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    • 2. 发明授权
    • Radicicol derivatives
    • 蓝霉素衍生物
    • US06316491B1
    • 2001-11-13
    • US09091752
    • 1998-06-24
    • Yoji InoNobuyoshi AmishiroMayumi MiyataChikara MurakataHarumi OgawaTadakazu AkiyamaShiro AkinagaShiro SogaYukimasa Shiotsu
    • Yoji InoNobuyoshi AmishiroMayumi MiyataChikara MurakataHarumi OgawaTadakazu AkiyamaShiro AkinagaShiro SogaYukimasa Shiotsu
    • A61K3135
    • C07D493/04C07D313/00
    • Radioicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: wherein R1 and R2 are the same or different, and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl or tert-butyldimethylsilyl; R3 represents Y—R5 (wherein Y represents substituted or unsubstituted alkylene; and R5 represents CONR6R7 (wherein R6 represents hydrogen, hydroxyl, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl, and the like; R7 represents hydroxyl, substituted lower alkyl, and the like), CO2R12 (wherein R12 represents substituted lower alkyl, substituted or unsubstituted higher alkyl, and the like), and the like) and the like; X represents halogen or is combined together with R4 to represent a single bond; and R4 is combined together with X to represent a single bond, or represents hydrogen, alkanoyl, and the like.
    • 由具有酪氨酸激酶抑制活性的下式(I)表示的放射性标记衍生物或其药理学上可接受的盐:其中R1和R2相同或不同,并且各自表示氢,烷酰基,烯酰基,叔丁基二苯基甲硅烷基或叔丁基二甲基甲硅烷基; R3表示Y-R5(其中Y表示取代或未取代的亚烷基; R5表示CONR6R7(其中R6表示氢,羟基,取代或未取代的低级烷基,取代或未取代的高级烷基等; R7表示羟基,取代的低级烷基, 等),CO 2 R 12(其中R 12表示取代的低级烷基,取代或未取代的高级烷基等)等)等; X表示卤素或与R 4一起表示单键; 并且R 4与X结合以表示单键,或表示氢,烷酰基等。
    • 4. 发明授权
    • Radicicol derivatives
    • 蓝霉素衍生物
    • US06635662B2
    • 2003-10-21
    • US09791602
    • 2001-02-26
    • Yoji InoNobuyoshi AmishiroMayumi MiyataChikara MurakataHarumi OgawaTadakazu AkiyamaShiro AkinagaShiro SogaYukimasa Shiotsu
    • Yoji InoNobuyoshi AmishiroMayumi MiyataChikara MurakataHarumi OgawaTadakazu AkiyamaShiro AkinagaShiro SogaYukimasa Shiotsu
    • A61K3144
    • C07D493/04C07D313/00
    • Radicicol derivatives represented by the following formula (I) having tyrosine kinase inhibition activity or pharmacologically acceptable salts thereof: wherein R1 and R2 are the same or different, and each represents hydrogen, alkanoyl, alkenoyl, tert-butyldiphenylsilyl or tert-butyldimethylsilyl; R3 represents Y—R5 {wherein Y represents substituted or unsubstituted alkylene; and R5 represents CONR5R7 (wherein R6 represents hydrogen, hydroxyl, substituted or unsubstituted lower alkyl, substituted or unsubstituted higher alkyl, and the like; R7 represents hydroxyl, substituted lower alkyl, and the like), CO2R12 (wherein R12 represents substituted lower alkyl, substituted or unsubstituted higher alkyl, and the like), and the like} and the like; X represents halogen or is combined together with R4 to represent a single bond; and R4 is combined together with X to represent a single bond, or represents hydrogen, alkanoyl, and the like.
    • 由下式(I)表示的具有酪氨酸激酶抑制活性的衍生物衍生物或其药理学上可接受的盐:其中R 1和R 2相同或不同,各自表示氢,链烷酰基,烯酰基,叔丁基二苯基甲硅烷基或 叔丁基二甲基甲硅烷基; R 3表示Y-R 5 {其中Y表示取代或未取代的亚烷基; 并且R 5表示CONR 5 R 7(其中R 6表示氢,羟基,取代或未取代的低级烷基,取代或未取代的高级烷基等; R 7表示羟基,取代的低级 烷基等),CO 2 R 12(其中R 12表示取代的低级烷基,取代或未取代的高级烷基等)等}等; X表示卤素或与R 4结合以表示单键;并且R 4与X一起组合以表示单键,或表示氢,烷酰基等。