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1. 发明授权

US07767224B2 Method for the continuous production and coating of self-adhesive compounds on the basis of SBC that includes at least one pharmaceutically active substance 有权
标题翻译：基于包含至少一种药物活性物质的SBC的连续生产和涂覆自粘性化合物的方法
公开(公告)号：US07767224B2
公开(公告)日：2010-08-03
申请号：US10484816
申请日：2002-07-31
申请人： Andreas Kummer , Matthias Wasner , Jens-Uwe Wüstling
发明人： Andreas Kummer , Matthias Wasner , Jens-Uwe Wüstling
IPC分类号： A61F13/02
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/60 , A61K38/556 , A61L15/585 , C09J7/10 , C09J7/381 , C09J2453/00 , C08L53/02
摘要： A process for the solvent-free and mastication-free production of a self-adhesive composition which is based on SBC and comprises a pharmaceutically active substance, in a continuously operating apparatus which comprises a feeding section and a compounding section. The SBC is added to the feeding section and the pharmaceutically active substance is added to the feed section and/or the compounding section, and the composition is homogenized in the compounding section.
摘要翻译：一种在包含进料部分和配混部分的连续操作装置中无溶剂和无咀嚼形成基于SBC并包含药物活性物质的自粘组合物的方法。将SBC加入给料部分，并将药物活性物质加入进料部分和/或配混部分中，并将组合物在配混部分中均化。

2. 发明授权

US06506404B1 Release of ibuprofen from hot melt adhesive compositions through addition of pharmaceutical auxiliaries 失效
标题翻译：通过添加药物辅助剂从热熔胶组合物中释放布洛芬
公开(公告)号：US06506404B1
公开(公告)日：2003-01-14
申请号：US09363212
申请日：1999-07-29
申请人： Robert Mayan , Matthias Wasner , Peter Philipp
发明人： Robert Mayan , Matthias Wasner , Peter Philipp
IPC分类号： A61K970
CPC分类号： A61K9/7053
摘要： Use of auxiliaries to improve the release of ibuprofen from hot melt adhesive compositions.
摘要翻译：使用助剂来改善布洛芬从热熔胶组合物的释放

3. 发明授权

US06488958B1 Plasters containing active substances 失效
标题翻译：含有活性物质的膏药
公开(公告)号：US06488958B1
公开(公告)日：2002-12-03
申请号：US08982358
申请日：1997-12-02
申请人： Peter Himmelsbach , Helmut Linder , Katharina Broschk , Marike Sinnen , Matthias Wasner
发明人： Peter Himmelsbach , Helmut Linder , Katharina Broschk , Marike Sinnen , Matthias Wasner
IPC分类号： A61F1302
CPC分类号： A61K36/81 , A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/455 , A61L15/44 , A61L15/58 , A61L2300/40 , A61K2300/00 , C08L53/02
摘要： Plasters containing active substance, comprising a backing material and, applied thereon, a hot-melt self-adhesive composition, characterized in that the hot-melt self-adhesive composition comprises at least one hyper-aemic active substance.
摘要翻译：包含活性物质的膏药，包含背衬材料，并在其上施加热熔自粘组合物，其特征在于，所述热熔自粘组合物包含至少一种超贫血活性物质。

4. 发明授权

US06555130B2 Process for the continuous production and coating of self-adhesive compositions based on polyisobutylene with at least one active pharmaceutical substance 失效
标题翻译：基于聚异丁烯与至少一种活性药物物质连续生产和涂覆自粘组合物的方法
公开(公告)号：US06555130B2
公开(公告)日：2003-04-29
申请号：US09759559
申请日：2001-01-12
申请人： Jens-Uwe Wüstling , Matthias Wasner , Joachim Kirchner , Reinhard Uphus , Sören Struckmann
发明人： Jens-Uwe Wüstling , Matthias Wasner , Joachim Kirchner , Reinhard Uphus , Sören Struckmann
IPC分类号： A61F1302
CPC分类号： A61K9/7053 , A61K9/7076 , C09J7/381 , C09J2423/00
摘要： A process for the continuous solvent-free and mastication-free production of self-adhesive compositions based on polyisobutylene with at least one active pharmaceutical substance in a continuously operating apparatus having a filling section and a compounding section, comprising the following steps: a) feeding an initial batch comprising granulated polyisobutylene, at least one release auxiliary and at least one active pharmaceutical substance into the filling section of the apparatus; if desired, feeding low molecular mass polyisobutylene, fillers, plasticizers, tackifiers and/or resins, b) transferring the feed components of the self-adhesive composition from the filling section to the compounding section, c) if desired, adding the components of the self-adhesive composition that have not been introduced in the filling section, such as low molecular mass polyisobutylene, fillers, plasticizers, tackifiers and/or resins, to the compounding section, d) if desired, adding further pharmaceutical substances to the compounding section of the apparatus, e) preparing a homogeneous self-adhesive composition in the compounding section, and f) discharging the self-adhesive composition.
摘要翻译：一种在具有填充部分和配混部分的连续操作装置中连续无溶剂和无咀嚼形成基于聚异丁烯与至少一种活性药物物质的自粘组合物的方法，包括以下步骤：a）包含颗粒状聚异丁烯，至少一种释放助剂和至少一种活性药物物质的初始批料进入装置的填充部分; 如果需要，进料低分子量聚异丁烯，填料，增塑剂，增粘剂和/或树脂，b）将自粘合剂组合物的进料组分从填充部分转移到复合部分，c）如果需要，加入在配制部中未引入填充部分的低粘度组合物，例如低分子量聚异丁烯，填料，增塑剂，增粘剂和/或树脂，d）如果需要，向其配制部分添加其它药物该装置，e）在配混部分中制备均匀的自粘组合物，和f）排出自粘组合物。

5. 发明申请

US20050019382A1 Method for the continuous production and coating of self-adhesive compounds on the basis of sbc that includes at least one pharmaceutically active substance 有权
标题翻译：基于包含至少一种药物活性物质的sbc连续生产和涂覆自粘性化合物的方法
公开(公告)号：US20050019382A1
公开(公告)日：2005-01-27
申请号：US10484816
申请日：2002-07-31
申请人： Andreas Kummer , Matthias Wasner , Jean-Uwe Wustling
发明人： Andreas Kummer , Matthias Wasner , Jean-Uwe Wustling
IPC分类号： A61K9/70 , A61K31/60 , A61K38/55 , A61L15/58 , C09J7/00 , C09J7/02 , A61F13/02 , A61L15/16 , C09J5/02
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/60 , A61K38/556 , A61L15/585 , C09J7/10 , C09J7/381 , C09J2453/00 , C08L53/02
摘要： A process for the solvent-free and mastication-free production of a self-adhesive composition which is based on SBC and comprises a pharmaceutically active substance, in a continuously operating apparatus which comprises a feeding section and a compounding section. The SBC is added to the feeding section and the pharmaceutically active substance is added to the feed section and/or the compounding section, and the composition is homogenized in the compounding section.
摘要翻译：一种在包含进料部分和配混部分的连续操作装置中无溶剂和无咀嚼形成基于SBC并包含药物活性物质的自粘组合物的方法。将SBC加入给料部分，并将药物活性物质加入进料部分和/或配混部分中，并将组合物在配混部分中均化。

6. 发明授权

US06656491B1 Active substance plasters 失效
标题翻译：活性物质膏药
公开(公告)号：US06656491B1
公开(公告)日：2003-12-02
申请号：US09719114
申请日：2000-12-07
申请人： Katharina Brosck , Peter Jauchen , Ulrich Köhler , Peter Himmelsbach , Matthias Wasner
发明人： Katharina Brosck , Peter Jauchen , Ulrich Köhler , Peter Himmelsbach , Matthias Wasner
IPC分类号： A61F1302
CPC分类号： A61K9/7053 , A61K9/7076 , A61L15/425 , A61L15/44 , A61L15/58 , A61L2300/00 , C08L53/02 , C08L53/00
摘要： Active substance plasters consisting of a backing material and an at least partially applied adhesive composition, characterized in that a component comprising one or more active substances is additionally applied in the form of spun fibres or filaments to the backing material, this component having an at least partly thermoplastic basis.
摘要翻译：由背衬材料和至少部分施加的粘合剂组合物组成的活性物质膏药，其特征在于，包含一种或多种活性物质的组分以纺丝纤维或细丝的形式另外以背衬材料施加，该组分至少具有部分热塑性基础。

7. 发明授权

US07001613B2 Skin friendly active substance patch for transdermal administration of hyperemic active substances 失效
标题翻译：皮肤友好的活性物质补片，用于透皮给药充血活性物质
公开(公告)号：US07001613B2
公开(公告)日：2006-02-21
申请号：US10436542
申请日：2003-05-12
申请人： Detlev Radloff , Matthias Wasner
发明人： Detlev Radloff , Matthias Wasner
IPC分类号： A61F13/02 , A61L15/16 , A61K9/14
CPC分类号： A61K9/7053 , A61K9/7061
摘要： An active substance matrix patch for controlled delivery of at least one hyperemic active substance to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitive adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and comprising: a) from 25 to 90% by weight of synthetic framework polymers based on polyisobutylene, b) from 5 to 40% by weight of amorphous poly-α-olefin, c) from 10 to 60% by weight of an insoluble hydrophilic filler having an average particle size of less than 100 μm, and d) from 0.001 to 20% by weight of the hyperemic active substance.
摘要翻译：一种活性物质基质贴剂，其用于将至少一种充满活性的物质控制递送至皮肤，包括柔性覆盖层和不溶于水的压敏粘合剂活性物质基质，其中所述粘合剂基质不含矿物油和增粘树脂，并且包括

8. 发明申请

US20050191339A1 Skin friendly active ingredient plaster based on SBC, containing at least 34 WT.% of a pharmaceutical active ingredient and production thereof 审中-公开
标题翻译：基于SBC的皮肤友好的活性成分石膏，含有至少34％WT。％的药物活性成分及其生产
公开(公告)号：US20050191339A1
公开(公告)日：2005-09-01
申请号：US11050670
申请日：2005-02-07
申请人： Andreas Kummer , Matthias Wasner , Jens-Uwe Wuestling
发明人： Andreas Kummer , Matthias Wasner , Jens-Uwe Wuestling
IPC分类号： A61K9/70 , A61L15/58 , A61F13/00
CPC分类号： A61K9/7053 , A61L15/58 , C08L53/02
摘要： An active ingredient containing bandage for the controlled delivery of a pharmaceutically active ingredient to the skin. The bandage comprises a flexible cover layer and a water-insoluble, adhesive styrene block copolymer (SBC)-based matrix that comprises at least 34% by weight of the pharmaceutically active ingredient.
摘要翻译：一种含有绷带以将药物活性成分控制递送至皮肤的活性成分。绷带包括柔性覆盖层和包含至少34重量％的药物活性成分的基于水不溶性粘合剂苯乙烯嵌段共聚物（SBC）的基质。

9. 发明授权

US06652876B2 Active substance patch, kind to the skin, for transdermal administration of nonsteroidal antirheumatics 失效
标题翻译：活性物质贴片，适合皮肤，用于透皮给药非甾体抗风湿药
公开(公告)号：US06652876B2
公开(公告)日：2003-11-25
申请号：US09745613
申请日：2000-12-21
申请人： Detlev Radloff , Matthias Wasner
发明人： Detlev Radloff , Matthias Wasner
IPC分类号： A61L1516
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/192 , A61K31/196 , A61K31/5415 , Y10T442/2525
摘要： An active substance matrix patch for controlled delivery of nonsteroidal antirheumatics to the skin, comprising a flexible cover layer and a water insoluble, pressure sensitively adhesive active substance matrix, wherein said adhesive matrix is free from mineral oils and tackifier resins and is composed of a) from 25 to 90% by weight of synthetic framework polymers based on polyisobutylene, b) from 5 to 40% by weight of amorphous poly-&agr;-olefin, c) from 10 to 60% by weight of an insoluble hydrophilic filler having an average particle size of less than 100 &mgr;m, and d) from 0.001 to 20% by weight of a drug.
摘要翻译：一种活性物质基质贴剂，其用于将非甾体抗风湿药物控制递送至皮肤，其包括柔性覆盖层和不溶于水的压敏敏感粘合剂活性物质基质，其中所述粘合剂基质不含矿物油和增粘树脂，并且由以下组成：a） 25至90重量％的基于聚异丁烯的合成骨架聚合物，b）5至40重量％的无定形聚-α-烯烃，c）10至60重量％的具有平均粒度的不溶性亲水填料小于100mg，和d）0.001至20重量％的药物。

10. 发明授权

US6143317A Active substance plasters 失效
标题翻译：活性物质膏药
公开(公告)号：US6143317A
公开(公告)日：2000-11-07
申请号：US175160
申请日：1998-10-19
申请人： Peter Himmelsbach , Peter Jauchen , Katharina Broschk , Ulrich Kohler , Matthias Wasner
发明人： Peter Himmelsbach , Peter Jauchen , Katharina Broschk , Ulrich Kohler , Matthias Wasner
IPC分类号： A61K9/70 , B32B7/12
CPC分类号： A61K9/7053 , A61K9/7076 , Y10T428/2883
摘要： Active substance plasters comprising a backing material and, applied at least partially thereon, an adhesive composition, whereina) the adhesive composition comprises at least on active substance,b) the adhesive composition is a hotmelt adhesive composition, andc) the adhesive composition is foamed.
摘要翻译：活性物质膏药包括背衬材料，并且至少部分地施加有粘合剂组合物，其中a）所述粘合剂组合物至少包含活性物质，b）所述粘合剂组合物是热熔粘合剂组合物，和c）所述粘合剂组合物是发泡。

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