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1. 发明申请

US20080249072A1 Use of Low Dose Chemically Modified Tetracylines to Reduce Inflammatory Mediators 审中-公开
标题翻译：使用低剂量化学修饰的四酰胺来减少炎症介质
公开(公告)号：US20080249072A1
公开(公告)日：2008-10-09
申请号：US11663325
申请日：2005-09-21
申请人： Lorne M. Golub , Maria Emanuel Ryan , Hsi Ming Lee
发明人： Lorne M. Golub , Maria Emanuel Ryan , Hsi Ming Lee
IPC分类号： A61K31/65 , A61P1/02 , A61P9/12 , A61P29/00
CPC分类号： A61K31/65
摘要： The invention is a method for reducing the production of inflammatory mediators, and/or treating conditions characterized by increased levels of inflammatory mediators, in a mammal in need thereof, by administering a 4-dedimethlaminosancycline to the mammal.
摘要翻译：本发明是通过向哺乳动物施用4-去谷氨酰胺素环丁西亚，在有需要的哺乳动物中减少炎性介质的产生和/或治疗特征在于增加炎症介质水平的病症的方法。

2. 发明授权

US5929055A Therapeutic method for management of diabetes mellitus 失效
标题翻译：治疗糖尿病的治疗方法
公开(公告)号：US5929055A
公开(公告)日：1999-07-27
申请号：US880945
申请日：1997-06-23
申请人： Maria Emanuel Ryan , Lorne M. Golub , Nungavaram S. Ramamurthy , Thomas F. McNamara
发明人： Maria Emanuel Ryan , Lorne M. Golub , Nungavaram S. Ramamurthy , Thomas F. McNamara
IPC分类号： A61K45/00 , A61K31/155 , A61K31/175 , A61K31/426 , A61K31/65 , A61K38/28 , A61P3/10
CPC分类号： A61K38/28 , Y10S514/866
摘要： A method for treating diabetes in a mammal by moderately controlling blood glucose concentration in the mammal together with administering to the mammal an amount of a tetracycline compound effective to reduce complications associated with diabetic hyperglycemia. The method enables long term management of diabetes by avoiding the problems associated with tight control of blood glucose concentrations, i.e., hypoglycemia tolerance and seizures, while simultaneously avoiding the problems associated with conventional moderate control of blood glucose concentrations, i.e., pathological complications associated with hyperglycemia, such as nephropathy, retinopathy, etc. Blood glucose concentration can be controlled by moderate administration (e.g., fewer injections per day) of insulin or another glucose-modulating agent, while pathological complications characteristic of diabetic hyperglycemia are ameliorated through the activity of tetracycline compound, the latter preferably administered in an amount that is substantially non-antimicrobial.
摘要翻译：一种通过适度控制哺乳动物中的血糖浓度来治疗哺乳动物的糖尿病的方法，同时向哺乳动物施用一定量的有效减少与糖尿病性高血糖相关并发症的四环素化合物。该方法能够通过避免与血糖浓度的严格控制（即低血糖耐受和癫痫发作）相关的问题，同时避免与常规的中度控制血糖浓度相关的问题，即与高血糖相关的病理性并发症，如肾病，视网膜病变等。血糖浓度可以通过中度给药（例如，每天更少的注射）胰岛素或另一种葡萄糖调节剂来控制，而通过四环素化合物的活性来改善糖尿病性高血糖症状的病理并发症，后者优选以基本上非抗微生物的量施用。

3. 发明授权

US06914057B1 Inhibitor of cataract formation 失效
标题翻译：抑制白内障形成
公开(公告)号：US06914057B1
公开(公告)日：2005-07-05
申请号：US09787866
申请日：1999-09-28
申请人： Maria Emanuel Ryan , Lorne M. Golub , Nungavaram S. Ramamurthy
发明人： Maria Emanuel Ryan , Lorne M. Golub , Nungavaram S. Ramamurthy
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： Methods of reducing the risk of cataract development in a mammal are provided and include administering to the mammal an effective amount of a tetracycline derivative. A preferred tetracycline derivative administered according to the methods of the present invention is 6α-deoxy 5-hydroxy-4-dedimethylaminotetracycline.
摘要翻译：提供降低哺乳动物白内障发展风险的方法，包括向哺乳动物施用有效量的四环素衍生物。根据本发明方法施用的优选的四环素衍生物是6α-脱氧-5-羟基-4-脱二甲基氨基四环素。

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