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1. 发明授权

US06976639B2 Apparatus and method for droplet steering 有权
标题翻译：液滴转向装置及方法
公开(公告)号：US06976639B2
公开(公告)日：2005-12-20
申请号：US10006489
申请日：2001-12-06
申请人： Roger O. Williams , Michael Van Tuyl , Michael Forbush
发明人： Roger O. Williams , Michael Van Tuyl , Michael Forbush
IPC分类号： B41J2/14 , B05B1/28
CPC分类号： B41J2/14008
摘要： An apparatus and method for droplet steering is disclosed herein. A throated structure having a nozzle defines a converging throat with an inlet and an outlet and a vectored fluid stream directed therethrough. The fluid stream is driven through the system via a vacuum pump. As the fluid approaches the outlet, its velocity increases and is drawn away from the nozzle through a connecting channel. As a droplet is ejected from a liquid therebelow, it will have a first trajectory until it is introduced to the high velocity fluid stream at the perimeter of the interior walls of the nozzle. The fluid accordingly steers the momentum of the droplet such that it obtains a second or corrected trajectory. Alternative variations include an electrically chargeable member, e.g., a pin, positionable to be in apposition to the outlet and capillary tubes for controlling the ejection surface of the pool of source fluid.
摘要翻译：本文公开了一种用于液滴转向的装置和方法。具有喷嘴的带喉的结构限定了具有入口和出口的会聚喉部以及从其中引导的向量流体流。流体流经真空泵驱动通过系统。当流体接近出口时，其速度增加，并通过连接通道从喷嘴中拉出。当液滴从其下方的液体喷射时，它将具有第一轨迹，直到其被引入喷嘴内壁周边处的高速流体流。流体相应地引导液滴的动量，使得其获得第二或校正的轨迹。替代的变型包括可定位成与出口相配合的可引起电荷的构件，用于控制源流体池的喷射表面的毛细管。

2. 发明申请

US20080092968A1 ACOUSTICALLY MEDIATED FLUID TRANSFER METHODS AND USES THEREOF 审中-公开
标题翻译：主动介质流体传输方法及其用途
公开(公告)号：US20080092968A1
公开(公告)日：2008-04-24
申请号：US11958354
申请日：2007-12-17
申请人： Roger WILLIAMS , Tarlochan Singh , N. Mansour , Lawrence Lee , Michael Forbush
发明人： Roger WILLIAMS , Tarlochan Singh , N. Mansour , Lawrence Lee , Michael Forbush
IPC分类号： F15C1/02
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2400/0433 , B01L2400/0436 , B05B17/0615 , C40B30/04 , C40B40/02 , C40B40/04 , C40B40/08 , C40B40/10 , C40B50/00 , C40B60/14 , F04F7/00 , G01N21/11 , Y10T137/206 , Y10T137/2196 , Y10T436/2575
摘要： Acoustic waves are used to transfer small amounts of fluid in a non-contact manner. Acoustic waves are propagated through a pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precise automation of a wide variety of procedures including screening and synthesis procedures commonly used in biotechnology.
摘要翻译：声波用于以非接触方式转移少量流体。声波以这样的方式传播通过源流体池，使得从池的表面喷射单个微滴。液滴以足够的力朝向目标喷射以提供液滴与靶的接触。由于流体不被诸如移液管之类的任何流体转移装置接触，污染的机会被最小化。可以采用方法将流体从源位置阵列转移到靶位点阵列，从而能够精确自动化各种程序，包括通常用于生物技术的筛选和合成过程。

3. 发明申请

US20060011744A1 Apparatus and method for droplet steering 有权
公开(公告)号：US20060011744A1
公开(公告)日：2006-01-19
申请号：US11231579
申请日：2005-09-21
申请人： Roger Williams , Michael Van Tuyl , Michael Forbush
发明人： Roger Williams , Michael Van Tuyl , Michael Forbush
IPC分类号： B05B1/28
CPC分类号： B41J2/14008
摘要： An apparatus and method for droplet steering is disclosed herein. A throated structure having a nozzle defines a converging throat with an inlet and an outlet and a vectored fluid stream directed therethrough. The fluid stream is driven through the system via a vacuum pump. As the fluid approaches the outlet, its velocity increases and is drawn away from the nozzle through a connecting channel. As a droplet is ejected from a liquid therebelow, it will have a first trajectory until it is introduced to the high velocity fluid stream at the perimeter of the interior walls of the nozzle. The fluid accordingly steers the momentum of the droplet such that it obtains a second or corrected trajectory. Alternative variations include an electrically chargeable member, e.g., a pin, positionable to be in apposition to the outlet and capillary tubes for controlling the ejection surface of the pool of source fluid.

4. 发明申请

US20050193805A1 Acoustic method for determining the viscosity and/or surface tension of a liquid 有权
标题翻译：用于确定液体的粘度和/或表面张力的声学方法
公开(公告)号：US20050193805A1
公开(公告)日：2005-09-08
申请号：US11088436
申请日：2005-03-24
申请人： Roger Williams , James Chiao , Humphrey Chow , Michael Forbush , Andrew Rose
发明人： Roger Williams , James Chiao , Humphrey Chow , Michael Forbush , Andrew Rose
IPC分类号： G01N11/10
CPC分类号： G01N13/02 , B41J2/14008 , G01N11/16
摘要： The present invention comprises a noncontact method for measuring viscosity and/or surface tension information of a liquid in a liquid containment structure. The steps of the method include exciting a surface of the liquid with an excitation burst of acoustic energy that causes the surface to oscillate; generating a positional data set comprised of a plurality of positional measurements related to the detected position of the surface at a plurality of times after the surface is excited; generating a frequency domain data set from the positional data set, the amplitude spectrum of the frequency domain data set comprising information about the oscillation frequency of at least one vibrational mode of the of the surface as it oscillates; and processing the frequency domain data set and/or the positional data set to yield information about the surface tension and/or viscosity of the liquid. A Fast Fourier Transform technique may be used in generating the frequency domain data set.
摘要翻译：本发明包括用于测量液体容纳结构中的液体的粘度和/或表面张力信息的非接触方法。该方法的步骤包括以引起表面振荡的声能的激发脉冲激发液体的表面; 在所述表面被激发之后，多次生成与所述表面的检测位置有关的多个位置测量值的位置数据集; 从所述位置数据集生成频域数据集，所述频域数据集的振幅谱包括关于所述表面的至少一个振动模式的振荡频率在振荡时的振荡频率的信息; 并且处理频域数据集和/或位置数据集以产生关于液体的表面张力和/或粘度的信息。快速傅立叶变换技术可用于产生频域数据集。

5. 发明申请

US20080103062A1 ACOUSTICALLY MEDIATED FLUID TRANSFER METHODS AND USES THEREOF 审中-公开
公开(公告)号：US20080103062A1
公开(公告)日：2008-05-01
申请号：US11963648
申请日：2007-12-21
申请人： Roger Williams , Tarlochan Singh , N. Mansour , Lawrence Lee , Michael Forbush
发明人： Roger Williams , Tarlochan Singh , N. Mansour , Lawrence Lee , Michael Forbush
IPC分类号： C40B40/00 , C40B50/08 , G10K15/00 , C40B40/10
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2400/0433 , B01L2400/0436 , B05B17/0615 , C40B30/04 , C40B40/02 , C40B40/04 , C40B40/08 , C40B40/10 , C40B50/00 , C40B60/14 , F04F7/00 , G01N21/11 , Y10T137/206 , Y10T137/2196 , Y10T436/2575
摘要： Acoustic waves are used to transfer small amounts of fluid in a non-contact manner. Acoustic waves are propagated through a pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precise automation of a wide variety of procedures including screening and synthesis procedures commonly used in biotechnology.

6. 发明申请

US20080103054A1 ACOUSTICALLY MEDIATED FLUID TRANSFER METHODS AND USES THEREOF 有权
标题翻译：主动介质流体传输方法及其用途
公开(公告)号：US20080103054A1
公开(公告)日：2008-05-01
申请号：US11964628
申请日：2007-12-26
申请人： Roger WILLIAMS , Tarlochan Jutty , N. Mansour , Lawrence Lee , Michael Forbush
发明人： Roger WILLIAMS , Tarlochan Jutty , N. Mansour , Lawrence Lee , Michael Forbush
IPC分类号： B05B17/06 , C40B30/00 , C40B40/00
CPC分类号： B01L3/0268 , B01J19/0046 , B01J2219/00362 , B01J2219/00378 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00725 , B01L2300/0819 , B01L2400/0433 , B01L2400/0436 , B05B17/0615 , C40B30/04 , C40B40/02 , C40B40/04 , C40B40/08 , C40B40/10 , C40B50/00 , C40B60/14 , F04F7/00 , G01N21/11 , Y10T137/206 , Y10T137/2196 , Y10T436/2575
摘要： Invention methods employ the use of acoustic waves to transfer small amounts of fluid in a non-contact manner. In invention methods, acoustic waves are propagated through a separated pool of a source fluid in such a manner that causes the ejection of a single micro-droplet from the surface of the pool. The droplet is ejected towards a target with sufficient force to provide for contact of the droplet with the target. Because the fluid is not contacted by any fluid transfer device such as a pipette, the opportunities for contamination are minimized. Invention methods may be employed to transfer fluids from an array of source sites to an array of target sites, thereby enabling the precision automation of a wide variety of procedures including screening, and synthesis procedures commonly used in biotechnology.
摘要翻译：本发明的方法采用声波以非接触方式传送少量流体。在本发明的方法中，声波以这样的方式传播通过源流体的分离池，使得从池的表面喷出单个微滴。液滴以足够的力朝向目标喷射以提供液滴与靶的接触。由于流体不被诸如移液管之类的任何流体转移装置接触，污染的机会被最小化。可以采用本发明的方法将流体从源位置阵列转移到目标位点阵列，从而能够精确自动化多种程序，包括生物技术中通常使用的筛选和合成方法。

7. 发明授权

US07083117B2 Apparatus and method for droplet steering 失效
公开(公告)号：US07083117B2
公开(公告)日：2006-08-01
申请号：US10282790
申请日：2002-10-28
申请人： Roger O. Williams , Michael Van Tuyl , Michael Forbush
发明人： Roger O. Williams , Michael Van Tuyl , Michael Forbush
IPC分类号： B05B1/28 , B05B1/08
CPC分类号： B41J2/14008
摘要： An apparatus and method for droplet steering is disclosed herein. A throated structure having a nozzle defines a converging throat with an inlet and an outlet and a vectored fluid stream directed therethrough. The fluid stream is driven through the system via a vacuum pump. As the fluid approaches the outlet, its velocity increases and is drawn away from the nozzle through a connecting channel. As a droplet is ejected from a liquid therebelow, it will have a first trajectory until it is introduced to the high velocity fluid stream at the perimeter of the interior walls of the nozzle. The fluid accordingly steers the momentum of the droplet such that it obtains a second or corrected trajectory. Alternative variations include an electrically chargeable member, e.g., a pin, positionable to be in apposition to the outlet and capillary tubes for controlling the ejection surface of the pool of source fluid.

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