(公告)号：US06637463B1
公开(公告)日：2003-10-28
申请号：US10142555
申请日：2002-05-10
申请人： Ming Lei , Nils B. Adey , Michael R. McNeely
发明人： Ming Lei , Nils B. Adey , Michael R. McNeely
IPC分类号： F15B2100
CPC分类号： B01F5/0403 , B01F5/064 , B01F5/0642 , B01F13/0059 , B01F15/0232 , B01F2015/0221 , B01F2215/0037 , B01J19/0093 , B01J2219/00837 , B01J2219/00891 , B01J2219/00995 , B01L3/502723 , B01L3/502738 , B01L3/502746 , B01L99/00 , B01L2200/025 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/12 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0883 , B01L2300/0887 , B01L2300/165 , B01L2300/18 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , B01L2400/086 , F15C1/14 , F15C1/146 , F28F2210/02 , F28F2245/04 , F28F2260/02 , G01N35/08 , G01N35/1004 , G01N2035/00237 , G01N2035/00366 , G01N2035/00544 , Y10T137/206 , Y10T137/2076 , Y10T137/2267
摘要： Methods and apparatus are presented for controlling fluid flow through flow paths with pressure gradient fluid control. Passive fluid flow barriers may be used to act as valves, thereby allowing the flow of fluids through flow paths to be regulated so as to allow fluids to be introduced via a single channel and subsequently split into multiple channels. Flow through the flow paths can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. Each flow path may have multiple segments, at least one of which is designed to balance the pressure drops of the flow paths to provide uniform flow of fluids through the flow paths. The configurations of the wells may also be modified by adding vents or flow dividers to enhance fluid flushing and gas removal capability.
摘要翻译：提出了通过压力梯度流体控制来控制通过流动路径的流体流动的方法和装置。被动流体阻流层可以用作阀门，从而允许流体通过流动路径的流动被调节，以允许流体经由单个通道被引入并随后被分成多个通道。可以调节通过流路的流动，以允许一系列姐妹井或腔室在流体流过任何一个姐妹井或腔室之前全部填充。每个流动路径可以具有多个段，其中至少一个被设计成平衡流动路径的压降以提供流体通过流动路径的均匀流动。也可以通过添加通风口或分流器来改进孔的构造，以增强流体冲洗和气体去除能力。

6. 发明授权

US06615856B2 Remote valving for microfluidic flow control 失效
公开(公告)号：US06615856B2
公开(公告)日：2003-09-09
申请号：US09922451
申请日：2001-08-03
申请人： Michael R. McNeely , Mark K. Spute
发明人： Michael R. McNeely , Mark K. Spute
IPC分类号： F15C104
CPC分类号： F15C1/146 , B01L3/502738 , B01L2200/146 , B01L2300/0816 , B01L2300/0864 , B01L2400/0406 , B01L2400/0487 , B01L2400/0694 , B81B1/00 , F16K99/0001 , F16K99/0017 , F16K99/0034 , F16K99/0057 , F16K2099/0074 , F16K2099/0076 , F16K2099/0078 , F16K2099/0084 , Y10T137/0396 , Y10T137/2071 , Y10T137/2076 , Y10T137/218 , Y10T137/2224
摘要： A method of controlling fluid flow within a microfluidic circuit using external valves and pumps connected to the circuit is disclosed. The external valves and pumps, which are not a part of the microfluidic substrate, control fluid pumping pressure and the displacement of air out of the fluid circuit as fluid enters into the circuit. If a valve is closed, air cannot be displaced out of circuit, which creates a pneumatic barrier that prevents fluid from advancing within the circuit (under normal operating pressures). Applications of this method of fluid control are explained.

7. 发明授权

US06601613B2 Fluid circuit components based upon passive fluid dynamics 失效
公开(公告)号：US06601613B2
公开(公告)日：2003-08-05
申请号：US09967402
申请日：2001-09-27
申请人： Michael R. McNeely , Arnold R. Oliphant , Mark K. Spute
发明人： Michael R. McNeely , Arnold R. Oliphant , Mark K. Spute
IPC分类号： G05D700
CPC分类号： B01L3/5027 , B01F5/0403 , B01F5/064 , B01F5/0642 , B01F13/0059 , B01F15/0232 , B01F2015/0221 , B01F2215/0037 , B01J19/0093 , B01J2219/00783 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00891 , B01J2219/00952 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/025 , B01L2200/0621 , B01L2200/10 , B01L2200/12 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/165 , B01L2300/18 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , B81B2201/058 , B81C3/001 , F15C1/14 , F15C1/146 , F28F2245/04 , F28F2260/02 , G01N35/08 , G01N2035/00237 , G01N2035/00366 , G01N2035/00544 , Y10T137/2076 , Y10T137/2224 , Y10T137/2267
摘要： Methods of controlling fluid flow through microchannels by use of passive valves or stopping means in the microchannels is presented. The passive valves act as pressure barriers impeding flow of solution past the stopping means until enough force is built up to overcome the force of the pressure barrier. Well planned use of such stopping means acting as passive valves allows the flow of fluids through microchannels to be regulated so as to allow fluids to be mixed or diluted after being introduced via a single channel, or to be split into multiple channels without the need for individual pipetting. Flow through the multiple channels can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. The filling of sister wells or chambers in this manner allows all wells or chambers to undergo reactions in unison. The use of air ducts to prevent trapping of air in the microchannels is also presented.

8. 发明授权

US06591852B1 Fluid circuit components based upon passive fluid dynamics 失效
标题翻译：基于被动流体动力学的流体回路部件
公开(公告)号：US06591852B1
公开(公告)日：2003-07-15
申请号：US10060442
申请日：2002-01-30
申请人： Michael R. McNeely , Mark K. Spute , Arnold R. Oliphant
发明人： Michael R. McNeely , Mark K. Spute , Arnold R. Oliphant
IPC分类号： F15B2100
CPC分类号： G01N35/08 , B01F5/0403 , B01F5/064 , B01F5/0642 , B01F13/0059 , B01F15/0232 , B01F2015/0221 , B01F2215/0037 , B01J19/0093 , B01L3/502738 , B01L2200/025 , B01L2200/0621 , B01L2200/10 , B01L2200/12 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/165 , B01L2300/18 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , F15C1/14 , F15C1/146 , F28F2245/04 , F28F2260/02 , G01N2035/00237 , G01N2035/00366 , G01N2035/00544 , Y10T137/0396 , Y10T137/2076 , Y10T137/2224 , Y10T137/2267
摘要： Methods and apparatus for controlling fluid flow through microchannels by use of passive valves or stopping means comprised of abrupt microchannel widenings in the microchannels are presented. Such passive fluid flow barriers create pressure barriers impeding flow of solution past the passive fluid flow barriers until enough force is built up to overcome the force of the pressure barrier. Use of such stopping means acting as passive barriers or valves allows the flow of fluids through microchannels to be regulated so as to allow fluids to be mixed or diluted after being introduced via a single channel, or to be split into multiple channels without the need for individual pipetting. Flow through the multiple channels can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. The filling of sister wells or chambers in this manner allows all wells or chambers to undergo reactions in unison. The use of air ducts in microchannels to prevent trapping of air in the microchannels is also presented.
摘要翻译：提出了通过使用被动阀或通过在微通道中突然的微通道加宽构成的停止装置来控制通过微通道的流体流动的方法和装置。这种被动流体流动障碍物产生阻碍溶液流过被动流体流动屏障的压力屏障，直到形成足够的力以克服压力屏障的力。作为被动屏障或阀门的这种停止装置的使用允许流体通过微通道的流动被调节，以便在通过单个通道引入流体之后混合或稀释流体，或者被分成多个通道而不需要单独移液可以调节通过多个通道的流动，以允许一系列姐妹井或腔室在流体流过任何一个姐妹井或腔室之前全部填充。以这种方式填充姐妹井或室允许所有井或室一致地进行反应。还提出了在微通道中使用空气管道来防止空气在微通道中的捕获。

9. 发明授权

US06296020B1 Fluid circuit components based upon passive fluid dynamics 失效
标题翻译：基于被动流体动力学的流体回路部件
公开(公告)号：US06296020B1
公开(公告)日：2001-10-02
申请号：US09417691
申请日：1999-10-13
申请人： Michael R. McNeely , Arnold R Oliphant , Mark K. Spute
发明人： Michael R. McNeely , Arnold R Oliphant , Mark K. Spute
IPC分类号： F15B2100
CPC分类号： F15C1/14 , B01F5/0403 , B01F5/064 , B01F5/0642 , B01F13/0059 , B01F15/0232 , B01F2015/0221 , B01F2215/0037 , B01J19/0093 , B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2200/025 , B01L2200/0621 , B01L2200/0684 , B01L2200/10 , B01L2200/12 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/165 , B01L2300/18 , B01L2400/0406 , B01L2400/0487 , B01L2400/0688 , B01L2400/0694 , F15C1/146 , F28F2245/04 , F28F2260/02 , G01N2035/00237 , G01N2035/00366 , G01N2035/00544 , Y10S366/03 , Y10T137/2076 , Y10T137/2224 , Y10T137/2267
摘要： Methods of controlling fluid flow through microchannels by use of passive valves or stopping means in the microchannels is presented. The passive valves act as pressure barriers impeding flow of solution past the stopping means until enough force is built up to overcome the force of the pressure barrier. Well planned use of such stopping means acting as passive valves allows the flow of fluids through microchannels to be regulated so as to allow fluids to be mixed or diluted after being introduced via a single channel, or to be split into multiple channels without the need for individual pipetting. Flow through the multiple channels can be regulated to allow a series of sister wells or chambers to all fill prior to the fluid flowing beyond any one of the sister wells or chambers. The filling of sister wells or chambers in this manner allows all wells or chambers to undergo reactions in unison. The use of air ducts to prevent trapping of air in the microchannels is also presented.
摘要翻译：提出了通过使用被动阀或微通道中的停止装置来控制通过微通道的流体流动的方法。被动阀作为阻碍溶液流过停止装置的压力屏障，直到形成足够的力以克服压力屏障的力。充分计划使用这种停止装置作为被动阀允许流体通过微通道的流动被调节，以便在通过单个通道引入之后使流体混合或稀释，或者被分成多个通道而不需要单独移液可以调节通过多个通道的流动，以允许一系列姐妹井或腔室在流体流过任何一个姐妹井或腔室之前全部填充。以这种方式填充姐妹井或室允许所有井或室一致地进行反应。还提出了使用空气管道来防止空气在微通道中的捕获。

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