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1. 发明申请

US20130192841A1 DUAL GRADIENT MANAGED PRESSURE DRILLING 有权
标题翻译：双级管理压力钻井
公开(公告)号：US20130192841A1
公开(公告)日：2013-08-01
申请号：US13752804
申请日：2013-01-29
申请人： Guy F. Feasey , David Pavel , Mark A. Mitchell
发明人： Guy F. Feasey , David Pavel , Mark A. Mitchell
IPC分类号： E21B21/08
CPC分类号： E21B21/08 , E21B7/12 , E21B21/001
摘要： A method of drilling a subsea wellbore includes drilling the wellbore by injecting drilling fluid through a tubular string extending into the wellbore from an offshore drilling unit (ODU) and rotating a drill bit disposed on a bottom of the tubular string. The method further includes, while drilling the wellbore: mixing lifting fluid with drilling returns at a flow rate proportionate to a flow rate of the drilling fluid, thereby forming a return mixture. The lifting fluid has a density substantially less than a density of the drilling fluid. The return mixture has a density substantially less than the drilling fluid density. The method further includes, while drilling the wellbore: measuring a flow rate of the returns or the return mixture; and comparing the measured flow rate to the drilling fluid flow rate to ensure control of a formation being drilled.
摘要翻译：钻井海底钻井的方法包括通过从钻井单元（ODU）延伸到井筒中的管柱注入钻井液并旋转设置在管柱的底部上的钻头来钻井孔。该方法还包括：在钻井井的同时：将提升液与钻井液混合，流量与钻井液的流量成比例，从而形成回流混合物。提升流体的密度显着小于钻井液的密度。回流混合物的密度显着小于钻井液密度。该方法还包括在钻井井时：测量回油或回流混合物的流速; 并将测量的流量与钻井液流量进行比较，以确保正在钻取的地层的控制。

2. 发明授权

US07567990B2 Transfering database workload among multiple database systems 有权
标题翻译：在多个数据库系统之间传输数据库工作负载
公开(公告)号：US07567990B2
公开(公告)日：2009-07-28
申请号：US11638647
申请日：2006-12-13
申请人： Mark A. Mitchell , Thomas A. Fastner
发明人： Mark A. Mitchell , Thomas A. Fastner
IPC分类号： G06F17/00
CPC分类号： G06F17/30575 , Y10S707/99953
摘要： A system includes at least two database systems that both store a common portion of a relational database and that are configured to share in execution of a database workload against that relational database. The system also includes a system-management component configured to receive indication that a first one of the database systems is ceasing operation and, in response, take a second one of the database systems to an operational state in which at least a portion of the database workload that is scheduled to be carried out by the first database system is transferred to the second database system.
摘要翻译：系统包括至少两个数据库系统，其两者都存储关系数据库的公共部分，并且被配置为在针对该关系数据库执行数据库工作负载时共享。系统还包括被配置为接收数据库系统中的第一个停止操作的指示的系统管理组件，并且作为响应，使数据库系统中的第二个数据库系统处于操作状态，其中数据库的至少一部分计划由第一数据库系统执行的工作负载被传送到第二数据库系统。

3. 发明授权

US10239009B2 Continuously-operable flow stream processing system and method 有权
公开(公告)号：US10239009B2
公开(公告)日：2019-03-26
申请号：US13827855
申请日：2013-03-14
申请人： Mark A. Mitchell , Brian Anderson
发明人： Mark A. Mitchell , Brian Anderson
IPC分类号： B01D29/00 , B01D29/60 , B01D29/66 , B01D46/18 , B01D46/00
摘要： A continuously-operable flow stream processing system and method has two or more fluid processing media arranged in a fluid conduit network to provide alternate flow paths for a flow stream to be processed (e.g. filtered). Valves and other flow control devices, e.g. controller module and sensors, are used to redirect the flow stream from one or more service-needed fluid processing media to service-ready fluid processing media without taking the system offline to remove, repair, replace, clean in situ, or otherwise service the service-needed fluid processing media, so that the system may operate continuously to process the flow stream without stoppage. Redirection into alternative flow paths and media may be automatically implemented based on a predetermined threshold or trigger condition, such as may be detected by sensors directly or indirectly monitoring media condition.

4. 发明授权

US08146564B2 Engine intake air flow control assembly 有权
标题翻译：发动机进气流量控制组件
公开(公告)号：US08146564B2
公开(公告)日：2012-04-03
申请号：US12651674
申请日：2010-01-04
申请人： Jian Jun Zhang , Mark A. Mitchell , Ko-Jen Wu
发明人： Jian Jun Zhang , Mark A. Mitchell , Ko-Jen Wu
IPC分类号： F02B31/08
CPC分类号： F02M35/10085 , F02B31/06 , F02D9/1095 , Y02T10/146
摘要： An engine assembly may include a cylinder head, an intake manifold assembly, first and second vanes, and an actuation mechanism. The first and second vanes may be rotatably coupled to the intake manifold assembly. The first vane may be located within an outlet of a first intake passage and the second vane may be located within an outlet of a second intake passage. The first and second vanes may be displaceable from an open position to a closed position. The first vane may extend along a wall defining the first intake passage when in the open position and the second vane may extend along a wall defining the second intake passage when in the open position. The actuation mechanism may be coupled to the first and second vanes to rotate the first and second vanes between the open and closed positions.
摘要翻译：发动机组件可以包括气缸盖，进气歧管组件，第一和第二叶片以及致动机构。第一和第二叶片可以可旋转地联接到进气歧管组件。第一叶片可以位于第一进气通道的出口内，并且第二叶片可以位于第二进气通道的出口内。第一和第二叶片可以从打开位置移动到关闭位置。当处于打开位置时，第一叶片可以沿着限定第一进气通道的壁延伸，并且当处于打开位置时，第二叶片可以沿着限定第二进气通道的壁延伸。致动机构可以联接到第一和第二叶片，以使第一和第二叶片在打开位置和关闭位置之间旋转。

5. 发明申请

US20110162611A1 ENGINE INTAKE AIR FLOW CONTROL ASSEMBLY 有权
标题翻译：发动机吸入空气流量控制装置
公开(公告)号：US20110162611A1
公开(公告)日：2011-07-07
申请号：US12651674
申请日：2010-01-04
申请人： JIAN JUN ZHANG , MARK A. MITCHELL , KO-JEN WU
发明人： JIAN JUN ZHANG , MARK A. MITCHELL , KO-JEN WU
IPC分类号： F02M35/10
CPC分类号： F02M35/10085 , F02B31/06 , F02D9/1095 , Y02T10/146
摘要： An engine assembly may include a cylinder head, an intake manifold assembly, first and second vanes, and an actuation mechanism. The first and second vanes may be rotatably coupled to the intake manifold assembly. The first vane may be located within an outlet of a first intake passage and the second vane may be located within an outlet of a second intake passage. The first and second vanes may be displaceable from an open position to a closed position. The first vane may extend along a wall defining the first intake passage when in the open position and the second vane may extend along a wall defining the second intake passage when in the open position. The actuation mechanism may be coupled to the first and second vanes to rotate the first and second vanes between the open and closed positions.
摘要翻译：发动机组件可以包括气缸盖，进气歧管组件，第一和第二叶片以及致动机构。第一和第二叶片可以可旋转地联接到进气歧管组件。第一叶片可以位于第一进气通道的出口内，并且第二叶片可以位于第二进气通道的出口内。第一和第二叶片可以从打开位置移动到关闭位置。当处于打开位置时，第一叶片可以沿着限定第一进气通道的壁延伸，并且当处于打开位置时，第二叶片可以沿着限定第二进气通道的壁延伸。致动机构可以联接到第一和第二叶片，以使第一和第二叶片在打开位置和关闭位置之间旋转。

6. 发明申请

US20110155379A1 ROTATING CONTINUOUS FLOW SUB 有权
标题翻译：旋转连续流程
公开(公告)号：US20110155379A1
公开(公告)日：2011-06-30
申请号：US12984429
申请日：2011-01-04
申请人： THOMAS F. BAILEY , MARK A. MITCHELL , DAVID PAVEL , LEV RING , RAM K. BANSAL , DAVID IBLINGS
发明人： THOMAS F. BAILEY , MARK A. MITCHELL , DAVID PAVEL , LEV RING , RAM K. BANSAL , DAVID IBLINGS
IPC分类号： E21B34/00 , E21B7/00
CPC分类号： E21B17/18 , E21B7/00 , E21B19/16 , E21B21/10 , E21B21/106 , E21B21/12 , E21B2034/005
摘要： A method for drilling a wellbore includes drilling the wellbore by advancing the tubular string longitudinally into the wellbore; stopping drilling by holding the tubular string longitudinally stationary; adding a tubular joint or stand of joints to the tubular string while injecting drilling fluid into a side port of the tubular string, rotating the tubular string, and holding the tubular string longitudinally stationary; and resuming drilling of the wellbore after adding the joint or stand.
摘要翻译：用于钻井井的方法包括通过将管柱纵向前进到井眼中钻井孔; 通过将管状柱纵向固定停止钻孔; 将管状接头或接头支架连接到管状管柱上，同时将钻井液注入管状管柱的侧端口，旋转管状管柱并将管状管柱纵向固定; 并在加入接头或支架后恢复钻井。

7. 发明授权

US5739350A CC-1065 analogs 失效
标题翻译： CC-1065类似物
公开(公告)号：US5739350A
公开(公告)日：1998-04-14
申请号：US479231
申请日：1995-06-07
申请人： Robert C. Kelly , Mark A. Mitchell , Paul A. Aristoff
发明人： Robert C. Kelly , Mark A. Mitchell , Paul A. Aristoff
IPC分类号： A61K31/40 , A61K38/00 , A61K47/48 , A61P31/12 , A61P35/00 , C07D487/04 , C07D487/10 , C07F9/6561 , C07K1/113 , C07K5/06 , C07K5/062 , C07K5/08 , C07K16/00 , C07K17/06 , C07D487/08
CPC分类号： C07D487/04 , A61K47/4813 , A61K47/48246 , A61K47/48407 , C07D487/10 , C07F9/6561 , C07K17/06 , C07K5/06026 , C07K5/06034 , C07K5/06043 , C07K5/06052 , C07K5/0802 , A61K38/00
摘要： This invention provides some new synthetically obtained compounds of formula I and II ##STR1## which are useful as chemical intermediates. Representative formula I or II compounds have also been shown to possess useful ranges of antitumor activity in standard laboratory animal tests. In addition, the compounds of formula I or II can be linked to monoclonal antibodies, either directly or via known linking group, as a means of selectively delivering the CC-1065 analogs (Compounds of Formula I and II) to those target cells expressing the target antigen and thus selectively eliminating those diseased cells from the animal or human. Further, the compounds of formula I and II can be linked to soluble human CD4 or a soluble human CD4 protein fragment capable of binding to the gp120 envelope protein of the human immuno-virus and thus eliminate virally infected cells.
摘要翻译：本发明提供一些新的合成的式I和II化合物，其可用作化学中间体。代表性的式I或II化合物也已被证明在标准实验室动物试验中具有有效的抗肿瘤活性范围。此外，式I或II的化合物可以直接或通过已知的连接基团与单克隆抗体连接，作为选择性递送CC-1065类似物（式I和II的化合物）到表达靶抗原，从而选择性地从动物或人中除去那些患病细胞。此外，式I和II的化合物可以与能够与人免疫病毒的gp120包膜蛋白结合的可溶性人CD4或可溶性人CD4蛋白片段连接，从而消除病毒感染的细胞。

8. 发明申请

US20140263085A1 Continously-Operable Flow Stream Processing System and Method 审中-公开
标题翻译：连续可行的流程处理系统和方法
公开(公告)号：US20140263085A1
公开(公告)日：2014-09-18
申请号：US13827855
申请日：2013-03-14
申请人： Mark A. Mitchell , Brian Anderson
发明人： Mark A. Mitchell , Brian Anderson
IPC分类号： B01D29/00 , B01D29/60 , B01D29/66
CPC分类号： B01D46/18 , B01D46/0058
摘要： A continuously-operable flow stream processing system and method has two or more fluid processing media arranged in a fluid conduit network to provide alternate flow paths for a flow stream to be processed (e.g. filtered). Valves and other flow control devices, e.g. controller module and sensors, are used to redirect the flow stream from one or more service-needed fluid processing media to service-ready fluid processing media without taking the system offline to remove, repair, replace, clean in situ, or otherwise service the service-needed fluid processing media, so that the system may operate continuously to process the flow stream without stoppage. Redirection into alternative flow paths and media may be automatically implemented based on a predetermined threshold or trigger condition, such as may be detected by sensors directly or indirectly monitoring media condition.
摘要翻译：连续可操作的流动流处理系统和方法具有布置在流体管道网络中的两个或更多个流体处理介质，以为要处理（例如过滤）的流动流提供交替的流动路径。阀和其它流量控制装置，例如控制器模块和传感器用于将来自一个或多个服务需要的流体处理介质的流量重定向到服务就绪流体处理介质，而不使系统脱机以移除，修复，替换，原位清洁或以其他方式服务该服务 - 所需的流体处理介质，使得系统可以连续地操作以处理流动而不停止。可以基于预定的阈值或触发条件自动实现重定向到替代流路径和媒体，诸如可以由传感器直接或间接地监视媒体条件来检测。

9. 发明授权

US08627890B2 Rotating continuous flow sub 有权
标题翻译：旋转连续流动
公开(公告)号：US08627890B2
公开(公告)日：2014-01-14
申请号：US12984429
申请日：2011-01-04
申请人： Thomas F. Bailey , Mark A. Mitchell , David Pavel , Lev Ring , Ram K. Bansal , David Iblings
发明人： Thomas F. Bailey , Mark A. Mitchell , David Pavel , Lev Ring , Ram K. Bansal , David Iblings
IPC分类号： E21B21/02 , E21B34/00
CPC分类号： E21B17/18 , E21B7/00 , E21B19/16 , E21B21/10 , E21B21/106 , E21B21/12 , E21B2034/005
摘要： A method for drilling a wellbore includes drilling the wellbore by advancing the tubular string longitudinally into the wellbore; stopping drilling by holding the tubular string longitudinally stationary; adding a tubular joint or stand of joints to the tubular string while injecting drilling fluid into a side port of the tubular string, rotating the tubular string, and holding the tubular string longitudinally stationary; and resuming drilling of the wellbore after adding the joint or stand.
摘要翻译：用于钻井井的方法包括通过将管柱纵向前进到井眼中钻井孔; 通过将管状柱纵向固定停止钻孔; 将管状接头或接头支架连接到管状管柱上，同时将钻井液注入管状管柱的侧端口，旋转管状管柱并将管状管柱纵向固定; 并在加入接头或支架后恢复钻井。

10. 发明授权

US07026339B2 Inhibitors of HCV NS5B polymerase 失效
标题翻译： HCV NS5B聚合酶抑制剂
公开(公告)号：US07026339B2
公开(公告)日：2006-04-11
申请号：US10981128
申请日：2004-11-03
申请人： Fan Yang , Bo Zhang , Nancy Anne Wicnienski , Jeffrey Allen Pfefferkorn , Meredith L. Greene , Ke Chen , Richard A. Nugent , Matthew Todd Reding , Robert Charles Kelly , Mark A. Mitchell , Lee A. Funk , Richard Frederick Heier, III , Rebecca Merry Anderson
发明人： Fan Yang , Bo Zhang , Nancy Anne Wicnienski , Jeffrey Allen Pfefferkorn , Meredith L. Greene , Ke Chen , Richard A. Nugent , Matthew Todd Reding , Robert Charles Kelly , Mark A. Mitchell , Lee A. Funk , Richard Frederick Heier, III , Rebecca Merry Anderson
IPC分类号： A61K31/255 , A61K31/44 , C07C309/73 , C07C309/75 , C07D213/44
CPC分类号： C07C251/86 , C07C309/67 , C07C309/73 , C07C309/74 , C07C309/75 , C07C309/77 , C07C311/21 , C07C311/49 , C07C317/28 , C07C317/32 , C07C317/44 , C07C323/62 , C07C2601/14 , C07C2602/42 , C07C2603/74 , C07D207/277 , C07D207/337 , C07D209/18 , C07D213/56 , C07D213/61 , C07D213/65 , C07D213/71 , C07D213/75 , C07D213/81 , C07D213/82 , C07D231/12 , C07D231/18 , C07D233/28 , C07D233/64 , C07D263/32 , C07D277/32 , C07D285/14 , C07D307/24 , C07D307/54 , C07D307/79 , C07D317/60 , C07D333/24 , C07D333/34 , C07D409/04 , C07D413/04
摘要： The present invention relates to compounds, process for their synthesis, compositions and methods for the treatment and prevention of hepatitis C virus (HCV) infection. In particular, the present invention provides novel compounds, pharmaceutical compositions containing such compounds and methods for using these compounds in the treatment or prevention of HCV infection. The present invention also provides processes and intermediates for the synthesis of these compounds.
摘要翻译：本发明涉及化合物，其合成方法，用于治疗和预防丙型肝炎病毒（HCV）感染的组合物和方法。特别地，本发明提供新型化合物，含有这些化合物的药物组合物和使用这些化合物治疗或预防HCV感染的方法。本发明还提供了合成这些化合物的方法和中间体。

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