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1. 发明授权

US08790395B2 Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient 有权
标题翻译：用于在患者心脏中的植入部位中定位和锚定瓣膜假体的支架
公开(公告)号：US08790395B2
公开(公告)日：2014-07-29
申请号：US13896905
申请日：2013-05-17
申请人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
发明人： Helmut Straubinger , Johannes Jung , Michael J. Girard , Arnulf Mayer
IPC分类号： A61F2/82 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2412 , A61F2220/0058 , A61F2220/0075 , A61F2230/0023 , A61F2230/0054
摘要： The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.
摘要翻译：本发明涉及一种用于在患者心脏中的植入部位定位和锚定瓣膜假体的支架。具体地，本发明涉及用于治疗心脏瓣膜变窄和/或心脏瓣膜功能不全的内用假体的可扩张支架。为了确保即使给予心脏的蠕动运动，固定在支架上的瓣膜假体也不会相对于支架的植入状态发生纵向位移，所以根据本发明的支架包括至少一个紧固部分瓣膜假体可以通过其连接到支架上。支架还包括定位拱门和保持拱门，由此至少一个定位弓连接到至少一个保持拱。

2. 发明授权

US08100821B2 Low friction delivery tool for a cardiac support device 有权
标题翻译：用于心脏支持装置的低摩擦递送工具
公开(公告)号：US08100821B2
公开(公告)日：2012-01-24
申请号：US12333045
申请日：2008-12-11
申请人： Aaron J. Hjelle , Louis Labrousse , Robert G. Walsh , Paul Andrew Pignato , Michael J. Girard
发明人： Aaron J. Hjelle , Louis Labrousse , Robert G. Walsh , Paul Andrew Pignato , Michael J. Girard
IPC分类号： A61F2/00
CPC分类号： A61F2/2481 , A61F2002/2484
摘要： A delivery device for efficiently delivering a cardiac support device of the type having a jacket. The device includes a body, a deployment mechanism and an actuating mechanism. The deployment mechanism is for releasable connection to a cardiac support device and movable within the jacket between retracted and extended states to drive the jacket between collapsed and open configurations. At least portions of the deployment mechanism within the jacket have a lubricious surface to substantially reduce friction between the jacket and a heart onto which the jacket is being positioned. The actuating mechanism moves the deployment mechanism between the retracted and extended states.
摘要翻译：一种用于有效地输送具有护套的类型的心脏支持装置的输送装置。该装置包括主体，展开机构和致动机构。展开机构用于可释放地连接到心脏支撑装置，并且在收缩和伸展状态之间在护套内可移动，以在收缩和打开构型之间驱动护套。护套内的展开机构的至少部分具有光滑的表面，以显着地减少外套与夹套所在的心脏之间的摩擦。致动机构使展开机构在缩回状态和伸展状态之间移动。

3. 发明申请

US20110166413A1 COMPLIANT CARDIAC SUPPORT DEVICE 审中-公开
标题翻译：合规心脏辅助装置
公开(公告)号：US20110166413A1
公开(公告)日：2011-07-07
申请号：US13049499
申请日：2011-03-16
申请人： Clifton A. ALFERNESS , Donald G. ROHRBAUGH , James Edward SHAPLAND , Michael J. GIRARD , Donald F. PALME, II , James E. COX
发明人： Clifton A. ALFERNESS , Donald G. ROHRBAUGH , James Edward SHAPLAND , Michael J. GIRARD , Donald F. PALME, II , James E. COX
IPC分类号： A61F2/00
CPC分类号： A61F2/2481 , Y10S623/904
摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.
摘要翻译：生物相容材料的护套具有尺寸设计用于心脏顶点的内部容积，以将其插入体积中并使护套滑过心脏。护套具有在上下端之间的纵向尺寸，足以使护套围绕心脏的下部围绕心脏的瓣膜环并且进一步围绕下部以至少覆盖心脏的心室下端。护套适于固定在心脏上，护套至少围绕瓣膜环和心室下肢。护套在心脏上是可调节的，以贴合地符合心脏的外部几何形状，并假设护套的最大调节体积以约束舒张期心脏超过最大调节体积的周向扩张，并允许心脏收缩期间不受阻碍的收缩。

4. 发明申请

US20100249923A1 COLLAPSIBLE/EXPANDABLE PROSTHETIC HEART VALVES WITH NATIVE CALCIFIED LEAFLET RETENTION FEATURES 有权
标题翻译：具有先前计算的叶片保持特征的可拆卸/可扩展的前置心脏瓣膜
公开(公告)号：US20100249923A1
公开(公告)日：2010-09-30
申请号：US12733763
申请日：2008-09-26
申请人： Yousef F. Alkhatib , Michael J. Girard
发明人： Yousef F. Alkhatib , Michael J. Girard
IPC分类号： A61F2/24
CPC分类号： A61F2/2409 , A61F2/2412 , A61F2/2418 , A61F2230/0006 , A61F2230/0054 , A61F2230/0069 , A61F2230/0076
摘要： A prosthetic heart valve is circumferentially collapsible for less invasive delivery into a patient. The valve re-expands to operating size at the implant site in the patient. A frame structure of the valve includes restraining structure that can help to push one or more of the patient's native heart valve leaflets radially outwardly so that this native leaflet tissue does not interfere with the operation or service life of the prosthetic valve.
摘要翻译：假体心脏瓣膜是周向可折叠的，用于较少侵入性地输送到患者体内。瓣膜在病人的植入部位重新扩大到操作尺寸。阀的框架结构包括限制结构，其可以帮助推动病人的天然心脏瓣膜叶片中的一个或多个径向向外，使得该天然小叶组织不会干扰人工瓣膜的操作或使用寿命。

5. 发明申请

US20090131743A1 LOW FRICTION DELIVERY TOOL FOR A CARDIAC SUPPORT DEVICE 有权
标题翻译：用于CARDIAC支持设备的低摩擦输送工具
公开(公告)号：US20090131743A1
公开(公告)日：2009-05-21
申请号：US12333045
申请日：2008-12-11
申请人： Aaron J. HJELLE , Louis Labrousse , Robert G. Walsh , Paul Andrew Pignato , Michael J. Girard
发明人： Aaron J. HJELLE , Louis Labrousse , Robert G. Walsh , Paul Andrew Pignato , Michael J. Girard
IPC分类号： A61F2/02
CPC分类号： A61F2/2481 , A61F2002/2484
摘要： A delivery device for efficiently delivering a cardiac support device of the type having a jacket. The device includes a body, a deployment mechanism and an actuating mechanism. The deployment mechanism is for releasable connection to a cardiac support device and movable within the jacket between retracted and extended states to drive the jacket between collapsed and open configurations. At least portions of the deployment mechanism within the jacket have a lubricious surface to substantially reduce friction between the jacket and a heart onto which the jacket is being positioned. The actuating mechanism moves the deployment mechanism between the retracted and extended states.
摘要翻译：一种用于有效地输送具有护套的类型的心脏支持装置的输送装置。该装置包括主体，展开机构和致动机构。展开机构用于可释放地连接到心脏支撑装置，并且在收缩和伸展状态之间在护套内可移动，以在收缩和打开构型之间驱动护套。护套内的展开机构的至少部分具有光滑的表面，以显着地减少外套与夹套所在的心脏之间的摩擦。致动机构使展开机构在缩回状态和伸展状态之间移动。

6. 发明授权

US06482146B1 Cardiac disease treatment and device 有权
标题翻译：心脏病治疗及器械
公开(公告)号：US06482146B1
公开(公告)日：2002-11-19
申请号：US09593251
申请日：2000-06-13
申请人： Clifton A. Alferness , Donald G. Rohrbaugh , J. Edward Shapland , Michael J. Girard , Donald F. Palme, II , James E. Cox
发明人： Clifton A. Alferness , Donald G. Rohrbaugh , J. Edward Shapland , Michael J. Girard , Donald F. Palme, II , James E. Cox
IPC分类号： A61F200
CPC分类号： A61F2/2481 , Y10S623/904
摘要： A jacket of biological compatible material has an internal volume dimensioned for an apex of the heart to be inserted into the volume and for the jacket to be slipped over the heart. The jacket has a longitudinal dimension between upper and lower ends sufficient for the jacket to surround a lower portion of the heart with the jacket surrounding a valvular annulus of the heart and further surrounding the lower portion to cover at least the ventricular lower extremities of the heart. The jacket is adapted to be secured to the heart with the jacket surrounding at least the valvular annulus and the ventricular lower extremities. The jacket is adjustable on the heart to snugly conform to an external geometry of the heart and assume a maximum adjusted volume for the jacket to constrain circumferential expansion of the heart beyond the maximum adjusted volume during diastole and to permit unimpeded contraction of the heart during systole.
摘要翻译：生物相容材料的护套具有尺寸设计用于心脏顶点的内部容积，以将其插入体积中并使护套滑过心脏。护套具有在上下端之间的纵向尺寸，足以使护套围绕心脏的下部围绕心脏的瓣膜环并且进一步围绕下部以至少覆盖心脏的心室下端。护套适于固定在心脏上，护套至少围绕瓣膜环和心室下肢。护套在心脏上是可调节的，以贴合地符合心脏的外部几何形状，并假设护套的最大调节体积以约束舒张期心脏超过最大调节体积的周向扩张，并允许心脏收缩期间不受阻碍的收缩。

7. 发明授权

US06358278B1 Heart valve prosthesis with rotatable cuff 有权
标题翻译：具有可旋转袖口的心脏瓣膜假体
公开(公告)号：US06358278B1
公开(公告)日：2002-03-19
申请号：US09406275
申请日：1999-09-24
申请人： Avrom M. Brendzel , William R. Kramlinger , Michael J. Girard , Jonas A. Runquist
发明人： Avrom M. Brendzel , William R. Kramlinger , Michael J. Girard , Jonas A. Runquist
IPC分类号： A61F224
CPC分类号： A61F2/2409
摘要： A prosthetic heart valve includes an orifice ring adapted to carry blood therethrough. An annular recess is formed in an outer surface of the orifice ring and has first and second axially spaced walls. A sewing cuff is adapted to be coupled to a native tissue annulus of a heart and includes an inner annular cuff portion adapted to conform to the first and second recess walls in the orifice ring. A cuff retaining ring extends around the inner annular fabric portion such that the inner annular cuff portion is positioned between the cuff retaining ring and the annular recess. The cuff retaining ring is further adapted to exert a substantially axially directed force directed against the annular cuff portion and first and second axially spaced walls of the annular recess, which is substantially greater than a radial force directed substantially inwardly by the cuff retaining ring against an annulus of the recess located between the first and second walls, whereby a controllable torque to rotate the cuff relative to the orifice ring is developed substantially due to friction between the first and second recess walls cuff portion and the annular recess.
摘要翻译：假体心脏瓣膜包括适于携带血液的孔口环。环形凹部形成在孔环的外表面中并具有第一和第二轴向隔开的壁。缝合箍适于联接到心脏的天然组织环，并且包括适于与孔环中的第一和第二凹陷壁一致的内环形箍部分。袖带保持环围绕内部环形织物部分延伸，使得内部环形箍部分位于袖带保持环和环形凹部之间。套箍保持环还适于施加指向环形箍部分和环形凹部的第一和第二轴向隔开的壁的基本上轴向的力，其基本上大于由套箍保持环基本向内指向的径向力位于第一和第二壁之间的凹部的环形空间，由此基本上由于第一和第二凹部壁箍部分和环形凹部之间的摩擦而使袖带相对于孔环旋转的可控转矩变大。

8. 发明授权

US06176877B1 Two piece prosthetic heart valve 失效
标题翻译：两片假体心脏瓣膜
公开(公告)号：US06176877B1
公开(公告)日：2001-01-23
申请号：US09062822
申请日：1998-04-20
申请人： Eric S. Buchanan , Bob Allan , Michael J. Girard , William R. Holmberg , Kimberly A. Anderson
发明人： Eric S. Buchanan , Bob Allan , Michael J. Girard , William R. Holmberg , Kimberly A. Anderson
IPC分类号： A61F224
CPC分类号： A61F2/2427 , A61B17/064 , A61B17/068 , A61B17/072 , A61B17/1155 , A61B2017/0649 , A61B2017/07214 , A61F2/2409 , A61F2250/006
摘要： A prosthetic heart valve for implantation in a heart includes an outer orifice ring for coupling to a tissue annulus of a heart. An inner orifice ring includes at least one leaflet occluder carried in a lumen of the inner orifice ring which is movable between an open position, which allows blood flow through the lumen, and a closed position which blocks blood flow through the lumen. The inner orifice ring is adapted to be coupled to the outer orifice ring after the outer orifice ring has been attached to the tissue annulus.
摘要翻译：用于植入心脏的假心脏瓣膜包括用于联接到心脏组织环的外孔环。内孔环包括携带在内孔环的内腔中的至少一个小叶闭塞器，其能够在允许血液流过内腔的打开位置和阻断通过管腔的血液流动的关闭位置之间移动。在外孔环已经附着到组织环之后，内孔环适于联接到外孔环。

9. 发明授权

US6155972A Cardiac constraint jacket construction 有权
标题翻译：心脏约束夹克结构
公开(公告)号：US6155972A
公开(公告)日：2000-12-05
申请号：US241706
申请日：1999-02-02
申请人： Kay A. Nauertz , James E. Cox , Michael J. Girard
发明人： Kay A. Nauertz , James E. Cox , Michael J. Girard
IPC分类号： A61F2/00 , A61F13/00
CPC分类号： A61F2/2481 , A61F2002/0068
摘要： A jacket for placement over a heart to constrain congestive heart failure related expansion includes a biocompatible fabric formed into a pouch having a base end and an apical end with an interior of the pouch sized to receive a patient's heart. The base end has a peripheral edge defining a base opening sized to pass an apex of the heart through the base opening. The heart is slipped into the interior of the pouch with the apical end facing the apex of the heart and with the base end facing toward a base of the heart. At the base end, the fabric is folded over for the peripheral edge to have at least a double layer of the fabric. The double layer terminates at a free edge on an outer surface of the pouch and is spaced from the peripheral edge. In an additional embodiment, the fabric includes a side edge of opposing fabric surfaces extending from the apical end to the base end. The opposing fabric surfaces are joined by a stitch assembly. The stitch assembly includes a first stitch line spaced from free edges of the surfaces to define a junction of the fabric surfaces. The free edges are folded back onto the fabric surfaces to define at least a double layer of fabric on opposite sides of the junction. A second stitch line is placed over the junction and through the double layers on the opposite sides of the junction.
摘要翻译：用于放置在心脏上以限制充血性心力衰竭相关扩张的护套包括形成为具有基端和顶端的生物相容性织物，其具有尺寸适于接纳患者心脏的袋的内部。基端具有限定基部开口的外围边缘，该基部开口的尺寸适于使心脏的顶点通过基部开口。心脏被滑入袋的内部，其顶端面向心脏的顶点，并且基端朝向心脏的基部。在基端，将织物折叠成外围边缘以至少具有双层织物。双层在袋的外表面上的自由边缘终止并且与周边边缘隔开。在另外的实施例中，织物包括从顶端延伸到基端的相对织物表面的侧边缘。相对的织物表面通过缝合组件接合。缝合组件包括与表面的自由边缘间隔开以限定织物表面的接合处的第一缝合线。自由边缘被折回到织物表面上以在结的相对侧上限定至少一层双层织物。第二针迹线放置在结点上方，并穿过连接处相对两侧的双层。

10. 发明授权

US5814101A Holder for heart valve prosthesis 失效
标题翻译：心脏瓣膜假体支架
公开(公告)号：US5814101A
公开(公告)日：1998-09-29
申请号：US719568
申请日：1996-09-25
申请人： Margaret A. Wallner , David R. Elizondo , Kimberly A. Anderson , Guy P. Vanney , Kurt D. Krueger , Michael J. Girard , Stephen A. Petersen , Darrin J. Bergman , Terry L. Shepherd
发明人： Margaret A. Wallner , David R. Elizondo , Kimberly A. Anderson , Guy P. Vanney , Kurt D. Krueger , Michael J. Girard , Stephen A. Petersen , Darrin J. Bergman , Terry L. Shepherd
IPC分类号： A61F2/24 , A61M5/00
CPC分类号： A61F2/2427
摘要： A holder for engaging a heart valve prosthesis during implantation includes a holder body and stem. The stem is adapted to receive a handle used to manipulate the prostheses during implantation. The stem is moveable between a standard implantation position and a low profile delivery position.
摘要翻译：在植入期间用于接合心脏瓣膜假体的保持器包括保持器主体和杆。杆适于在植入期间接收用于操纵假体的手柄。杆可在标准植入位置和低轮廓输送位置之间移动。

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