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    • 1. 发明授权
    • Bicyclic lactones, perfumery uses thereof, processes for preparing same and intermediates therefor
    • 双环内酯,其香料用途,其制备方法及其中间体
    • US07169747B2
    • 2007-01-30
    • US10705786
    • 2003-11-10
    • Richard A. WeissMark A. SpreckerMarie R. HannaCharles E. J. BeckHarold W. Jackson
    • Richard A. WeissMark A. SpreckerMarie R. HannaCharles E. J. BeckHarold W. Jackson
    • A61K7/46
    • A61K8/498A61L9/01A61L9/012A61Q13/00C07D311/02C07D311/74C11B9/008C11D3/2096C11D3/50
    • Described are bicyclic lactones, both fused ring lactones defined according to the generic structure: and spiro lactones defined according to the generic structure: uses thereof in augmenting, enhancing or imparting aromas in or to perfume compositions, perfumed articles, colognes and perfumed polymers; processes for preparing such bicyclic lactones and intermediates therefor. In the structure: Z is one of the moieties: one of R1 or R3 is methyl and the other is hydrogen; and R4, R5, R6, R7, R8 and R9 hydrogen or nonadjacent C1–C3 alkyl. In the structure: Y represents C2–C12 substituted or unsubstituted alkylidenyl, alkenylidenyl or alkadienylidenyl having the structure: and completes a C5–C15 cycloalkyl, cycloalkadienyl or cycloalkenyl ring moiety; and wherein R12, R13, R14, R16, R17, R28, R29, R30 and R31 represent hydrogen or C1–C3 nonadjacent alkyl; wherein s is an integer of from 0 up to 10; t is an integer of from 0 up to 10; and v is an integer of 1 or 2; with the proviso that the sum of s and t is between 0 and 10 according to the inequalities: 0≦s+t≦10; 0≦S≦10; and 0≦t≦10.
    • 描述的是双环内酯,根据通用结构定义的稠环内酯和根据通用结构定义的螺内酯:用于增强,增强或赋予香料组合物,香料制品,古龙水和加香聚合物中的香气; 制备此类双环内酯的方法及其中间体。 在结构中:Z是部分之一:R 1或R 3中的一个是甲基,另一个是氢; 和R 4,R 5,R 6,R 7,R 8, 和R 9的氢或不相邻的C 1 -C 3烷基。 在结构中:Y表示具有以下结构的取代或未取代的亚烷基,亚烯基或链二烯基的取代或未取代的C 1 -C 12 - C 15环烷基,环链二烯基或环烯基环部分; 并且其中R 12,R 13,R 14,R 16,R 17, >,R 28,R 29,R 30和R 31表示氢或C 1〜 N 3 -C 3不相邻的烷基; 其中s为0至10的整数; t是0到10的整数; v为1或2的整数; 条件是根据不等式,s和t之和在0和10之间:0 <= s + t <= 10; 0 <= S <= 10; 0 <= t <= 10。
    • 3. 发明授权
    • Single phase liquid mixture of benzophenone and mixture of at least two
other normally solid perfumery substances and perfumery uses thereof
    • 二苯甲酮的单相液体混合物和至少两种其它通常固体香料物质的混合物及其香料用途
    • US6090774A
    • 2000-07-18
    • US169994
    • 1998-10-13
    • Murray MosconaMark A. SpreckerRichard A. Weiss
    • Murray MosconaMark A. SpreckerRichard A. Weiss
    • A61K8/02A61K8/35A61Q13/00C08J3/20C08L101/00C11B9/00C11D3/50A61K7/46C11D9/44C08J3/40C08L3/40
    • A61Q13/00A61K8/02A61K8/35C11B9/00C11D3/50
    • Described is a single phase liquid mixture of benzophenone and a mixture of at least two other normally solid perfumery substances which mixture contains from about 25% up to about 60% by weight of benzophenone and from about 60% down to about 25% by weight of a mixture of normally crystalline perfumery ingredients, each of which has a melting point of between about 35.degree. C. and about 120.degree. C. at about 1 atmosphere pressure, containing at least two substances of the following classes:(i) coumarin derivatives;(ii) vanillin derivatives;(iii) resorcylic acid derivatives;(iv) methylene dioxybenzene derivatives;(v) trichloro-.alpha.-phenylethyl esters;(vi) polycyclic musks;(vii) aryl alkanoic acids; and(viii) p-oxoalkylphenolsand uses of such mixtures in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles, including but not limited to solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, fabric softener articles, hair preparations, cosmetic powders and perfumed polymers.
    • 描述了二苯甲酮和至少两种其它通常固体香料物质的混合物的单相液体混合物,其混合物含有约25重量%至约60重量%的二苯甲酮和约60重量%至约25重量%的二苯甲酮 通常结晶香料成分的混合物,其每一种在大约1大气压下具有约35℃至约120℃的熔点,其含有至少两种以下类别的物质:(i)香豆素衍生物; (ii)香草醛衍生物; (iii)间苯二酸衍生物; (iv)亚甲基二氧苯衍生物; (v)三氯-α-苯乙基酯; (vi)多环麝香; (vii)芳基链烷酸; 包括但不限于固体或液体阴离子阳离子,非离子或两性离子洗涤剂,织物柔软剂组合物,织物柔软剂,和/或其混合物,以及(viii)对 - 氧代烷基苯酚和这些混合物用于增强或增强香料组合物,古龙水和香料制品 制品,头发制剂,化妆粉和加香聚合物。
    • 4. 发明授权
    • Methyl substituted propyl-substituted pentamethyl indane derivatives,
processes for producing same and perfumery uses thereof
    • 甲基取代的丙基取代的五甲基二氢化茚衍生物,其制备方法和香料用途
    • US5583272A
    • 1996-12-10
    • US428429
    • 1995-04-25
    • Mark A. SpreckerOlivier J. Gillotin
    • Mark A. SpreckerOlivier J. Gillotin
    • C11B9/00C11D3/50C07C17/093
    • C11B9/0053C11B9/0049C11B9/008C11D3/50
    • Described are methyl, substituted propyl-substituted pentamethyl indane derivatives defined according to the structure: ##STR1## wherein R.sub.1 represents hydroxyl or methyl; and R.sub.2 represents hydrogen, chloro or OR.sub.6 ; and R.sub.3 represents hydrogen or methyl with the provisos:(i) when R.sub.1 is hydroxyl, R.sub.2 is hydrogen and R.sub.3 is methyl; and(ii) when R.sub.1 is methyl, one of R.sub.2 is chloro or OR.sub.6 and R.sub.3 is hydrogenand wherein the structure represents a mixture wherein in the mixture in one of the compounds R.sub.4 and R.sub.4 ' are both methyl and R.sub.7 is methyl (about 90% by weight); and in the other compounds one of R.sub.4 or R.sub.4 ' is methyl and the other is ethyl and R.sub.7 is hydrogen (about 10% by weight of the compounds); and wherein R.sub.6 is methyl, ethyl, n-propyl or i-propyl; and uses thereof in augmenting, enhancing or imparting aromas in or to perfume compositions, colognes and perfumed articles including but not limited to solid or liquid anionic, cationic, nonionic or zwitterionic detergents, perfumed polymers, fabric softener compositions, fabric softener articles, cosmetic powders and hair preparations.
    • 描述了根据以下结构定义的甲基取代的丙基取代的五甲基二氢化茚衍生物:其中R 1表示羟基或甲基; 并且R 2表示氢,氯或OR 6; 并且R 3表示氢或甲基,条件是:(ⅰ)当R 1是羟基时,R 2是氢,R 3是甲基; 和(ii)当R 1是甲基时,R 2是氯或OR 6,R 3是氢,并且其中该结构表示一种混合物,其中一种化合物R4和R4'的混合物都是甲基,而R7是甲基(约90 重量%); 在其它化合物中,R4或R4'之一为甲基,另一个为乙基,R7为氢(约占该化合物的10重量%); 其中R6是甲基,乙基,正丙基或异丙​​基; 包括但不限于固体或液体阴离子,阳离子,非离子或两性离子洗涤剂,加香聚合物,织物柔软剂组合物,织物柔软剂制品,化妆品粉末,香料和香料 和头发制剂。
    • 5. 发明授权
    • Methyl substituted propyl-substituted pentamethyl indane derivatives
processes for producing same and perfumery uses thereof
    • 甲基取代的丙基取代的五甲基二氢茚衍生物的制备方法及其香料用途
    • US5502031A
    • 1996-03-26
    • US309505
    • 1994-09-22
    • Mark A. SpreckerOlivier J. Gillotin
    • Mark A. SpreckerOlivier J. Gillotin
    • C11B9/00C11D3/50A61K7/46
    • C11B9/0049C11B9/0053C11B9/008C11D3/50
    • Described are methyl, substituted propyl-substituted pentamethyl indane derivatives defined according to the structure: ##STR1## wherein R.sub.1 represents chloro, hydroxyl or OR.sub.6 ; and R.sub.5 represents methyl or hydrogen with the proviso that when R.sub.1 is chloro, R.sub.5 is hydrogen, and wherein the structure represents a mixture wherein in the mixture in one of the compounds R.sub.4 and R.sub.4 ' are both methyl and R.sub.7 is methyl (about 90% by weight); and in the other compounds one of R.sub.4 or R.sub.4 ' is methyl and the other is ethyl (about 10% by weight of the compounds) and R.sub.7 is hydrogen; and uses thereof in augmenting, enhancing or imparting aromas in or to perfume compositions.Also described are processes for preparing such methyl, substituted propyl-substituted pentamethyl indane derivatives using as a starting material the mixture of compounds defined according to the structure: ##STR2## also know as GALAXOLIDE.RTM. (trademark of International Flavors & Fragrances Inc.).
    • 描述了根据以下结构定义的甲基取代的丙基取代的五甲基二氢茚衍生物:其中R 1表示氯,羟基或OR 6; 并且R 5表示甲基或氢,条件是当R 1是氯时,R 5是氢,并且其中该结构表示一种混合物,其中一种化合物R4和R4'的混合物都是甲基,R7是甲基(约90% 重量); 在其它化合物中,R4或R4'之一是甲基,另一个是乙基(约10重量%的化合物),而R7是氢; 及其用于增加,增强或赋予香料或香料组合物中的香味。 还描述了使用根据以下结构定义的化合物的混合物作为原料制备这种甲基取代的丙基取代的五甲基二氢化茚衍生物的方法:也称为GALAXOLIDE TM(International Flavors&amp; Fragrances Inc.的商标)。
    • 8. 发明授权
    • Alkyl-substituted tetra- or hexahydrobenzopyran derivatives,
organoleptic uses thereof and process for preparing same
    • 烷基取代的四或六氢苯并吡喃衍生物,其感官用途及其制备方法
    • US5023352A
    • 1991-06-11
    • US546356
    • 1990-06-29
    • Mark A. SpreckerRobert P. BelkoMarie R. HannaCharles E. J. BeckSalvatore M. Brucato
    • Mark A. SpreckerRobert P. BelkoMarie R. HannaCharles E. J. BeckSalvatore M. Brucato
    • C07D311/74C07D311/94C11B9/00C11D3/50
    • C07D311/74C07D311/94C11B9/008C11D3/50
    • Described are alkyl-substituted tetra- or hexahydrobenzopyran derivatives defined according to one of the generic structures: ##STR1## wherein Z is a moiety in the alternative either ##STR2## wherein in the moiety having the structure: ##STR3## R' is methyl or ethyl and in the moiety having the structure: ##STR4## one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines represent carbon-carbon single bonds; wherein R.sub.1 and R.sub.2 taken separately represent hydrogen or C.sub.1 -C.sub.3 lower alkyl (with the proviso that R.sub.1 and R.sub.2 are not both hydrogen) or R.sub.1 and R.sub.2 taken together complete a C.sub.5 or C.sub.6 cycloalkyl moiety; and uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles including but not limited to solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, fabric softener articles, hair preparations, cosmetic powder and perfumed polymers. Also described are synthesis processes for preparing such alkyl-substituted tetra- or hexahydrobenzopyran derivatives by means of reacting isopulegol or an isomer thereof with an acetal or ketal.
    • 描述了根据以下通用结构之一定义的烷基取代的四或六氢苯并吡喃衍生物:其中Z是可选择的部分或其中的“IMAGE”或“IMAGE”,其中在具有以下结构的部分中: R'是甲基或乙基,并且在具有以下结构的部分中:虚线之一是碳 - 碳双键,虚线中的每一个代表碳 - 碳单键; 其中R1和R2分别代表氢或C1-C3低级烷基(前提是R1和R2不同时为氢)或R1和R2一起形成C5或C6环烷基部分; 包括但不限于固体或液体阴离子,阳离子,非离子或两性离子洗涤剂,织物柔软剂组合物,织物柔软剂制品,毛发制剂,化妆品粉末和加香聚合物的香料组合物,古龙水和香料制品的香气。 。 还描述了通过异丙醇或其异构体与缩醛或缩酮反应制备这种烷基取代的四或六氢苯并吡喃衍生物的合成方法。
    • 10. 发明授权
    • Polyalkyl indanyl n-propyl and allyl ethers and perfumery uses thereof
    • 聚烷基茚基丙基正丙基和烯丙基醚及其香料用途
    • US4902672A
    • 1990-02-20
    • US371294
    • 1989-06-26
    • Mark A. SpreckerRobert P. BelkoRonald S. Fenn
    • Mark A. SpreckerRobert P. BelkoRonald S. Fenn
    • C07C43/188C11B9/00C11D3/50
    • C11B9/0049C07C43/188C11D3/50C07C2102/24
    • Described are polyalkyl indanyl n-propyl and allyl ethers defined according to the structure: ##STR1## wherein R.sub.3 represents methyl or hydrogen; wherein R.sub.1, R.sub.2, R.sub.4 and R.sub.5 each represents methyl or ethyl and wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond with the provisos that:1. at least three of R.sub.1, R.sub.2, R.sub.4 and R.sub.5 represents methyl;2. when each of R.sub.1, R.sub.2, R.sub.4 and R.sub.5 is methyl, then R.sub.3 is methyl; and3. when the dashed line is a carbon-carbon double bond and R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each methyland uses thereof in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles including but not limited to perfumed polymers, solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, fabric softener articles, cosmetic powders and hair preparations.
    • 描述了根据以下结构定义的聚烷基茚满基丙基和烯丙基醚:其中R 3表示甲基或氢; 其中R1,R2,R4和R5各自表示甲基或乙基,其中虚线表示碳 - 碳单键或碳 - 碳双键,条件是:1. R1,R2,R4和R5中的至少三个 代表甲基; 当R1,R2,R4和R5各自为甲基时,则R3为甲基; 和3.当虚线是碳 - 碳双键时,R 1,R 2,R 3,R 4和R 5各自是甲基,并且其用途用于增强或增强香水组合物,古龙水和香料制品的香气,包括但不限于香料 聚合物,固体或液体阴离子,阳离子,非离子或两性离子洗涤剂,织物柔软剂组合物,织物柔软剂制品,化妆粉和头发制剂。