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    • 2. 发明申请
    • Event Prediction Using Hierarchical Event Features
    • 使用分层事件特征的事件预测
    • US20130006900A1
    • 2013-01-03
    • US13608714
    • 2012-09-10
    • Michael J. TaylorVishwa VinayYauhen Shnitko
    • Michael J. TaylorVishwa VinayYauhen Shnitko
    • G06F15/18
    • G06F17/30958G06F17/30867
    • Event prediction using hierarchical event features is described. In an embodiment a search engine monitors search results presented to users and whether users click on those search results. For example, features describing the search result events are universal resource locator prefix levels which are inherently hierarchically related. In an embodiment a graphical data structure is created and stored and used to represent the hierarchical relationships between features. An online training process is used in examples which enables knowledge to be propagated through the graphical data structure according to the hierarchical relations between features. In an example, the graphical data structure is used to predict whether a user will click on a search result and those predictions are used by the search engine to rank search results for future searches. In another example the events are advertisement impressions and the predictions are used by an online advertisement system.
    • 描述使用分层事件特征的事件预测。 在一个实施例中,搜索引擎监视呈现给用户的搜索结果以及用户是否点击这些搜索结果。 例如,描述搜索结果事件的特征是通常的资源定位符前缀级别,其本质上是分层相关的。 在一个实施例中,创建和存储图形数据结构并用于表示特征之间的分层关系。 在实例中使用在线训练过程,使知识能够通过图形数据结构根据特征之间的层次关系进行传播。 在一个示例中,图形数据结构用于预测用户是否将点击搜索结果,并且搜索引擎使用这些预测来对未来搜索的搜索结果进行排序。 在另一个例子中,事件是广告印象,并且预测被在线广告系统使用。
    • 3. 发明授权
    • Method for isolating cellular products by cryopreservation
    • 通过冷冻保存分离细胞产物的方法
    • US08252589B2
    • 2012-08-28
    • US12654147
    • 2009-12-11
    • Michael J. TaylorDavid E. Pegg
    • Michael J. TaylorDavid E. Pegg
    • C12N5/02
    • C12N5/0677A01N1/0221
    • Methods of isolating cellular products, such as pancreatic islets, may be used in diabetes research and therapeutic transplantation. The methods may involve providing a tissue having desired cells that are less prone to destructive freezing and undesired cells that are more prone to destructive freezing, or pre-treating a tissue to have such characteristics. The methods may involve freezing the tissue, disrupting the tissue, warming the tissue, and separating the desired cells from undesired cellular material to obtain the cellular product. The methods may thereby provide an enzyme-free or reduced-enzyme method of isolating a cellular product that is more consistent, reliable and less toxic than conventional methods. The methods may also yield an optimum quantity of cellular product that retain sufficient functional integrity to be useful as a transplantation resource.
    • 分离细胞产物(如胰岛)的方法可用于糖尿病研究和治疗性移植。 所述方法可以包括提供具有不太易于破坏性冷冻的期望细胞的组织和更易于破坏性冷冻的不想要的细胞或预处理组织以具有这些特征的组织。 所述方法可以包括冷冻组织,破坏组织,加热组织,以及将期望的细胞与不期望的细胞材料分离以获得细胞产物。 因此,该方法可以提供与常规方法更一致,可靠和毒性更低的细胞产物的无酶或还原酶方法。 所述方法还可以产生保持足够的功能完整性作为移植资源有用的最佳量的细胞产物。
    • 5. 发明申请
    • Merging Search Results
    • 合并搜索结果
    • US20100306213A1
    • 2010-12-02
    • US12473158
    • 2009-05-27
    • Michael J. TaylorFiliip RadlinskiMilad Shokouhi
    • Michael J. TaylorFiliip RadlinskiMilad Shokouhi
    • G06F17/30
    • G06F17/30867
    • Merging search results is required, for example, where an information retrieval system issues a query to multiple sources and obtains multiple results lists. In an embodiment a search engine at an Enterprise domain sends a query to the Enterprise search engine and also to a public Internet search engine. In embodiments, results lists obtained from different sources are merged using a merging model which is learnt using a machine learning process and updates when click-through data is observed for example. In examples, user information available in the Enterprise domain is used to influence the merging process to improve the relevance of results. In some examples, the user information is used for query modification. In an embodiment a user is able to impersonate a user of a specified group in order to promote particular results.
    • 需要合并搜索结果,例如,信息检索系统向多个源发出查询并获得多个结果列表。 在一个实施例中,企业域的搜索引擎向Enterprise搜索引擎以及公共因特网搜索引擎发送查询。 在实施例中,使用使用机器学习过程学习的合并模型来合并从不同来源获得的结果列表,并且例如在观察到点击数据时进行更新。 在示例中,Enterprise域中可用的用户信息用于影响合并过程以提高结果的相关性。 在一些示例中,用户信息用于查询修改。 在一个实施例中,用户能够模拟指定组的用户以便促进特定结果。
    • 7. 发明授权
    • Solutions for tissue preservation and bloodless surgery and methods
using same
    • 组织保存和无血手术的解决方案及其使用方法
    • US5405742A
    • 1995-04-11
    • US92456
    • 1993-07-16
    • Michael J. Taylor
    • Michael J. Taylor
    • A61K38/00A01N1/02A61K31/045A61K31/19A61K31/66A61K31/70A61K31/715A61K33/00A61K33/06A61K38/06A61K38/38A61P7/08A61M37/00
    • A01N1/0226A01N1/02A61K33/06A61K38/063A61K38/38Y10S514/832
    • A solution suitable as a hypothermic blood substitute for replacing blood in euthermic subjects during surgery are provided. The blood substitute contains a purge solution and a maintenance solution, the latter of which is useful for organ preservation. The purge solution contains an aqueous solution of electrolytes at physiological concentrations, a macromolecular oncotic agent, a biological pH buffer effective under physiological and hypothermic conditions, a simple sugar, and a substrate for the regeneration of ATP. The maintenance solution contains a second aqueous solution of electrolytes containing potassium ions at a concentration range of from 35 to 45 mM, sodium ions at a concentration range of from 80 to 120 mM, magnesium ions at a concentration range of from 2 to 10 mM, chloride ions at a concentration range of from 15 to 20 mM, and calcium ions at a concentration range of from 0.01 to 0.1 mM, an impermeant anion, mannitol, a macromolecular oncotic agent, at least one simple sugar, a substrate for the regeneration of ATP, and a biological pH buffer effective under physiological hypothermic conditions pH. Glutathione is an optional but preferred additive. The blood substitute solutions are also useful for preserving organs for later transplantation in subjects. Skin may be preserved in the maintenance solutions for extended periods under refrigeration.
    • 提供了适合作为低温血液替代物的解决方案,用于在手术期间替代非血液受试者的血液。 血液替代品含有清洗溶液和维护液,后者适用于器官保存。 清洗溶液含有生理浓度的电解质的水溶液,大分子肿瘤剂,在生理和低温条件下有效的生物pH缓冲液,简单的糖和用于再生ATP的底物。 维持溶液含有含有浓度范围为35至45mM的钾离子,浓度范围为80至120mM的钠离子,浓度范围为2-10mM的镁离子的电解质的第二水溶液, 浓度范围为15至20mM的氯离子和浓度范围为0.01至0.1mM的钙离子,不饱和阴离子,甘露醇,大分子肿瘤剂,至少一种简单的糖,用于再生的底物 ATP和生物pH缓冲液在生理低温条件下有效。 谷胱甘肽是可选但优选的添加剂。 血液替代品也可用于保存器官用于受试者的后期移植。 皮肤可能在制冷过程中长时间保存在维护溶液中。