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1. 发明授权

US08567053B2 Methods of manufacturing printed circuit boards 有权
标题翻译：制造印刷电路板的方法
公开(公告)号：US08567053B2
公开(公告)日：2013-10-29
申请号：US13153254
申请日：2011-06-03
申请人： Rajesh Kumar , Monte P. Dreyer , Michael J. Taylor
发明人： Rajesh Kumar , Monte P. Dreyer , Michael J. Taylor
IPC分类号： H01K3/10
CPC分类号： H05K3/4623 , H05K3/4069 , H05K3/4614 , H05K2201/0195 , H05K2201/096 , H05K2203/061 , Y10T29/49124 , Y10T29/49126 , Y10T29/49146 , Y10T29/49165 , Y10T29/532
摘要： Systems and methods of manufacturing printed circuit boards using blind and internal micro vias to couple subassemblies. An embodiment of the invention provides a method of manufacturing a printed circuit including attaching a plurality of metal layer carriers to form a first subassembly including at least one copper foil pad on a first surface, applying an encapsulation material onto the first surface of the first subassembly, curing the encapsulation material and the first subassembly; applying a lamination adhesive to a surface of the cured encapsulation material, forming at least one via in the lamination adhesive and the cured encapsulation material to expose the at least one copper foil pad, attaching a plurality of metal layer carriers to form a second subassembly, and attaching the first subassembly and the second subassembly.
摘要翻译：使用盲孔和内部微通孔来制造印刷电路板来耦合子组件的系统和方法。本发明的一个实施例提供一种制造印刷电路的方法，包括附接多个金属层载体以形成第一子组件，该第一子组件包括在第一表面上的至少一个铜箔焊盘，将封装材料施加到第一子组件的第一表面上固化封装材料和第一子组件; 在所述固化的包封材料的表面上施加层压粘合剂，在所述层压粘合剂和所述固化的封装材料中形成至少一个通孔，以暴露所述至少一个铜箔垫，附接多个金属层载体以形成第二子组件，以及附接第一子组件和第二子组件。

2. 发明申请

US20130006900A1 Event Prediction Using Hierarchical Event Features 有权
标题翻译：使用分层事件特征的事件预测
公开(公告)号：US20130006900A1
公开(公告)日：2013-01-03
申请号：US13608714
申请日：2012-09-10
申请人： Michael J. Taylor , Vishwa Vinay , Yauhen Shnitko
发明人： Michael J. Taylor , Vishwa Vinay , Yauhen Shnitko
IPC分类号： G06F15/18
CPC分类号： G06F17/30958 , G06F17/30867
摘要： Event prediction using hierarchical event features is described. In an embodiment a search engine monitors search results presented to users and whether users click on those search results. For example, features describing the search result events are universal resource locator prefix levels which are inherently hierarchically related. In an embodiment a graphical data structure is created and stored and used to represent the hierarchical relationships between features. An online training process is used in examples which enables knowledge to be propagated through the graphical data structure according to the hierarchical relations between features. In an example, the graphical data structure is used to predict whether a user will click on a search result and those predictions are used by the search engine to rank search results for future searches. In another example the events are advertisement impressions and the predictions are used by an online advertisement system.
摘要翻译：描述使用分层事件特征的事件预测。在一个实施例中，搜索引擎监视呈现给用户的搜索结果以及用户是否点击这些搜索结果。例如，描述搜索结果事件的特征是通常的资源定位符前缀级别，其本质上是分层相关的。在一个实施例中，创建和存储图形数据结构并用于表示特征之间的分层关系。在实例中使用在线训练过程，使知识能够通过图形数据结构根据特征之间的层次关系进行传播。在一个示例中，图形数据结构用于预测用户是否将点击搜索结果，并且搜索引擎使用这些预测来对未来搜索的搜索结果进行排序。在另一个例子中，事件是广告印象，并且预测被在线广告系统使用。

3. 发明授权

US08252589B2 Method for isolating cellular products by cryopreservation 有权
标题翻译：通过冷冻保存分离细胞产物的方法
公开(公告)号：US08252589B2
公开(公告)日：2012-08-28
申请号：US12654147
申请日：2009-12-11
申请人： Michael J. Taylor , David E. Pegg
发明人： Michael J. Taylor , David E. Pegg
IPC分类号： C12N5/02
CPC分类号： C12N5/0677 , A01N1/0221
摘要： Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a tissue having desired cells that are less prone to destructive freezing and undesired cells that are more prone to destructive freezing, or pre-treating a tissue to have such characteristics. The methods may involve freezing the tissue, disrupting the tissue, warming the tissue, and separating the desired cells from undesired cellular material to obtain the cellular product. The methods may thereby provide an enzyme-free or reduced-enzyme method of isolating a cellular product that is more consistent, reliable and less toxic than conventional methods. The methods may also yield an optimum quantity of cellular product that retain sufficient functional integrity to be useful as a transplantation resource.
摘要翻译：分离细胞产物（如胰岛）的方法可用于糖尿病研究和治疗性移植。所述方法可以包括提供具有不太易于破坏性冷冻的期望细胞的组织和更易于破坏性冷冻的不想要的细胞或预处理组织以具有这些特征的组织。所述方法可以包括冷冻组织，破坏组织，加热组织，以及将期望的细胞与不期望的细胞材料分离以获得细胞产物。因此，该方法可以提供与常规方法更一致，可靠和毒性更低的细胞产物的无酶或还原酶方法。所述方法还可以产生保持足够的功能完整性作为移植资源有用的最佳量的细胞产物。

4. 发明授权

US07856706B2 Methods of manufacturing printed circuit boards with stacked micro vias 有权
标题翻译：制造具有堆叠微通孔的印刷电路板的方法
公开(公告)号：US07856706B2
公开(公告)日：2010-12-28
申请号：US12381925
申请日：2009-03-17
申请人： Raj Kumar , Monte Dreyer , Michael J. Taylor
发明人： Raj Kumar , Monte Dreyer , Michael J. Taylor
IPC分类号： H05K3/36
CPC分类号： H05K3/4623 , H05K3/205 , H05K3/386 , H05K3/4069 , H05K3/423 , H05K3/4614 , H05K3/4617 , H05K3/462 , H05K2201/0355 , H05K2201/0394 , H05K2201/09309 , H05K2201/096 , H05K2203/0191 , H05K2203/0271 , H05K2203/0502 , H05K2203/061 , H05K2203/0733 , H05K2203/107 , H05K2203/1461 , H05K2203/1536 , H05K2203/304 , Y10T29/49126 , Y10T29/49155 , Y10T29/49165
摘要： A method of manufacturing at least a portion of a printed circuit board. The method includes: applying a lamination adhesive on a first plural-layer substrate that includes a plurality of circuit layers with at least one first metal pad on a first side of the first plural-layer substrate; applying a protective film on the lamination adhesive; forming at least one via into the lamination adhesive to expose the at least one metal pad on the first side of the first plural-layer substrate; filling at least one conductive paste into the at least one via formed in the lamination adhesive; removing the protective film to expose the lamination adhesive on the first plural-layer substrate; and attaching the first plural-layer substrate with a second plural-layer substrate that includes a plurality of circuit layers with at least one second metal pad on a second side of the second plural-layer substrate.
摘要翻译：一种制造印刷电路板的至少一部分的方法。该方法包括：在第一多层基板上施加层压粘合剂，该第一多层基板包括多个电路层，在第一多层基板的第一侧具有至少一个第一金属焊盘; 在层压粘合剂上涂上保护膜; 将至少一个通孔形成到所述层压粘合剂中以暴露所述第一多层基板的第一侧上的所述至少一个金属焊盘; 将至少一个导电浆料填充到在层压粘合剂中形成的至少一个通孔中; 去除所述保护膜以将所述层叠粘合剂暴露在所述第一多层基板上; 以及在所述第二多层基板的第二面上，将具有包含多个电路层的第二多层基板与至少一个第二金属焊盘连接的第一多层基板。

5. 发明申请

US20100306213A1 Merging Search Results 有权
标题翻译：合并搜索结果
公开(公告)号：US20100306213A1
公开(公告)日：2010-12-02
申请号：US12473158
申请日：2009-05-27
申请人： Michael J. Taylor , Filiip Radlinski , Milad Shokouhi
发明人： Michael J. Taylor , Filiip Radlinski , Milad Shokouhi
IPC分类号： G06F17/30
CPC分类号： G06F17/30867
摘要： Merging search results is required, for example, where an information retrieval system issues a query to multiple sources and obtains multiple results lists. In an embodiment a search engine at an Enterprise domain sends a query to the Enterprise search engine and also to a public Internet search engine. In embodiments, results lists obtained from different sources are merged using a merging model which is learnt using a machine learning process and updates when click-through data is observed for example. In examples, user information available in the Enterprise domain is used to influence the merging process to improve the relevance of results. In some examples, the user information is used for query modification. In an embodiment a user is able to impersonate a user of a specified group in order to promote particular results.
摘要翻译：需要合并搜索结果，例如，信息检索系统向多个源发出查询并获得多个结果列表。在一个实施例中，企业域的搜索引擎向Enterprise搜索引擎以及公共因特网搜索引擎发送查询。在实施例中，使用使用机器学习过程学习的合并模型来合并从不同来源获得的结果列表，并且例如在观察到点击数据时进行更新。在示例中，Enterprise域中可用的用户信息用于影响合并过程以提高结果的相关性。在一些示例中，用户信息用于查询修改。在一个实施例中，用户能够模拟指定组的用户以便促进特定结果。

6. 发明授权

US06406907B1 Bovine tumor necrosis factor receptor-1 and methods of use 失效
标题翻译：牛肿瘤坏死因子受体-1及其使用方法
公开(公告)号：US06406907B1
公开(公告)日：2002-06-18
申请号：US09513007
申请日：2000-02-25
申请人： Michael J. Taylor , Marcus E. Kehrli, Jr. , Eun-Kyung Lee
发明人： Michael J. Taylor , Marcus E. Kehrli, Jr. , Eun-Kyung Lee
IPC分类号： C07H2104
CPC分类号： C07K14/70575
摘要： The invention relates to nucleic acid sequences encoding a bovine tumor necrosis factor receptor-I (TNF-RI). Also within the invention is a soluble bovine TNF-RI, which is a potent inhibitor of bovine tumor necrosis factor-&agr; (TNF-&agr;). The invention demonstrates that soluble bovine TNF-RI has therapeutic value as an inhibitor of TNF in cattle suffering from coliform mastitis or other inflammatory disease.
摘要翻译：本发明涉及编码牛肿瘤坏死因子受体-I（TNF-RI）的核酸序列。本发明还有一种可溶性牛TNF-RI，其是牛肿瘤坏死因子-α（TNF-α）的有效抑制剂。本发明表明，可溶性牛TNF-RI具有作为大肠杆菌性乳腺炎或其它炎性疾病的牛的TNF抑制剂的治疗价值。

7. 发明授权

US5405742A Solutions for tissue preservation and bloodless surgery and methods using same 失效
标题翻译：组织保存和无血手术的解决方案及其使用方法
公开(公告)号：US5405742A
公开(公告)日：1995-04-11
申请号：US92456
申请日：1993-07-16
申请人： Michael J. Taylor
发明人： Michael J. Taylor
IPC分类号： A61K38/00 , A01N1/02 , A61K31/045 , A61K31/19 , A61K31/66 , A61K31/70 , A61K31/715 , A61K33/00 , A61K33/06 , A61K38/06 , A61K38/38 , A61P7/08 , A61M37/00
CPC分类号： A01N1/0226 , A01N1/02 , A61K33/06 , A61K38/063 , A61K38/38 , Y10S514/832
摘要： A solution suitable as a hypothermic blood substitute for replacing blood in euthermic subjects during surgery are provided. The blood substitute contains a purge solution and a maintenance solution, the latter of which is useful for organ preservation. The purge solution contains an aqueous solution of electrolytes at physiological concentrations, a macromolecular oncotic agent, a biological pH buffer effective under physiological and hypothermic conditions, a simple sugar, and a substrate for the regeneration of ATP. The maintenance solution contains a second aqueous solution of electrolytes containing potassium ions at a concentration range of from 35 to 45 mM, sodium ions at a concentration range of from 80 to 120 mM, magnesium ions at a concentration range of from 2 to 10 mM, chloride ions at a concentration range of from 15 to 20 mM, and calcium ions at a concentration range of from 0.01 to 0.1 mM, an impermeant anion, mannitol, a macromolecular oncotic agent, at least one simple sugar, a substrate for the regeneration of ATP, and a biological pH buffer effective under physiological hypothermic conditions pH. Glutathione is an optional but preferred additive. The blood substitute solutions are also useful for preserving organs for later transplantation in subjects. Skin may be preserved in the maintenance solutions for extended periods under refrigeration.
摘要翻译：提供了适合作为低温血液替代物的解决方案，用于在手术期间替代非血液受试者的血液。血液替代品含有清洗溶液和维护液，后者适用于器官保存。清洗溶液含有生理浓度的电解质的水溶液，大分子肿瘤剂，在生理和低温条件下有效的生物pH缓冲液，简单的糖和用于再生ATP的底物。维持溶液含有含有浓度范围为35至45mM的钾离子，浓度范围为80至120mM的钠离子，浓度范围为2-10mM的镁离子的电解质的第二水溶液，浓度范围为15至20mM的氯离子和浓度范围为0.01至0.1mM的钙离子，不饱和阴离子，甘露醇，大分子肿瘤剂，至少一种简单的糖，用于再生的底物 ATP和生物pH缓冲液在生理低温条件下有效。谷胱甘肽是可选但优选的添加剂。血液替代品也可用于保存器官用于受试者的后期移植。皮肤可能在制冷过程中长时间保存在维护溶液中。

8. 发明授权

US4381423A High capacitance bus bar manufacturing technique 失效
标题翻译：高电容母线制造技术
公开(公告)号：US4381423A
公开(公告)日：1983-04-26
申请号：US249703
申请日：1981-03-31
申请人： Michael J. Taylor
发明人： Michael J. Taylor
IPC分类号： H02G5/00 , H05K1/02 , H05K1/16 , H01B5/00 , H01B5/14
CPC分类号： H02G5/005 , H05K1/0263 , H05K1/162
摘要： A method of assembling a miniaturized bus bar which has high capacitance comprises forming a layer of ceramic material directly upon a bus bar conductor or directly upon a supporting metal strip which is attached to a first bus bar conductor. The exposed surface of the layer of ceramic material is subsequently mechanically and electrically bonded to a second bus bar conductor which extends parallelly with respect to the first bus conductor.
摘要翻译：组装具有高电容的小型化汇流条的方法包括直接在汇流条导体上形成陶瓷材料层，或者直接在连接到第一母线导体上的支撑金属带上形成。陶瓷材料层的暴露表面随后机械地和电接合到相对于第一总线导体平行延伸的第二母线导体。

9. 发明授权

US4236038A High capacitance multilayer bus bar and method of manufacture thereof 失效
标题翻译：高电容多层母线及其制造方法
公开(公告)号：US4236038A
公开(公告)日：1980-11-25
申请号：US59068
申请日：1979-07-19
申请人： Michael J. Taylor
发明人： Michael J. Taylor
IPC分类号： H01B7/00 , H01B13/00 , H02G5/00 , H05K1/02 , H05K1/16 , H01B5/14
CPC分类号： H01B7/0018 , H02G5/005 , H05K1/0263 , H05K1/162 , Y10T29/49126
摘要： A high capacitance bus bar is presented having at least two separated conductive plates between which a plurality of capacitive ceramic dielectric chips are positioned and adhered. The outer surfaces of the dielectric chips are metalized and have a roughened or coarse finish to provide contact between the dielectric chips and the conductive plates, thereby permitting use of nonconductive adhesive to bond the parts of the assembly together.
摘要翻译：呈现出具有至少两个分离的导电板的高电容母线，多个电容性陶瓷电介质芯片在其间定位和粘附。电介质芯片的外表面被金属化并且具有粗糙或粗糙的表面，以在电介质芯片和导电板之间提供接触，从而允许使用非导电粘合剂将组件的部分粘合在一起。

10. 发明授权

US09834756B2 Methods for increasing isolation yields of cellular products 有权
公开(公告)号：US09834756B2
公开(公告)日：2017-12-05
申请号：US13183961
申请日：2011-07-15
申请人： Michael J. Taylor , Simona C. Baicu , David Kravitz
发明人： Michael J. Taylor , Simona C. Baicu , David Kravitz
IPC分类号： C12N5/071 , A01N1/02
CPC分类号： C12N5/0676 , A01N1/0247
摘要： Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a donor tissue having desired cells and undesired cells, perfusing the donor tissue with a perfusion solution, developing edema during perfusion of the donor tissue to form a swelled tissue, and separating the desired cells from undesired cellular material to obtain a cellular product. The methods may also include disrupting the tissue, and separating the desired cells from undesired cellular material to obtain the cellular product. The methods may result in an increased yield of cellular product that retains sufficient functional integrity to be useful as a transplantation resource.

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