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1. 发明授权

US5358509A Atherectomy catheter with improved fluid infusion 失效
标题翻译：动脉粥样硬化切除导管，改善输液
公开(公告)号：US5358509A
公开(公告)日：1994-10-25
申请号：US69903
申请日：1993-06-01
申请人： Michael J. Fine , Enora S. Rogers
发明人： Michael J. Fine , Enora S. Rogers
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61B19/00 , A61M25/00
CPC分类号： A61B17/320758 , A61B2090/3933
摘要： According to the invention there is provided an intravascular catheter and thrombectomy procedure utilizing the catheter. The catheter comprises a flexible jacket with a distal working head having a canalizing tip rotatable at high speeds for removing thrombus from the lumen of a vessel. A flexible drive assembly extends through the jacket to rotate the tip and a plurality of infusion ports are formed adjacent the distal end of the jacket, capable of delivering a fluid contrast media at relatively high volumetric flow rates into the lumen of the vessel to locate the site of the thrombus. The canalizing tip is then rotated at high speed to homogenize and remove the thrombus from the lumen.
摘要翻译：根据本发明，提供了使用该导管的血管内导管和血栓切除术。导管包括柔性护套，其具有远端工作头，该远端工作头具有可高速旋转的导管末端，用于从血管内腔去除血栓。柔性驱动组件延伸穿过护套以旋转尖端，并且多个输注端口邻近护套的远端形成，能够以相当高的体积流速将流体造影剂输送到血管的内腔中，血栓部位。然后，将引流尖端高速旋转以均质化并从内腔中除去血栓。

2. 发明授权

US5417689A Thermal balloon catheter and method 失效
标题翻译：热球囊导管及方法
公开(公告)号：US5417689A
公开(公告)日：1995-05-23
申请号：US182776
申请日：1994-01-18
申请人： Michael J. Fine
发明人： Michael J. Fine
IPC分类号： A61B17/00 , A61B17/22 , A61B18/04 , A61B18/08 , A61F7/12 , A61M29/02 , A61B17/36
CPC分类号： A61M25/104 , A61B18/08 , A61B2017/00092 , A61B2017/22001 , A61B2018/046 , A61F2007/126 , A61M2205/36 , A61M2205/3653
摘要： The method and apparatus of the present invention is for treating a blood vessel stenosis region in a subject. The method comprises the steps of inserting a catheter into a subject until a balloon located at a distal end portion of the catheter is within a treatment region of a blood vessel. The catheter comprises an elongated tubular body member having first and second axially extending passages. The balloon is located at a distal end portion of the tubular body member and is in fluid communication with the first and second passages. A mechanism supplies fluid under pressure through the first passage to a first axial end portion of the balloon to inflate the balloon. A heater located within the balloon elevates the temperature of the fluid to a first temperature. The first temperature is maintained for a predetermined time interal. A thermocouple senses the temperature of the fluid within the balloon. A control establishes the temperature during a thermal treatment cycle in response to the temperature of the fluid sensed by the thermocouple. The second passage conducts the heated fluid from the balloon at a second axially opposite end portion of the balloon after the thermal treatment cycle. The heated fluid removed from the balloon is replaced with a fluid at a second temperature less than the first temperature through the first passage.
摘要翻译：本发明的方法和装置用于治疗受试者的血管狭窄区域。该方法包括以下步骤：将导管插入受试者，直到位于导管的远端部分的气囊在血管的治疗区域内。导管包括具有第一和第二轴向延伸通道的细长管状本体构件。气囊位于管状本体构件的远端部分并且与第一和第二通道流体连通。机构将压力下的液体通过第一通道提供给球囊的第一轴向端部，以使球囊膨胀。位于球囊内的加热器将流体的温度升高到第一温度。第一温度在内部保持预定时间。热电偶检测气囊内液体的温度。控制器响应于由热电偶感测的流体的温度在热处理循环期间建立温度。在热处理循环之后，第二通道在球囊的第二轴向相对端部处从球囊导管加热的流体。从气球移除的被加热流体在第一温度低于第一温度的第二温度下被流体替代。

3. 发明授权

US5261877A Method of performing a thrombectomy procedure 失效
标题翻译：执行血栓切除手术的方法
公开(公告)号：US5261877A
公开(公告)日：1993-11-16
申请号：US734381
申请日：1991-07-22
申请人： Michael J. Fine , Enora S. Rogers
发明人： Michael J. Fine , Enora S. Rogers
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61B19/00 , A61M25/00 , A61M31/00
CPC分类号： A61B17/320758 , A61B2090/3933
摘要： According to the invention there is provided an intravascular catheter and thrombectomy procedure utilizing the catheter. The catheter comprises a flexible jacket with a distal working head having a canalizing tip rotatable at high speeds for removing thrombus from the lumen of a vessel. A flexible drive assembly extends through the jacket to rotate the tip and a plurality of infusion ports are formed adjacent the distal end of the jacket, capable of delivering a fluid contrast media at relatively high volumetric flow rates into the lumen of the vessel to locate the site of the thrombus. The canalizing tip is then rotated at high speed to homogenize and remove the thrombus from the lumen.

4. 发明申请

US20140279257A1 CONTENT CURATION AND PRODUCT LINKING SYSTEM AND METHOD 审中-公开
标题翻译：内容固化与产品连接系统及方法
公开(公告)号：US20140279257A1
公开(公告)日：2014-09-18
申请号：US13947029
申请日：2013-07-20
申请人： Michael J. FINE , Jesse ERLBAUM
发明人： Michael J. FINE , Jesse ERLBAUM
IPC分类号： G06Q30/06
CPC分类号： G06Q30/0625
摘要： A computer-implemented method of operating a user-searchable database system of curated, themed digital content data, which method includes operating a Connects function to process and store heterogeneous digital content comprising topic data as curated topic data and identified connections between each topic and other topics, and operating a user interface to enable users to search the curated topics and present a search results page in a way that invites further investigation of topics searched, including a list or compilation of topics matching terms defining the search. The method also includes displaying topic elements corresponding to the list or compilation of matching topics in prioritized order based on each topic's relatedness to the search.
摘要翻译：一种计算机实现的操作用户可搜索的数字内容数据库的数据库系统，该方法包括操作连接功能，以处理和存储包含主题数据的异构数字内容，作为策划的主题数据，并确定每个主题与其他主题之间的连接主题和操作用户界面，使用户能够搜索策划的主题并呈现搜索结果页面，方式是邀请对搜索主题进行进一步调查，包括与定义搜索的术语匹配的主题列表或汇编。该方法还包括基于每个主题与搜索的相关性以优先顺序显示与列表相对应的主题元素或编辑匹配主题。

5. 发明授权

US5800516A Deployable and retrievable shape memory stent/tube and method 失效
标题翻译：可部署和可回收的形状记忆支架/管和方法
公开(公告)号：US5800516A
公开(公告)日：1998-09-01
申请号：US693708
申请日：1996-08-08
申请人： Michael J. Fine , Kenneth S. Solovay
发明人： Michael J. Fine , Kenneth S. Solovay
IPC分类号： A61F2/00 , A61F2/82 , A61F2/06
CPC分类号： A61F2/82 , A61F2/958 , A61F2210/0023
摘要： A method for the deployment and retrieval of a tubular member. The method is achieved by first introducing a tubular member having a first diameter to a preselected treatment site, wherein said tubular member exhibits shape memory characteristics. The tubular member is then expanded to a second diameter at the treatment site and deployed at the treatment site. After a predetermined time, the tubular member is retrieved from the treatment site by causing the tubular member to return to its first diameter and withdrawing the tubular member from the treatment site. A tubular member with shape memory characteristics for use in accordance with the method is also provided.
摘要翻译：一种用于部署和取回管状构件的方法。该方法通过首先将具有第一直径的管状构件引入预选的处理位置来实现，其中所述管状构件呈现形状记忆特性。然后将管状构件在治疗部位扩张至第二直径，并在治疗部位展开。在预定时间之后，通过使管状构件返回其第一直径并从处理部位取出管状构件，从处理部位取出管状构件。还提供了具有根据该方法使用的形状记忆特性的管状构件。

6. 发明授权

US5290295A Insertion tool for an intraluminal graft procedure 失效
标题翻译：用于腔内移植手术的插入工具
公开(公告)号：US5290295A
公开(公告)日：1994-03-01
申请号：US913208
申请日：1992-07-15
申请人： Luis A. Querals , Michael J. Fine
发明人： Luis A. Querals , Michael J. Fine
IPC分类号： A61F2/06 , A61F2/84 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61F2/95 , A61F2/97 , A61F2/07
摘要： A tool for the intraluminal insertion and deployment of a tubular graft within a blood vessel includes a flexible insertion shaft with a tapered distal end, a tubular sheath, a deployment slider and a safety locking tube. The deployment slider and the graft are slideably mounted, end to end, on a cylindrical portion of the shaft. A tubular sheath, which is slideably mounted to cover the graft and a distal portion of the deployment slider, includes a tapered distal end portion with tabs extending into a circumferential groove in the shaft. The graft is deployed, or released, by first removing the safety lock tube and then the tubular sheath is withdrawn over the proximal end of the shaft, exposing the graft from the outside and from the distal end of the tool. Then the shaft is then withdrawn as the deployment slider is held in place to prevent the withdrawal of the graft. Prior to deployment, the safety locking tube is locked on the proximal end of the shaft in an end to end relationship with the tubular sheath, thereby preventing premature deployment by preventing the withdrawal of the tubular sheath. An alternative version of the tool includes an electrical heating element to aid in the softening and dilating of tissues, and a second alternative version of the tool includes an angioplasty balloon at the distal end, so that obstructions can be cleared by angioplasty as the tool is advanced along a blood vessel.
摘要翻译：用于在血管内管腔移植物的腔内插入和展开的工具包括具有锥形远端的柔性插入轴，管状护套，展开滑块和安全锁定管。展开滑块和移植物在轴的圆筒部分端对端可滑动地安装。可滑动地安装以覆盖移植物和展开滑块的远侧部分的管状护套包括锥形的远端部分，突出部延伸到轴中的周向凹槽中。移植物被部署或释放，首先移除安全锁定管，然后将管状护套从轴的近端伸出，将移植物从外部和从工具的远端露出。然后当部署滑块保持在适当位置时轴被抽出以防止移植物的抽出。在展开之前，安全锁定管以与管状护套成端对关系的方式锁定在轴的近端上，从而通过防止管状护套的撤回来防止过早展开。该工具的替代形式包括电加热元件以帮助组织的软化和扩张，并且该工具的第二替代形式包括在远端处的血管成形术球囊，使得障碍物可以通过血管成形术来清除，因为该工具是沿着血管进展。

7. 发明授权

US4922927A Transvenous defibrillating and pacing lead 失效
标题翻译：经静脉除颤和起搏引导
公开(公告)号：US4922927A
公开(公告)日：1990-05-08
申请号：US348869
申请日：1989-05-08
申请人： Michael J. Fine , Richard V. Calfee
发明人： Michael J. Fine , Richard V. Calfee
IPC分类号： A61N1/05 , A61N1/372 , A61N1/39
CPC分类号： A61N1/3956 , A61N1/056
摘要： A transvenous lead for defibrillation and pacing of the heart includes a single defibrillating coil electrode adapted to be introduced into the right ventricle of the heart. The coil constitutes a relatively long flexible large surface area electrode conformable to the shape of the ventricle and thereby readily disposed along the entire length of the vertricle for use in delivering defibrillating shocks. A pacing electrode at the tip of the lead is used both in stimulating the heart with pacing pulses and in sensing the response of the heart to the pulses and to shocks. The coil electrode is multi-filar, composed of a plurality of wires tightly wound side by side, each wire composed of copper-zirconium alloy wrapped with tantalum, and is flared from the diameter at its ends to a lager diameter intermediate its ends to increase the exposed surface area thereof in the ventricle.
摘要翻译：用于心脏除颤和起搏的静脉导线包括适于引入心脏右心室的单个除颤线圈电极。线圈构成一个相对较长的柔性大表面电极，其符合心室的形状，从而容易地沿着垂直的整个长度设置，用于输送除颤冲击。在引线尖端的起搏电极用于刺激心脏与起搏脉冲并且感测心脏对脉冲的响应和冲击。线圈电极是多丝的，由多根紧密缠绕的电线组成，每条电线由钽包裹的铜 - 锆合金构成，并且从其端部的直径扩展到其末端的较大直径，以增加其在脑室中的暴露表面积。

8. 发明授权

US4827932A Implantable defibrillation electrodes 失效
标题翻译：植入式除颤电极
公开(公告)号：US4827932A
公开(公告)日：1989-05-09
申请号：US19670
申请日：1987-02-27
申请人： Raymond E. Ideker , Michael J. Fine , Ross G. Baker, Jr. , Richard V. Calfee
发明人： Raymond E. Ideker , Michael J. Fine , Ross G. Baker, Jr. , Richard V. Calfee
IPC分类号： A61N1/06 , A61N1/05 , A61N1/39
CPC分类号： A61N1/0587
摘要： A pair of defibrillation patch electrodes is adapted for close fitting placement over the ventricles of the heart, either epicardially or pericardially. One of the patches is contoured to fit over the right ventricle, and the other is contoured to fit over the left ventricle in spaced relationship to the first patch to form a substantially uniform gap between confronting borders of the two. The gap is sufficiently wide to avoid the shunting of current between edges of the patches upon delivery of defibrillation shocks, as well as to accommodate the ventricular septum and the major coronary arteries therein. The size and shape of the patches is such that they encompass most of the ventricular myocardium within and between their borders, to establish a nearly uniform potential gradient field throughout the entire ventricular mass when a defibrillation shock is delivered to the electrodes. Flat versions of the two electrodes provide ease of manufacture.

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